The DOI matches its Crossref record; 30 of the 31 references it cites were found in a registry or an index.
Synaptic scaling mediated by glial TNF-α
Abstract
Two general forms of synaptic plasticity that operate on different timescales are thought to contribute to the activity-dependent refinement of neural circuitry during development: (1) long-term potentiation (LTP) and long-term depression (LTD), which involve rapid adjustments in the strengths of individual synapses in response to specific patterns of correlated synaptic activity, and (2) homeostatic synaptic scaling, which entails uniform adjustments in the strength of all synapses on a cell in response to prolonged changes in the cell's electrical activity. Without homeostatic synaptic scaling, neural networks can become unstable and perform suboptimally. Although much is known about the mechanisms underlying LTP and LTD, little is known about the mechanisms responsible for synaptic scaling except that such scaling is due, at least in part, to alterations in receptor content at synapses. Here we show that synaptic scaling in response to prolonged blockade of activity is mediated by the pro-inflammatory cytokine tumour-necrosis factor-alpha (TNF-alpha). Using mixtures of wild-type and TNF-alpha-deficient neurons and glia, we also show that glia are the source of the TNF-alpha that is required for this form of synaptic scaling. We suggest that by modulating TNF-alpha levels, glia actively participate in the homeostatic activity-dependent regulation of synaptic connectivity.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“This model is based on the observations that TNFa levels are elevated by prolonged (48 h) activity blockade, acute application of TNFa (or conditioned media from activity-blocked cultures) increases mEPSC amplitude, and scaling up in response to prolonged activity blockade is prevented by blocking TNFa signaling (Beattie et al. 2002;Stellwagen et al. 2005;Stellwagen and Malenka 2006).”
From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Stellwagen and Malenka 2006
In the citing paper
“This model is based on the observations that TNFa levels are elevated by prolonged (48 h) activity blockade, acute application of TNFa (or conditioned media from activity-blocked cultures) increases mEPSC amplitude, and scaling up in response to prolonged activity blockade is prevented by blocking TNFa signaling (Beattie et al. 2002;Stellwagen et al. 2005;Stellwagen and Malenka 2006).”
From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Stellwagen and Malenka 2006
In the citing paper
“It was recently proposed that prolonged activity blockade (with TTX) increases glial release of TNFa, which then acts on neurons to enhance AMPAR insertion and scale up mEPSC amplitude (Stellwagen and Malenka 2006).”
From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Stellwagen and Malenka 2006
In the citing paper
“This model is based on the observations that TNFa levels are elevated by prolonged (48 h) activity blockade, acute application of TNFa (or conditioned media from activity-blocked cultures) increases mEPSC amplitude, and scaling up in response to prolonged activity blockade is prevented by blocking TNFa signaling (Beattie et al. 2002;Stellwagen et al. 2005;Stellwagen and Malenka 2006).”
From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Stellwagen and Malenka 2006
In the citing paper
“Interestingly, the TNFa involved in scaling up synaptic strengths in response to TTX originates from glia rather than neurons, because wild-type neurons grown on TNFa 2/2 glia did not scale up synaptic strengths in response to 48 h of TTX treatment, whereas TNFa 2/2 neurons grown on wild-type glia did (Stellwagen and Malenka 2006).”
From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Stellwagen and Malenka 2006
In the citing paper
“Inconsistent with the above model is the observation that scaling is a gradual and cumulative process evident after as little as 4-6 h of activity blockade (Sutton et al. 2006;Ibata et al. 2008), whereas TNFa-dependent scaling was only observed after prolonged activity block (48 h) (Stellwagen and Malenka 2006).”
