The DOI matches its Crossref record; 30 of the 31 references it cites were found in a registry or an index.
Synaptic scaling mediated by glial TNF-α
Abstract
Two general forms of synaptic plasticity that operate on different timescales are thought to contribute to the activity-dependent refinement of neural circuitry during development: (1) long-term potentiation (LTP) and long-term depression (LTD), which involve rapid adjustments in the strengths of individual synapses in response to specific patterns of correlated synaptic activity, and (2) homeostatic synaptic scaling, which entails uniform adjustments in the strength of all synapses on a cell in response to prolonged changes in the cell's electrical activity. Without homeostatic synaptic scaling, neural networks can become unstable and perform suboptimally. Although much is known about the mechanisms underlying LTP and LTD, little is known about the mechanisms responsible for synaptic scaling except that such scaling is due, at least in part, to alterations in receptor content at synapses. Here we show that synaptic scaling in response to prolonged blockade of activity is mediated by the pro-inflammatory cytokine tumour-necrosis factor-alpha (TNF-alpha). Using mixtures of wild-type and TNF-alpha-deficient neurons and glia, we also show that glia are the source of the TNF-alpha that is required for this form of synaptic scaling. We suggest that by modulating TNF-alpha levels, glia actively participate in the homeostatic activity-dependent regulation of synaptic connectivity.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“This model is based on the observations that TNFa levels are elevated by prolonged (48 h) activity blockade, acute application of TNFa (or conditioned media from activity-blocked cultures) increases mEPSC amplitude, and scaling up in response to prolonged activity blockade is prevented by blocking TNFa signaling (Beattie et al. 2002;Stellwagen et al. 2005;Stellwagen and Malenka 2006).”
From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Stellwagen and Malenka 2006
In the citing paper
“This model is based on the observations that TNFa levels are elevated by prolonged (48 h) activity blockade, acute application of TNFa (or conditioned media from activity-blocked cultures) increases mEPSC amplitude, and scaling up in response to prolonged activity blockade is prevented by blocking TNFa signaling (Beattie et al. 2002;Stellwagen et al. 2005;Stellwagen and Malenka 2006).”
From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Stellwagen and Malenka 2006
In the citing paper
“It was recently proposed that prolonged activity blockade (with TTX) increases glial release of TNFa, which then acts on neurons to enhance AMPAR insertion and scale up mEPSC amplitude (Stellwagen and Malenka 2006).”
From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Stellwagen and Malenka 2006
In the citing paper
“This model is based on the observations that TNFa levels are elevated by prolonged (48 h) activity blockade, acute application of TNFa (or conditioned media from activity-blocked cultures) increases mEPSC amplitude, and scaling up in response to prolonged activity blockade is prevented by blocking TNFa signaling (Beattie et al. 2002;Stellwagen et al. 2005;Stellwagen and Malenka 2006).”
From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Stellwagen and Malenka 2006
In the citing paper
“Interestingly, the TNFa involved in scaling up synaptic strengths in response to TTX originates from glia rather than neurons, because wild-type neurons grown on TNFa 2/2 glia did not scale up synaptic strengths in response to 48 h of TTX treatment, whereas TNFa 2/2 neurons grown on wild-type glia did (Stellwagen and Malenka 2006).”
From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Stellwagen and Malenka 2006
In the citing paper
“Inconsistent with the above model is the observation that scaling is a gradual and cumulative process evident after as little as 4-6 h of activity blockade (Sutton et al. 2006;Ibata et al. 2008), whereas TNFa-dependent scaling was only observed after prolonged activity block (48 h) (Stellwagen and Malenka 2006).”
