Oxytocin mediates entrainment of sensory stimuli to social cues of opposing valence
Open accessAbstract
Meaningful social interactions modify behavioral responses to sensory stimuli. The neural mechanisms underlying the entrainment of neutral sensory stimuli to salient social cues to produce social learning remain unknown. We used odor-driven behavioral paradigms to ask if oxytocin, a neuropeptide implicated in various social behaviors, plays a crucial role in the formation of learned associations between odor and socially significant cues. Through genetic, optogenetic, and pharmacological manipulations, we show that oxytocin receptor signaling is crucial for entrainment of odor to social cues but is dispensable for entrainment to nonsocial cues. Furthermore, we demonstrate that oxytocin directly impacts the piriform, the olfactory sensory cortex, to mediate social learning. Lastly, we provide evidence that oxytocin plays a role in both appetitive and aversive social learning. These results suggest that oxytocin conveys saliency of social stimuli to sensory representations in the piriform cortex during odor-driven social learning.
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OTR play a critical role in learning during aversive social contexts.
“It has been previously reported that OTR play a critical role in learning during aversive social contexts (76).”
From Oxytocin receptors in the anteromedial bed nucleus of the stria terminalis promote stress-induced social avoidance in female California mice (2018) · cites this paper as [76]
When the presence of a home-cage conspecific is controlled for, as in this study, modulatory effects of oxytocin on fear acquisition are not seen.
“When this factor is controlled for, as in this study (and see ref. 28), modulatory effects of oxytocin on fear acquisition are not seen.”
From Oxytocin enhances observational fear in mice (2017) · cites this paper as [28]
Mean belief update was significantly smaller than 0 in study 1 (BU = −1.76, t(1,97) = 2.98, P = 0.004) and study 2 (BU = −1.37, t(1,94) = 2.80, P = 0.006), indicating reliable optimistic updating across OT and PL groups.
“A one-sample test revealed that the mean BU was significantly smaller than 0 [study 1: BU = −1.76, t(1,97) = 2.98, P = 0.004; study 2: BU = −1.37, t(1,94) = 2.80, P = 0.006], indicating reliable optimistic updating across OT and PL groups and replicating previous findings (21, 22).”
From Distinct oxytocin effects on belief updating in response to desirable and undesirable feedback (2016) · cites this paper as [22]
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- Authors
- Choe, H. K., Reed, M. D., Benavidez, N., Montgomery, D., Soares, N., Yim, Y. S., & Choi, G. B.
- Affiliations
- McGovern Institute for Brain Research (US)
- Corresponding author
- Choi, Gloria B.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 87
- Issue
- 1
- Pages
- 152-163
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC4689302
- OpenAlex
- W1961491865
- Cited by
- 124
- References
- 65
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 9 · 2023: 10 · 2022: 9 · 2021: 14 · 2020: 9 · 2019: 12 · 2018: 18 · 2017: 17 · 2016: 12 · 2015: 2
- FWCI
- 26.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-nd)
- Funders
- National Institute of Mental Health (R01MH106497, T32MH074249)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- oxytocin, oxytocin receptor, social learning, piriform cortex, social cues, neuropeptide signaling
- MeSH terms
- Animals, Association Learning, Cues, Female, Learning, Male, Neurons, Oxytocin, Paraventricular Hypothalamic Nucleus, Smell, Social Perception, Receptors, Oxytocin, Mice, Optogenetics, Olfactory Cortex, Piriform Cortex
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