From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Stellwagen and Malenka 2006
In the citing paper
“Interestingly, the delayed potentiation in visual cortex following lid suture requires TNFa and Arc signaling (Kaneko et al. 2008;McCurry et al. 2011) as does synaptic scaling in vitro (Shepherd et al. 2006;Stellwagen and Malenka 2006;Steinmetz and Turrigiano 2010); however, both these manipulations likely affect many forms of plasticity, so it still remains to be seen if synaptic scaling”
From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Stellwagen and Malenka 2006
Citations
Cites
Malenka, R. C., & Bear, M. F. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.012 · Cited by 3,968
Self-citationA simple method for organotypic cultures of nervous tissue
Stoppini, L., Buchs, P., & Muller, D. (1991) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(91)90128-m · Cited by 3,096
Homeostatic plasticity in the developing nervous system
Turrigiano, G. G., & Nelson, S. B. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1327 · Cited by 2,485
Synaptic plasticity: taming the beast
Abbott, L. F., & Nelson, S. B. (2000) · Nature Neuroscience · doi:10.1038/81453 · Cited by 2,263
Activity-dependent scaling of quantal amplitude in neocortical neurons
Turrigiano, G. G., Leslie, K. R., Desai, N. S., Rutherford, L. C., & Nelson, S. B. (1998) · Nature · doi:10.1038/36103 · Cited by 2,226
Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis
Christopherson, K. S., Ullian, E. M., Stokes, C. C. A., Mullowney, C. E., Hell, J. W., Agah, A., Lawler, J., Mosher, D. F., Bornstein, P., & Barres, B. A. (2005) · Cell · doi:10.1016/j.cell.2004.12.020 · Cited by 1,688
Hayashi, Y., Shi, S.-H., Esteban, J. A., Piccini, A., Poncer, J.-C., & Malinow, R. (2000) · Science · doi:10.1126/science.287.5461.2262 · Cited by 1,524
Control of Synapse Number by Glia
Ullian, E. M., Sapperstein, S. K., Christopherson, K. S., & Barres, B. A. (2001) · Science · doi:10.1126/science.291.5504.657 · Cited by 1,380
Control of Synaptic Strength by Glial TNFα
Beattie, E. C., Stellwagen, D., Morishita, W., Bresnahan, J. C., Ha, B. K., Von Zastrow, M., Beattie, M. S., & Malenka, R. C. (2002) · Science · doi:10.1126/science.1067859 · Cited by 1,344
Self-citationRapid Spine Delivery and Redistribution of AMPA Receptors After Synaptic NMDA Receptor Activation
Shi, S.-H., Hayashi, Y., Petralia, R. S., Zaman, S. H., Wenthold, R. J., Svoboda, K., & Malinow, R. (1999) · Science · doi:10.1126/science.284.5421.1811 · Cited by 1,276
Flagged first, then by citations
1 of the 31 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 601–700 of 1,004
Role of astrocytes in synapse formation and maturation
Tan, C. X., Burrus, C. J., & Eroğlu, Ç. (2021) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2020.12.010 · Cited by 66
Bradley, S. J., & Challiss, R. A. J. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.04.009 · Cited by 66
Lee, R., Mills, E. A., Schwartz, N., Bell, M. R., Deeg, K. E., Ruthazer, E. S., Marsh‐Armstrong, N., & Aizenman, C. D. (2010) · Neural Development · doi:10.1186/1749-8104-5-2 · Cited by 66
Novel insights into gliotransmitters
Petrelli, F., & Bezzi, P. (2015) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2015.11.010 · Cited by 66
Strauss, K. I., & Elisevich, K. V. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0727-z · Cited by 66
Immune system: The “seventh sense”
Kipnis, J. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20172295 · Cited by 66
Perispinal etanercept: Potential as an Alzheimer therapeutic
Griffin, W. S. T. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-3 · Cited by 66
Growth factors in synaptic function
Poon, V. Y., Choi, S., & Park, M. (2013) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2013.00006 · Cited by 65
Ormel, P. R., Böttcher, C., Gigase, F. A. J., Missall, R. D., van Zuiden, W., Zapata, M. C. F., Ilhan, D., de Goeij, M. H. M., Udine, E., Sommer, I. E., et al. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.08.012 · Cited by 65
Early amplitude‐integrated EEG correlates with cord TNF‐α and brain injury in very preterm infants
