Cited by 2,814Adipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and AdiposityDiabetes, Cardiovascular Risks, and Lipoproteins

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Mechanisms linking obesity with cardiovascular disease

Van Gaal, Luc F., Mertens, Ilse L., De Block, Christophe E.·2006·Nature

DOI 10.1038/nature05487

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Abstract

Obesity increases the risk of cardiovascular disease and premature death. Adipose tissue releases a large number of bioactive mediators that influence not only body weight homeostasis but also insulin resistance - the core feature of type 2 diabetes - as well as alterations in lipids, blood pressure, coagulation, fibrinolysis and inflammation, leading to endothelial dysfunction and atherosclerosis. We are now beginning to understand the underlying mechanisms as well as the ways in which smoking and dyslipidaemia increase, and physical activity attenuates, the adverse effects of obesity on cardiovascular health.

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Fukuhara, A., Matsuda, M., Nishizawa, M., Segawa, K., Tanaka, M., Kishimoto, K., Matsuki, Y., Murakami, M., Ichisaka, T., Murakami, H., et al. (2005) · Science · doi:10.1126/science.1097243 · Cited by 1,906
Retracted
Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study
Yusuf, S., Hawken, S., Ôunpuu, S., Dans, T., Avezum, A., Lanas, F., McQueen, M., Budaj, A., Pais, P., Varigos, J., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17018-9 · Cited by 12,026
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Inflammation and Atherosclerosis
Libby, P., Ridker, P. M., & Maseri, A. (2002) · Circulation · doi:10.1161/hc0902.104353 · Cited by 7,724
Association between Multiple Cardiovascular Risk Factors and Atherosclerosis in Children and Young Adults
Berenson, G. S., Srinivasan, S. R., Bao, W., Newman, W. P., Tracy, R. E., & Wattigney, W. A. (1998) · New England Journal of Medicine · doi:10.1056/nejm199806043382302 · Cited by 4,032
Obesity and Cardiovascular Disease: Pathophysiology, Evaluation, and Effect of Weight Loss: An Update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease From the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism
Poirier, P., Giles, T. D., Bray, G. A., Hong, Y., Stern, J. S., Pi-Sunyer, F. X., & Eckel, R. H. (2006) · Circulation · doi:10.1161/circulationaha.106.171016 · Cited by 3,165
Obesity and the risk of heart failure
Kenchaiah, S., Evans, J. C., Levy, D., Wilson, P. W. F., Benjamin, E. J., Larson, M. G., Kannel, W. B., & Vasan, R. S. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa020245 · Cited by 3,093
Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case–control study
Yusuf, S., Hawken, S., Ôunpuu, S., Bautista, L., Franzosi, M. G., Commerford, P., Lang, C. C., Rumboldt, Z., Onen, C. L., Lisheng, L., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67663-5 · Cited by 2,903
A Potential Decline in Life Expectancy in the United States in the 21st Century
Olshansky, S. J., Passaro, D. J., Hershow, R. C., Layden, J., Carnes, B. A., Brody, J., Hayflick, L., Butler, R. N., Allison, D. B., & Ludwig, D. S. (2005) · New England Journal of Medicine · doi:10.1056/nejmsr043743 · Cited by 2,612
Overweight, Obesity, and Mortality in a Large Prospective Cohort of Persons 50 to 71 Years Old
Adams, K. F., Schatzkin, A. G., Harris, T. B., Kipnis, V., Mouw, T., Ballard-Barbash, R. R., Hollenbeck, A. R., & Leitzmann, M. F. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa055643 · Cited by 2,147

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Di Angelantonio, E., Bhupathiraju, S. N., Wormser, D., Gao, P., Kaptoge, S., de Gonzalez, A. B., Cairns, B. J., Huxley, R., Jackson, C. L., Joshy, G., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)30175-1 · Cited by 2,821
Pathophysiology of human visceral obesity: an update
Tchernof, A., & Després, J.-P. (2013) · Physiological Reviews · doi:10.1152/physrev.00033.2011 · Cited by 2,583
