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A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Open accessAbstract
Exercise benefits a variety of organ systems in mammals, and some of the best-recognized effects of exercise on muscle are mediated by the transcriptional co-activator PPAR-γ co-activator-1 α (PGC1-α). Here we show in mouse that PGC1-α expression in muscle stimulates an increase in expression of FNDC5, a membrane protein that is cleaved and secreted as a newly identified hormone, irisin. Irisin acts on white adipose cells in culture and in vivo to stimulate UCP1 expression and a broad program of brown-fat-like development. Irisin is induced with exercise in mice and humans, and mildly increased irisin levels in the blood cause an increase in energy expenditure in mice with no changes in movement or food intake. This results in improvements in obesity and glucose homeostasis. Irisin could be therapeutic for human metabolic disease and other disorders that are improved with exercise.
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“When originally described, it was found to exert browning of WAT, increase energy expenditure, improve insulin sensitivity, and induce weight loss, through upregulation of UCP1 in exercised mice overexpressing PGC-1α [57].”
From The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review (2020) · cites this paper as [57]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The myokines irisin [57] and BAIBA [104] have been described to directly induce WAT “browning” both in vitro and in vivo, by upregulating genes involved in mitochondrial biogenesis, FAO, oxidative phosphorylation, and thermogenesis (1).”
From The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review (2020) · cites this paper as [57]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“FNDC-5 is known to drive development of brown-fat-like cells in WAT, which enhances lipid metabolism/oxidation via mitochondrial uncoupling protein 1 (UCP-1) activity [12].”
From β-hydroxy-β -methylbutyrate supplementation benefits the effects of resistance training on body fat reduction via increased irisin expression in white adipose tissue (2021) · cites this paper as [12]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“However, only the irisin precursor FNDC5 was able to promote the differentiation of stromal vascular cells isolated from WAT from beige mice (browning phenomenon; Bostrom et al., 2012).”
From Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases (2018) · cites this paper as Bostrom et al., 2012
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Irisin is a myokine that promotes white adipose tissue browning, originally identified through animal studies [38] and subsequently confirmed in humans [39].”
From Exercise-Induced Myokines in Obesity-Related Metabolic Disorders and Cardiovascular Protection: A Narrative Review (2026) · cites this paper as [38]
The cited source says what the claim attributes to it.
In the citing paper
“which is known to upregulate the WAT browning myokines FNDC5-irisin [57], METRNL [274], and BAIBA [104].”
The cited source says what the claim attributes to it.
In the citing paper
“Irisin is stimulated by ‘Peroxisome proliferator-activated receptor-Gamma Coactivator 1α’ (PGC1α), and mediates beneficial metabolic effects through the beiging of white AT [17,49], thereby activating UCP1 and inducing enhanced thermogenesis within the white AT.”
From Optimised Skeletal Muscle Mass as a Key Strategy for Obesity Management (2025) · cites this paper as [49]
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In the citing paper
“Thus, following the characterization of irisin as a myokine capable of activating adipose tissue browning in rodents in response to exercise (Bostrom et al., 2012) the concept that factors secreted by SkM could signal to other organs has grown and developed.”
From Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases (2018) · cites this paper as Bostrom et al., 2012
The cited source says what the claim attributes to it.
In the citing paper
“Irisin, formerly called Iris, is a recently identified myokine, released into the circulation by SkM in an exercise-dependent manner.”
From Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases (2018) · cites this paper as Bostrom et al., 2012
The cited source says what the claim attributes to it.
In the citing paper
“It is reported to have the ability to convert WAT to BAT, a phenomenon known as browning; a phenotype set of adaptations that results in increasing total energy expenditure (Bostrom et al., 2012).”
From Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases (2018) · cites this paper as Bostrom et al., 2012
The cited source says what the claim attributes to it.
In the citing paper
“Five candidate proteins were found to be mediated by PGC-1α in the muscle: IL-15, Fndc5, VEGFβ, Lrg1, and TIMP4.”
From Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases (2018) · cites this paper as Bostrom et al., 2012
The cited source says what the claim attributes to it.