From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Stellwagen and Malenka 2006
In the citing paper
“Interestingly, the delayed potentiation in visual cortex following lid suture requires TNFa and Arc signaling (Kaneko et al. 2008;McCurry et al. 2011) as does synaptic scaling in vitro (Shepherd et al. 2006;Stellwagen and Malenka 2006;Steinmetz and Turrigiano 2010); however, both these manipulations likely affect many forms of plasticity, so it still remains to be seen if synaptic scaling”
From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Stellwagen and Malenka 2006
Citations
Cites
Malenka, R. C., & Bear, M. F. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.012 · Cited by 3,968
Self-citationA simple method for organotypic cultures of nervous tissue
Stoppini, L., Buchs, P., & Muller, D. (1991) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(91)90128-m · Cited by 3,096
Homeostatic plasticity in the developing nervous system
Turrigiano, G. G., & Nelson, S. B. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1327 · Cited by 2,485
Synaptic plasticity: taming the beast
Abbott, L. F., & Nelson, S. B. (2000) · Nature Neuroscience · doi:10.1038/81453 · Cited by 2,263
Activity-dependent scaling of quantal amplitude in neocortical neurons
Turrigiano, G. G., Leslie, K. R., Desai, N. S., Rutherford, L. C., & Nelson, S. B. (1998) · Nature · doi:10.1038/36103 · Cited by 2,226
Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis
Christopherson, K. S., Ullian, E. M., Stokes, C. C. A., Mullowney, C. E., Hell, J. W., Agah, A., Lawler, J., Mosher, D. F., Bornstein, P., & Barres, B. A. (2005) · Cell · doi:10.1016/j.cell.2004.12.020 · Cited by 1,688
Hayashi, Y., Shi, S.-H., Esteban, J. A., Piccini, A., Poncer, J.-C., & Malinow, R. (2000) · Science · doi:10.1126/science.287.5461.2262 · Cited by 1,524
Control of Synapse Number by Glia
Ullian, E. M., Sapperstein, S. K., Christopherson, K. S., & Barres, B. A. (2001) · Science · doi:10.1126/science.291.5504.657 · Cited by 1,380
Control of Synaptic Strength by Glial TNFα
Beattie, E. C., Stellwagen, D., Morishita, W., Bresnahan, J. C., Ha, B. K., Von Zastrow, M., Beattie, M. S., & Malenka, R. C. (2002) · Science · doi:10.1126/science.1067859 · Cited by 1,344
Self-citationRapid Spine Delivery and Redistribution of AMPA Receptors After Synaptic NMDA Receptor Activation
Shi, S.-H., Hayashi, Y., Petralia, R. S., Zaman, S. H., Wenthold, R. J., Svoboda, K., & Malinow, R. (1999) · Science · doi:10.1126/science.284.5421.1811 · Cited by 1,276
Flagged first, then by citations
1 of the 31 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 101–200 of 1,004
Neural reflexes in inflammation and immunity
Andersson, U., & Tracey, K. J. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20120571 · Cited by 388
Astrocyte Heterogeneity: Impact to Brain Aging and Disease
Matias, I., Morgado, J., & Gomes, F. C. A. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00059 · Cited by 387
Do glia drive synaptic and cognitive impairment in disease?
Chung, W.-S., Welsh, C. A., Barres, B. A., & Stevens, B. (2015) · Nature Neuroscience · doi:10.1038/nn.4142 · Cited by 385
TNFα Controls Glutamatergic Gliotransmission in the Hippocampal Dentate Gyrus
Santello, M., Bezzi, P., & Volterra, A. (2011) · Neuron · doi:10.1016/j.neuron.2011.02.003 · Cited by 384
Chemokines and Chemokine Receptors: Standing at the Crossroads of Immunobiology and Neurobiology
Ransohoff, R. M. (2009) · Immunity · doi:10.1016/j.immuni.2009.09.010 · Cited by 384
Astrocyte Calcium Signaling Transforms Cholinergic Modulation to Cortical Plasticity In Vivo