Global Burden of Hypertension and Systolic Blood Pressure of at Least 110 to 115 mm Hg, 1990-2015
Forouzanfar, M. H., Liu, P., Roth, G. A., Ng, M., Biryukov, S., Marczak, L., Alexander, L., Estep, K., Hassen Abate, K., Akinyemiju, T. F., et al. (2017) · JAMA · doi:10.1001/jama.2016.19043 · Cited by 2,381
Dynamics of fat cell turnover in humans
Spalding, K. L., Arner, E., Westermark, P. O., Bernard, S., Buchholz, B. A., Bergmann, O., Blomqvist, L., Hoffstedt, J., Näslund, E., Britton, T., et al. (2008) · Nature · doi:10.1038/nature06902 · Cited by 2,357
Reactive Oxygen Species in Metabolic and Inflammatory Signaling
Forrester, S. J., Kikuchi, D. S., Hernandes, M. S., Xu, Q., & Griendling, K. K. (2018) · Circulation Research · doi:10.1161/circresaha.117.311401 · Cited by 2,081
American Association of Clinical Endocrinologists and American College of Endocrinology Comprehensive Clinical Practice Guidelines For Medical Care of Patients with Obesity
Garvey, W. T., Mechanick, J. I., Brett, E. M., Garber, A. J., Hurley, D. L., Jastreboff, A. M., Nadolsky, K., Pessah-Pollack, R., & Plodkowski, R. (2016) · Endocrine Practice · doi:10.4158/ep161365.gl · Cited by 1,914
Dyslipidemia in obesity: Mechanisms and potential targets
Klop, B., Elte, J., & Cabezas, M. (2013) · Nutrients · doi:10.3390/nu5041218 · Cited by 1,665
“All these mechanisms have been related to the higher incidence of cardiovascular disease seen in obesity [82].”
Background
Adipose tissue dysfunction as determinant of obesity-associated metabolic complications
Longo, M., Zatterale, F., Naderi, J., Parrillo, L., Formisano, P., Raciti, G. A., Beguinot, F., & Miele, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092358 · Cited by 1,575
“Obesity-induced IR is also linked to a wide cluster of obesity-associated metabolic abnormalities, such as dyslipidemia, non-alcoholic fatty liver disease (NAFLD), hypertension [11], coronary heart disease, and stroke [12].”
Background
Body Fat Distribution and Risk of Cardiovascular Disease: An Update
Després, J.-P. (2012) · Circulation · doi:10.1161/circulationaha.111.067264 · Cited by 1,481
Immune and Inflammatory Mechanisms of Atherosclerosis
Galkina, E., & Ley, K. F. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132620 · Cited by 1,480
From NASH to HCC: current concepts and future challenges
Anstee, Q. M., Reeves, H. L., Kotsiliti, E., Govaere, O., & Heikenwalder, M. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0145-7 · Cited by 1,392
Effects of stress on immune function: The good, the bad, and the beautiful
Dhabhar, F. S. (2014) · Immunologic Research · doi:10.1007/s12026-014-8517-0 · Cited by 1,343
Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies
The Emerging Risk Factors Collaboration (2011) · The Lancet · doi:10.1016/s0140-6736(11)60105-0 · Cited by 1,216
Adipose tissue browning and metabolic health
Bartelt, A., & Heeren, J. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.204 · Cited by 1,177
Effects of liraglutide in the treatment of obesity: A randomised, double-blind, placebo-controlled study
Astrup, A., Rössner, S., Van Gaal, L., Rissanen, A., Niskanen, L., Al Hakim, M., Madsen, J., Rasmussen, M. F., & Lean, M. E. (2009) · The Lancet · doi:10.1016/s0140-6736(09)61375-1 · Cited by 1,163
Metabolic mediators of the effects of body-mass index, overweight, and obesity on coronary heart disease and stroke: a pooled analysis of 97 prospective cohorts with 1·8 million participants
(2014) · The Lancet · doi:10.1016/s0140-6736(13)61836-x · Cited by 1,121
Adipokines in health and disease
Fasshauer, M., & Blüher, M. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.04.014 · Cited by 1,050
Obesity, inflammation, and atherosclerosis
Rocha, V. Z., & Libby, P. (2009) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2009.55 · Cited by 994
Type 2 diabetes and cardiovascular disease: Have all risk factors the same strength?
