The DOI matches its Crossref record; 86 of the 86 references it cites were found in a registry or an index.
Mechanisms linking obesity with cardiovascular disease
Abstract
Obesity increases the risk of cardiovascular disease and premature death. Adipose tissue releases a large number of bioactive mediators that influence not only body weight homeostasis but also insulin resistance - the core feature of type 2 diabetes - as well as alterations in lipids, blood pressure, coagulation, fibrinolysis and inflammation, leading to endothelial dysfunction and atherosclerosis. We are now beginning to understand the underlying mechanisms as well as the ways in which smoking and dyslipidaemia increase, and physical activity attenuates, the adverse effects of obesity on cardiovascular health.
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In the citing paper
“Obesity is strongly associated with the development of major risk factors for atherosclerotic disease such as hypertension, hyperlipidemia, and diabetes (79, 89, 358).”
From Cardiac remodeling in obesity (2008) · cites this paper as [358]
In the citing paper
“In addition, endothelial dysfunction is widely present in obesity and the metabolic syndrome (84, 325, 358).”
From Cardiac remodeling in obesity (2008) · cites this paper as [358]
In the citing paper
“In other populations, such as those in the STRONG heart study (native Americans of the western United States) and the Framingham heart study, diabetes or the metabolic syndrome do appear to be significant risk factors for LV hypertrophy (272, 306, 358).”
From Cardiac remodeling in obesity (2008) · cites this paper as [358]
Citations
Cites
1 retracted
Visfatin: A Protein Secreted by Visceral Fat That Mimics the Effects of Insulin
Fukuhara, A., Matsuda, M., Nishizawa, M., Segawa, K., Tanaka, M., Kishimoto, K., Matsuki, Y., Murakami, M., Ichisaka, T., Murakami, H., et al. (2005) · Science · doi:10.1126/science.1097243 · Cited by 1,906
RetractedYusuf, S., Hawken, S., Ôunpuu, S., Dans, T., Avezum, A., Lanas, F., McQueen, M., Budaj, A., Pais, P., Varigos, J., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17018-9 · Cited by 12,026
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Inflammation and Atherosclerosis
Libby, P., Ridker, P. M., & Maseri, A. (2002) · Circulation · doi:10.1161/hc0902.104353 · Cited by 7,724
Berenson, G. S., Srinivasan, S. R., Bao, W., Newman, W. P., Tracy, R. E., & Wattigney, W. A. (1998) · New England Journal of Medicine · doi:10.1056/nejm199806043382302 · Cited by 4,032
Poirier, P., Giles, T. D., Bray, G. A., Hong, Y., Stern, J. S., Pi-Sunyer, F. X., & Eckel, R. H. (2006) · Circulation · doi:10.1161/circulationaha.106.171016 · Cited by 3,165
Obesity and the risk of heart failure
Kenchaiah, S., Evans, J. C., Levy, D., Wilson, P. W. F., Benjamin, E. J., Larson, M. G., Kannel, W. B., & Vasan, R. S. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa020245 · Cited by 3,093
Yusuf, S., Hawken, S., Ôunpuu, S., Bautista, L., Franzosi, M. G., Commerford, P., Lang, C. C., Rumboldt, Z., Onen, C. L., Lisheng, L., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67663-5 · Cited by 2,903
A Potential Decline in Life Expectancy in the United States in the 21st Century
Olshansky, S. J., Passaro, D. J., Hershow, R. C., Layden, J., Carnes, B. A., Brody, J., Hayflick, L., Butler, R. N., Allison, D. B., & Ludwig, D. S. (2005) · New England Journal of Medicine · doi:10.1056/nejmsr043743 · Cited by 2,612
Overweight, Obesity, and Mortality in a Large Prospective Cohort of Persons 50 to 71 Years Old
