Assessment of circadian function in fibroblasts of patients with bipolar disorder

Yang, S; Van Dongen, H P A; Wang, K; Berrettini, W; Bućan, M

doi:10.1038/mp.2008.10

Cited by 113Circadian rhythm and melatoninBipolar Disorder and TreatmentSleep and Wakefulness Research

Assessment of circadian function in fibroblasts of patients with bipolar disorder

Yang, S, Van Dongen, H P A, Wang, K, Berrettini, W, Bućan, M·2009·Molecular Psychiatry

DOI 10.1038/mp.2008.10

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Abstract

Previous studies have implicated the circadian system in the pathophysiology of bipolar disorder, but conclusive evidence for altered circadian clocks is lacking. Cultured fibroblasts harbor circadian clocks representative of those in the master clock resident in the suprachiasmatic nuclei, providing a new avenue to investigate the core clock machinery in patients with bipolar illness. We examined the rhythmic expression patterns of core clock genes (BMAL1, PER1, PER2, REV-ERBalpha, DEC2, DBP) in fibroblasts from 12 bipolar patients and 12 healthy controls. Although we did not detect differences in the circadian period between bipolar patients and controls, the amplitude of rhythmic expression for BMAL1, REV-ERBalpha and DBP, as well as the overall mRNA expression level for DEC2 and DBP was reduced in fibroblasts from bipolar patients. Bonferroni's correction for multiple comparisons still resulted in significantly reduced DBP expression level, and trends toward reduced overall expression level of DEC2 and circadian amplitude of BMAL1, in fibroblasts from bipolar patients. We next examined an expanded cohort of 18 bipolar patients and 35 healthy controls for mRNA expression levels of four kinases (CKIdelta, CKIepsilon, GSK3alpha and GSK3beta) and the protein and phosphorylation levels of two of them (GSK3alpha and GSK3beta). We did not detect differences in steady-state mRNA levels or protein levels of these kinases between bipolar patients and controls, but the level of GSK3beta phosphorylation was significantly reduced in bipolar patients within an Old Order Amish bipolar kindred. Our results suggest that the reduced amplitudes and overall expression levels of circadian genes, and the decreased phosphorylation level of GSK3beta may lead to dysregulation of downstream genes, which could explain some pathological features of bipolar disorder.

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Circadian dysfunction associated with psychiatric illnesses likely represents uncoupling of autonomous oscillators in the suprachiasmatic nucleus or disruptions in the output from the suprachiasmatic nucleus to other parts of the brain.
“Circadian dysfunction associated with psychiatric illnesses likely represents uncoupling of autonomous oscillators in the SCN or disruptions in the output from the SCN to other parts of the brain (Yang et al., 2008).”
From Biological rhythms, higher brain function, and behavior: Gaps, opportunities, and challenges (2009) · cites this paper as Yang et al., 2008
Sensitive and specific sleep biomarkers of psychiatric disorders have not been validated.
“Despite some promising early leads, sensitive and specific sleep biomarkers of psychiatric disorders have not been validated (Yang et al., 2008).”
From Biological rhythms, higher brain function, and behavior: Gaps, opportunities, and challenges (2009) · cites this paper as Yang et al., 2008
Intercellular coupling of circadian oscillators can compensate for genetic deficiencies in individual clock components.
“Because intercellular coupling of circadian oscillators can compensate for genetic deficiencies in individual clock components, further understanding of the regulation of coupling could provide novel insight into the mechanisms of increasing”
From Biological rhythms, higher brain function, and behavior: Gaps, opportunities, and challenges (2009) · cites this paper as Yang et al., 2008
Fibroblasts from bipolar patients and healthy individuals show reduced amplitudes and overall expression levels of some circadian genes, and decreased phosphorylation level of GSK3β, which may lead to dysregulation of downstream genes and might account for some pathological features of bipolar disorder.
“Their results suggest that reduced amplitudes and overall expression levels of some circadian genes, and the decreased phosphorylation level of GSK3β, may lead to dysregulation of downstream genes, which might account for some pathological features of bipolar disorder.”
From Biological rhythms, higher brain function, and behavior: Gaps, opportunities, and challenges (2009) · cites this paper as Yang et al., 2008