Timon, I. M. (2014) · World Journal of Diabetes · doi:10.4239/wjd.v5.i4.444 · Cited by 1,019
Overview of Epidemiology and Contribution of Obesity to Cardiovascular Disease
Bastien, M., Poirier, P., Lemieux, I., & Després, J.-P. (2014) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2013.10.016 · Cited by 1,125
Inflammation in Atherosclerosis: From Vascular Biology to Biomarker Discovery and Risk Prediction
Packard, R. R. S., & Libby, P. (2008) · Clinical Chemistry · doi:10.1373/clinchem.2007.097360 · Cited by 925
Trends in insulin resistance: insights into mechanisms and therapeutic strategy
Li, M., Chi, X., Wang, Y., Setrerrahmane, S., Xie, W., & Xu, H. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01073-0 · Cited by 939
Enhancing versus Suppressive Effects of Stress on Immune Function: Implications for Immunoprotection and Immunopathology
Dhabhar, F. S. (2009) · Neuroimmunomodulation · doi:10.1159/000216188 · Cited by 903
Association between body-mass index and risk of death in more than 1 million Asians
Zheng, W., McLerran, D. F., Rolland, B., Zhang, X., Inoue, M., Matsuo, K., He, J., Gupta, P. C., Ramadas, K., Tsugane, S., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1010679 · Cited by 885
Insulin resistance and hyperglycaemia in cardiovascular disease development
Laakso, M., & Kuusisto, J. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.29 · Cited by 884
Insulin-sensitive obesity
Klöting, N., Fasshauer, M., Dietrich, A., Kovacs, P., Schön, M. R., Kern, M., Stumvoll, M., & Blüher, M. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00586.2009 · Cited by 856
Persistent Systemic Inflammation is Associated with Poor Clinical Outcomes in COPD: A Novel Phenotype
Agustí, A. G. N., Edwards, L. D., Rennard, S. I., MacNee, W., Tal‐Singer, R., Miller, B. E., Vestbo, J., Lomas, D. A., Calverley, P. M. A., Wouters, E. F. �., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037483 · Cited by 873
“In contrast, the fact that persistently inflamed patients were more obese supports a potential systemic origin of inflammation [39], although other potential mechanisms, such as the presence of airway bacterial colonization [40] and/or sleep apnea syndrome overlap [41] cannot be excluded because they were not investig…”
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Gross, B., Pawlak, M., Lefebvre, P., & Staels, B. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.135 · Cited by 778
Safety, tolerability and sustained weight loss over 2 years with the once-daily human GLP-1 analog, liraglutide
on behalf of the NN8022-1807 Investigators, Astrup, A., Carraro, R., Finer, N., Harper, A., Kunesova, M., Lean, M. E. J., Niskanen, L., Rasmussen, M. F., Rissanen, A., et al. (2012) · International Journal of Obesity · doi:10.1038/ijo.2011.158 · Cited by 757
Ambient Air Pollution Exaggerates Adipose Inflammation and Insulin Resistance in a Mouse Model of Diet-Induced Obesity
Sun, Q., Yue, P., Deiuliis, J. A., Lumeng, C. N.-K., Kampfrath, T., Mikolaj, M. B., Cai, Y., Ostrowski, M. C., Lü, B., Parthasarathy, S., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.799015 · Cited by 765
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Mika Kivimaki, B., Kuosma, E., Ferrie, J. E., Luukkonen, R. A., Nyberg, S. T., Alfredsson, L. S., Batty, G. D., Brunner, E. J., Fransson, E. I., Goldberg, M., et al. (2017) · The Lancet Public Health · doi:10.1016/s2468-2667(17)30074-9 · Cited by 695
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Ghoshal, S., Witta, J., Zhong, J., de Villiers, W., & Eckhardt, E. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m800156-jlr200 · Cited by 662
Complex chronic comorbidities of COPD
Fabbri, L. M., Luppi, F., Beghé, B., & Rabe, K. F. (2008) · European Respiratory Journal · doi:10.1183/09031936.00114307 · Cited by 660
Obesity and C ‐reactive protein in various populations: a systematic review and meta‐analysis
Choi, J., Joseph, L., & Pilote, L. (2012) · Obesity Reviews · doi:10.1111/obr.12003 · Cited by 657
“Adipose tissue is an active endocrine organ that releases a variety of hormones and cytokines that contributes to CRP elevation (2).”
Background
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Blüher, M. (2010) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3283346ccc · Cited by 632
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“First, central obesity measured by WHR is associated with visceral fat accumulation and an adverse metabolic profile compared with BMI, which is a measure of both lean and fat mass (23, 24).”
