Cited by 2,814Adipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and AdiposityDiabetes, Cardiovascular Risks, and Lipoproteins

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Mechanisms linking obesity with cardiovascular disease

Van Gaal, Luc F., Mertens, Ilse L., De Block, Christophe E.·2006·Nature

DOI 10.1038/nature05487

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Abstract

Obesity increases the risk of cardiovascular disease and premature death. Adipose tissue releases a large number of bioactive mediators that influence not only body weight homeostasis but also insulin resistance - the core feature of type 2 diabetes - as well as alterations in lipids, blood pressure, coagulation, fibrinolysis and inflammation, leading to endothelial dysfunction and atherosclerosis. We are now beginning to understand the underlying mechanisms as well as the ways in which smoking and dyslipidaemia increase, and physical activity attenuates, the adverse effects of obesity on cardiovascular health.

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The Heartwarming Effect of Brown Adipose Tissue
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Evaluating the association between the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet, mental health, and cardio-metabolic risk factors among individuals with obesity
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Potato protein hydrolysate attenuates high fat diet-induced cardiac apoptosis through SIRT1/ PGC-1á/Akt signalling
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Plasminogen activator inhibitor 1 and visceral obesity during pronounced weight loss after bariatric surgery
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“Among them, diabetes is known to have strong association with the development of cardiovascular diseases [1,2].”
Background
Mutation in Caenorhabditis elegans Krüppel-like factor, KLF-3 results in fat accumulation and alters fatty acid composition
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Leptin regulates ACE activity in mice
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Plasminogen Activator Inhibitor-1 Level Correlates with Lipoprotein Subfractions in Obese Nondiabetic Subjects
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Background
Syntheses and Biological Activities of New Hybrid Molecules Containing Different Heterocyclic Moieties
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Childhood Metabolic Syndrome
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Effects of Body Fat on the Associations of High-Molecular-Weight Adiponectin, Leptin and Soluble Leptin Receptor with Metabolic Syndrome in Chinese
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Improvement of Exercise Capacity and Peripheral Metaboreflex After Bariatric Surgery
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“Our results also showed a strong positive correlation among palmitoylcarnitine, LDL-cholesterol, and oxLDL levels, and higher palmitoylcarnitine was also associated with smaller LDL particle size and lower HDL-cholesterol concentrations, which are known as independent CVD risk factors (27,28).”
BackgroundInfluential
Associations of Platelet Indices with Body Fat Mass and Fat Distribution
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Background
Circulating cell adhesion molecules in metabolically healthy obesity
Mulhem, A., Moulla, Y., Klöting, N., Ebert, T., Tönjes, A., Faßhauer, M., Dietrich, A., Schön, M. R., Stümvoll, M., Richter, V., et al. (2020) · International Journal of Obesity · doi:10.1038/s41366-020-00667-4 · Cited by 32
Açaí seed extract (ASE) rich in proanthocyanidins improves cardiovascular remodeling by increasing antioxidant response in obese high-fat diet-fed mice
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Risk of Cardiovascular and All-Cause Mortality: Impact of Impaired Health-Related Functioning and Diabetes
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How could complementary feeding patterns affect the susceptibility to NCD later in life?
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“Owing to the well documented associations of overweight and obesity, and in particular, the increased risk of cardiometabolic diseases related to excess central and visceral fat [12,13], feeding practices and patterns of dietary intake that promote excess energy intake and early obesity development are a key concern.”
Background
Cardiovascular autonomic dysfunction and oxidative stress induced by fructose overload in an experimental model of hypertension and menopause
Conti, F. F., Brito, J. D. O., Bernardes, N., Dias, D. D. S., Sanches, Í. C., Malfitano, C., Llesuy, S., Irigoyen, M. C., & Angelis, K. D. (2014) · BMC Cardiovascular Disorders · doi:10.1186/1471-2261-14-185 · Cited by 32
“These substances negatively influence glucose and lipid homeostasis, blood pressure, coagulation, fibrinolysis and inflammation, which may lead to endothelial dysfunction and atherosclerosis [28,29].”
BackgroundInfluential
Less liver fibrosis in metabolically healthy compared with metabolically unhealthy obese patients with non-alcoholic fatty liver disease
Gutiérrez-Grobe, Y., Juárez-Hernández, E., Sánchez-Jimenez, B., Uribe-Ramos, M. H., Ramos-Ostos, M. H., Uribe, M., & Chávez-Tapia, N. C. (2017) · Diabetes & Metabolism · doi:10.1016/j.diabet.2017.02.007 · Cited by 32
Maximal Exercise Alters the Inflammatory Phenotype and Response of Mononuclear Cells
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Selective targeting of glucagon‐like peptide‐1 signalling as a novel therapeutic approach for cardiovascular disease in diabetes
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“…an elevation in circulating adhesion molecules, such as intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1), and an increased propensity to develop atherosclerosis which is typified by inflammatory cell infiltration and plaque formation (Van Gaal et al., 2006).”
Background
Protein, Carbohydrates, and Fats
Singh, P., Kesharwani, R. K., & Keservani, R. K. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805413-0.00006-5 · Cited by 31
The Relationship Between Specific Fatty Acids of Serum Lipids and Serum High Sensitivity C- Reactive Protein Levels in Morbidly Obese Women
Kaska, Ł., Mika, A., Stepnowski, P., Proczko, M., Ratnicki‐Sklucki, K., Śledziński, T., Goyke, E., & Świerczyński, J. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000366324 · Cited by 31
Effects of a nutraceutical combination containing berberine (BRB), policosanol, and red yeast rice (RYR), on lipid profile in hypercholesterolemic patients: A meta-analysis of randomised controlled trials
Millán, J., Cicero, A. F. G., Torres, F., & Anguera, A. (2016) · Clínica e Investigación en Arteriosclerosis · doi:10.1016/j.arteri.2016.03.002 · Cited by 31
Nonalcoholic fatty liver disease and sarcopenia: Where do we stand?
Mikolasevic, I., Pavic, T., Filipec Kanizaj, T., Bender, D. V., Domislovic, V., & Krznaric, Z. (2020) · Canadian Journal of Gastroenterology and Hepatology · doi:10.1155/2020/8859719 · Cited by 30
“, TNF-α, high-sensitivity C-reactive protein (hsCRP), and IL-6) with low muscle mass and progressive course of NAFLD [18, 24, 28, 31].”
Background

Authors: Van Gaal, L. F., Mertens, I. L., & De Block, C. E.
Affiliations: University of Antwerp (BE)
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2006-12
Volume: 444
Issue: 7121
Pages: 875-880
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature05487
OpenAlex: W1964607854
Cited by: 2,814
References: 86
Citations by year: 2026: 64 · 2025: 97 · 2024: 126 · 2023: 137 · 2022: 151 · 2021: 172 · 2020: 179 · 2019: 204 · 2018: 172 · 2017: 173 · 2016: 168 · 2015: 193 · 2014: 194 · 2013: 152 · 2012: 128
FWCI: 11.30
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: obesity, cardiovascular disease, adipose tissue, adipokines, insulin resistance, type 2 diabetes, dyslipidemia, blood pressure, coagulation, fibrinolysis, inflammation, endothelial dysfunction, atherosclerosis, smoking, physical activity, premature mortality
MeSH terms: Cardiovascular Diseases, Endothelium, Vascular, Humans, Insulin Resistance, Obesity, Oxidative Stress, Adiposity

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