Prevalence, Severity, and Comorbidity of 12-Month DSM-IV Disorders in the National Comorbidity Survey Replication
Kessler, R. C., Chiu, W. T., Demler, O., & Walters, E. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.617 · Cited by 12,052 · see citing works
Coordination of circadian timing in mammals
Reppert, S. M., & Weaver, D. R. (2002) · Nature · doi:10.1038/nature00965 · Cited by 4,379 · see citing works
The Geometry of Biological Time
Winfree, A. T. (1980) · doi:10.1007/978-3-662-22492-2 · Cited by 3,613 · see citing works
A molecular mechanism for the effect of lithium on development.
Klein, P. S., & Melton, D. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8455 · Cited by 2,305 · see citing works
The Orphan Nuclear Receptor REV-ERBα Controls Circadian Transcription within the Positive Limb of the Mammalian Circadian Oscillator
Preitner, N., Damiola, F., Luis-Lopez-Molina, Zakany, J., Duboule, D., Albrecht, U., & Schibler, U. (2002) · Cell · doi:10.1016/s0092-8674(02)00825-5 · Cited by 2,198 · see citing works
A Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells
Balsalobre, A., Damiola, F., & Schibler, U. (1998) · Cell · doi:10.1016/s0092-8674(00)81199-x · Cited by 2,001 · see citing works
Role of the CLOCK Protein in the Mammalian Circadian Mechanism
Gekakis, N., Staknis, D., Nguyen, H. B., Davis, F. C., Wilsbacher, L. D., King, D. P., Takahashi, J. S., & Weitz, C. J. (1998) · Science · doi:10.1126/science.280.5369.1564 · Cited by 1,997 · see citing works
Resetting of circadian time in peripheral tissues by glucocorticoid signaling
Balsalobre, A., Brown, S. A., Marcacci, L., Tronche, F., Kellendonk, C., Reichardt, H. M., Schütz, G., & Schibler, U. (2000) · Science · doi:10.1126/science.289.5488.2344 · Cited by 1,859 · see citing works
Suprachiasmatic nucleus : the mind's clock
Klein, D. C., Moore, R. Y., & Reppert, S. M. (1991) · Cited by 1,713 · see citing works
Molecular components of the mammalian circadian clock
Ko, C. H., & Takahashi, J. S. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl207 · Cited by 1,657 · see citing works
Mop3 is an essential component of the master circadian pacemaker in mammals.
Bunger, M. K., Wilsbacher, L. D., Moran, S. M., Clendenin, C., Radcliffe, L. A., Hogenesch, J. B., Simon, M. C., Takahashi, J. S., & Bradfield, C. A. (2000) · Cell · doi:10.1016/s0092-8674(00)00205-1 · Cited by 1,621 · see citing works
mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop
Kume, K., Zylka, M. J., Sriram, S., Shearman, L. P., Weaver, D. R., Jin, X., Maywood, E. S., Hastings, M. H., & Reppert, S. M. (1999) · Cell · doi:10.1016/s0092-8674(00)81014-4 · Cited by 1,617 · see citing works
Positional Cloning of the Mouse Circadian Gene
King, D. P., Zhao, Y., Sangoram, A. M., Wilsbacher, L. D., Tanaka, M., Antoch, M. P., Steeves, T. D. L., Vitaterna, M. H., Kornhauser, J. M., Lowrey, P. L., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80245-7 · Cited by 1,382 · see citing works
Interacting molecular loops in the mammalian circadian clock
Shearman, L. P., Sriram, S., Weaver, D. R., Maywood, E. S., Chaves, I., Zheng, B., Kume, K., Lee, C. C., van der, G. T. J., Horst, et al. (2000) · Science · doi:10.1126/science.288.5468.1013 · Cited by 1,367 · see citing works
The Geometry of Biological Time
Winfree, A. T. (2001) · Interdisciplinary applied mathematics · doi:10.1007/978-1-4757-3484-3 · Cited by 1,242 · see citing works
A clockwork web: circadian timing in brain and periphery, in health and disease
Hastings, M. H., Reddy, A. B., & Maywood, E. S. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1177 · Cited by 1,189 · see citing works
Analysis of Longitudinal Data.
Have, T. R. T., Diggle, P. J., Liang, K., & Zeger, S. L. (1995) · Journal of the American Statistical Association · doi:10.2307/2291352 · Cited by 1,171 · see citing works
Lithium salts in the treatment of psychotic excitement
Cade, J. F. (1999) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/j.1440-1614.1999.06241.x · Cited by 1,146 · see citing works
Circadian Gene Expression in Individual Fibroblasts
Nagoshi, E., Saini, C., Bauer, C. R., Laroche, T., Naef, F., & Schibler, U. (2004) · Cell · doi:10.1016/j.cell.2004.11.015 · Cited by 1,003 · see citing works
Mammalian circadian biology: elucidating genome-wide levels of temporal organization
Lowrey, P. L., & Takahashi, J. S. (2004) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.5.061903.175925 · Cited by 976 · see citing works
A transcription factor response element for gene expression during circadian night
Ueda, H. R., Chen, W., Adachi, A. A., Wakamatsu, H., Hayashi, S., Takasugi, T., Nagano, M., Nakahama, K., Suzuki, Y., Sugano, S., et al. (2002) · Nature · doi:10.1038/nature00906 · Cited by 850 · see citing works
double-time Is a Novel Drosophila Clock Gene that Regulates PERIOD Protein Accumulation
Price, J. L., Blau, J., Rothenfluh, A., Abodeely, M., Kloss, B., & Young, M. W. (1998) · Cell · doi:10.1016/s0092-8674(00)81224-6 · Cited by 839 · see citing works
Mania-like behavior induced by disruption of CLOCK
Roybal, K., Theobold, D., Graham, A., DiNieri, J. A., Russo, S. J., Krishnan, V., Chakravarty, S., Peevey, J., Oehrlein, N., Birnbaum, S., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609625104 · Cited by 803 · see citing works
The basic-helix–loop–helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors
Hogenesch, J. B., Gu, Y.-Z., Jain, S. R., & Bradfield, C. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.10.5474 · Cited by 781 · see citing works
Circadian Cycling of the Mouse Liver Transcriptome, as Revealed by cDNA Microarray, Is Driven by the Suprachiasmatic Nucleus
Akhtar, R. A., Reddy, A. B., Maywood, E. S., Clayton, J. D., King, V. M., Smith, A. G., Gant, T. W., Hastings, M. H., & Kyriacou, C. P. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00759-5 · Cited by 777 · see citing works
Bioluminescence imaging of individual fibroblasts reveals persistent, independently phased circadian rhythms of clock gene expression
Welsh, D. K., Yoo, S.-H., Liu, A. C., Takahashi, J. S., & Kay, S. A. (2004) · Current Biology · doi:10.1016/j.cub.2004.11.057 · Cited by 726 · see citing works
Dec1 and Dec2 are regulators of the mammalian molecular clock
Honma, S., Kawamoto, T., Takagi, Y., Fujimoto, K., Sato, F., Noshiro, M., Kato, Y., & Honma, K. (2002) · Nature · doi:10.1038/nature01123 · Cited by 693 · see citing works
Differential regulation of mammalian Period genes and circadian rhythmicity by cryptochromes 1 and 2
Vitaterna, M. H., Selby, C. P., Todo, T., Niwa, H., Thompson, C., Fruechte, E. M., Hitomi, K., Thresher, R. J., Ishikawa, T., Miyazaki, J., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.21.12114 · Cited by 690 · see citing works
The Drosophila Clock Gene double-time Encodes a Protein Closely Related to Human Casein Kinase Iε
Kloss, B., Price, J. L., Sáez, L., Blau, J., Rothenfluh, A., Wesley, C. S., & Young, M. W. (1998) · Cell · doi:10.1016/s0092-8674(00)81225-8 · Cited by 682 · see citing works
The genetics of schizophrenia and bipolar disorder: dissecting psychosis
Craddock, N., O’Donovan, M. C., & Owen, M. J. (2005) · Journal of Medical Genetics · doi:10.1136/jmg.2005.030718 · Cited by 574 · see citing works
Nuclear Receptor Rev-erbα Is a Critical Lithium-Sensitive Component of the Circadian Clock
Yin, L., Wang, J., Klein, P. S., & Lazar, M. A. (2006) · Science · doi:10.1126/science.1121613 · Cited by 556 · see citing works
The hypothalamic integrator for circadian rhythms
Saper, C. B., Lü, J., Chou, T. C., & Gooley, J. J. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2004.12.009 · Cited by 528 · see citing works
A Role for the Segment Polarity Gene shaggy/GSK-3 in the Drosophila Circadian Clock
Martinek, S., Inonog, S., Manoukian, A. S., & Young, M. W. (2001) · Cell · doi:10.1016/s0092-8674(01)00383-x · Cited by 513 · see citing works
Anatomic Demarcation by Positional Variation in Fibroblast Gene Expression Programs
Rinn, J. L., Bondre, C., Gladstone, H. B., Brown, P. O., & Chang, H. Y. (2006) · PLoS Genetics · doi:10.1371/journal.pgen.0020119 · Cited by 505 · see citing works
Multiple signaling pathways elicit circadian gene expression in cultured Rat-1 fibroblasts
Balsalobre, A., Marcacci, L., & Schibler, U. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00758-2 · Cited by 485 · see citing works
Molecular Mechanisms of the Biological Clock in Cultured Fibroblasts
Yagita, K., Tamanini, F., van der Horst, G. T. J., & Okamura, H. (2001) · Science · doi:10.1126/science.1059542 · Cited by 464 · see citing works