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“[6] Van Gaal LF, Mertens IL, De Block CE (2006).”
Background
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Schiattarella, G. G., Sannino, A., Toscano, E., Giugliano, G., Gargiulo, G., Franzone, A., Trimarco, B., Esposito, G., & Perrino, C. (2017) · European Heart Journal · doi:10.1093/eurheartj/ehx342 · Cited by 563
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Caleyachetty, R., Thomas, G. N., Toulis, K. A., Mohammed, N., Gokhale, K. M., Balachandran, K., & Nirantharakumar, K. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.07.763 · Cited by 574
“Our finding that obesity was associated with a lower risk of PVD was surprising, considering that it may influence the atherosclerotic process (25).”
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Cardiovascular disease risk in type 2 diabetes mellitus: insights from mechanistic studies
Mazzone, T., Chait, A., & Plutzky, J. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60768-0 · Cited by 552
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Stefan, N., Kantartzis, K., & Häring, H. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0009 · Cited by 535
Body mass index classification misses subjects with increased cardiometabolic risk factors related to elevated adiposity
Gómez-Ambrosi, J., Silva, C., Galofré, J. C., Escalada, J., Santos, S., Millán, D., Vila, N., Ibañez, P., Gil, M. J., Valentí, V, et al. (2012) · International Journal of Obesity · doi:10.1038/ijo.2011.100 · Cited by 615
Interferon-γ, a Th1 Cytokine, Regulates Fat Inflammation
Rocha, V. Z., Folco, E. J. E., Sukhova, G. K., Shimizu, K., Gotsman, I., Vernon, A. H., & Libby, P. (2008) · Circulation Research · doi:10.1161/circresaha.108.177105 · Cited by 540
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Han, T. S., & Lean, M. E. (2016) · JRSM Cardiovascular Disease · doi:10.1177/2048004016633371 · Cited by 500
“Anti-obesity drugs or other agents such as PPARg agonists and GLP-1R agonists may also be considered as primary prevention of metabolic syndrome and CVD.”
Background
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“Alteration of vascular function is a key pathogenic process common to many important and highly diffuse human pathologies [83].”
Background
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Bariatric surgery: an IDF statement for obese Type 2 diabetes
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Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1α transcription coactivator
Li, X., Monks, B., Ge, Q., & Birnbaum, M. J. (2007) · Nature · doi:10.1038/nature05861 · Cited by 487
Adipocyte dysfunction, inflammation and metabolic syndrome
Klöting, N., & Blüher, M. (2014) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-014-9301-0 · Cited by 487
“to obesity –related MetS and macrovascular complications [1, 2].”
Background
Obesity and hypertension
Jiang, S.-Z., Lu, W., Zong, X.-F., Ruan, H., & Liu, Y. (2016) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2016.3667 · Cited by 499
“Major organs feeling the brunt of obesity, include heart (37), liver (38), kidney (39), lungs (40), colon (41), skin (42), vessels (43) and brain (44).”
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Panchal, S. K., Poudyal, H., Iyer, A., Nazer, R., Alam, M. A., Diwan, V., Kauter, K., Sernia, C., Campbell, F., Ward, L. C., et al. (2010) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e3181feb90a · Cited by 457
Berberine suppresses proinflammatory responses through AMPK activation in macrophages
Jeong, H. W., Hsu, K. C., Lee, J.-W., Ham, M., Huh, J. Y., Shin, H. J., Kim, W. S., & Kim, J. B. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90599.2008 · Cited by 458
Effects of Exercise to Improve Cardiovascular Health
Pinckard, K. M., Baskin, K. K., & Stanford, K. I. (2019) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00069 · Cited by 517
Association of Obesity with Disease Severity Among Patients with Coronavirus Disease 2019
Kalligeros, M., Shehadeh, F., Mylona, E. K., Benitez, G., Beckwith, C. G., Chan, P. A., & Mylonakis, E. E. (2020) · Obesity · doi:10.1002/oby.22859 · Cited by 448
“Interestingly, we also found an association between preexisting heart disease (which is often associated with obesity as well [16]) and the need for IMV.”
