Oxytocin enhances attractiveness of unfamiliar female faces independent of the dopamine reward system
Abstract
Evidence from animal studies suggests that the social attraction and bonding effects of the neuropeptide oxytocin (OXT) are mediated by its modulation of dopamine (DA) release in brain reward centers, but this has not yet been demonstrated in humans. DA release can be measured by positron emission tomography (PET) using the radioligand [11C]raclopride. Its binding to DA D2 receptors (D2R) is sensitive and reciprocally related to endogenous DA, especially in the striatum. In a randomized double-blind placebo-controlled within-subjects trial on 18 adult male volunteers we combined [11C]raclopride PET and a facial attractiveness rating task to establish whether intranasal OXT (24 IU) increased both the perceived attractiveness of unfamiliar female faces and striatal DA release compared with placebo administration. While our behavioral data confirmed that subjects rated unfamiliar female faces as more attractive following OXT treatment, and this correlated with an increased perfusion rate in the striatum, there was no evidence for altered [11C]raclopride binding in the striatum or pallidum. Instead under OXT we rather observed an increased [11C]raclopride binding and reduced perfusion rate in subregions of the right dorsomedial prefrontal gyrus and superior parietal gyrus. The absence of OXT effects on dopamine release and D2 receptors in brain reward centers, despite increased striatal activity, implies that the peptide may facilitate perceived attraction via non-dopaminergic actions.
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Social touch in general and the oxytocin effect on hedonic value and neural response to human touch in particular are context dependent.
“Our results strongly corroborate the notion that social touch in general and the OXT effect on hedonic value and neural response to human touch in particular are context dependent (Scheele et al, 2012; Striepens et al, 2014; Striepens et al, 2012).”
From An oxytocin-induced facilitation of neural and emotional responses to social touch correlates inversely with autism traits (2014) · cites this paper as Striepens et al, 2014
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- Authors
- Striepens, N., Matusch, A., Kendrick, K. M., Mihov, Y., Elmenhorst, D., Becker, B., Lang, M., Coenen, H. H., Maier, W., Hurlemann, R., & Bauer, A.
- Affiliations
- University of Bonn (DE)
- Forschungszentrum Jülich (DE)
- University of Electronic Science and Technology of China (CN)
- Corresponding author
- Hurlemann, René
- ORCID
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 39
- Pages
- 74-87
- ISSN
- 0306-4530 (ISSN-L)
- OpenAlex
- W2158733443
- Semantic Scholar
- ebf077e3c18886f1e2da994547631642825bc4b3
- Cited by
- 71
- References
- 63
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 5 · 2023: 2 · 2022: 4 · 2021: 10 · 2020: 3 · 2019: 4 · 2018: 6 · 2017: 9 · 2016: 7 · 2015: 10 · 2014: 8
- FWCI
- 12.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- DZNE Pub (submittedVersion)
- Funders
- Ministry of Innovation, Science, Research & Technology of the German State of North Rhine-Westphalia
- University of Bonn
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Evolutionary Psychology and Human Behavior
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- oxytocin, facial attractiveness, female faces, dopamine release, dopamine D2 receptor, striatum, brain reward system, [11C]raclopride PET, social attraction, dorsomedial prefrontal cortex, superior parietal gyrus, intranasal oxytocin
- MeSH terms
- Adult, Corpus Striatum, Dopamine, Double-Blind Method, Face, Female, Humans, Male, Oxytocin, Radionuclide Imaging, Raclopride
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