Analysis of Longitudinal Data.
Diggle, P. J., Liang, K.-Y., & Zeger, S. L. (1997) · Biometrics · doi:10.2307/2533983 · Cited by 448 · see citing works
Inhibitory Phosphorylation of Glycogen Synthase Kinase-3 (GSK-3) in Response to Lithium
Zhang, F., Phiel, C. J., Spece, L. J., Gurvich, N., & Klein, P. S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212635200 · Cited by 436 · see citing works
CLOCK, an essential pacemaker component, controls expression of the circadian transcription factor DBPPreprint
Ripperger, J. A., Shearman, L. P., Reppert, S. M., & Schibler, U. (2000) · Genes & Development · doi:10.1101/gad.14.6.679 · Cited by 429 · see citing works
Toward constructing an endophenotype strategy for bipolar disorders
Hasler, G., Drevets, W. C., Gould, T. D., Gottesman, I. I., & Manji, H. K. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.11.006 · Cited by 423 · see citing works
Disintegration of the sleep-wake cycle and circadian timing in Huntington's disease
Morton, A. J., Wood, N. I., Hastings, M. H., Hurelbrink, C., Barker, R. A., & Maywood, E. S. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3842-04.2005 · Cited by 403 · see citing works
Photic Induction of mPer1 and mPer2 in Cry -Deficient Mice Lacking a Biological Clock
Okamura, H., Miyake, S., Sumi, Y., Yamaguchi, S., Yasui, A., Muijtjens, M., Hoeijmakers, J. H. J., & van der Horst, G. T. J. (1999) · Science · doi:10.1126/science.286.5449.2531 · Cited by 375 · see citing works
A Role for Glycogen Synthase Kinase-3β in the Mammalian Circadian Clock
Iitaka, C., Miyazaki, K., Akaike, T., & Ishida, N. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503526200 · Cited by 373 · see citing works
Transgenic Mice Overexpressing Glycogen Synthase Kinase 3β: A Putative Model of Hyperactivity and Mania
Prickaerts, J., Moechars, D., Cryns, K., Lenaerts, I., van Craenendonck, H., Goris, I., Daneels, G., Bouwknecht, J. A., & Steckler, T. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.5216-05.2006 · Cited by 341 · see citing works
Influence of CLOCK gene polymorphism on circadian mood fluctuation and illness recurrence in bipolar depression
Benedetti, F., Serretti, A., Colombo, C., Barbini, B., Lorenzi, C., Campori, E., & Smeraldi, E. (2003) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20038 · Cited by 324 · see citing works
Actigraphic assessment of circadian activity and sleep patterns in bipolar disorder
Jones, S. H., Hare, D. J., & Evershed, K. (2005) · Bipolar Disorders · doi:10.1111/j.1399-5618.2005.00187.x · Cited by 323 · see citing works
The Period Length of Fibroblast Circadian Gene Expression Varies Widely among Human Individuals
Brown, S. A., Fleury-Olela, F., Nagoshi, E., Hauser, C., Juge-Aubry, C. E., Meier, C. A., Chicheportiche, R., Dayer, J., Albrecht, U., & Schibler, U. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030338 · Cited by 315 · see citing works
Stopping Time: The Genetics of Fly and Mouse Circadian Clocks
Allada, R., Emery, P., Takahashi, J. S., & Rosbash, M. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1091 · Cited by 315 · see citing works
Suggestive evidence for association of the circadian genes PERIOD3 and ARNTL with bipolar disorder
Nievergelt, C. M., Kripke, D. F., Barrett, T. B., Burg, E., Remick, R. A., Sadovnick, A. D., McElroy, S. L., Keck, P. E., Schork, N. J., & Kelsoe, J. R. (2006) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30252 · Cited by 294 · see citing works
Association study of eight circadian genes with bipolar I disorder, schizoaffective disorder and schizophrenia
Mansour, H. A., Wood, J., Logue, T., Chowdari, K. V., Dayal, M., Kupfer, D. J., Monk, T. H., Devlin, B., & Nimgaonkar, V. L. (2006) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2005.00147.x · Cited by 293 · see citing works
Control of Intracellular Dynamics of Mammalian Period Proteins by Casein Kinase I ε (CKIε) and CKIδ in Cultured Cells
Akashi, M., Tsuchiya, Y., Yoshino, T., & Nishida, E. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.6.1693-1703.2002 · Cited by 292 · see citing works
Involvement of the MAP kinase cascade in resetting of the mammalian circadian clockPreprint
Akashi, M., & Nishida, E. (2000) · Genes & Development · doi:10.1101/gad.14.6.645 · Cited by 269 · see citing works
Endophenotypes in bipolar disorder
Lenox, R. H., Gould, T. D., & Manji, H. K. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.10360 · Cited by 264 · see citing works
Forskolin induces circadian gene expression of rPer1, rPer2 and dbp in mammalian rat‐1 fibroblasts
Yagita, K., & Okamura, H. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01724-x · Cited by 258 · see citing works
Role of DBP in the Circadian Oscillatory Mechanism
Yamaguchi, S., Mitsui, S., Yan, L., Yagita, K., Miyake, S., & Okamura, H. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.13.4773-4781.2000 · Cited by 252 · see citing works
Influence of sleep-wake and circadian rhythm disturbances in psychiatric disorders.
Boivin, D. B. (2000) · PubMed Central · Cited by 247 · see citing works
Actigraphy and Motion Analysis: New Tools for Psychiatry
Teicher, M. H. (1995) · Harvard Review of Psychiatry · doi:10.3109/10673229509017161 · Cited by 231 · see citing works
The mouse Clock mutation reduces circadian pacemaker amplitude and enhances efficacy of resetting stimuli and phase–response curve amplitude
Vitaterna, M. H., Ko, C. H., Chang, A., Buhr, E. D., Fruechte, E. M., Schook, A. C., Antoch, M. P., Turek, F. W., & Takahashi, J. S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603601103 · Cited by 222 · see citing works
Candidate genes, pathways and mechanisms for bipolar (manic-depressive) and related disorders: an expanded convergent functional genomics approach
Ogden, C. A., Rich, M. E., Schork, N. J., Paulus, M. P., Geyer, M. A., Lohr, J. B., Kuczenski, R., & Niculescu, A. B. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001547 · Cited by 221 · see citing works
Identifying a series of candidate genes for mania and psychosis: a convergent functional genomics approach
Niculescu, A. B., Segal, D. S., Kuczenski, R. T., Barrett, T. B., Hauger, R. L., & Kelsoe, J. R. (2000) · Physiological Genomics · doi:10.1152/physiolgenomics.2000.4.1.83 · Cited by 206 · see citing works
Twenty-four-hour profiles of body temperature and plasma TSH in bipolar patients during depression and during remission and in normal control subjects
Souêtre, E., Salvati, E., Wehr, T. A., Sack, D. A., Krebs, B., & DARCOURT, G. (1988) · American Journal of Psychiatry · doi:10.1176/ajp.145.9.1133 · Cited by 188 · see citing works
The sleep of remitted bipolar outpatients: a controlled naturalistic study using actigraphy
Millar, A., Espie, C. A., & Scott, J. L. (2003) · Journal of Affective Disorders · doi:10.1016/s0165-0327(03)00055-7 · Cited by 179 · see citing works
Lithium lengthens the circadian period of individual suprachiasmatic nucleus neurons
Abe, M., Herzog, E. D., & Block, G. D. (2000) · Neuroreport · doi:10.1097/00001756-200009280-00042 · Cited by 169 · see citing works
Circadian secretion of cortisol in bipolar disorder.
Cervantes, P., Gelber, S., Kin, F. N. K. N. Y., Nair, V. N. P., & Schwartz, G. J. (2001) · PubMed Central · Cited by 163 · see citing works
Attenuated Circadian Rhythms in Mice Lacking theProkineticin 2Gene
Li, J., Hu, W., Boehmer, L. N., Cheng, M., Lee, A. G., Jilek, A., Siegel, J. M., & Zhou, Q. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3679-06.2006 · Cited by 160 · see citing works
The Amplitude of Circadian Oscillations: Temperature Dependence, Latitudinal Clines, and the Photoperiodic Time Measurement
Pittendrigh, C. S., Kyner, W. T., & Takamura, T. (1991) · Journal of Biological Rhythms · doi:10.1177/074873049100600402 · Cited by 155 · see citing works
Human casein kinase Iδ phosphorylation of human circadian clock proteins period 1 and 2
Camacho, F., Cilio, M., Guo, Y., Virshup, D. M., Patel, K., Khorkova, O., Styren, S. D., Morse, B., Yao, Z., & Keesler, G. A. (2001) · FEBS Letters · doi:10.1016/s0014-5793(00)02434-0 · Cited by 153 · see citing works
Circadian genes and bipolar disorder
Mansour, H., Monk, T. H., & Nimgaonkar, V. L. (2005) · Annals of Medicine · doi:10.1080/07853890510007377 · Cited by 142 · see citing works
Imaging of single light-responsive clock cells reveals fluctuating free-running periods
Carr, A. F., & Whitmore, D. (2005) · Nature Cell Biology · doi:10.1038/ncb1232 · Cited by 133 · see citing works
Nocturnal melatonin and 24-hour 6-sulphatoxymelatonin levels in various phases of bipolar affective disorder