Takata, N., Mishima, T., Hisatsune, C., Nagai, T., Ebisui, E., Mikoshiba, K., & Hirase, H. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5289-11.2011 · Cited by 382
Targeting p38 MAPK pathway for the treatment of Alzheimer's disease
Munoz, L., & Ammit, A. J. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.11.010 · Cited by 381
Matrix metalloproteinases in brain development and remodeling: Synaptic functions and targets
Ethell, I. M., & Ethell, D. W. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21273 · Cited by 378
The role of AMPA receptors in postsynaptic mechanisms of synaptic plasticity
Chater, T. E., & Goda, Y. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00401 · Cited by 377
Network Homeostasis and State Dynamics of Neocortical Sleep
Watson, B. O., Levenstein, D., Greene, J. P., Gelinas, J. N., & Buzsáki, G. (2016) · Neuron · doi:10.1016/j.neuron.2016.03.036 · Cited by 375
Microglia Protect Neurons against Ischemia by Synthesis of Tumor Necrosis Factor
Lambertsen, K. L., Clausen, B. H., Babcock, A. A., Gregersen, R., Fenger, C., Nielsen, H. H., Haugaard, L. S., Wirenfeldt, M., Nielsen, M., Dagnæs‐Hansen, F., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5505-08.2009 · Cited by 374
Montgomery, S. L., & Bowers, W. J. (2011) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-011-9287-2 · Cited by 372
Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition
Pasciuto, E., Burton, O. T., Roca, C. P., Lagou, V., Rajan, W. D., Theys, T., Mancuso, R., Tito, R. Y., Kouser, L., Callaerts-Vegh, Z., et al. (2020) · Cell · doi:10.1016/j.cell.2020.06.026 · Cited by 368
Oligodendrocyte Progenitor Cells Become Regionally Diverse and Heterogeneous with Age
Spitzer, S. O., Sitnikov, S., Kamen, Y., Evans, K. A., Kronenberg-Versteeg, D., Dietmann, S., de Faria, O., Agathou, S., & Káradóttir, R. T. (2019) · Neuron · doi:10.1016/j.neuron.2018.12.020 · Cited by 364
Understanding brain dysfunction in sepsis
Sonneville, R., Verdonk, F., Rauturier, C., Klein, I. F., Wolff, M., Annane, D., Chrétien, F., & Sharshar, T. (2013) · Annals of Intensive Care · doi:10.1186/2110-5820-3-15 · Cited by 362
A Path Toward Precision Medicine for Neuroinflammatory Mechanisms in Alzheimer's Disease
Hampel, H., Caraci, F., Cuello, A. C., Caruso, G., Nisticò, R., Corbo, M., Baldacci, F., Toschi, N., Garaci, F., Chiesa, P. A., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00456 · Cited by 360
Postmortem evidence of cerebral inflammation in schizophrenia: a systematic review
Trépanier, M. O., Hopperton, K. E., Mizrahi, R., Mechawar, N., & Bazinet, R. P. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.90 · Cited by 360
Khairova, R. A., Machado-Vieira, R., Du, J., & Manji, H. K. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709009924 · Cited by 350
Astrocyte regulation of synaptic behavior
Allen, N. J. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100913-013053 · Cited by 343
Homeostatic Regulation of Eye-Specific Responses in Visual Cortex during Ocular Dominance Plasticity
Mrsic-Flogel, T. D., Hofer, S. B., Ohki, K., Reid, R. C., Bonhoeffer, T., & Hübener, M. (2007) · Neuron · doi:10.1016/j.neuron.2007.05.028 · Cited by 330
Microglial Physiology and Pathophysiology: Insights from Genome-wide Transcriptional Profiling
Crotti, A., & Ransohoff, R. M. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.013 · Cited by 323
Regulation of CNS synapses by neuronal MHC class I
Goddard, C. A., Butts, D. A., & Shatz, C. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702023104 · Cited by 322
Plasticity of Astrocytic Coverage and Glutamate Transporter Expression in Adult Mouse Cortex
Genoud, C., Quairiaux, C., Steiner, P., Hirling, H., Welker, E., & Knott, G. W. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040343 · Cited by 321