In the citing paper
“Other papers have demonstrated that exercise induces upregulation in skeletal muscle of PGC1α, a transcriptional co-activator of mitochondrial biogenesis and oxidative metabolism in brown adipose tissue and muscle. In muscle, the increase of PGC1α expression stimulates an upregulation of FNDC5, a membrane protein that is cleaved and secreted into the circulation as the myokine irisin [237].”
From Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer (2020) · cites this paper as [237]
In the citing paper
“Irisin is a PPARγ-coactivator-1α (PGCα)-dependent myokine that stimulates browning in subcutaneous adipose tissues and induces increased energy expenditure, which improves obesity and IR through the MAPK and ERK pathways [92,93].”
From Sarcopenic obesity, insulin resistance, and their implications in cardiovascular and metabolic consequences (2020) · cites this paper as [92]
In the citing paper
“Irisin is released by skeletal muscles and has been shown to increase thermogenesis and energy expenditure by promoting the browning of subcutaneous adipocytes.”
From Diet and physical exercise as key players to tackle MASLD through improvement of insulin resistance and metabolic flexibility (2024) · cites this paper as [88]
In the citing paper
“Moreover, resistance exercise may improve MASLD through muscle-liver crosstalk mediated by a myokine called irisin (88, 89).”
From Diet and physical exercise as key players to tackle MASLD through improvement of insulin resistance and metabolic flexibility (2024) · cites this paper as [88]
In the citing paper
“It also exhibits regulatory effects on lipid metabolism in hepatocytes (88).”
From Diet and physical exercise as key players to tackle MASLD through improvement of insulin resistance and metabolic flexibility (2024) · cites this paper as [88]
In the citing paper
“The main and well-described function of irisin is to induce WAT browning and thus UCP-1-dependent mitochondrial uncoupling [206].”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [206]
In the citing paper
“Thus, whether exercise can brown WAT in humans, especially through an irisin-mediated pathway, remains controversial55,83,84,90.”
From Exerkines in health, resilience and disease (2022) · cites this paper as [84]
In the citing paper
“Transgenic mice that overexpress muscle peroxisome proliferator-activated receptor-γ coactivator 1-α (PGClα) have higher circulating levels of irisin and increased WAT browning than control mice84.”
From Exerkines in health, resilience and disease (2022) · cites this paper as [84]
In the citing paper
“In a mouse model, fibronectin type III domain containing 5 is cleaved in the muscle cell and secreted as irisin, which induces WAT browning to increase energy expenditure and consequently reduce obesity84.”
From Exerkines in health, resilience and disease (2022) · cites this paper as [84]
In the citing paper
“The first paper to describe irisin, a PGC1α-dependent myokine, that drives ‘browning’ of WAT in an animal model”
From Exerkines in health, resilience and disease (2022) · cites this paper as [84]
In the citing paper
“FNDC5 induces thermogenesis and elevates mitochondrial gene expression [131], and resilient mice have increased NAc metabolism [132].”
From The molecular and cellular mechanisms of depression: a focus on reward circuitry (2019) · cites this paper as [131]
In the citing paper
“recent studies have identified secreted proteins that stimulate brown adipocyte thermogenesis and recruit brown (or beige) adipocytes to white adipose tissue [60] [61].”
From Regulation of obesity and insulin resistance by nitric oxide (2014) · cites this paper as [61]
In the citing paper
“Interestingly, a moderate increase (threefold) in irisin blood levels in mice enhanced energy expenditure and improved obesity and glucose homeostasis ([12](#B12)).”
From Mitochondrial fatty acid oxidation in obesity (2013) · cites this paper as [12]
In the citing paper
“Recent landmark studies have identified novel secreted proteins, such as liver FGF21 ([72](#B72)), cardiac natriuretic peptides ([11](#B11)), and irisin ([12](#B12)), that stimulate brown adipocyte thermogenesis.”
From Mitochondrial fatty acid oxidation in obesity (2013) · cites this paper as [12]
In the citing paper
“Irisin was shown to trigger WAT remodeling by increasing p38 signaling, UCP1 expression, and therefore browning 115, 116.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [115]
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Citations
Cites
2 retracted
Wenz, T., