Cited by 1,114Genomics and Chromatin DynamicsChromatin Remodeling and CancerEpigenetics and DNA Methylation

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Chromatin remodelling during development

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Ho, Lena, Crabtree, Gerald R.·2010·Nature

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Abstract

New methods for the genome-wide analysis of chromatin are providing insight into its roles in development and their underlying mechanisms. Current studies indicate that chromatin is dynamic, with its structure and its histone modifications undergoing global changes during transitions in development and in response to extracellular cues. In addition to DNA methylation and histone modification, ATP-dependent enzymes that remodel chromatin are important controllers of chromatin structure and assembly, and are major contributors to the dynamic nature of chromatin. Evidence is emerging that these chromatin-remodelling enzymes have instructive and programmatic roles during development. Particularly intriguing are the findings that specialized assemblies of ATP-dependent remodellers are essential for establishing and maintaining pluripotent and multipotent states in cells.

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Authors: Ho, L., & Crabtree, G. R.
Affiliations: Stanford Medicine (US)
ORCID: Ho, Lena
Crabtree, Gerald R.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2010-01
Volume: 463
Issue: 7280
Pages: 474-484
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature08911
PMC: PMC3060774
OpenAlex: W1984249881
Cited by: 1,114
References: 105
Citations by year: 2026: 39 · 2025: 42 · 2024: 54 · 2023: 46 · 2022: 57 · 2021: 63 · 2020: 56 · 2019: 64 · 2018: 80 · 2017: 84 · 2016: 78 · 2015: 82 · 2014: 71 · 2013: 78 · 2012: 76
FWCI: 8.15
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: Howard Hughes Medical Institute
National Institutes of Health
National Institute of Neurological Disorders and Stroke (R01NS046789)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD055391)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords: chromatin remodeling, developmental regulation, histone modifications, DNA methylation, pluripotency, multipotency, chromatin structure, extracellular signalling
MeSH terms: Animals, DNA, DNA-Binding Proteins, Drosophila melanogaster, Humans, Nucleic Acid Conformation, Transcription Factors, Body Patterning, Drosophila Proteins, Chromatin Assembly and Disassembly, Genome-Wide Association Study, Mi-2 Nucleosome Remodeling and Deacetylase Complex

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