Wikström, S., Ley, D., Hansen‐Pupp, I., Rosén, I., & Hellström-Westas, L. K. (2008) · Acta Paediatrica · doi:10.1111/j.1651-2227.2008.00787.x · Cited by 65
Maggio, N., & Vlachos, A. (2018) · Journal of Molecular Medicine · doi:10.1007/s00109-018-1674-1 · Cited by 65
Grau, J. W., Huie, J. R., Lee, K. H., Hoy, K. C., Huang, Y.-J., Turtle, J. D., Strain, M. M., Baumbauer, K. M., Miranda, R. M., Hook, M. A., et al. (2014) · Frontiers in Neural Circuits · doi:10.3389/fncir.2014.00100 · Cited by 64
Degeneracy in epilepsy: multiple routes to hyperexcitable brain circuits and their repair
Stöber, T. M., Batulin, D., Triesch, J., Narayanan, R., & Jedlička, P. (2023) · Communications Biology · doi:10.1038/s42003-023-04823-0 · Cited by 65
Groth, R. D., Lindskog, M., Thiagarajan, T. C., Li, L., & Tsien, R. W. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018022108 · Cited by 64
Microglia in juvenile neuronal ceroid lipofuscinosis are primed toward a pro‐inflammatory phenotype
Xiong, J., & Kielian, T. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12385 · Cited by 64
Gerstner, J. R., Vanderheyden, W. M., LaVaute, T. M., Westmark, C. J., Rouhana, L., Pack, A. I., Wickens, M., & Landry, C. F. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.3228-11.2012 · Cited by 64
Perispinal etanercept: a new therapeutic paradigm in neurology
Tobinick, E. L. (2010) · Expert Review of Neurotherapeutics · doi:10.1586/ern.10.52 · Cited by 64
Modulators of neuronal cell death in epilepsy
Henshall, D. C., & Murphy, B. M. (2007) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2007.07.005 · Cited by 64
Critical branching neural networks.
Kello, C. T. (2013) · Psychological Review · doi:10.1037/a0030970 · Cited by 63
Tumor Necrosis Factor-α: The Next Marker of Stroke
Xue, Y., Zeng, X., Tu, W., & Zhao, J. (2022) · Disease Markers · doi:10.1155/2022/2395269 · Cited by 63
Chin, Y., Kishi, M., Sekino, M., Nakajo, F., Abe, Y., Terazono, Y., Ohsaki, H., Kato, F., Koizumi, S., Gachet, C., et al. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-95 · Cited by 63
Brain Oxidative Stress During Experimental Sepsis Is Attenuated by Simvastatin Administration
Catalão, C. H. R., Santos-Júnior, N. N., da Costa, L. H. A., Souza, A. D. O., Alberici, L. C., & Rocha, M. J. A. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0218-3 · Cited by 63
Matarredona, E. R., Talaverón, R., & Pastor, Á. M. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00268 · Cited by 63
Acharjee, S., Verbeek, M., Gómez, C., Bisht, K., Lee, B., Benoit, L., Sharkey, K. A., Benediktsson, A. M., Tremblay, M., & Pittman, Q. J. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.0398-18.2018 · Cited by 63
Székely, M., & Garai, J. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63912-7.00023-0 · Cited by 63
MicroRNA-186-5p controls GluA2 surface expression and synaptic scaling in hippocampal neurons
Silva, M. M., Rodrigues, B., Fernandes, J., Santos, S. D., Carreto, L. C., Santos, M. A. S., Pinheiro, P. S., & Carvalho, A. L. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1900338116 · Cited by 62
The Role of Glial Cells in Synaptic Dysfunction: Insights into Alzheimer's Disease Mechanisms
Yu, Y., Chen, R., Mao, K., Deng, M., & Li, Z. (2023) · Aging and Disease · doi:10.14336/ad.2023.0718 · Cited by 62
Neuroendocrine Regulation of Hydromineral Homeostasis
Mecawi, A. S., Ruginsk, S. G., Elias, L. L. K., Varanda, W. A., & Antunes‐Rodrigues, J. (2015) · Comprehensive physiology · doi:10.1002/cphy.c140031 · Cited by 62
Rae, M. G., & O’Malley, D. (2016) · Journal of Neurophysiology · doi:10.1152/jn.00248.2016 · Cited by 62
Microglial Modulation as a Target for Chronic Pain: From the Bench to the Bedside and Back
Haight, E. S., Forman, T. E., Cordonnier, S. A., James, M. L., & Tawfik, V. L. (2019) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000004033 · Cited by 62
Interleukin-4 receptor signaling modulates neuronal network activity
Hanuscheck, N., Thalman, C., Domingues, M., Schmaul, S., Muthuraman, M., Hetsch, F., Ecker, M., Endle, H., Oshaghi, M., Martino, G., et al. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20211887 · Cited by 61
Does Brain Inflammation Mediate Pathological Outcomes in Epilepsy?
