Cited by 2,814Adipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and AdiposityDiabetes, Cardiovascular Risks, and Lipoproteins

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Mechanisms linking obesity with cardiovascular disease

Van Gaal, Luc F., Mertens, Ilse L., De Block, Christophe E.·2006·Nature

DOI 10.1038/nature05487

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Abstract

Obesity increases the risk of cardiovascular disease and premature death. Adipose tissue releases a large number of bioactive mediators that influence not only body weight homeostasis but also insulin resistance - the core feature of type 2 diabetes - as well as alterations in lipids, blood pressure, coagulation, fibrinolysis and inflammation, leading to endothelial dysfunction and atherosclerosis. We are now beginning to understand the underlying mechanisms as well as the ways in which smoking and dyslipidaemia increase, and physical activity attenuates, the adverse effects of obesity on cardiovascular health.

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Authors: Van Gaal, L. F., Mertens, I. L., & De Block, C. E.
Affiliations: University of Antwerp (BE)
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2006-12
Volume: 444
Issue: 7121
Pages: 875-880
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature05487
OpenAlex: W1964607854
Cited by: 2,814
References: 86
Citations by year: 2026: 64 · 2025: 97 · 2024: 126 · 2023: 137 · 2022: 151 · 2021: 172 · 2020: 179 · 2019: 204 · 2018: 172 · 2017: 173 · 2016: 168 · 2015: 193 · 2014: 194 · 2013: 152 · 2012: 128
FWCI: 11.30
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: obesity, cardiovascular disease, adipose tissue, adipokines, insulin resistance, type 2 diabetes, dyslipidemia, blood pressure, coagulation, fibrinolysis, inflammation, endothelial dysfunction, atherosclerosis, smoking, physical activity, premature mortality
MeSH terms: Cardiovascular Diseases, Endothelium, Vascular, Humans, Insulin Resistance, Obesity, Oxidative Stress, Adiposity

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Mechanisms linking obesity with cardiovascular disease

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