Kennedy, S. H., Kutcher, S., Ralevski, E., & Brown, G. M. (1996) · Psychiatry Research · doi:10.1016/0165-1781(96)02910-1 · Cited by 133 · see citing works
Mixed-Model Regression Analysis and Dealing with Interindividual Differences
Dongen, H. P. A. V., Olofsen, E., Dinges, D. F., & Maislin, G. (2004) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(04)84010-2 · Cited by 131 · see citing works
Glycogen synthase kinase 3, circadian rhythms, and bipolar disorder: a molecular link in the therapeutic action of lithium
Kaladchibachi, S., Doble, B. W., Anthopoulos, N., Woodgett, J. R., & Manoukian, A. S. (2007) · Journal of Circadian Rhythms · doi:10.1186/1740-3391-5-3 · Cited by 128 · see citing works
CIRCADIAN RHYTHMS, MULTILEVEL MODELS OF EMOTION AND BIPOLAR DISORDER—AN INITIAL STEP TOWARDS INTEGRATION?
Jones, S. H. (2001) · Clinical Psychology Review · doi:10.1016/s0272-7358(01)00111-8 · Cited by 126 · see citing works
It’s All in the Timing: Many Clocks, Many Outputs
Panda, S., & Hogenesch, J. B. (2004) · Journal of Biological Rhythms · doi:10.1177/0748730404269008 · Cited by 125 · see citing works
Rhythm and blues. Neurochemical, neuropharmacological and neuropsychological implications of a hypothesis of circadian rhythm dysfunction in the affective disorders
Healy, D. (1987) · Psychopharmacology · doi:10.1007/bf00187243 · Cited by 123 · see citing works
The 24-Hour Profiles of Cortisol, Prolactin, and Growth Hormone Secretion in Mania
Linkowski, P. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950080028004 · Cited by 116 · see citing works
Circadian rhythm disturbances in manic-depressive illness.
Wehr, T. A., Sack, D. A., Rosenthal, N. E., Duncan, W. R., & Gillin, J. C. (1983) · PubMed · Cited by 111 · see citing works
Lithium Regulates Glycogen Synthase Kinase-3β in Human Peripheral Blood Mononuclear Cells: Implication in the Treatment of Bipolar Disorder
Li, X., Friedman, A. B., Zhu, W., Wang, L., Boswell, S., May, R., Davis, L. L., & Jope, R. S. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.027 · Cited by 110 · see citing works
Phenomic, Convergent Functional Genomic, and biomarker studies in a stress‐reactive genetic animal model of bipolar disorder and co‐morbid alcoholism
Le-Niculescu, H., McFarland, M. J., Ogden, C. A., Balaraman, Y., Patel, S. D., Tan, J., Rodd, Z. A., Paulus, M. P., Geyer, M. A., Edenberg, H. J., et al. (2008) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30707 · Cited by 108 · see citing works
Amplitude Model for the Effects of Mutations and Temperature on Period and Phase Resetting of the Neurospora Circadian Oscillator
Lakin‐Thomas, P. L., Brody, S., & Coté, G. G. (1991) · Journal of Biological Rhythms · doi:10.1177/074873049100600401 · Cited by 103 · see citing works
Effect of lithium on the circadian rhythms of locomotor activity and glycogen synthase kinase-3 protein expression in the mouse suprachiasmatic nuclei
Iwahana, E., Akiyama, M., Miyakawa, K., Uchida, A., Kasahara, J., Fukunaga, K., Hamada, T., & Shibata, S. (2004) · European Journal of Neuroscience · doi:10.1111/j.0953-816x.2004.03322.x · Cited by 103 · see citing works
Hypothalamic‐pituitary‐adrenocortical function in mixed and pure mania
Swann, A. C., Stokes, P. E., Casper, R. C., Secunda, S. K., Bowden, C. L., Berman, N., Katz, M. M., & Robins, E. (1992) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1992.tb01468.x · Cited by 101 · see citing works
Multiple Mechanisms Regulate Circadian Expression of the Gene for Cholesterol 7α-Hydroxylase (Cyp7a) , a Key Enzyme in Hepatic Bile Acid Biosynthesis
Noshiro, M., Usui, E., Kawamoto, T., Kubo, H., Fujimoto, K., Furukawa, M., Honma, S., Makishima, M., Honma, K., & Kato, Y. (2007) · Journal of Biological Rhythms · doi:10.1177/0748730407302461 · Cited by 97 · see citing works
Lithium- and Valproate-Induced Alterations in Circadian Locomotor Behavior in Drosophila
Dokucu, M. E., Yu, L., & Taghert, P. H. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300764 · Cited by 96 · see citing works
Internal interactions within the human circadian system: the masking effect
Wever, R. (1985) · Cellular and Molecular Life Sciences · doi:10.1007/bf02004495 · Cited by 95 · see citing works
Physiologic Indexes in Chronic Insomnia During a Constant Routine: Evidence for General Hyperarousal?
Varkevisser, M., Dongen, H. P. A. V., & KERKHOF, G. A. (2005) · SLEEP · doi:10.1093/sleep/28.12.1588 · Cited by 95 · see citing works
Chronic Treatment with Prednisolone Represses the Circadian Oscillation of Clock Gene Expression in Mouse Peripheral Tissues
Koyanagi, S., Okazawa, S., Kuramoto, Y., Ushijima, K., Shimeno, H., Soeda, S., Okamura, H., & Ohdo, S. (2005) · Molecular Endocrinology · doi:10.1210/me.2005-0165 · Cited by 93 · see citing works
Circadian rhythms in depression
Tsujimoto, T., Yamada, N., Shimoda, K., Hanada, K., & Takahashi, S. (1990) · Journal of Affective Disorders · doi:10.1016/0165-0327(90)90037-9 · Cited by 90 · see citing works
Sleep and circadian rhythms in children and adolescents with bipolar disorder
HARVEY, A. G., MULLIN, B. C., & HINSHAW, S. P. (2006) · Development and Psychopathology · doi:10.1017/s095457940606055x · Cited by 88 · see citing works
Deficient nocturnal surge of TSH secretion during sleep and sleep deprivation in rapid-cycling bipolar illness
Sack, D. A., JAMES, S. P., Rosenthal, N. E., & Wehr, T. A. (1988) · Psychiatry Research · doi:10.1016/0165-1781(88)90008-x · Cited by 76 · see citing works
Comparing linear and nonlinear mixed model approaches to cosinor analysis
Mikulich, S. K., Zerbe, G. O., Jones, R. H., & Crowley, T. J. (2003) · Statistics in Medicine · doi:10.1002/sim.1560 · Cited by 72 · see citing works
The Cortisol Awakening Response in Bipolar Illness: A Pilot Study
Deshauer, D., Duffy, A. C., Alda, M., Grof, E., Albuquerque, J., & Grof, P. (2003) · The Canadian Journal of Psychiatry · doi:10.1177/070674370304800706 · Cited by 65 · see citing works
Glycogen Synthase Kinase 3β as a Likely Target for the Action of Lithium on Circadian Clocks
Padiath, Q. S., Paranjpe, D., Jain, S., & Sharma, V. K. (2004) · Chronobiology International · doi:10.1081/cbi-120027981 · Cited by 64 · see citing works
Autorhythmometry in manic-depressives.
Atkinson, M., Kripke, D. F., & Wolf, S. R. (1976) · PubMed · Cited by 60 · see citing works
Lithium salts in the treatment of psychotic excitement. 1949.
Cade, J. F. (2000) · PubMed · Cited by 57 · see citing works
Editorial
Manji, H. K., & Lenox, R. H. (1998) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00021-9 · Cited by 56 · see citing works
Circadian rhythms in depression
Tsujimoto, T., Yamada, N., Shimoda, K., Hanada, K., & Takahashi, S. (1990) · Journal of Affective Disorders · doi:10.1016/0165-0327(90)90036-8 · Cited by 54 · see citing works
Clock genes, feedback loops and their possible role in the etiology of bipolar disorders: an integrative model
Mitterauer, B. (2000) · Medical Hypotheses · doi:10.1054/mehy.1999.1039 · Cited by 41 · see citing works
Biochemical, molecular and behavioral phenotypes of Rab3A mutations in the mouse
Yang, S., Farias, M. L. C., Kapfhamer, D., Tobias, J. W., Grant, G. R., Abel, T. G., & Bućan, M. (2006) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2006.00235.x · Cited by 36 · see citing works
Self-citation
Why the Rat-1 Fibroblast Should Replace the SCN as the In Vitro Model of Choice
Rosbash, M. (1998) · Cell · doi:10.1016/s0092-8674(00)81197-6 · Cited by 32 · see citing works
The Impact of Diagnoses on Genetic Linkage Study for Bipolar Affective Disorders among the Amish
Egeland, J. A., Sussex, J. N., Endicott, J., Hostetter, A. M., Offord, D. R., Schwab, J. J., Allen, C. R., & Pauls, D. L. (1990) · Psychiatric Genetics · doi:10.1097/00041444-199001020-00002 · Cited by 24 · see citing works
Rhythm and blues
Chaplin, J. (2003) · Routledge eBooks · doi:10.4324/9780203977224-19 · Cited by 23 · see citing works
Diurnal variation of urinary MHPG in unipolar and bipolar depressives
Giedke, H., and, H. J. G., & Mahal, A. (1982) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1982.tb00932.x · Cited by 21 · see citing works
Disruption of circadian MHPG rhythmicity in major depression
Piletz, J. E., DeMet, E. M., Gwirtsman, H. E., & Halaris, A. E. (1994) · Biological Psychiatry · doi:10.1016/0006-3223(94)90018-3 · Cited by 8 · see citing works
Circadian variation in total plasma tryptophan. Antidepressant treatment: Drugs and phase advance
Candito, M., Pringuey, D., Iordache, A., Souêtre, E., Chambon, P., & DARCOURT, G. (1992) · Life Sciences · doi:10.1016/0024-3205(92)90178-r · Cited by 6 · see citing works

