The DOI matches its Crossref record; 30 of the 31 references it cites were found in a registry or an index.
Synaptic scaling mediated by glial TNF-α
Abstract
Two general forms of synaptic plasticity that operate on different timescales are thought to contribute to the activity-dependent refinement of neural circuitry during development: (1) long-term potentiation (LTP) and long-term depression (LTD), which involve rapid adjustments in the strengths of individual synapses in response to specific patterns of correlated synaptic activity, and (2) homeostatic synaptic scaling, which entails uniform adjustments in the strength of all synapses on a cell in response to prolonged changes in the cell's electrical activity. Without homeostatic synaptic scaling, neural networks can become unstable and perform suboptimally. Although much is known about the mechanisms underlying LTP and LTD, little is known about the mechanisms responsible for synaptic scaling except that such scaling is due, at least in part, to alterations in receptor content at synapses. Here we show that synaptic scaling in response to prolonged blockade of activity is mediated by the pro-inflammatory cytokine tumour-necrosis factor-alpha (TNF-alpha). Using mixtures of wild-type and TNF-alpha-deficient neurons and glia, we also show that glia are the source of the TNF-alpha that is required for this form of synaptic scaling. We suggest that by modulating TNF-alpha levels, glia actively participate in the homeostatic activity-dependent regulation of synaptic connectivity.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“This model is based on the observations that TNFa levels are elevated by prolonged (48 h) activity blockade, acute application of TNFa (or conditioned media from activity-blocked cultures) increases mEPSC amplitude, and scaling up in response to prolonged activity blockade is prevented by blocking TNFa signaling (Beattie et al. 2002;Stellwagen et al. 2005;Stellwagen and Malenka 2006).”
From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Stellwagen and Malenka 2006
In the citing paper
“This model is based on the observations that TNFa levels are elevated by prolonged (48 h) activity blockade, acute application of TNFa (or conditioned media from activity-blocked cultures) increases mEPSC amplitude, and scaling up in response to prolonged activity blockade is prevented by blocking TNFa signaling (Beattie et al. 2002;Stellwagen et al. 2005;Stellwagen and Malenka 2006).”
From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Stellwagen and Malenka 2006
In the citing paper
“It was recently proposed that prolonged activity blockade (with TTX) increases glial release of TNFa, which then acts on neurons to enhance AMPAR insertion and scale up mEPSC amplitude (Stellwagen and Malenka 2006).”
From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Stellwagen and Malenka 2006
In the citing paper
“This model is based on the observations that TNFa levels are elevated by prolonged (48 h) activity blockade, acute application of TNFa (or conditioned media from activity-blocked cultures) increases mEPSC amplitude, and scaling up in response to prolonged activity blockade is prevented by blocking TNFa signaling (Beattie et al. 2002;Stellwagen et al. 2005;Stellwagen and Malenka 2006).”
From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Stellwagen and Malenka 2006
In the citing paper
“Interestingly, the TNFa involved in scaling up synaptic strengths in response to TTX originates from glia rather than neurons, because wild-type neurons grown on TNFa 2/2 glia did not scale up synaptic strengths in response to 48 h of TTX treatment, whereas TNFa 2/2 neurons grown on wild-type glia did (Stellwagen and Malenka 2006).”
From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Stellwagen and Malenka 2006
In the citing paper
“Inconsistent with the above model is the observation that scaling is a gradual and cumulative process evident after as little as 4-6 h of activity blockade (Sutton et al. 2006;Ibata et al. 2008), whereas TNFa-dependent scaling was only observed after prolonged activity block (48 h) (Stellwagen and Malenka 2006).”