Wilcox, K. S., & Vezzani, A. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-94-017-8914-1_14 · Cited by 62
Vlachos, A., Becker, D., Jedlička, P., Winkels, R., Roeper, J., & Deller, T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032883 · Cited by 61
Greenhill, S., Ranson, A., & Fox, K. D. (2015) · Neuron · doi:10.1016/j.neuron.2015.09.025 · Cited by 61
Lisboa, S. F. D. S., Gomes, F. V., Silva, A. L., Uliana, D. L., Camargo, L. H. A., Guimarães, F. S., Cunha, F. Q., Joca, S. R. L., & Resstel, L. B. M. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv005 · Cited by 61
Astrocyte expression of the Drosophila TNF-alpha homologue, Eiger, regulates sleep in flies
Vanderheyden, W. M., Goodman, A. G., Taylor, R. H., Frank, M. G., Dongen, H. P. A. V., & Gerstner, J. R. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007724 · Cited by 61
The Role of the Classical Complement Cascade in Synapse Loss During Development and Glaucoma
Rosen, A. M., & Stevens, B. (2010) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4419-5635-4_6 · Cited by 60
How Stress Shapes Neuroimmune Function: Implications for the Neurobiology of Psychiatric Disorders
Koo, J. W., & Wohleb, E. S. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.11.007 · Cited by 60
Wang, Y.-B., Li, X., Bing, Y., Zhang, Q., Fei-Tong, J., Minghong, W., Xiangxiang, Z., Le, K., Li, Y., Ping, S., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04765-1 · Cited by 60
Jolly, S., Bazargani, N., Quiroga, A. C., Pringle, N. P., Attwell, D., Richardson, W. D., & Li, H. (2017) · Glia · doi:10.1002/glia.23198 · Cited by 60
Mironets, E., Osei‐Owusu, P., Bracchi-Ricard, V. C., Fischer, R., Owens, E. A., Ricard, J., Wu, D., Saltos, T. M., Collyer, E., Hou, S., et al. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.2376-17.2018 · Cited by 60
Visual Experience-Dependent Expression of Fn14 Is Required for Retinogeniculate Refinement
Cheadle, L., Tzeng, C. P., Kalish, B. T., Harmin, D. A., Rivera, S. A., Ling, E., Nagy, M. A., Hrvatin, S., Hu, L. S., Stroud, H., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.06.036 · Cited by 60
Kemp, G. M., Altimimi, H. F., Nho, Y., Heir, R., Klyczek, A., & Stellwagen, D. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01737-x · Cited by 59
Self-citationCortical maps: a role for astrocytes?
López-Hidalgo, M. A., & Schummers, J. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.11.001 · Cited by 59
Yin, H. Z., Hsu, C.-I., Yu, S. W., Rao, S. D., Sorkin, L. S., & Weiss, J. H. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.08.004 · Cited by 59
Madsen, P. M., Clausen, B. H., Degn, M., Thyssen, S., Kristensen, L. K., Svensson, M., Ditzel, N., Finsen, B. R., Deierborg, T., Brambilla, R., et al. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x15610339 · Cited by 59
Grau, J. W., Huang, Y.-J., Turtle, J. D., Strain, M. M., Miranda, R. C., Garraway, S. M., & Hook, M. A. (2016) · Journal of Neurotrauma · doi:10.1089/neu.2016.4626 · Cited by 59
Namba, M. D., Kupchik, Y. M., Spencer, S. M., García‐Keller, C., Goenaga, J. G., Powell, G. L., Vicino, I., Hogue, I. B., & Gipson, C. D. (2019) · Addiction Biology · doi:10.1111/adb.12797 · Cited by 59
Multiple realizability and the spirit of functionalism
Cao, R. (2022) · Synthese · doi:10.1007/s11229-022-03524-1 · Cited by 58
Spolidoro, M., Putignano, E., Munafò, C., Maffei, L., & Pizzorusso, T. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhr158 · Cited by 58
Astrocyte signaling and neurodegeneration
Brambilla, L., Martorana, F., & Rossi, D. (2013) · Prion · doi:10.4161/pri.22512 · Cited by 58
Astrocytes: Emerging stars in leukodystrophy pathogenesis
Lanciotti, A., Brignone, M. S., Bertini, E., Petrucci, T. C., Aloisi, F., & Ambrosini, E. (2013) · Translational Neuroscience · doi:10.2478/s13380-013-0118-1 · Cited by 58
The role of GABAergic inhibition in ocular dominance plasticity
Heimel, J. A., van Versendaal, D., & Levelt, C. N. (2011) · Neural Plasticity · doi:10.1155/2011/391763 · Cited by 57
Microglia as therapeutic target in central nervous system disorders
Fatoba, O., Itokazu, T., & Yamashita, T. (2020) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2020.07.004 · Cited by 57