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Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes
(2018) · doi:10.1016/j.cell.2018.05.046 · Cited by 744 · see citing works
Self-citation
Circadian rhythms, sleep deprivation, and human performance
Goel, N., Basner, M., Rao, H., & Dinges, D. F. (2013) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-396971-2.00007-5 · Cited by 400 · see citing works
Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopamine Production and Mood Regulation
Chung, S., Lee, E. J., Yun, S., Choe, H. K., Park, S., Son, H. J., Kim, K., Dluzen, D. E., Lee, I., Hwang, O., et al. (2014) · Cell · doi:10.1016/j.cell.2014.03.039 · Cited by 298 · see citing works
Circadian rhythms and sleep in bipolar disorder
Murray, G., & Harvey, A. G. (2010) · Bipolar Disorders · doi:10.1111/j.1399-5618.2010.00843.x · Cited by 250 · see citing works
Biomarkers in bipolar disorder: a positional paper from the international society for bipolar disorders biomarkers task force.
Frey, B. N., Andreazza, A. C., Houenou, J., Jamain, S., Goldstein, B. I., Frye, M. A., Leboyer, M., Berk, M., Malhi, G. S., Lopez-Jaramillo, C., et al. (2013) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867413478217 · Cited by 234 · see citing works
Cellular Circadian Clocks in Mood Disorders
McCarthy, M. J., & Welsh, D. K. (2012) · Journal of Biological Rhythms · doi:10.1177/0748730412456367 · Cited by 203 · see citing works
Convergent functional genomics of genome‐wide association data for bipolar disorder: Comprehensive identification of candidate genes, pathways and mechanisms
Le‐Niculescu, H., Patel, S. D., Bhat, M., Kuczenski, R., Faraone, S. V., Tsuang, M. T., McMahon, F. J., Schork, N. J., Nurnberger, J. I., & Niculescu, A. B. (2009) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30887 · Cited by 201 · see citing works
Lithium Impacts on the Amplitude and Period of the Molecular Circadian Clockwork
Li, J., Lu, W., Beesley, S., Loudon, A. S. I., & Meng, Q. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033292 · Cited by 169 · see citing works
Genetic and clinical factors predict lithium’s effects on PER2 gene expression rhythms in cells from bipolar disorder patients
McCarthy, M. J., Wei, H., Marnoy, Z., Darvish, R. M., McPhie, D. L., Cohen, B. M., & Welsh, D. K. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.90 · Cited by 137 · see citing works
Neurobiological and behavioral mechanisms of circadian rhythm disruption in bipolar disorder: A critical multi‐disciplinary literature review and agenda for future research from the ISBD task force on chronobiology
McCarthy, M. J., Gottlieb, J. F., Gonzalez, R., McClung, C. A., Alloy, L. B., Cain, S., Dulcis, D., Etain, B., Frey, B. N., Garbazza, C., et al. (2022) · Bipolar Disorders · doi:10.1111/bdi.13165 · Cited by 136 · see citing works
Current understanding of bipolar disorder: Toward integration of biological basis and treatment strategies
Kato, T. (2019) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12852 · Cited by 138 · see citing works
Biological rhythms, higher brain function, and behavior: Gaps, opportunities, and challenges
Benca, R., Duncan, M. J., Frank, E., McClung, C., Nelson, R. J., & Vicentic, A. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.09.005 · Cited by 125 · see citing works
The circadian system of patients with bipolar disorder differs in episodes of mania and depression
Nováková, M., Praško, J., Látalová, K., Sládek, M., & Sumová, A. (2015) · Bipolar Disorders · doi:10.1111/bdi.12270 · Cited by 123 · see citing works
Altered circadian clock gene expression in patients with schizophrenia
Johansson, A.-S., Owe-Larsson, B., Hetta, J., & Lundkvist, G. B. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.04.029 · Cited by 120 · see citing works
Circadian Rhythms in Sleepiness, Alertness, and Performance
Minkel, J. D., & Dinges, D. F. (2009) · Elsevier eBooks · doi:10.1016/b978-008045046-9.01622-3 · Cited by 115 · see citing works
Genetic and functional abnormalities of the melatonin biosynthesis pathway in patients with bipolar disorder
Étain, B., Dumaine, A., Bellivier, F., Pagan, C., Francelle, L., Goubran‐Botros, H., Moreno, S., Deshommes, J., Moustafa, K., Dudal, K. L., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds227 · Cited by 105 · see citing works
Sleep- and circadian rhythm–associated pathways as therapeutic targets in bipolar disorder
Bellivier, F., Geoffroy, P.-A., Etain, B., & Scott, J. (2015) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2015.1018822 · Cited by 104 · see citing works
Molecular neurobiology of bipolar disorder: a disease of ‘mood-stabilizing neurons’?
Kato, T. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.07.007 · Cited by 102 · see citing works
Valproic Acid Phase Shifts the Rhythmic Expression of PERIOD2::LUCIFERASE
Johansson, A.-S., Brask, J., Owe-Larsson, B., Hetta, J., & Lundkvist, G. B. S. (2011) · Journal of Biological Rhythms · doi:10.1177/0748730411419775 · Cited by 97 · see citing works
Functional genetic variation in the Rev-Erbαpathway and lithium response in the treatment of bipolar disorder
McCarthy, M. J., Nievergelt, C. M., Shekhtman, T., Kripke, D. F., Welsh, D. K., & Kelsoe, J. R. (2011) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2011.00725.x · Cited by 97 · see citing works
Clinical classification in mental health at the cross-roads: which direction next?
Hickie, I. B., Scott, J. L., Hermens, D. F., Scott, E. M., Naismith, S. L., Guastella, A. J., Glozier, N., & McGorry, P. D. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-125 · Cited by 88 · see citing works
Transcriptome study of differential expression in schizophrenia
Sanders, A. R., Göring, H. H. H., Duan, J., Drigalenko, E. I., Moy, W., Freda, J., S, D. H. B., Shi, J., & Gejman, P. V. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt350 · Cited by 87 · see citing works
Genetic contributions to circadian activity rhythm and sleep pattern phenotypes in pedigrees segregating for severe bipolar disorder
Pagani, L., Clair, P. A. S., Teshiba, T. M., Service, S. K., Fears, S. C., Araya, C., Araya, X., Bejarano, J., Ramirez, M., Castrillón, G., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1513525113 · Cited by 88 · see citing works
Circadian biomarkers, circadian genes and bipolar disorders
Milhiet, V., Étain, B., Boudebesse, C., & Bellivier, F. (2011) · Journal of Physiology-Paris · doi:10.1016/j.jphysparis.2011.07.002 · Cited by 87 · see citing works
Association between circadian genes, bipolar disorders and chronotypes
Étain, B., Jamain, S., Milhiet, V., Lajnef, M., Boudebesse, C., Dumaine, A., Mathieu, F., Gombert, A., Dudal, K. L., Gard, S., et al. (2014) · Chronobiology International · doi:10.3109/07420528.2014.906445 · Cited by 83 · see citing works
Peripheral Biomarkers Revisited: Integrative Profiling of Peripheral Samples for Psychiatric Research
Hayashi‐Takagi, A., Vawter, M. P., & Iwamoto, K. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.09.035 · Cited by 80 · see citing works
Mitochondrial dysfunction as a critical event in the pathophysiology of bipolar disorder
Scaini, G., Andrews, T., Lima, C. N. D. C., Benevenuto, D., STRECK, E. L., & Quevedo, J. (2020) · Mitochondrion · doi:10.1016/j.mito.2020.12.002 · Cited by 77 · see citing works
Coming to grips with complex disorders: Genetic risk prediction in bipolar disorder using panels of genes identified through convergent functional genomics
Patel, S. D., Le-Niculescu, H., Koller, D. L., Green, S. D., Lahiri, D. K., McMahon, F. J., Nürnberger, J. I., & Niculescu, A. B. (2010) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31087 · Cited by 74 · see citing works
Glymphatic Dysfunction: A Bridge Between Sleep Disturbance and Mood Disorders
Yan, T., Qiu, Y., Yu, X., & Yang, L. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.658340 · Cited by 75 · see citing works
Human Peripheral Clocks: Applications for Studying Circadian Phenotypes in Physiology and Pathophysiology
Saini, C., Brown, S. A., & Dibner, C. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00095 · Cited by 71 · see citing works
Mood‐related central and peripheral clocks
Ketchesin, K. D., Becker‐Krail, D. D., & McClung, C. A. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14253 · Cited by 60 · see citing works
Neural function of Bmal1: an overview
Zheng, Y., Pan, L., Wang, F., Yan, J., Wang, T., Xia, Y., Yao, L., Deng, K., Zheng, Y., Xia, X., et al. (2023) · Cell & Bioscience · doi:10.1186/s13578-022-00947-8 · Cited by 60 · see citing works
Cellular models to study bipolar disorder: A systematic review