Background
Molecular basis and mechanisms of progression of non-alcoholic steatohepatitis
Marra, F., Gastaldelli, A., Svegliati‐Baroni, G., Tell, G., & Tiribelli, C. (2008) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2007.12.003 · Cited by 427
A maternal ‘junk food’ diet in pregnancy and lactation promotes an exacerbated taste for ‘junk food’ and a greater propensity for obesity in rat offspring
Bayol, S. A., Farrington, S. J., & Stickland, N. C. (2007) · British Journal of Nutrition · doi:10.1017/s0007114507812037 · Cited by 417
Metabolic endotoxemia with obesity: Is it real and is it relevant?
Boutagy, N. E., McMillan, R. P., Frisard, M. I., & Hulver, M. W. (2016) · Biochimie · doi:10.1016/j.biochi.2015.06.020 · Cited by 413
Heart-Rate Variability—More than Heart Beats?
Ernst, G. (2017) · Frontiers in Public Health · doi:10.3389/fpubh.2017.00240 · Cited by 416
“This leads to decreased glucose uptake with possible consequences for cardiac cell metabolism (88, 89) and is a rather complex process also involving coagulation factors and the immune system (88).”
Background
Adipose tissue dysfunction contributes to obesity related metabolic diseases
Blüher, M. (2013) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2013.02.005 · Cited by 430
Metabolic Alterations and Systemic Inflammation in Obstructive Sleep Apnea among Nonobese and Obese Prepubertal Children
Gozal, D., Capdevila, Ó. S., & Gozal, D. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200711-1670oc · Cited by 413
Metabolically healthy obesity and cardiovascular events: a systematic review and meta-analysis.
Eckel, N., Meidtner, K., Kalle-Uhlmann, T., Stefan, N., & Schulze, M. B. (2016) · European Journal of Preventive Cardiology · doi:10.1177/2047487315623884 · Cited by 405
“Abdominal visceral fat is known to be one of the main health hazards of obesity.(4,61) Therefore a favourable fat distribution, marked by low WC or WHR, might identify a subgroup not at increased risk among people with a large general body fat content.”
Background
Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice
Nomiyama, T., Perez-Tilve, D., Ogawa, D., Gizard, F., Zhao, Y., Heywood, E. B., Jones, K. L., Kawamori, R., Cassis, L. A., Tschöp, M. H., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31986 · Cited by 401
From leptin to other adipokines in health and disease: Facts and expectations at the beginning of the 21st century
Blüher, M., & Mantzoros, C. S. (2014) · Metabolism · doi:10.1016/j.metabol.2014.10.016 · Cited by 415
Strengths and Limitations of BMI in the Diagnosis of Obesity: What is the Path Forward?
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“…a South Asian, Chinese, other Asian, Middle Eastern, Black African, or African-Caribbean family background are prone to central adiposity and their cardiometabolic risk occurs at lower BMI, justifying the use of lower BMI thresholds in defining overweight and obesity in these populations [21–23].”
Background
Obesity as a Disease
Upadhyay, J., Farr, O. M., Perakakis, N., Ghaly, W., & Mantzoros, C. S. (2017) · Medical Clinics of North America · doi:10.1016/j.mcna.2017.08.004 · Cited by 425
High-Fat-Diet-Induced Obesity and Heart Dysfunction Are Regulated by the TOR Pathway in Drosophila
Birse, R. T., Choi, J., Reardon, K., Rodriguez, J., Graham, S. M., Diop, S. B., Ocorr, K. A., Bodmer, R., & Oldham, S. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.09.014 · Cited by 402
Adipsin Is an Adipokine that Improves β Cell Function in Diabetes
Lo, J. C., Ljubicic, S., Leibiger, B., Kern, M., Leibiger, I. B., Moede, T., Kelly, M. E., Bhowmick, D. C., Murano, I., Cohen, P., et al. (2014) · Cell · doi:10.1016/j.cell.2014.06.005 · Cited by 390
Association between Adiposity and Cardiovascular Outcomes: An Umbrella Review and Meta-Analysis
Kim, M. S., Kim, W. J., Khera, A. V., Kim, J. Y., Yon, D. K., Lee, S. W., Shin, J. I., & Won, H. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehab454 · Cited by 400
“Adipose tissues release bioactive mediators that influence alterations in lipids, coagulation, fibrinolysis, and inflammation, leading to endothelial dysfunction and atherosclerosis.(53) Atherosclerosis is the principal origin of CVD(54,55); it synergistically interacts with hypertension, and both factors aggravate on…”
Increased risk of cardiovascular disease in non-alcoholic fatty liver disease: causal effect or epiphenomenon?