Perspective on Nanofluidic Memristors: From Mechanism to Application
Xie, B., Xiong, T., Li, W., Gao, T., Zong, J., Liu, Y., & Yu, P. (2022) · Chemistry - An Asian Journal · doi:10.1002/asia.202200682 · Cited by 57
Rosiglitazone attenuates the age-related changes in astrocytosis and the deficit in LTP
Cowley, T. R., O’Sullivan, J. B., Blau, C. W., Deighan, B. F., Jones, R. S., Kerskens, C., Richardson, J. C., Virley, D. J., Upton, N., & Lynch, M. A. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.02.002 · Cited by 57
Crawford, D. C., Jiang, X., Taylor, A., & Mennerick, S. J. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2604-12.2012 · Cited by 57
The Glial Perspective on Sleep and Circadian Rhythms
Artiushin, G., & Sehgal, A. (2020) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-091819-094557 · Cited by 57
Çalışkan, G., French, T., Lacalle, S. E., del Ángel, M., Steffen, J., Heimesaat, M. M., Dunay, I. R., & Stork, O. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.10.007 · Cited by 58
Neuroinflammation in Alzheimer's disease: protector or promoter?
Žilka, N., Ferencĭk, M., & Hulín, I. (2006) · Bratislavské lekárske listy/Bratislava medical journal · doi:10.1007/bf03656856 · Cited by 58
Cantaut-Belarif, Y., Antri, M., Pizzarelli, R., Colasse, S., Vaccari, I., Soares, S., Renner, M., Dallel, R., Triller, A., & Bessis, A. (2017) · Journal of Cell Biology · doi:10.1083/jcb.201607048 · Cited by 56
Picchioni, D., Reith, R. M., Nadel, J., & Smith, C. B. (2014) · Brain Sciences · doi:10.3390/brainsci4010150 · Cited by 56
Neural ECM molecules in axonal and synaptic homeostatic plasticity
Frischknecht, R., Chang, K.-J., Rasband, M. N., & Seidenbecher, C. I. (2014) · Progress in brain research · doi:10.1016/b978-0-444-63486-3.00004-9 · Cited by 56
Homeostatic plasticity and synaptic scaling in the adult mouse auditory cortex
Teichert, M., Liebmann, L., Hübner, C. A., & Bolz, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-17711-5 · Cited by 56
Amyloid-Beta Mediates Homeostatic Synaptic Plasticity
Galanis, C., Fellenz, M., Becker, D., Bold, C. S., Lichtenthaler, S. F., Müller, U., Deller, T., & Vlachos, A. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.1820-20.2021 · Cited by 56
Saliba, R. S., Gu, Z., Yan, Z., & Moss, S. J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.040071 · Cited by 56
Perispinal etanercept for neuroinflammatory disorders
Tobinick, E. L. (2008) · Drug Discovery Today · doi:10.1016/j.drudis.2008.10.005 · Cited by 56
Atkin, S. D., Patel, S., Kocharyan, A., Holtzclaw, L. A., Weerth, S. H., Schram, V., Pickel, J. M., & Russell, J. T. (2009) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2009.05.006 · Cited by 56
Microglial Cytokines Mediate Plasticity Induced by 10 Hz Repetitive Magnetic Stimulation
Eichler, A., Kleidonas, D., Turi, Z., Fliegauf, M., Kirsch, M., Pfeifer, D., Masuda, T., Prinz, M., Lenz, M., & Vlachos, A. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.2226-22.2023 · Cited by 56
Pregnant serum induces neuroinflammation and seizure activity via TNFα
Cipolla, M. J., Pusic, A. D., Grinberg, Y. Y., Chapman, A. C., Poynter, M. E., & Kraig, R. P. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.01.005 · Cited by 55
Regulation of microglia effector functions by tumor necrosis factor signaling
Harms, A. S., Lee, J., Nguyen, T. A., Chang, J., Ruhn, K. M., Treviño, I., & Tansey, M. G. (2011) · Glia · doi:10.1002/glia.21254 · Cited by 55
Proteasome-independent polyubiquitin linkage regulates synapse scaffolding, efficacy, and plasticity
Ma, Q., Ruan, H., Peng, L., Zhang, M., Gack, M. U., & Yao, W. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1620153114 · Cited by 55
Peineau, S., Rabiant, K., Pierrefiche, O., & Potier, B. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.01.018 · Cited by 56
Ma, D., Feng, L., Cheng, Y., Xin, M., You, J., Yin, X. L., Hao, Y., Cui, L., & Feng, J. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1230-5 · Cited by 55
Understanding microglial diversity and implications for neuronal function in health and disease
Schepper, S. D., Crowley, G., & Hong, S. Y. (2020) · Developmental Neurobiology · doi:10.1002/dneu.22777 · Cited by 54
Risk and protective factors for sporadic Alzheimer's disease.