From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Stellwagen and Malenka 2006
In the citing paper
“Interestingly, the delayed potentiation in visual cortex following lid suture requires TNFa and Arc signaling (Kaneko et al. 2008;McCurry et al. 2011) as does synaptic scaling in vitro (Shepherd et al. 2006;Stellwagen and Malenka 2006;Steinmetz and Turrigiano 2010); however, both these manipulations likely affect many forms of plasticity, so it still remains to be seen if synaptic scaling”
From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Stellwagen and Malenka 2006
Citations
Cites
Malenka, R. C., & Bear, M. F. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.012 · Cited by 3,968
Self-citationA simple method for organotypic cultures of nervous tissue
Stoppini, L., Buchs, P., & Muller, D. (1991) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(91)90128-m · Cited by 3,096
Homeostatic plasticity in the developing nervous system
Turrigiano, G. G., & Nelson, S. B. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1327 · Cited by 2,485
Synaptic plasticity: taming the beast
Abbott, L. F., & Nelson, S. B. (2000) · Nature Neuroscience · doi:10.1038/81453 · Cited by 2,263
Activity-dependent scaling of quantal amplitude in neocortical neurons
Turrigiano, G. G., Leslie, K. R., Desai, N. S., Rutherford, L. C., & Nelson, S. B. (1998) · Nature · doi:10.1038/36103 · Cited by 2,226
Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis
Christopherson, K. S., Ullian, E. M., Stokes, C. C. A., Mullowney, C. E., Hell, J. W., Agah, A., Lawler, J., Mosher, D. F., Bornstein, P., & Barres, B. A. (2005) · Cell · doi:10.1016/j.cell.2004.12.020 · Cited by 1,688
Hayashi, Y., Shi, S.-H., Esteban, J. A., Piccini, A., Poncer, J.-C., & Malinow, R. (2000) · Science · doi:10.1126/science.287.5461.2262 · Cited by 1,524
Control of Synapse Number by Glia
Ullian, E. M., Sapperstein, S. K., Christopherson, K. S., & Barres, B. A. (2001) · Science · doi:10.1126/science.291.5504.657 · Cited by 1,380
Control of Synaptic Strength by Glial TNFα
Beattie, E. C., Stellwagen, D., Morishita, W., Bresnahan, J. C., Ha, B. K., Von Zastrow, M., Beattie, M. S., & Malenka, R. C. (2002) · Science · doi:10.1126/science.1067859 · Cited by 1,344
Self-citationRapid Spine Delivery and Redistribution of AMPA Receptors After Synaptic NMDA Receptor Activation
Shi, S.-H., Hayashi, Y., Petralia, R. S., Zaman, S. H., Wenthold, R. J., Svoboda, K., & Malinow, R. (1999) · Science · doi:10.1126/science.284.5421.1811 · Cited by 1,276
Cited by
Sorted by citations
Items 401–500 of 1,004
Ortega, F. J., Gimeno‐Bayón, J., Espinosa‐Parrilla, J. F., Carrasco, J. L., Batlle, M., Pugliese, M., Mahy, N., & Rodríguez, M. J. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.02.010 · Cited by 114
Synapse elimination during development and disease: immune molecules take centre stage
Schafer, D. P., & Stevens, B. (2010) · Biochemical Society Transactions · doi:10.1042/bst0380476 · Cited by 114
Porkka‐Heiskanen, T. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.02.010 · Cited by 114
GABAergic neuronal IL-4R mediates T cell effect on memory
Herz, J., Fu, Z., Kim, K., Dykstra, T., Wall, M. K., Li, H., Salvador, A. F., Zou, B., Yan, N., Blackburn, S. M., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.10.022 · Cited by 113
Impaired striatal GABA transmission in experimental autoimmune encephalomyelitis
Rossi, S., Muzio, L., De Chiara, V., Grasselli, G., Musella, A., Musumeci, G., Mandolesi, G., De Ceglia, R., Maida, S., Biffi, E., et al. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.10.004 · Cited by 112
PICK1 loss of function occludes homeostatic synaptic scaling
Anggono, V., Clem, R. L., & Huganir, R. L. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5633-10.2011 · Cited by 111