Viswanath, B., Jose, S. P., Squassina, A., Thirthalli, J., Purushottam, M., Mukherjee, O., Vladimirov, V. I., Patrinos, G. P., Zompo, M. D., & Jain, S. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.05.037 · Cited by 58 · see citing works
Altered Dynamics in the Circadian Oscillation of Clock Genes in Dermal Fibroblasts of Patients Suffering from Idiopathic Hypersomnia
Lippert, J., Halfter, H., Heidbreder, A., Röhr, D., Gess, B., Boentert, M., Osada, N., & Young, P. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085255 · Cited by 58 · see citing works
Lithium differentially affects clock gene expression in serum-shocked NIH-3T3 cells
Osland, T. M., Fernø, J., Håvik, B., Heuch, I., Ruoff, P., Lærum, O. D., & Steen, V. M. (2010) · Journal of Psychopharmacology · doi:10.1177/0269881110379508 · Cited by 56 · see citing works
Chronotherapeutics and psychiatry: Setting the clock to relieve the symptoms
Coogan, A. N., & Thome, J. (2011) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2011.598389 · Cited by 53 · see citing works
Disruption of circadian rhythmicity and suprachiasmatic action potential frequency in a mouse model with constitutive activation of glycogen synthase kinase 3
Paul, J. R., Johnson, R. L., Jope, R. S., & Gamble, K. L. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.08.047 · Cited by 51 · see citing works
Modeling and Validating Chronic Pharmacological Manipulation of Circadian Rhythms
Kim, J. K., Forger, D. B., Marconi, M., Wood, D., Doran, A. C., Wager, T. T., Chang, C., & Walton, K. (2013) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1038/psp.2013.34 · Cited by 49 · see citing works
Circadian abnormalities as markers of susceptibility in bipolar disorders
Étain, B. (2014) · Frontiers in Bioscience-Scholar · doi:10.2741/s419 · Cited by 47 · see citing works
Genomic Landscape of a Three-Generation Pedigree Segregating Affective Disorder
Yang, S., Wang, K., Gregory, B. L., Berrettini, W. H., Wang, L., Hakonarson, H. H., & Bućan, M. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004474 · Cited by 42 · see citing works
Self-citation
The long-term abnormalities in circadian expression of Period 1 and Period 2 genes in response to stress is normalized by agomelatine administered immediately after exposure
Koresh, O., Kozlovsky, N., Kaplan, Z., Zohar, J., Matar, M. A., & Cohen, H. (2012) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2011.07.012 · Cited by 40 · see citing works
Human cellular differences in cAMP ‐ CREB signaling correlate with light‐dependent melatonin suppression and bipolar disorder
Gaspar, L., van de Werken, M., Johansson, A.-S., Moriggi, E., Owe‐Larsson, B., Kocks, J. W. H., Lundkvist, G. B. S., Gordijn, M. C. M., & Brown, S. A. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12602 · Cited by 38 · see citing works
Genetic adaptation of the human circadian clock to day-length latitudinal variations and relevance for affective disorders
Forni, D., Pozzoli, U., Cagliani, R., Tresoldi, C., Menozzi, G., Riva, S., Guerini, F. R., Comi, G. P., Bolognesi, E., Bresolin, N., et al. (2014) · Genome biology · doi:10.1186/s13059-014-0499-7 · Cited by 35 · see citing works
Human dermal fibroblasts in psychiatry research
Kalman, J. L., Garbett, K. A., Janka, Z., & Mirnics, K. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.01.067 · Cited by 38 · see citing works
Lithium acts to modulate abnormalities at behavioral, cellular, and molecular levels in sleep deprivation‐induced mania‐like behavior
Andrabi, M., Andrabi, M. M., Kunjunni, R., Sriwastva, M. K., Bose, S., Sagar, R., Srivastava, A. K., Mathur, R., Jain, S., & Subbiah, V. (2019) · Bipolar Disorders · doi:10.1111/bdi.12838 · Cited by 34 · see citing works
Patient fibroblast circadian rhythms predict lithium sensitivity in bipolar disorder
Sanghani, H., Jagannath, A., Humberstone, T., Ebrahimjee, F., Thomas, J. M., Churchill, G. C., Cipriani, A., Attenburrow, M.-J., Perestenko, O. V., Cowley, S. A., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0769-6 · Cited by 33 · see citing works
Sleep Phenotyping in a Mouse Model of Extreme Trait Anxiety
Jakubcakova, V., Flachskamm, C., Landgraf, R., & Kimura, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040625 · Cited by 30 · see citing works
Valproic acid disrupts the oscillatory expression of core circadian rhythm transcription factors
Griggs, C. A., Malm, S. W., Jaime-Frias, R., & Smith, C. L. (2017) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2017.12.005 · Cited by 30 · see citing works
Moléculas que marcam o tempo: implicações para os fenótipos circadianos
Pereira, D. S., Tufik, S., & Pedrazzoli, M. (2009) · Brazilian Journal of Psychiatry · doi:10.1590/s1516-44462009000100015 · Cited by 25 · see citing works
The impact of lithium on circadian rhythms and implications for bipolar disorder pharmacotherapy
Rohr, K. E., & McCarthy, M. J. (2022) · Neuroscience Letters · doi:10.1016/j.neulet.2022.136772 · Cited by 27 · see citing works
Circadian Rhythms in Mood Disorders
Scott, M. R., & McClung, C. A. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-81147-1_9 · Cited by 26 · see citing works
Circadian Rhythms in Sleepiness, Alertness, and Performance
Goel, N., Dongen, H. P. A. V., & Dinges, D. F. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4160-6645-3.00038-4 · Cited by 26 · see citing works
Finding Rare, Disease-Associated Variants in Isolated Groups: Potential Advantages of Mennonite Populations
Lopes, F. L., Hou, L., Boldt, A. B. W., Kassem, L., Alves, V. D. M., Nardi, A. E., & McMahon, F. J. (2016) · Human Biology · doi:10.13110/humanbiology.88.2.0109 · Cited by 25 · see citing works
Circadian Disruptions in the Myshkin Mouse Model of Mania Are Independent of Deficits in Suprachiasmatic Molecular Clock Function
Timothy, J. W. S., Klas, N., Sanghani, H., Al-Mansouri, T., Hughes, A. T. L., Kirshenbaum, G. S., Brienza, V., Belle, M. D. C., Ralph, M. R., Clapcote, S. J., et al. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.04.018 · Cited by 25 · see citing works
Convergent functional genomics of psychiatric disorders
Niculescu, A. B. (2013) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32163 · Cited by 24 · see citing works
Clock genes in health and diseases
Mongrain, V., & Cermakian, N. (2009) · Journal of Applied Biomedicine · doi:10.32725/jab.2009.002 · Cited by 23 · see citing works
Identification of circadian gene variants in bipolar disorder in Latino populations
Gonzalez, R., Gonzalez, S., Villa, E. C., Ramírez, M., Zavala, J., Armas, R., Contreras, J., Dassori, A. M., Leach, R. J., Flores, D. L., et al. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.07.014 · Cited by 23 · see citing works
Application of an ex vivo cellular model of circadian variation for bipolar disorder research: a proof of concept study
Bamne, M. N., Ponder, C. A., Wood, J. A., Mansour, H., Frank, E., Kupfer, D. J., Young, M. W., & Nimgaonkar, V. L. (2013) · Bipolar Disorders · doi:10.1111/bdi.12095 · Cited by 22 · see citing works
Combined cortisol and melatonin measurements with detailed parameter analysis can assess the circadian rhythms in bipolar disorder patients
Fang, L., Yu, Q., Yin, F., Yu, J., Zhang, Y., Zhang, Y., Zhu, D., & Qin, X. (2021) · Brain and Behavior · doi:10.1002/brb3.2186 · Cited by 21 · see citing works
Baseline Clinical and Biomarker Characteristics of Biobank Innovations for Chronic Cerebrovascular Disease With Alzheimer’s Disease Study: BICWALZS
Roh, H. W., Kim, N., Lee, D. A., Cheong, J. Y., Seo, S. W., Choi, S. H., Kim, E., Cho, S. H., Kim, B. C., Kim, S. Y., et al. (2022) · Psychiatry Investigation · doi:10.30773/pi.2021.0335 · Cited by 20 · see citing works
Measuring Circadian Clock Function in Human Cells
Gaspar, L., & Brown, S. A. (2015) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2014.10.023 · Cited by 21 · see citing works
Post-stroke depression and the aging brain
Cojocaru, G. R., Popa‐Wagner, A., Stănciulescu, E. C., Babadan, L., & Buga, A.-M. (2013) · Journal of Molecular Psychiatry · doi:10.1186/2049-9256-1-14 · Cited by 20 · see citing works
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Genetic factors in the etiology of bipolar disorder
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Fibroblasts as an in vitro model of circadian genetic and genomic studiesPreprint
Francia, M., Bot, M. H. M., Boltz, T. A., Hoz, J. D. L., Boks, M. P., Kahn, R. S., & Ophoff, R. A. (2024) · Research Square · doi:10.21203/rs.3.rs-4397132/v1 · Cited by 1 · see citing works
Decoding the Genetics and Underlying Mechanisms of Mood Disorders Sevilla D. Detera-Wadleigh and Takeo Yoshikawa
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Circadian Rhythms and Clock Genes in Inter-episode Bipolar Disorder
McGlinchey, E. L. (2012) · eScholarship (California Digital Library)