Stožická, Z., Žilka, N., & Novák, M. (2007) · PubMed · Cited by 55
Short- and Long-Term Outcomes of Preeclampsia in Offspring: Review of the Literature
Koulouraki, S., Paschos, V., Pervanidou, P., Christopoulos, P., Gerede, A., & Eleftheriades, M. I. (2023) · Children · doi:10.3390/children10050826 · Cited by 54
Neonates at Risk: Understanding the Impact of High-Risk Pregnancies on Neonatal Health
Sokou, R., Lianou, A., Lampridou, M., Panagiotounakou, P., Kafalidis, G., Paliatsiou, S., Volaki, P., Tsantes, A. G., Boutsikou, Τ., Iliodromiti, Z., et al. (2025) · Medicina · doi:10.3390/medicina61061077 · Cited by 54
Regional variations in the glial influence on synapse development in the mouse CNS
Steinmetz, C. C., Buard, I., Claudepierre, T., Nägler, K., & Pfrieger, F. W. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.117358 · Cited by 54
Monomeric IgG Is Neuroprotective via Enhancing Microglial Recycling Endocytosis and TNF-α
Hulse, R. E., Swenson, W. G., Kunkler, P. E., White, D. M., & Kraig, R. P. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3856-08.2008 · Cited by 54
Reduced synaptic activity precedes synaptic stripping in vagal motoneurons after axotomy
Yamada, J., Hayashi, Y., Jinno, S., Wu, Z., Inoue, K., Kohsaka, S., & Nakanishi, H. (2008) · Glia · doi:10.1002/glia.20711 · Cited by 54
The Innate Immune Receptor PGRP-LC Controls Presynaptic Homeostatic Plasticity
Harris, N., Braiser, D. J., Dickman, D. K., Fetter, R. D., Tong, A., & Davis, G. W. (2015) · Neuron · doi:10.1016/j.neuron.2015.10.049 · Cited by 54
Is there a link between TNF gene expression and cognitive deficits in depression?
Bobińska, K., Gałecka, E., Szemraj, J., Gałecki, P., & Talarowska, M. E. (1970) · Acta Biochimica Polonica · doi:10.18388/abp.2016_1276 · Cited by 54
The malleable brain: plasticity of neural circuits and behavior – a review from students to students
Schaefer, N., Rotermund, C., Blumrich, E., Lourenco, M. V., Joshi, P., Hegemann, R. U., Jamwal, S., Ali, N., Romero, E. M. G., Sharma, S., et al. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14107 · Cited by 54
Hyperexcitability and homeostasis in fragile X Syndrome.
