Cited by 501Neuroscience and Neuropharmacology ResearchSchizophrenia research and treatmentGenetics and Neurodevelopmental Disorders

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Control of cortical GABA circuitry development by Nrg1 and ErbB4 signalling

Fazzari, Pietro, Paternain, Ana V., Valiente, Manuel, Pla, Ramón, Luján, Rafael, Lloyd, Kent, Lerma, Juan, Marín, Oscar, Rico, Beatriz·2010·Nature

DOI 10.1038/nature08928

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Abstract

Schizophrenia is a complex disorder that interferes with the function of several brain systems required for cognition and normal social behaviour. Although the most notable clinical aspects of the disease only become apparent during late adolescence or early adulthood, many lines of evidence suggest that schizophrenia is a neurodevelopmental disorder with a strong genetic component. Several independent studies have identified neuregulin 1 (NRG1) and its receptor ERBB4 as important risk genes for schizophrenia, although their precise role in the disease process remains unknown. Here we show that Nrg1 and ErbB4 signalling controls the development of inhibitory circuitries in the mammalian cerebral cortex by cell-autonomously regulating the connectivity of specific GABA (gamma-aminobutyric acid)-containing interneurons. In contrast to the prevalent view, which supports a role for these genes in the formation and function of excitatory synapses between pyramidal cells, we found that ErbB4 expression in the mouse neocortex and hippocampus is largely confined to certain classes of interneurons. In particular, ErbB4 is expressed by many parvalbumin-expressing chandelier and basket cells, where it localizes to axon terminals and postsynaptic densities receiving glutamatergic input. Gain- and loss-of-function experiments, both in vitro and in vivo, demonstrate that ErbB4 cell-autonomously promotes the formation of axo-axonic inhibitory synapses over pyramidal cells, and that this function is probably mediated by Nrg1. In addition, ErbB4 expression in GABA-containing interneurons regulates the formation of excitatory synapses onto the dendrites of these cells. By contrast, ErbB4 is dispensable for excitatory transmission between pyramidal neurons. Altogether, our results indicate that Nrg1 and ErbB4 signalling is required for the wiring of GABA-mediated circuits in the postnatal cortex, providing a new perspective to the involvement of these genes in the aetiology of schizophrenia.

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Interneurons of the neocortical inhibitory system
Markram, H., Toledo-Rodriguez, M., Wang, Y., Gupta, A., Silberberg, G., & Wu, C. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1519 · Cited by 2,954
Parvalbumin neurons and gamma rhythms enhance cortical circuit performance
Sohal, V. S., Zhang, F., Yizhar, O., & Deisseroth, K. (2009) · Nature · doi:10.1038/nature07991 · Cited by 2,606
Driving fast-spiking cells induces gamma rhythm and controls sensory responses
Cardin, J. A., Carlén, M., Meletis, K., Knoblich, U., Zhang, F., Deisseroth, K., Tsai, L.-H., & Moore, C. I. (2009) · Nature · doi:10.1038/nature08002 · Cited by 2,603
Cortical inhibitory neurons and schizophrenia
Lewis, D. A., Hashimoto, T., & Volk, D. W. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1648 · Cited by 2,297
Neuronal Diversity and Temporal Dynamics: The Unity of Hippocampal Circuit Operations
Klausberger, T., & Somogyi, P. (2008) · Science · doi:10.1126/science.1149381 · Cited by 2,050
Neuregulin 1 and Susceptibility to Schizophrenia
Stefánsson, H., Pétursson, H., Sigurðsson, E., Steinthórsdóttir, V., Bjornsdottir, S., Sigmundsson, T., Ghosh, S., Brynjolfsson, J., Gunnarsdottir, S., Ivarsson, O., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/342734 · Cited by 1,671
Human gamma-frequency oscillations associated with attention and memory
Jensen, O. B., Kaiser, J., & Lachaux, J.-P. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.05.001 · Cited by 1,239
Schizophrenia as a Disorder of Neurodevelopment
Lewis, D. A., & Levitt, P. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142754 · Cited by 1,163
Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor
Gassmann, M., Casagranda, F., Orioli, D., Simon, H. H., Lai, C., Klein, R., & Lemke, G. (1995) · Nature · doi:10.1038/378390a0 · Cited by 1,151
Rat hippocampal neurons in dispersed cell culture.
Banker, G. A., & Cowan, W. M. (1977) · Brain Research · doi:10.1016/0006-8993(77)90594-7 · Cited by 1,110

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Flames, N. et al. Short- and long-range attraction of cortical GABAergic interneurons by neuregulin-1. Neuron 44, 251–261 (2004) · DOI · Paper page

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Self-citation

Authors: Fazzari, P., Paternain, A. V., Valiente, M., Pla, R., Luján, R., Lloyd, K., Lerma, J., Marín, O., & Rico, B.
Affiliations: Consejo Superior de Investigaciones Científicas (ES)
University of Castilla-La Mancha (ES)
University of California, Davis (US)
Corresponding author: Rico, Beatriz
ORCID: Fazzari, Pietro
Paternain, Ana V.
Valiente, Manuel
Pla, Ramón
Luján, Rafael
Lloyd, Kent
Lerma, Juan
Rico, Beatriz
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2010-04
Volume: 464
Issue: 7293
Pages: 1376-1380
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature08928
OpenAlex: W2031755128
Cited by: 501
References: 42
Citations by year: 2026: 18 · 2025: 19 · 2024: 24 · 2023: 28 · 2022: 28 · 2021: 48 · 2020: 23 · 2019: 26 · 2018: 34 · 2017: 29 · 2016: 35 · 2015: 29 · 2014: 39 · 2013: 30 · 2012: 28
FWCI: 15.49
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords: neuregulin-1, ErbB4, schizophrenia, GABAergic interneurons, cortical circuit development, axo-axonic synapses, parvalbumin interneurons, chandelier cells, basket cells, synaptic adhesion proteins, neurodevelopmental disorders, neocortex, hippocampus, inhibitory synapse formation, genetic risk factors
MeSH terms: Animals, Cell Differentiation, Cerebral Cortex, Dendrites, Embryo, Mammalian, Female, gamma-Aminobutyric Acid, Interneurons, Neural Inhibition, Neural Pathways, Schizophrenia, Synapses, Signal Transduction, Pyramidal Cells, Excitatory Postsynaptic Potentials, Neuregulin-1, Mice, ErbB Receptors, Receptor, ErbB-4, In Vitro Techniques

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Control of cortical GABA circuitry development by Nrg1 and ErbB4 signalling

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