Evidence for the existence of dopamine d2-oxytocin receptor heteromers in the ventral and dorsal striatum with facilitatory receptor–receptor interactions
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D2 receptor-oxytocin receptor heteromers with facilitatory interactions exist in the striatum.
“and there are also D2R-OXTR heteromers with facilitatory receptor-receptor interactions in the striatum (16).”
From Oxytocin enhances brain reward system responses in men viewing the face of their female partner (2013) · cites this paper as [16]
An increase in the BRET signal after OXT and quinpirole co-stimulation could also be explained by co-location/co-presence of OXTR and D2R in small endocytic vesicles, but this is considered less likely.
“An increase in the BRET signal after OXT and quinpirole co-stimulation could also be explained by the co-location/co-presence of OXTR and D2R in small endocytic vesicles (Gomes et al., 2016). However, while this possibility cannot be excluded, it is considered less likely in view of the experimental data reported previously (Romero-Fernandez et al., 2013).”
From Evidence for the existence of facilitatory interactions between the dopamine D2 receptor and the oxytocin receptor in the amygdala of the rat relevance for anxiolytic actions (2023) · cites this paper as Romero-Fernandez et al., 2013
D2R-OXTR heterocomplexes were previously shown to occur in the nucleus accumbens shell and dorsal striatum of the rat in terms of D2R signaling and recognition.
“Previously, heterocomplexes formed by D2R and OXTR protomers were shown to take place in the nucleus accumbens shell and the dorsal striatum of the rat in terms of D2R signaling and recognition (Romero-Fernandez et al., 2013; Borroto-Escuela et al., 2022).”
From Evidence for the existence of facilitatory interactions between the dopamine D2 receptor and the oxytocin receptor in the amygdala of the rat relevance for anxiolytic actions (2023) · cites this paper as Romero-Fernandez et al., 2013
Co-location/co-presence of OXTR and D2R in small endocytic vesicles is a less likely explanation for the increase in BRET signal after OXT and quinpirole co-stimulation.
“An increase in the BRET signal after OXT and quinpirole co-stimulation could also be explained by the co-location/co-presence of OXTR and D2R in small endocytic vesicles (Gomes et al., 2016). However, while this possibility cannot be excluded, it is considered less likely in view of the experimental data reported previously (Romero-Fernandez et al., 2013).”
From Evidence for the existence of facilitatory interactions between the dopamine D2 receptor and the oxytocin receptor in the amygdala of the rat relevance for anxiolytic actions (2023) · cites this paper as Romero-Fernandez et al., 2013
Oxytocin increases D2R Gi/o coupling in accumbal membranes.
“It was found that oxytocin increased D2R Gi/o coupling in accumbal membranes, using the GTP gamma S accumulation assay (Romero-Fernandez et al., 2013).”
From The oxytocin receptor represents a key hub in the GPCR heteroreceptor network: Potential relevance for brain and behavior (2022) · cites this paper as Romero-Fernandez et al., 2013
Oxytocin at 3 nM increases the maximal binding capacity (Bmax) values for the D2R antagonist in accumbal membranes.
“In D2R binding saturation experiments in accumbal membranes using 3H-raclopride (D2R antagonist), oxytocin at 3 nM increased the maximal binding capacity (Bmax) values for the D2R antagonist”
From The oxytocin receptor represents a key hub in the GPCR heteroreceptor network: Potential relevance for brain and behavior (2022) · cites this paper as Romero-Fernandez et al., 2013
Oxytocin (3 nM) highly significantly increases the affinity of the high-affinity D2R agonist binding sites in accumbal membranes.
“In 3H-raclopride competition experiments with dopamine (DA), oxytocin (3 nM) highly significantly increased the affinity of the high-affinity D2R agonist binding sites”
From The oxytocin receptor represents a key hub in the GPCR heteroreceptor network: Potential relevance for brain and behavior (2022) · cites this paper as Romero-Fernandez et al., 2013
D2R-OXTR heterocomplexes exist in the nucleus accumbens and the caudate putamen of rats.
“In 2013, evidence was obtained for the existence of D2R-OXTR heterocomplexes in the nucleus accumbens and the caudate putamen (Romero-Fernandez et al., 2013) using in situ proximity ligation assay”
From The oxytocin receptor represents a key hub in the GPCR heteroreceptor network: Potential relevance for brain and behavior (2022) · cites this paper as Romero-Fernandez et al., 2013
The OXTR forms heteroreceptor complexes with dopamine D2R, 5-HT2AR, and 5-HT2CR protomers.
“In this review, we will deal with the discovered OXTR heteroreceptor complexes and their function, in which the dopamine D2R protomers (Romero-Fernandez et al., 2013; de la Mora et al., 2016), 5-HT2AR and 5-HT2CR protomers (Chruścicka et al., 2019, 2021; Wallace Fitzsimons et al., 2019) participate”
From The oxytocin receptor represents a key hub in the GPCR heteroreceptor network: Potential relevance for brain and behavior (2022) · cites this paper as Romero-Fernandez et al., 2013
D2R-OXTR heterocomplexes play a significant role in social behavior.
“Based on the outstanding work of Young and colleagues on the interactions between DA and OXT systems (Young and Wang, 2004) and in line with the results of Romero-Fernandez (Romero-Fernandez et al., 2013), it seems likely that the D2R-OXTR heterocomplexes play a significant role in social behavior.”
From The oxytocin receptor represents a key hub in the GPCR heteroreceptor network: Potential relevance for brain and behavior (2022) · cites this paper as Romero-Fernandez et al., 2013
A specific crosstalk between OXTR and 5-HT2AR exists, and OXTR had already been demonstrated in a D2R-OXTR heterocomplex.
“Therefore, a specific crosstalk between the OXTR and the 5-HT2AR receptors exists and the OXTR had also already been demonstrated in another heterocomplex of D2R-OXTR (Romero-Fernandez et al., 2013; Figures 1, 2).”
From The oxytocin receptor represents a key hub in the GPCR heteroreceptor network: Potential relevance for brain and behavior (2022) · cites this paper as Romero-Fernandez et al., 2013
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- Authors
- Romero-Fernandez, W., Borroto-Escuela, D. O., Agnati, L. F., & Fuxe, K.
- Affiliations
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Venue
- Molecular Psychiatry
- Published
- 2012-07-24
- Volume
- 18
- Issue
- 8
- Pages
- 849-850
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- OpenAlex
- W2026372472
- Cited by
- 179
- References
- 9
- Citations by year
- 2026: 4 · 2025: 18 · 2024: 14 · 2023: 7 · 2022: 17 · 2021: 13 · 2020: 24 · 2019: 7 · 2018: 20 · 2017: 14 · 2016: 13 · 2015: 10 · 2014: 7 · 2013: 11
- FWCI
- 3.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- dopamine D2 receptor, oxytocin receptor, receptor heteromers, ventral striatum, dorsal striatum, receptor-receptor interactions
- MeSH terms
- Allosteric Regulation, Animals, Corpus Striatum, Humans, Receptors, Dopamine D2, Receptors, Oxytocin, Receptor Cross-Talk, Rats, Protein Multimerization, HEK293 Cells
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