Peng, Y., He, S., Marie, H., Zeng, S.-Y., Ma, J., Tan, Z.-J., Lee, S. Y., Malenka, R. C., & Yu, X. (2009) · Neuron · doi:10.1016/j.neuron.2008.11.015 · Cited by 111
Self-citationPerspectives in affective disorders: Clocks and sleep
Wirz‐Justice, A., & Benedetti, F. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14362 · Cited by 111
Seeburg, D. P., & Sheng, M. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1853-08.2008 · Cited by 111
Extracellular matrix in plasticity and epileptogenesis
Dityatev, A. E., & Fellin, T. (2008) · Neuron Glia Biology · doi:10.1017/s1740925x09000118 · Cited by 111
Glial Regulation of Neuronal Function: From Synapse to Systems Physiology
Tasker, J. G., Oliet, S. H. R., Bains, J. S., Brown, C. H., & Stern, J. E. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02259.x · Cited by 110
Chen, X., Chang, J., Deng, Q., Xu, J., Nguyen, T. A., Martens, L. H., Cenik, B., Taylor, G., Hudson, K. F., Chung, J., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5336-12.2013 · Cited by 110
Zhang, H., Zhou, Y., Cui, B., Liu, Z., & Shen, H. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110086 · Cited by 110
Astroglia-specific contributions to the regulation of synapses, cognition and behaviour
Augusto‐Oliveira, M., Arrifano, G. D. P., Takeda, P. Y., Lopes-Araújo, A., Santos-Sacramento, L., Anthony, D. C., Verkhratsky, A., & Lopez, M. E. C. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.07.039 · Cited by 111
TNF-Mediated Homeostatic Synaptic Plasticity: From in vitro to in vivo Models
Heir, R., & Stellwagen, D. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.565841 · Cited by 109
Self-citationNeuroinflammation microenvironment sharpens seizure circuit
Villasana‐Salazar, B., & Vezzani, A. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106027 · Cited by 110
Delta Wave Power: An Independent Sleep Phenotype or Epiphenomenon?
Davis, C. J., Clinton, J. M., Jewett, K. A., Zielinski, M. R., & Krueger, J. M. (2011) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.1346 · Cited by 110
Rab3-GAP Controls the Progression of Synaptic Homeostasis at a Late Stage of Vesicle Release
Müller, M., Pym, E. C. G., Tong, A., & Davis, G. W. (2011) · Neuron · doi:10.1016/j.neuron.2011.01.025 · Cited by 109
Glia and Neurodevelopment: Focus on Fetal Alcohol Spectrum Disorders
Guizzetti, M., Zhang, X., Goeke, C. M., & Gavin, D. P. (2014) · Frontiers in Pediatrics · doi:10.3389/fped.2014.00123 · Cited by 110
The aging mouse brain: cognition, connectivity and calcium
Radulescu, C. I., Cerar, V., Haslehurst, P., Kopanitsa, M. V., & Barnes, S. J. (2021) · Cell Calcium · doi:10.1016/j.ceca.2021.102358 · Cited by 109
Multiple shared mechanisms for homeostatic plasticity in rodent somatosensory and visual cortex
Gainey, M. A., & Feldman, D. E. (2017) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2016.0157 · Cited by 109
Cell adhesion and matricellular support by astrocytes of the tripartite synapse
Hillen, A. E. J., Burbach, J. P. H., & Hol, E. M. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.02.002 · Cited by 108
Alterations in GABAA-Receptor Trafficking and Synaptic Dysfunction in Brain Disorders
Mele, M., Costa, R. O., & Duarte, C. B. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00077 · Cited by 108
Immune system gene dysregulation in autism and schizophrenia
Michel, M., Schmidt, M. J., & Mirnics, K. (2012) · Developmental Neurobiology · doi:10.1002/dneu.22044 · Cited by 107
Hou, Q., Gilbert, J. P., & Man, H. (2011) · Neuron · doi:10.1016/j.neuron.2011.10.011 · Cited by 107
Topper, L. A., Baculis, B. C., & Valenzuela, C. F. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0382-9 · Cited by 107