Neuroplastic changes in depression: A role for the immune system
Eyre, H., & Baune, B. T. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.03.019 · Cited by 319
Skvarc, D., Berk, M., Byrne, L. K., Dean, O. M., Dodd, S., Lewis, M., Marriott, A., Moore, E. M., Morris, G., Page, R. S., et al. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.11.011 · Cited by 318
Behaviorally consequential astrocytic regulation of neural circuits
Nagai, J., Yu, X., Papouin, T., Cheong, E., Freeman, M. R., Monk, K. R., Hastings, M. H., Haydon, P. G., Rowitch, D. H., Shaham, S., et al. (2020) · Neuron · doi:10.1016/j.neuron.2020.12.008 · Cited by 315
Neuroinflammation in schizophrenia especially focused on the role of microglia
Monji, A., Kato, T. A., Mizoguchi, Y., Horikawa, H., Seki, Y., Kasai, M., Yamauchi, Y., Yamada, S., & Kanba, S. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.12.002 · Cited by 314
Astrogliosis: An integral player in the pathogenesis of Alzheimer's disease
Osborn, L. M., Kamphuis, W., Wadman, W. J., & Hol, E. M. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.01.001 · Cited by 312
NS21: Re-defined and modified supplement B27 for neuronal cultures
Chen, Y., Stevens, B., Chang, J., Milbrandt, J., Barres, B. A., & Hell, J. W. (2008) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2008.03.013 · Cited by 309
Jeremic, D., Jiménez-Díaz, L., & Navarro-López, J. D. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101496 · Cited by 306
Neuronal Firing Rate Homeostasis Is Inhibited by Sleep and Promoted by Wake
Hengen, K. B., Pacheco, A. T., McGregor, J. N., Hooser, S. D. V., & Turrigiano, G. G. (2016) · Cell · doi:10.1016/j.cell.2016.01.046 · Cited by 302
Wohleb, E. S., McKim, D. B., Shea, D. T., Powell, N. D., Tarr, A. J., Sheridan, J. F., & Godbout, J. P. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.11.029 · Cited by 300
Activity-Dependent Regulation of Synapses by Retrograde Messengers
Regehr, W. G., Carey, M. R., & Best, A. R. (2009) · Neuron · doi:10.1016/j.neuron.2009.06.021 · Cited by 298
Benedetto, S. D., Müller, L., Wenger, E., Düzel, S., & Pawelec, G. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.01.044 · Cited by 295
Microglia in depression: current perspectives
Jia, X., Gao, Z., & Hu, H. (2020) · Science China Life Sciences · doi:10.1007/s11427-020-1815-6 · Cited by 288
Homeostatic signaling: the positive side of negative feedback
Turrigiano, G. G. (2007) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2007.04.004 · Cited by 284
Astroglial Excitability and Gliotransmission: An Appraisal of Ca 2+ as a Signalling Route
Zorec, R., Araque, A., Carmignoto, G., Haydon, P. G., Verkhratsky, A., & Parpura, V. (2012) · ASN NEURO · doi:10.1042/an20110061 · Cited by 280
Puberty and adolescence as a time of vulnerability to stressors that alter neurobehavioral processes
Holder, M. K., & Blaustein, J. D. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.10.004 · Cited by 279
Morrison, H., Young, K., Qureshi, M., Rowe, R. K., & Lifshitz, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-13581-z · Cited by 276
Homeostatic Signaling and the Stabilization of Neural Function
Davis, G. W. (2013) · Neuron · doi:10.1016/j.neuron.2013.09.044 · Cited by 276
Neuroinflammation, Sleep, and Circadian Rhythms
Zielinski, M. R., & Gibbons, A. J. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.853096 · Cited by 273
Glial and Neuroimmune Mechanisms as Critical Modulators of Drug Use and Abuse
Lacagnina, M. J., Rivera, P. D., & Bilbo, S. D. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.121 · Cited by 271
Astrocytes: Orchestrating synaptic plasticity?
