Cited by 247DNA Repair MechanismsDNA and Nucleic Acid ChemistryCarcinogens and Genotoxicity Assessment

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Preferential cis–syn thymine dimer bypass by DNA polymerase η occurs with biased fidelity

McCulloch, Scott D., Kokoska, Robert J., Masutani, Chikahide, Iwai, Shigenori, Hanaoka, Fumio, Kunkel, Thomas A.·2004·Nature

DOI 10.1038/nature02352

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Abstract

Human DNA polymerase eta (Pol eta) modulates susceptibility to skin cancer by promoting DNA synthesis past sunlight-induced cyclobutane pyrimidine dimers that escape nucleotide excision repair (NER). Here we have determined the efficiency and fidelity of dimer bypass. We show that Pol eta copies thymine dimers and the flanking bases with higher processivity than it copies undamaged DNA, and then switches to less processive synthesis. This ability of Pol eta to sense the dimer location as synthesis proceeds may facilitate polymerase switching before and after lesion bypass. Pol eta bypasses a dimer with low fidelity and with higher error rates at the 3' thymine than at the 5' thymine. A similar bias is seen with Sulfolobus solfataricus DNA polymerase 4, which forms a Watson-Crick base pair at the 3' thymine of a dimer but a Hoogsteen base pair at the 5' thymine (ref. 3). Ultraviolet-induced mutagenesis is also higher at the 3' base of dipyrimidine sequences. Thus, in normal people and particularly in individuals with NER-defective xeroderma pigmentosum who accumulate dimers, errors made by Pol eta during dimer bypass could contribute to mutagenesis and skin cancer.

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Masutani, C., Kusumoto, R., Yamada, A., Dohmae, N., Yokoi, M., Yuasa, M., Araki, M., Iwai, S., Takio, K., & Hanaoka, F. (1999) · Nature · doi:10.1038/21447 · Cited by 1,292
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Tian, F., Sharma, S., Zou, J., Lin, S., Wang, B., Rezvani, K. S., Wang, H., Parvin, J. D., Ludwig, T., Canman, C. E., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1306534110 · Cited by 48
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Kasiviswanathan, R., Gustafson, M. A., Copeland, W. C., & Meyer, J. N. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.306852 · Cited by 45
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Cruet-Hennequart, S., Gallagher, K., Sokòl, A. M., Villalan, S., Prendergast, Á. M., & Carty, M. P. (2009) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-90-481-3471-7_10 · Cited by 47
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Krijger, P. H. L., van den Berk, P. C. M., Wit, N., Langerak, P., Jansen, J. G., Reynaud, C., de Wind, N., & Jacobs, H. (2011) · DNA repair · doi:10.1016/j.dnarep.2011.08.005 · Cited by 50
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Han, J., Liu, T., Huen, M. S. Y., Hu, L. T., Chen, Z., & Huang, J. (2014) · The Journal of Cell Biology · doi:10.1083/jcb.201311007 · Cited by 45
Cooperative motion of a key positively charged residue and metal ions for DNA replication catalyzed by human DNA Polymerase-η
Genna, V., Gaspari, R., Peraro, M. D., & Vivo, M. D. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw128 · Cited by 44
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Genna, V., Colombo, M., Vivo, M. D., & Marcia, M. (2017) · Structure · doi:10.1016/j.str.2017.11.008 · Cited by 44
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Sakamoto, A. N., Stone, J. E., Kissling, G. E., McCulloch, S. D., Pavlov, Y. I., & Kunkel, T. A. (2007) · DNA repair · doi:10.1016/j.dnarep.2007.07.002 · Cited by 44
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Hedglin, M., Pandey, B., & Benkovic, S. J. (2016) · eLife · doi:10.7554/elife.19788 · Cited by 41
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Lehmann, A. R. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.06.005 · Cited by 40
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Livneh, Z. (2006) · Cell Cycle · doi:10.4161/cc.5.17.3193 · Cited by 38

Authors: McCulloch, S. D., Kokoska, R. J., Masutani, C., Iwai, S., Hanaoka, F., & Kunkel, T. A.
Affiliations: National Institutes of Health (US)
The University of Osaka (JP)
RIKEN (JP)
Corresponding author: Kunkel, Thomas A.
ORCID: Masutani, Chikahide
Iwai, Shigenori
Hanaoka, Fumio
Kunkel, Thomas A.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2004-03
Volume: 428
Issue: 6978
Pages: 97-100
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature02352
OpenAlex: W1581236180
Cited by: 246
References: 30
Citations by year: 2026: 2 · 2025: 3 · 2024: 6 · 2023: 3 · 2022: 5 · 2021: 5 · 2020: 6 · 2019: 5 · 2018: 9 · 2017: 9 · 2016: 9 · 2015: 15 · 2014: 9 · 2013: 12 · 2012: 12
FWCI: 8.17
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: Wellcome Trust
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
Keywords: DNA polymerase eta, cyclobutane pyrimidine dimers, polymerase fidelity, polymerase processivity, nucleotide excision repair, xeroderma pigmentosum, UV mutagenesis, Hoogsteen base pairing, skin cancer predisposition
MeSH terms: Y-Family DNA Polymerases, DNA, DNA Damage, DNA-Directed DNA Polymerase, Humans, Hydrogen Bonding, Pyrimidine Dimers, Mutagenesis, Sulfolobus, Base Pairing

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Preferential cis–syn thymine dimer bypass by DNA polymerase η occurs with biased fidelity

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