Patel, D. C., Wallis, G. J., Dahle, E. J., McElroy, P. B., Thomson, K. E., Tesi, R. J., Szymkowski, D. E., West, P. J., Smeal, R. M., Patel, M., et al. (2017) · eNeuro · doi:10.1523/eneuro.0105-17.2017 · Cited by 107
Picard, K., Bisht, K., Poggini, S., Garofalo, S., Golia, M. T., Basilico, B., Abdallah, F., Albanese, N. C., Amrein, I., Vernoux, N., et al. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.07.022 · Cited by 107
Mulas, G., Espa, E., Fenu, S., Spiga, S., Cossu, G., Pillai, E., Carboni, E., Simbula, G., Jadzic, D., Angius, F., et al. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.09.013 · Cited by 107
Neuroimmune regulation of homeostatic synaptic plasticity
Pribiag, H., & Stellwagen, D. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.06.008 · Cited by 106
Self-citationWalters, E. T. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.02.001 · Cited by 106
Astrocytes in Alzheimer's Disease: Emerging Roles in Calcium Dysregulation and Synaptic Plasticity
Vincent, A. J., Gasperini, R., Foa, L. C., & Small, D. H. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-101089 · Cited by 106
Neuron–astrocyte communication and synaptic plasticity
Paixão, S., & Klein, R. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.04.008 · Cited by 106
Parachikova, A. I., Vasilevko, V., Cribbs, D. H., LaFerla, F. M., & Green, K. N. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100204 · Cited by 104
Tiwari, V., Guan, Y., & Raja, S. N. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.05.002 · Cited by 104
Yang, G., Parkhurst, C. N., Hayes, S., & Gan, W. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1222895110 · Cited by 105
Glia- and neuron-specific functions of TrkB signalling during retinal degeneration and regeneration
Harada, C., Guo, X., Namekata, K., Kimura, A. K., Nakamura, K., Tanaka, K., Parada, L. F., & Harada, T. (2011) · Nature Communications · doi:10.1038/ncomms1190 · Cited by 103
Embedding Multiple Trajectories in Simulated Recurrent Neural Networks in a Self-Organizing Manner
Liu, J. K., & Buonomano, D. V. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2358-09.2009 · Cited by 103
Biomarkers of post-covid depression
Lorkiewicz, P., & Waszkiewicz, N. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10184142 · Cited by 102
Iijima, T., Miura, E., Watanabe, M., & Yuzaki, M. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07202.x · Cited by 102
Müller, L., Benedetto, S. D., & Müller, V. (2025) · Cells · doi:10.3390/cells14010054 · Cited by 102
Mirrione, M. M., Konomos, D. K., Gravanis, I., Dewey, S. L., Aguzzi, A., Heppner, F. L., & Tsirka, S. E. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.04.001 · Cited by 102
Targeting Synaptic Dysfunction in Alzheimer’s Disease Therapy
Nisticò, R., Pignatelli, M., Piccinin, S., Mercuri, N. B., & Collingridge, G. L. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8324-3 · Cited by 102
Rossi, S., Motta, C., Studer, V., Macchiarulo, G., Volpe, E., Barbieri, F. R., Ruocco, G., Buttari, F., Finardi, A., Mancino, R., et al. (2014) · Molecular Neurodegeneration · doi:10.1186/1750-1326-9-56 · Cited by 102
Computational models of neuron-astrocyte interaction in epilepsy
Volman, V., Bazhenov, M., & B, T. J. S. A. (2012) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2012.00058 · Cited by 101
Huang, L., Jin, J., Chen, K., You, S., Zhang, H., Sideris, A., Norcini, M., Recio‐Pinto, E., Wang, J., Gan, W., et al. (2021) · PLoS Biology · doi:10.1371/journal.pbio.3001337 · Cited by 100
Decoupling astrocytes in adult mice impairs synaptic plasticity and spatial learning
Hösli, L., Binini, N., Ferrari, K. D., Thieren, L., Looser, Z. J., Zuend, M., Zanker, H. S., Berry, S., Holub, M., Möbius, W., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110484 · Cited by 101
Baune, B. T., Ponath, G. D., Rothermundt, M., Rieß, O., Funke, H., & Berger, K. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.10.002 · Cited by 101