Liu, X., Kumar, V., Tsai, N.-P., & Auerbach, B. D. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.805929 · Cited by 53
Astrocytes Are the Source of TNF Mediating Homeostatic Synaptic Plasticity
Heir, R., Abbasi, Z., Komal, P., Altimimi, H. F., Franquin, M., Moschou, D., Chambon, J., & Stellwagen, D. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.2278-22.2024 · Cited by 53
Self-citationGlial Tumor Necrosis Factor Alpha (TNFα) Generates Metaplastic Inhibition of Spinal Learning
Huie, J. R., Baumbauer, K. M., Lee, K. H., Bresnahan, J. C., Beattie, M. S., Ferguson, A. R., & Grau, J. W. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039751 · Cited by 53
Homologous HSV1 and alpha-synuclein peptides stimulate a T cell response in Parkinson's disease
Caggiu, E., Paulus, K. S., Galleri, G., Arru, G., Manetti, R., Sechi, G., & Sechi, L. A. (2017) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2017.06.004 · Cited by 53
Synaptoimmunology - roles in health and disease
Nisticò, R., Salter, E. W., Nicolas, C. S., Feligioni, M., Mango, D., Bortolotto, Z. A., Gressèns, P., Collingridge, G. L., & Peineau, S. (2017) · Molecular Brain · doi:10.1186/s13041-017-0308-9 · Cited by 53
Zhong, L. R., Chen, X., Park, E., Südhof, T. C., & Chen, L. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.1133-18.2018 · Cited by 53
Air Travel and the Spread of Influenza: Important Caveats
Viboud, C. G., Miller, M. A., Grenfell, B. T., Bjørnstad, O. N., & Simonsen, L. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030503 · Cited by 53
Fractalkine/CX3CR1-Dependent Modulation of Synaptic and Network Plasticity in Health and Disease
Camacho-Hernández, N. P., & Peña‐Ortega, F. (2023) · Neural Plasticity · doi:10.1155/2023/4637073 · Cited by 52
Synergistic Actions of Microglia and Astrocytes in the Progression of Alzheimer's Disease
Bouvier, D. S., & Murai, K. K. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-143156 · Cited by 52
Sun, X., & Wolf, M. E. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06852.x · Cited by 52
David, B. T., Ratnayake, A., Amarante, M. A., Reddy, N. P., Dong, W., Sampath, S., Heary, R. F., & Elkabes, S. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.12.012 · Cited by 52
Astrocyte regulation of sleep circuits: experimental and modeling perspectives
Fellin, T., Ellenbogen, J. M., Pittà, M. D., Ben‐Jacob, E., & Halassa, M. M. (2012) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2012.00065 · Cited by 52
Photonic Neuromorphic Signal Processing and Computing
Tait, A. N., Nahmias, M. A., Tian, Y., Shastri, B. J., & Prucnal, P. R. (2013) · Nano-optics and nanophotonics · doi:10.1007/978-3-642-40224-1_8 · Cited by 52
Paul-Samojedny, M., Owczarek, A. J., Kowalczyk, M., Suchanek-Raif, R., Palacz, M., Kucia, K. A., Fila-Daniłow, A., Borkowska, P., & Kowalski, J. (2013) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.12020021 · Cited by 52
Rivera, P., Fernández‐Arjona, M. D. M., Silva‐Peña, D., Blanco, E., Vargas, A., López-Ávalos, M. D., Grondona, J. M., Serrano, A., Pavón, F. J., de Fonseca, F. R., et al. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.08.005 · Cited by 52
Wilhelm, J. C., Rich, M. M., & Wenner, P. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813058106 · Cited by 52
Metadata
- Authors
- Stellwagen, D., & Malenka, R. C.
- Affiliations
- Stanford Medicine (US)
- Corresponding author
- Malenka, Robert C.
- Venue
- Nature
- Published
- 2006-04-01
- Volume
- 440
- Issue
- 7087
- Pages
- 1054-1059
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1542136448
- Cited by
- 1,715
- References
- 31
- Citations by year
- 2026: 73 · 2025: 66 · 2024: 72 · 2023: 70 · 2022: 102 · 2021: 102 · 2020: 117 · 2019: 80 · 2018: 87 · 2017: 94 · 2016: 80 · 2015: 92 · 2014: 92 · 2013: 104 · 2012: 103
- FWCI
- 27.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- synaptic scaling, homeostatic plasticity, TNF-α, neuron-glia interactions, long-term potentiation, long-term depression, neural network stability
- MeSH terms
- Animals, Hippocampus, Nerve Net, Neuroglia, Neurons, Synapses, Tetrodotoxin, Tumor Necrosis Factor-alpha, Signal Transduction, Rats, Sprague-Dawley, Long-Term Potentiation, Receptors, AMPA, Receptors, Tumor Necrosis Factor, Excitatory Postsynaptic Potentials, Long-Term Synaptic Depression, Mice, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
