The VPAC2 Receptor Is Essential for Circadian Function in the Mouse Suprachiasmatic Nuclei
Open accessAbstract
The neuropeptides pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) are implicated in the photic entrainment of circadian rhythms in the suprachiasmatic nuclei (SCN). We now report that mice carrying a null mutation of the VPAC(2) receptor for VIP and PACAP (Vipr2(-/-)) are incapable of sustaining normal circadian rhythms of rest/activity behavior. These mice also fail to exhibit circadian expression of the core clock genes mPer1, mPer2, and mCry1 and the clock-controlled gene arginine vasopressin (AVP) in the SCN. Moreover, the mutants fail to show acute induction of mPer1 and mPer2 by nocturnal illumination. This study highlights the role of intercellular neuropeptidergic signaling in maintenance of circadian function within the SCN.
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VIPR2 has several important roles in regulating neurodevelopment and behavior.
“VIPR2 has several important roles in regulating neurodevelopment and behavior (Chaudhury et al., 2008; Harmar et al., 2002; Waschek, 1995).”
From CNVs: Harbingers of a Rare Variant Revolution in Psychiatric Genetics (2012) · cites this paper as Harmar et al., 2002
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- Authors
- Harmar, A. J., Marston, H. M., Shen, S., Spratt, C., West, K. M., Sheward, W. J., Morrison, C. F., Dorin, J. R., Piggins, H. D., Reubi, J.-C., Kelly, J. S., Maywood, E. S., & Hastings, M. H.
- Affiliations
- University of Edinburgh (GB)
- Western General Hospital (GB)
- University of Manchester (GB)
- University of Bern (CH)
- MRC Laboratory of Molecular Biology (GB)
- Corresponding author
- Harmar, Anthony J.
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2002-05
- Volume
- 109
- Issue
- 4
- Pages
- 497-508
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2096882849
- Cited by
- 549
- References
- 50
- Citations by year
- 2026: 8 · 2025: 14 · 2024: 18 · 2023: 19 · 2022: 16 · 2021: 20 · 2020: 33 · 2019: 20 · 2018: 27 · 2017: 19 · 2016: 27 · 2015: 23 · 2014: 23 · 2013: 22 · 2012: 23
- FWCI
- 8.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 4095 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- VPAC2 receptor, VIPR2, vasoactive intestinal peptide, PACAP, suprachiasmatic nucleus, circadian rhythm, light entrainment, clock genes, mPer1, mPer2, vasopressin
- MeSH terms
- Animals, Arginine Vasopressin, Biological Clocks, Circadian Rhythm, Eye Proteins, Flavoproteins, Gene Expression Regulation, Male, Motor Activity, Mutation, Neurons, Neuropeptides, Neurophysins, Nuclear Proteins, Peptide PHI, Photic Stimulation, RNA, Messenger, Suprachiasmatic Nucleus, Transcription Factors, Vasoactive Intestinal Peptide, Up-Regulation, Photoreceptor Cells, Invertebrate, Receptors, Vasoactive Intestinal Peptide, Mice, Knockout, Cell Cycle Proteins, Drosophila Proteins, Receptors, G-Protein-Coupled, Pituitary Adenylate Cyclase-Activating Polypeptide, Receptors, Vasoactive Intestinal Peptide, Type II, Mice, Basic Helix-Loop-Helix Proteins, ARNTL Transcription Factors, Cryptochromes, Period Circadian Proteins
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