Adams, K. F., Schatzkin, A. G., Harris, T. B., Kipnis, V., Mouw, T., Ballard-Barbash, R. R., Hollenbeck, A. R., & Leitzmann, M. F. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa055643 · Cited by 2,147
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Items 1,001–1,009 of 1,009
Lipocalin 13 regulation of glucose and lipid metabolism in obesity
Zhou, Y., & Rui, L. (2013) · Vitamins & Hormones · doi:10.1016/b978-0-12-407766-9.00015-8 · Cited by 28
Neighborhood walkability and mortality in a prospective cohort of women
India-Aldana, S., Rundle, A. G., Zeleniuch-Jacquotte, A., Quinn, J. W., Kim, B., Afanasyeva, Y., Clendenen, T. V., Koenig, K. L., Liu, M., Neckerman, K. M., et al. (2021) · Epidemiology · doi:10.1097/ede.0000000000001406 · Cited by 25
Anti-obesity drug therapy in clinical practice: Evidence of a poor prescriptive attitude
Squadrito, F., Rottura, M., Irrera, N., Minutoli, L., Bitto, A., Barbieri, M. A., Cicala, G., Mecchio, A., Pallio, G., Marino, S., et al. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110320 · Cited by 22
Impaired handgrip exercise-induced brachial artery flow-mediated dilation in young obese males
Slattery, D. J., Stuckless, T. J. R., King, T. J., & Pyke, K. E. (2016) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2015-0459 · Cited by 22
“…not all (Biasucci et al. 2010), studies have reported impaired 5 min RH-FMD in obese vs. healthy weight populations, and it is thought that endothelial dysfunction may provide an important mechanistic link between obesity and increased risk of cardiovascular disease (Van Gaal et al. 2006).”
BackgroundDelker, E., AlYami, B., Gallo, L. C., Ruiz, J. M., Szklo, M., & Allison, M. A. (2021) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000983 · Cited by 19
Pinneo, S., O'Mealy, C., Rosas Jr., M., Tsang, M., Liu, C., Kern, M., Hooshmand, S., & Hong, M. Y. (2022) · Journal of Medicinal Food · doi:10.1089/jmf.2021.0063 · Cited by 19
Caffeine-Stimulated Intestinal Epithelial Cells Suppress Lipid Accumulation in Adipocytes
MITANI, T., NAGANO, T., HARADA, K., YAMASHITA, Y., & ASHIDA, H. (2017) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.63.331 · Cited by 19
Resveratrol Inhibits Human Visceral Preadipocyte Proliferation and Differentiation in vitro
Sun, W., Yu, S., Han, H., Yuan, Q., Chen, J., & Xu, G. (2019) · Lipids · doi:10.1002/lipd.12196 · Cited by 11
Sixt, S., Beer, S., Bluher, M., Korff, N., Peschel, T., Sonnabend, M., Teupser, D., Thiery, J., Adams, V., Schuler, G., et al. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehp398 · Cited by 122
Metadata
- Authors
- Van Gaal, L. F., Mertens, I. L., & De Block, C. E.
- Affiliations
- University of Antwerp (BE)
- Venue
- Nature
- Published
- 2006-12
- Volume
- 444
- Issue
- 7121
- Pages
- 875-880
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1964607854
- Cited by
- 2,814
- References
- 86
- Citations by year
- 2026: 64 · 2025: 97 · 2024: 126 · 2023: 137 · 2022: 151 · 2021: 172 · 2020: 179 · 2019: 204 · 2018: 172 · 2017: 173 · 2016: 168 · 2015: 193 · 2014: 194 · 2013: 152 · 2012: 128
- FWCI
- 11.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- obesity, cardiovascular disease, adipose tissue, adipokines, insulin resistance, type 2 diabetes, dyslipidemia, blood pressure, coagulation, fibrinolysis, inflammation, endothelial dysfunction, atherosclerosis, smoking, physical activity, premature mortality
- MeSH terms
- Cardiovascular Diseases, Endothelium, Vascular, Humans, Insulin Resistance, Obesity, Oxidative Stress, Adiposity
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