Woodburn, S. C., Bollinger, J. L., & Wohleb, E. S. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100312 · Cited by 100
Upward synaptic scaling is dependent on neurotransmission rather than spiking
Fong, M., Newman, J. P., Potter, S. M., & Wenner, P. (2015) · Nature Communications · doi:10.1038/ncomms7339 · Cited by 100
Fontana, A., Gast, H., Reith, W., Recher, M., Birchler, T., & Bassetti, C. L. (2010) · Brain · doi:10.1093/brain/awq086 · Cited by 100
Charrier, C., Machado, P., Tweedie‐Cullen, R. Y., Rutishauser, D., Mansuy, I. M., & Triller, A. (2010) · Nature Neuroscience · doi:10.1038/nn.2645 · Cited by 100
LTP and adaptation to inactivity: Overlapping mechanisms and implications for metaplasticity
Thiagarajan, T. C., Lindskog, M., Malgaroli, A., & Tsien, R. W. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.07.030 · Cited by 99
Microglial modulation of neuronal activity in the healthy brain
York, E. M., Bernier, L., & MacVicar, B. A. (2018) · Developmental Neurobiology · doi:10.1002/dneu.22571 · Cited by 98
New Insights into Microglia–Neuron Interactions: A Neuron’s Perspective
Pósfai, B., Cserép, C., Orsolits, B., & Dénes, Á. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2018.04.046 · Cited by 98
Sleep: a synchrony of cell activity‐driven small network states
Krueger, J. M., Huang, Y. H., Rector, D. M., & Buysse, D. J. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12238 · Cited by 98
Horchar, M. J., & Wohleb, E. S. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.06.030 · Cited by 100
Maladaptive spinal plasticity opposes spinal learning and recovery in spinal cord injury
Ferguson, A. R., Huie, J. R., Crown, E. D., Baumbauer, K. M., Hook, M. A., Garraway, S. M., Lee, K. H., Hoy, K. C., & Grau, J. W. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00399 · Cited by 98
Astrocitos en las enfermedades neurodegenerativas (I): función y caracterización molecular
Guillamón-Vivancos, T., Gómez‐Pinedo, U., & Matías‐Guiu, J. (2013) · Neurología · doi:10.1016/j.nrl.2012.12.007 · Cited by 98
Adult cortical plasticity following injury: Recapitulation of critical period mechanisms?
Nahmani, M., & Turrigiano, G. G. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.04.029 · Cited by 97
Roles of glial cells in synapse development
Pfrieger, F. W. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0005-7 · Cited by 97
Montgomery, S. L., Mastrangelo, M. A., Habib, D., Narrow, W. C., Knowlden, S. A., Wright, T. W., & Bowers, W. J. (2011) · The American Journal of Pathology · doi:10.1016/j.ajpath.2011.07.001 · Cited by 96
Inflammation at the crossroads of COVID-19, cognitive deficits and depression
Silva, N. M. L. E., Barros‐Aragão, F. G. Q., Felice, F. G. D., & Ferreira, S. T. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109023 · Cited by 96
Dysregulation of Calcium Homeostasis in Alzheimer’s Disease
Small, D. H. (2009) · Neurochemical Research · doi:10.1007/s11064-009-9960-5 · Cited by 96
He, P., Liu, Q., Wu, J., & Shen, Y. (2011) · The FASEB Journal · doi:10.1096/fj.11-192716 · Cited by 96
Pittà, M. D., Volman, V., Berry, H., Parpura, V., Volterra, A., & Ben‐Jacob, E. (2012) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2012.00098 · Cited by 96
Brand, S., Moller, M., & Harvey, B. (2015) · Current Neuropharmacology · doi:10.2174/1570159x13666150307004545 · Cited by 95
Transcranial Electrical Stimulation Accelerates Human Sleep Homeostasis
Reato, D., Gasca, F., Datta, A., Bikson, M., Marshall, L., & Parra, L. C. (2013) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002898 · Cited by 95
The emerging tale of microglia in psychiatric disorders
Rahimian, R., Wakid, M., O’Leary, L. A., & Mechawar, N. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.09.023 · Cited by 96