Targher, G., Marra, F., & Marchesini, G. (2008) · Diabetologia · doi:10.1007/s00125-008-1135-4 · Cited by 379
Molecular and cellular mechanisms of skeletal muscle atrophy: an update
Fanzani, A., Conraads, V. M., Penna, F., & Martinet, W. (2012) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1007/s13539-012-0074-6 · Cited by 386
Lifestyle factors and risk of multimorbidity of cancer and cardiometabolic diseases: a multinational cohort study
Freisling, H., Viallon, V., Lennon, H., Bagnardi, V., Ricci, C., Butterworth, A. S., Sweeting, M., Muller, D., Romieu, I., Bazelle, P., et al. (2020) · BMC Medicine · doi:10.1186/s12916-019-1474-7 · Cited by 376
Omega-3 fatty acids and metabolic syndrome: Effects and emerging mechanisms of action
Poudyal, H., Panchal, S. K., Diwan, V., & Brown, L. (2011) · Progress in Lipid Research · doi:10.1016/j.plipres.2011.06.003 · Cited by 391
Endothelial permeability, LDL deposition, and cardiovascular risk factors—a review
Mundi, S., Massaro, M., Scoditti, E., Carluccio, M. A., van Hinsbergh, V. W. M., Iruela-Arispe, M. L., & De Caterina, R. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvx226 · Cited by 367
A Cardiac MicroRNA Governs Systemic Energy Homeostasis by Regulation of MED13
Grueter, C. E., van Rooij, E., Johnson, B. A., DeLeon, S. M., Sutherland, L. B., Qi, X., Gautron, L., Elmquist, J. K., Bassel‐Duby, R., & Olson, E. N. (2012) · Cell · doi:10.1016/j.cell.2012.03.029 · Cited by 368
Metabolically healthy obesity: Definitions, determinants and clinical implications
Phillips, C. M. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-013-9252-x · Cited by 368
“Using data from the Whitehall II cohort (17.7 year follow-up of 5,269 adults aged 39–62) Hinnouho et al., recently examined all-cause and CVDmortality amongMHO according to a range of metabolic health definitions including NCEP ATP III, the Matsuda and HOMA indices, as well as the Karelis and Wildman definitions [30].”
BackgroundInfluential
Narrative Review: The Emerging Clinical Implications of the Role of Aldosterone in the Metabolic Syndrome and Resistant Hypertension
Sowers, J. R., Whaley-Connell, A., & Epstein, M. (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-150-11-200906020-00005 · Cited by 351
Independent Association Between Nonalcoholic Fatty Liver Disease and Cardiovascular Disease in the US Population
Stepanova, M., & Younossi, Z. M. (2012) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2011.12.039 · Cited by 352
Progress and challenges in anti-obesity pharmacotherapy
Bessesen, D. H., & Van Gaal, L. F. (2018) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(17)30236-x · Cited by 347
Mechanisms of thrombosis in obesity
Blokhin, I. O., & Lentz, S. R. (2013) · Current Opinion in Hematology · doi:10.1097/moh.0b013e3283634443 · Cited by 352
Metabolic syndrome: from epidemiology to systems biology
Lusis, A. J., Attie, A., & Reue, K. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2468 · Cited by 345
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Arnardóttir, E. S., Mackiewicz, M., Gíslason, Þ., Teff, K. L., & Pack, A. I. (2009) · SLEEP · doi:10.1093/sleep/32.4.447 · Cited by 355
The effects of plant-based diets on the body and the brain: a systematic review
Medawar, E., Hühn, S., Villringer, A., & Witte, A. V. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0552-0 · Cited by 355
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Guo, C., Ricchiuti, V., Lian, B. Q., Yao, T. M., Coutinho, P., Romero, J. R., Li, J., Williams, G. H., & Adler, G. K. (2008) · Circulation · doi:10.1161/circulationaha.107.748640 · Cited by 342
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Vissers, D., Hens, W., Taeymans, J., Baeyens, J.-P., Poortmans, J., & Van Gaal, L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056415 · Cited by 331