Gene expression of circadian genes and CIART in bipolar disorder: A preliminary case-control study
Courtin, C., Cynthia Marie-claire, A., Gross, G., Hennion, V., Mundwiller, E., Guégan, J., Meyrel, M., Bellivier, F., & Étain, B. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110691 · Cited by 17 · see citing works
Fibroblasts as an in vitro model of circadian genetic and genomic studies: A temporal analysisPreprint
Francia, M., Bot, M. H. M., Boltz, T. A., Hoz, J. D. L., Boks, M. P., Kahn, R. S., & Ophoff, R. A. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.19.541494 · Cited by 3 · see citing works
Fibroblasts as an in vitro model of circadian genetic and genomic studiesPreprint
Francia, M., Bot, M. H. M., Boltz, T. A., Hoz, J. D. L., Boks, M. P., Kahn, R. S., & Ophoff, R. A. (2024) · Research Square · doi:10.21203/rs.3.rs-4397132/v1 · Cited by 1 · see citing works
Alterations in Circadian Clock Genes Linked to Bipolar Disorder
MECHCATIE, E. (2010) · Clinical Psychiatry News · doi:10.1016/s0270-6644(10)70082-5
Revving Up the Circadian Clock
(2006) · Science s STKE · doi:10.1126/stke.3232006tw73