Pittà, M. D., Brunel, N., & Volterra, A. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.04.001 · Cited by 272
Molecular signals of plasticity at the tetrapartite synapse
Dityatev, A., & Rusakov, D. A. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.12.006 · Cited by 267
DNA methylation analysis of the autistic brain reveals multiple dysregulated biological pathways
Nardone, S., Sharan Sams, D., Reuveni, E., Getselter, D., Oron, O., Karpuj, M., & Elliott, E. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.70 · Cited by 266
Sierra, A., Beccari, S., Díaz‐Aparicio, I., Encinas, J. M., Comeau, S., & Tremblay, M. (2014) · Neural Plasticity · doi:10.1155/2014/610343 · Cited by 268
The role of cytokines in modulating learning and memory and brain plasticity
Bourgognon, J.-M., & Cavanagh, J. (2020) · Brain and Neuroscience Advances · doi:10.1177/2398212820979802 · Cited by 262
Astrocyte dysfunction in Alzheimer disease
Acosta, C., Anderson, H. D., & Anderson, C. M. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24075 · Cited by 262
Pribiag, H., & Stellwagen, D. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0530-13.2013 · Cited by 260
Self-citationToll-like receptors in chronic pain
Nicotra, L. L., Loram, L. C., Watkins, L. R., & Hutchinson, M. R. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.09.038 · Cited by 258
Shaping Neuronal Fate: Functional Heterogeneity of Direct Microglia-Neuron Interactions
Cserép, C., Pósfai, B., & Dénes, Á. (2021) · Neuron · doi:10.1016/j.neuron.2020.11.007 · Cited by 256
Jakubs, K., Nanobashvili, A., Bonde, S., Ekdahl, C. T., Kokaia, Z., Kokaia, M., & Lindvall, O. (2006) · Neuron · doi:10.1016/j.neuron.2006.11.004 · Cited by 255
GLIA modulates synaptic transmission
Perea, G., & Araque, A. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.10.005 · Cited by 255
Microglial TNF-α Suppresses Cocaine-Induced Plasticity and Behavioral Sensitization
Lewitus, G. M., Konefal, S., Greenhalgh, A. D., Pribiag, H., Augereau, K., & Stellwagen, D. (2016) · Neuron · doi:10.1016/j.neuron.2016.03.030 · Cited by 256
Self-citationNeurological Diseases as Primary Gliopathies: A Reassessment of Neurocentrism
Verkhratsky, A., Sofroniew, M. V., Messing, A., deLanerolle, N. C., Rempe, D. A., Rodriguez, J. J., & Nedergaard, M. (2012) · ASN NEURO · doi:10.1042/an20120010 · Cited by 254
Sepsis Associated Encephalopathy
Chaudhry, N., & Duggal, A. K. (2014) · Advances in Medicine · doi:10.1155/2014/762320 · Cited by 254
TNFα in synaptic function: switching gears
Santello, M., & Volterra, A. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.06.001 · Cited by 253
Cytokines as emerging regulators of central nervous system synapses
Zipp, F., Bittner, S., & Schafer, D. P. (2023) · Immunity · doi:10.1016/j.immuni.2023.04.011 · Cited by 257
Platelet factors attenuate inflammation and rescue cognition in ageing
Schroer, A. B., Ventura, P. B., Sucharov, J., Misra, R., Chui, M. K. K., Bieri, G., Horowitz, A. M., Smith, L. K., Encabo, K., Tenggara, I., et al. (2023) · Nature · doi:10.1038/s41586-023-06436-3 · Cited by 252
Role of tumor necrosis factor-alpha in the central nervous system: a focus on autoimmune disorders
Caldito, N. G. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1213448 · Cited by 252
Goel, A., & Lee, H.-K. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.5038-06.2007 · Cited by 251
Microglia in the developing brain: a potential target with lifetime effects
Harry, G. J., & Kraft, A. D. (2012) · NeuroToxicology · doi:10.1016/j.neuro.2012.01.012 · Cited by 250
Rapid cognitive improvement in Alzheimer's disease following perispinal etanercept administration
Tobinick, E. L., & Gross, H. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-2 · Cited by 250
Neumann, H., & Takahashi, K. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.11.032 · Cited by 249
G-Protein-Coupled Receptors in Astrocyte–Neuron Communication