“[7] These novel risk factors and markers can not only influence body weight homeostasis but also insulin resistance, diabetes, lipid metabolism, inflammation, explaining premature atherosclerosis in obesity.[8] This has caused the hypothesis on the underlying mechanisms of the metabolic syndrome to shift towards an ad…”
Background
Epicardial and perivascular adipose tissues and their influence on cardiovascular disease: Basic mechanisms and clinical associations
Fitzgibbons, T. P., & Czech, M. P. (2014) · Journal of the American Heart Association · doi:10.1161/jaha.113.000582 · Cited by 331
Obesity, insulin resistance and diabetes: sex differences and role of oestrogen receptors
Meyer, M. R., Clegg, D. J., Prossnitz, E. R., & Barton, M. (2011) · Acta Physiologica · doi:10.1111/j.1748-1716.2010.02237.x · Cited by 338
Visfatin enhances ICAM-1 and VCAM-1 expression through ROS-dependent NF-κB activation in endothelial cells
Kim, S.-R., Bae, Y.-H., Bae, S., Choi, K.-S., Yoon, K., Koo, T. H., Jang, H.-O., Yun, I., Kim, K.-W., Kwon, Y., et al. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.01.004 · Cited by 314
The short-term stress response – Mother nature’s mechanism for enhancing protection and performance under conditions of threat, challenge, and opportunity
Dhabhar, F. S. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.03.004 · Cited by 377
“, CRP or IL-6) that are thought to contribute to disorders like cardiovascular disease, obesity, and depression [54; 55; 56].”
Background
Effects of SGLT2 inhibitors on systemic and tissue low-grade inflammation: The potential contribution to diabetes complications and cardiovascular disease
Bonnet, F., & Scheen, A. J. (2018) · Diabetes & Metabolism · doi:10.1016/j.diabet.2018.09.005 · Cited by 322
Similarity of mouse perivascular and brown adipose tissues and their resistance to diet-induced inflammation
Fitzgibbons, T. P., Kogan, S., Aouadi, M., Hendricks, G. M., Straubhaar, J., & Czech, M. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00376.2011 · Cited by 313
Inflammation: Roles in Skeletal Muscle Atrophy
Ji, Y., Li, M., Chang, M., Liu, R., Qiu, J., Wang, K., Deng, C., Shen, Y., Zhu, J., Wang, W., et al. (2022) · Antioxidants · doi:10.3390/antiox11091686 · Cited by 329
Cardiovascular Disease in Type 2 Diabetes From Population to Man to Mechanisms
Laakso, M. (2010) · Diabetes Care · doi:10.2337/dc09-0749 · Cited by 306
Adipose-resident group 1 innate lymphoid cells promote obesity-associated insulin resistance
O’Sullivan, T. E., Rapp, M., Fan, X., Weizman, O.-E., Bhardwaj, P., Adams, N. M., Walzer, T., Dannenberg, A. J., & Sun, J. C. (2016) · Immunity · doi:10.1016/j.immuni.2016.06.016 · Cited by 293
“In human studies, VAT inflammation in obese patients is thought to be the primary cause of obesity-induced insulin resistance (Van Gaal et al., 2006; Xu et al., 2003).”
Background
Role of MCP-1 in cardiovascular disease: molecular mechanisms and clinical implications
Niu, J., & Kolattukudy, P. E. (2009) · Clinical Science · doi:10.1042/cs20080581 · Cited by 297

Authors: Van Gaal, L. F., Mertens, I. L., & De Block, C. E.
Affiliations: University of Antwerp (BE)
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2006-12
Volume: 444
Issue: 7121
Pages: 875-880
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature05487
OpenAlex: W1964607854
Cited by: 2,814
References: 86
Citations by year: 2026: 64 · 2025: 97 · 2024: 126 · 2023: 137 · 2022: 151 · 2021: 172 · 2020: 179 · 2019: 204 · 2018: 172 · 2017: 173 · 2016: 168 · 2015: 193 · 2014: 194 · 2013: 152 · 2012: 128
FWCI: 11.30
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: obesity, cardiovascular disease, adipose tissue, adipokines, insulin resistance, type 2 diabetes, dyslipidemia, blood pressure, coagulation, fibrinolysis, inflammation, endothelial dysfunction, atherosclerosis, smoking, physical activity, premature mortality
MeSH terms: Cardiovascular Diseases, Endothelium, Vascular, Humans, Insulin Resistance, Obesity, Oxidative Stress, Adiposity

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