Cited by 2,814Adipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and AdiposityDiabetes, Cardiovascular Risks, and Lipoproteins

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Mechanisms linking obesity with cardiovascular disease

Van Gaal, Luc F., Mertens, Ilse L., De Block, Christophe E.·2006·Nature

DOI 10.1038/nature05487

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Abstract

Obesity increases the risk of cardiovascular disease and premature death. Adipose tissue releases a large number of bioactive mediators that influence not only body weight homeostasis but also insulin resistance - the core feature of type 2 diabetes - as well as alterations in lipids, blood pressure, coagulation, fibrinolysis and inflammation, leading to endothelial dysfunction and atherosclerosis. We are now beginning to understand the underlying mechanisms as well as the ways in which smoking and dyslipidaemia increase, and physical activity attenuates, the adverse effects of obesity on cardiovascular health.

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Background
Association of Chinese Visceral Adiposity Index and Its Dynamic Change With Risk of Carotid Plaque in a Large Cohort in China
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Epicardial adipose tissue, metabolic disorders, and cardiovascular diseases: recent advances classified by research methodologies
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Association analyses of GIP and GIPR polymorphisms with traits of the metabolic syndrome
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Blockade of lipid accumulation by silibinin in adipocytes and zebrafish
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Oxidized LDL and lysophosphatidylcholine stimulate plasminogen activator inhibitor-1 expression through reactive oxygen species generation and ERK1/2 activation in 3T3-L1 adipocytes
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RPS3A positively regulates the mitochondrial function of human periaortic adipose tissue and is associated with coronary artery diseases
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Is nonalcoholic fatty liver disease associated with the development of prostate cancer? A nationwide study with 10,516,985 Korean men
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A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism
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A review on mechanisms of action of bioactive peptides against glucose intolerance and insulin resistance
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Kefir prevented excess fat accumulation in diet-induced obese mice
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Molecular Mechanisms of Exercise and Healthspan
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“…playing important roles in disease progression of fatty liver disease, type 2 diabetes, Parkinson’s disease and heart failure (CodonerFranch et al., 2010; Desai et al., 2010; Dut et al., 2008; Hoek and Pastorino, 2002; Jenner, 2003; Mantena et al., 2008; Nojiri et al., 2006; Van Gaal et al., 2006).”
Background
Effect of Antibiotic Growth Promoters on Intestinal Microbiota in Food Animals: A Novel Model for Studying the Relationship between Gut Microbiota and Human Obesity?
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Associations of Adiponectin and Leptin with Incident Coronary Heart Disease and Ischemic Stroke in African Americans: The Jackson Heart Study
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“INTRODUCTION Significant research has been conducted in order to understand the obesity mechanisms related to cardiovascular disease (CVD) pathogenesis (1).”
Background
CD40L Deficiency Attenuates Diet-Induced Adipose Tissue Inflammation by Impairing Immune Cell Accumulation and Production of Pathogenic IgG-Antibodies
Wolf, D., Jehle, F., Rodríguez, A. O., Dufner, B., Hoppe, N., Colberg, C., Lozhkin, A. P., Bassler, N., Rupprecht, B., Wiedemann, A., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033026 · Cited by 42
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Background
Cardiometabolic benefits of exercise training in an experimental model of metabolic syndrome and menopause
Sanches, Í. C., Brito, J. D. O., Cândido, G. O., Dias, D. D. S., Jorge, L., Irigoyen, M. C., & Angelis, K. D. (2011) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e3182358c9c · Cited by 42
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Background
Impact of Visceral Adipose Tissue and Subcutaneous Adipose Tissue on Insulin Resistance in Middle-Aged Japanese
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An Evolutionary Perspective of Nutrition and Inflammation as Mechanisms of Cardiovascular Disease
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Background
Adiponectin and Its Receptors Are Differentially Expressed in Human Tissues and Cell Lines of Distinct Origin
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Association of dietary total antioxidant capacity to anthropometry in healthy women: A cross-sectional study
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Endothelial Dysfunction in Dyslipidaemia: Molecular Mechanisms and Clinical Implications
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Edible Mushrooms: Novel Medicinal Agents to Combat Metabolic Syndrome and Associated Diseases
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Effects of Lifestyle Intervention on Inflammatory Markers and Waist Circumference in Overweight/Obese Adults With Metabolic Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
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“Excessive fat accumulation might be connected to obesity-related MS and macrovascular complications via activation of the immune system and chronic low-grade inflammation (Esser et al., 2014; Van Gaal et al., 2006).”
Background
The Relationship Between Obesity and Atherosclerotic Progression and Prognosis Among Patients With Coronary Artery Bypass Grafts
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Adipose tissue gene expression and metabolic health of obese adults
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“This process may be mechanistically linked to the development of obesity-associated metabolic disorders (6;7).”

Authors: Van Gaal, L. F., Mertens, I. L., & De Block, C. E.
Affiliations: University of Antwerp (BE)
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2006-12
Volume: 444
Issue: 7121
Pages: 875-880
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature05487
OpenAlex: W1964607854
Cited by: 2,814
References: 86
Citations by year: 2026: 64 · 2025: 97 · 2024: 126 · 2023: 137 · 2022: 151 · 2021: 172 · 2020: 179 · 2019: 204 · 2018: 172 · 2017: 173 · 2016: 168 · 2015: 193 · 2014: 194 · 2013: 152 · 2012: 128
FWCI: 11.30
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: obesity, cardiovascular disease, adipose tissue, adipokines, insulin resistance, type 2 diabetes, dyslipidemia, blood pressure, coagulation, fibrinolysis, inflammation, endothelial dysfunction, atherosclerosis, smoking, physical activity, premature mortality
MeSH terms: Cardiovascular Diseases, Endothelium, Vascular, Humans, Insulin Resistance, Obesity, Oxidative Stress, Adiposity

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