Kofuji, P., & Araque, A. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.03.025 · Cited by 249
Astrocytes Control Food Intake by Inhibiting AGRP Neuron Activity via Adenosine A1 Receptors
Yang, L., Qi, Y., & Yang, Y. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.04.002 · Cited by 248
Losing your nerves? Maybe it's the antibodies
Diamond, B., Huerta, P. T., Mina-Osorio, P., Kowal, C., & Volpe, B. T. (2009) · Nature Reviews Immunology · doi:10.1038/nri2529 · Cited by 247
Post-COVID-19 Depressive Symptoms: Epidemiology, Pathophysiology, and Pharmacological Treatment
Mazza, M. G., Palladini, M., Poletti, S., & Benedetti, F. (2022) · CNS Drugs · doi:10.1007/s40263-022-00931-3 · Cited by 248
Fellin, T. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05830.x · Cited by 245
Optogenetic astrocyte activation modulates response selectivity of visual cortex neurons in vivo
Perea, G., Yang, A., Boyden, E. S., & Sur, M. (2014) · Nature Communications · doi:10.1038/ncomms4262 · Cited by 245
Arc/Arg3.1: Linking Gene Expression to Synaptic Plasticity and Memory
Tzingounis, A. V., & Nicoll, R. A. (2006) · Neuron · doi:10.1016/j.neuron.2006.10.016 · Cited by 245
Single-Cell Optogenetic Excitation Drives Homeostatic Synaptic Depression
Goold, C. P., & Nicoll, R. A. (2010) · Neuron · doi:10.1016/j.neuron.2010.09.020 · Cited by 244
Astrocytic control of synaptic function
Papouin, T., Dunphy, J. M., Tolman, M., Foley, J., & Haydon, P. G. (2017) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2016.0154 · Cited by 243
AMPA receptor trafficking and the mechanisms underlying synaptic plasticity and cognitive aging
Henley, J. M., & Wilkinson, K. A. (2013) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2013.15.1/jhenley · Cited by 242
Neuron-glia networks: integral gear of brain function
Perea, G., Sur, M., & Araque, A. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00378 · Cited by 241
Targeting Neuroinflammation to Treat Alzheimer’s Disease
Ardura-Fabregat, A., Boddeke, E., Boza‐Serrano, A., Brioschi, S., Castro‐Gomez, S., Ceyzériat, K., Dansokho, C., Dierkes, T., Gelders, G., Heneka, M. T., et al. (2017) · CNS Drugs · doi:10.1007/s40263-017-0483-3 · Cited by 241
Alzheimer’s Disease: From Firing Instability to Homeostasis Network Collapse
Frère, S. G. A., & Slutsky, I. (2018) · Neuron · doi:10.1016/j.neuron.2017.11.028 · Cited by 242
Glia: The many ways to modulate synaptic plasticity
Achour, S. B., & Pascual, O. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2010.02.013 · Cited by 240
Seeburg, D. P., Feliú-Mójer, M. I., Gaiottino, J., Pak, D. T. S., & Sheng, M. (2008) · Neuron · doi:10.1016/j.neuron.2008.03.021 · Cited by 239
Neuroimmune signaling in alcohol use disorder
Erickson, E. K., Grantham, E. K., Warden, A. S., & Harris, R. A. (2018) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2018.12.007 · Cited by 238
The roles of TNF in brain dysfunction and disease
Clark, I. A., Alleva, L. M., & Vissel, B. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.08.007 · Cited by 239
Exposure to polystyrene microplastics impairs hippocampus-dependent learning and memory in mice
Lee, C., Hsu, L., Wu, I.-L., Wang, Y., Chen, W.-C., Liu, Y., Yang, L.-T., Tan, C.-L., Luo, Y.-H., Wang, C.-C., et al. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.128431 · Cited by 237
Adult neurogenesis, glia, and the extracellular matrix
Cope, E. C., & Gould, E. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.03.023 · Cited by 236
Morris, G. P., Clark, I. A., Zinn, R., & Vissel, B. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.07.002 · Cited by 236
The Involvement and Therapy Target of Immune Cells After Ischemic Stroke
Jian, Z., Liu, R., Zhu, X., Smerin, D., Zhong, Y., Gu, L., Fang, W., & Xiong, X. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02167 · Cited by 236
IL-17 triggers the onset of cognitive and synaptic deficits in early stages of Alzheimer’s disease