Pathological Effect of Homeostatic Synaptic Scaling on Network Dynamics in Diseases of the Cortex
Frӧhlich, F., Bazhenov, M., & B, T. J. S. A. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4263-07.2008 · Cited by 95
Role of glia in developmental synapse formation
Allen, N. J. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.06.004 · Cited by 95
Role of Inflammation in Depression and Treatment Implications
Felger, J. C. (2018) · Handbook of experimental pharmacology · doi:10.1007/164_2018_166 · Cited by 94
Sandvig, I., Augestad, I. L., Håberg, A. K., & Sandvig, A. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.13959 · Cited by 94
Mariani, E., Cattini, L., Neri, S., Malavolta, M., Mocchegiani, E., Ravaglia, G., & Facchini, A. (2006) · Biogerontology · doi:10.1007/s10522-006-9060-8 · Cited by 94
Junctional Adhesion Molecule-1 Is Upregulated in Spontaneously Hypertensive Rats
Waki, H., Liu, B., Miyake, M., Katahira, K., Murphy, D., Kasparov, S., & Paton, J. F. R. (2007) · Hypertension · doi:10.1161/hypertensionaha.106.085589 · Cited by 94
Keck, T., Hübener, M., & Bonhoeffer, T. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.02.003 · Cited by 93
Inflammation at Birth is Associated With Subnormal Development in Very Preterm Infants
Hansen‐Pupp, I., Hallin, A., Hellström-Westas, L. K., Cilio, C., Berg, A., Stjernqvist, K., Fellman, V., & Ley, D. (2008) · Pediatric Research · doi:10.1203/pdr.0b013e318176144d · Cited by 93
A Hierarchy of Cell Intrinsic and Target-Derived Homeostatic Signaling
Bergquist, S. H., Dickman, D. K., & Davis, G. W. (2010) · Neuron · doi:10.1016/j.neuron.2010.03.023 · Cited by 93
Emerging Link between Alzheimer’s Disease and Homeostatic Synaptic Plasticity
Jang, S.-S., & Chung, H. J. (2016) · Neural Plasticity · doi:10.1155/2016/7969272 · Cited by 93
Gelman, B. B., Lisinicchia, J. G., Chen, T., Johnson, K. M., Jennings, K., Freeman, D. H., & Soukup, V. M. (2012) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-012-9345-4 · Cited by 92
Wang, G., Gilbert, J. P., & Man, H. (2012) · Neural Plasticity · doi:10.1155/2012/825364 · Cited by 91
Schilling, S., Chausse, B., Dikmen, H. O., Almouhanna, F., Hollnagel, J., Lewen, A., & Kann, O. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.05.013 · Cited by 91
Multifaceted aspects of inflammation in multiple sclerosis: The role of microglia
Muzio, L., Martino, G., & Furlan, R. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2007.09.016 · Cited by 91
Two opposing plasticity mechanisms pulling a single synapse
Rabinowitch, I., & Segev, I. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.05.005 · Cited by 91
Homeostatic Strengthening of Inhibitory Synapses Is Mediated by the Accumulation of GABAAReceptors
Rannals, M. D., & Kapur, J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4476-11.2011 · Cited by 90
Interleukin-13 and its receptor are synaptic proteins involved in plasticity and neuroprotection
Li, S., Heuvel, F. O., Rehman, R., Aousji, O., Fröhlich, A., Li, Z., Jark, R., Zhang, W., Conquest, A., Woelfle, S., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-35806-8 · Cited by 90
Penney, J., Tsurudome, K., Liao, E. H., Elazzouzi, F., Livingstone, M., González, M., Sonenberg, N., & Haghighi, A. P. (2012) · Neuron · doi:10.1016/j.neuron.2012.01.030 · Cited by 90
The TNF superfamily in 2009: new pathways, new indications, and new drugs
Tansey, M. G., & Szymkowski, D. E. (2009) · Drug Discovery Today · doi:10.1016/j.drudis.2009.10.002 · Cited by 89
Astrocyte‐mediated synapse remodeling in the pathological brain
Kim, S. K., Nabekura, J., & Koizumi, S. (2017) · Glia · doi:10.1002/glia.23169 · Cited by 89
The cytokine network in the pathogenesis of major depressive disorder. Close to translation?