Authors: Yang, S., Van Dongen, H. P. A., Wang, K., Berrettini, W., & Bućan, M.
Affiliations: University of Pennsylvania (US)
Corresponding author: Bućan, M
ORCID: Yang, S
Berrettini, W
Bućan, M
Venue: Molecular Psychiatry
Publisher: Springer Science and Business Media LLC
Published: 2008-02-26
Volume: 14
Issue: 2
Pages: 143-155
ISSN: 1359-4184 (ISSN-L)
1476-5578
DOI: 10.1038/mp.2008.10
OpenAlex: W2038664453
Cited by: 113
References: 106
Citations by year: 2026: 2 · 2025: 3 · 2024: 7 · 2023: 3 · 2022: 6 · 2021: 7 · 2020: 5 · 2019: 4 · 2018: 4 · 2017: 3 · 2016: 9 · 2015: 7 · 2014: 10 · 2013: 14 · 2012: 7
FWCI: 3.11
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Molecular Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (R21MH078179, R01MH604687)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords: bipolar disorder, circadian clock, fibroblasts, core clock genes, Bmal1, DBP, DEC2, NR1D1, Per1, Per2, GSK3β phosphorylation, suprachiasmatic nucleus, circadian rhythm amplitude
MeSH terms: Adult, Age Factors, Analysis of Variance, Bipolar Disorder, Cells, Cultured, Circadian Rhythm, Female, Fibroblasts, Gene Expression Regulation, Humans, Male, Middle Aged, Protein Kinases, RNA, Messenger, Time Factors, Gene Expression, Case-Control Studies, Culture Media, Serum-Free, Cell Cycle Proteins, Serum, Young Adult

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Assessment of circadian function in fibroblasts of patients with bipolar disorder

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