Brigas, H. C., Ribeiro, M. A., Coelho, J. E., Gomes, R., Gómez‐Murcia, V., Carvalho, K., Faivre, É., Costa-Pereira, S., Darrigues, J., de Almeida, A. A., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109574 · Cited by 236
Infectious immunity in the central nervous system and brain function
Klein, R. S., Garber, C., & Howard, N. (2017) · Nature Immunology · doi:10.1038/ni.3656 · Cited by 235
Cenik, B., Sephton, C. F., Cenik, B. K., Herz, J., & Yu, G. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.r112.399170 · Cited by 235
Astrocyte-Mediated Distributed Plasticity at Hypothalamic Glutamate Synapses
Gordon, G. R., Iremonger, K. J., Kantevari, S., Ellis‐Davies, G. C. R., MacVicar, B. A., & Bains, J. S. (2009) · Neuron · doi:10.1016/j.neuron.2009.10.021 · Cited by 234
Microglia-neuron crosstalk: Signaling mechanism and control of synaptic transmission
Marinelli, S., Basilico, B., Marrone, M. C., & Ragozzino, D. (2019) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2019.05.017 · Cited by 233
Benarroch, E. E. (2013) · Neurology · doi:10.1212/wnl.0b013e3182a4a577 · Cited by 232
Gliotransmission and the Tripartite Synapse
Santello, M., Calì, C., & Bezzi, P. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-3-7091-0932-8_14 · Cited by 229
Riazi, K., Galic, M. A., Kentner, A. C., Reid, A. Y., Sharkey, K. A., & Pittman, Q. J. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.4485-14.2015 · Cited by 228
Central and Peripheral Inflammation Link Metabolic Syndrome and Major Depressive Disorder
Chan, K. L., Cathomas, F., & Russo, S. J. (2019) · Physiology · doi:10.1152/physiol.00047.2018 · Cited by 227
Effect of cytokines on neuronal excitability
Schäfers, M., & Sorkin, L. S. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.03.052 · Cited by 225
Astrocytic dysfunction: Insights on the role in neurodegeneration
Rossi, D., & Volterra, A. (2009) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2009.07.012 · Cited by 225
TLR4-activated microglia require IFN-γ to induce severe neuronal dysfunction and death in situ
Papageorgiou, I. E., Lewen, A., Galow, L. V., Cesetti, T., Scheffel, J., Regen, T., Hanisch, U., & Kann, O. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1513853113 · Cited by 225
Neuronal synapse formation induced by microglia and interleukin 10
Lim, S.-H., Park, E., You, B., Jung, Y., Park, A.-R., Park, S. G., & Lee, J.-R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081218 · Cited by 224
Activity-Dependent Regulation of Synaptic AMPA Receptor Composition and Abundance by β3 Integrins
Cingolani, L. A., Thalhammer, A., Yu, L. M. Y., Catalano, M., Ramos, T., Colicos, M. A., & Goda, Y. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.011 · Cited by 223
Schiweck, J., Eickholt, B. J., & Murk, K. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00261 · Cited by 223
Metadata
- Authors
- Stellwagen, D., & Malenka, R. C.
- Affiliations
- Stanford Medicine (US)
- Corresponding author
- Malenka, Robert C.
- Venue
- Nature
- Published
- 2006-04-01
- Volume
- 440
- Issue
- 7087
- Pages
- 1054-1059
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1542136448
- Cited by
- 1,715
- References
- 31
- Citations by year
- 2026: 73 · 2025: 66 · 2024: 72 · 2023: 70 · 2022: 102 · 2021: 102 · 2020: 117 · 2019: 80 · 2018: 87 · 2017: 94 · 2016: 80 · 2015: 92 · 2014: 92 · 2013: 104 · 2012: 103
- FWCI
- 27.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- synaptic scaling, homeostatic plasticity, TNF-α, neuron-glia interactions, long-term potentiation, long-term depression, neural network stability
- MeSH terms
- Animals, Hippocampus, Nerve Net, Neuroglia, Neurons, Synapses, Tetrodotoxin, Tumor Necrosis Factor-alpha, Signal Transduction, Rats, Sprague-Dawley, Long-Term Potentiation, Receptors, AMPA, Receptors, Tumor Necrosis Factor, Excitatory Postsynaptic Potentials, Long-Term Synaptic Depression, Mice, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