Petralia, M. C., Mazzon, E., Fagone, P., Basile, M. S., Lenzo, V., Quattropani, M. C. A., Nuovo, S. D., Bendtzen, K., & Nicoletti, F. (2020) · Autoimmunity Reviews · doi:10.1016/j.autrev.2020.102504 · Cited by 89
Garcia, A. J., Zanella, S., Koch, H., Doi, A., & Ramirez, J. (2011) · Progress in brain research · doi:10.1016/b978-0-444-53825-3.00008-5 · Cited by 89
Cell adhesion and homeostatic synaptic plasticity
Thalhammer, A., & Cingolani, L. A. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.03.015 · Cited by 88
Should We Stop Saying ‘Glia’ and ‘Neuroinflammation’?
Masgrau, R., Guaza, C., Ransohoff, R. M., & Galea, E. (2017) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2017.04.005 · Cited by 88
Role of microglia-neuron interactions in diabetic encephalopathy
Liu, Y., Li, M., Zhang, Z., Ye, Y., & Zhou, J. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.12.005 · Cited by 88
A roadmap to integrate astrocytes into Systems Neuroscience
Kastanenka, K. V., Moreno‐Bote, R., Pittà, M. D., Perea, G., Eraso‐Pichot, A., Masgrau, R., Poskanzer, K. E., & Galea, E. (2019) · Glia · doi:10.1002/glia.23632 · Cited by 88
Kapila, A. K., Watts, H. R., Wang, T., & Ma, D. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-132258 · Cited by 88
ATP and the purine type 2 X7 receptor affect sleep
Krueger, J. M., Taishi, P., De, A., Davis, C. J., Winters, B. D., Clinton, J. M., Szentirmai, É., & Zielinski, M. R. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00586.2010 · Cited by 88
Heterogeneity in Synaptogenic Profile of Astrocytes from Different Brain Regions
Buosi, A. S., Matias, I. C. P., Araújo, A. P. B., Batista, C., & Gomes, F. C. A. (2017) · Molecular Neurobiology · doi:10.1007/s12035-016-0343-z · Cited by 88
Lana, D., Ugolini, F., & Giovannini, M. G. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.585833 · Cited by 92
Metadata
- Authors
- Stellwagen, D., & Malenka, R. C.
- Affiliations
- Stanford Medicine (US)
- Corresponding author
- Malenka, Robert C.
- Venue
- Nature
- Published
- 2006-04-01
- Volume
- 440
- Issue
- 7087
- Pages
- 1054-1059
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1542136448
- Cited by
- 1,715
- References
- 31
- Citations by year
- 2026: 73 · 2025: 66 · 2024: 72 · 2023: 70 · 2022: 102 · 2021: 102 · 2020: 117 · 2019: 80 · 2018: 87 · 2017: 94 · 2016: 80 · 2015: 92 · 2014: 92 · 2013: 104 · 2012: 103
- FWCI
- 27.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- synaptic scaling, homeostatic plasticity, TNF-α, neuron-glia interactions, long-term potentiation, long-term depression, neural network stability
- MeSH terms
- Animals, Hippocampus, Nerve Net, Neuroglia, Neurons, Synapses, Tetrodotoxin, Tumor Necrosis Factor-alpha, Signal Transduction, Rats, Sprague-Dawley, Long-Term Potentiation, Receptors, AMPA, Receptors, Tumor Necrosis Factor, Excitatory Postsynaptic Potentials, Long-Term Synaptic Depression, Mice, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
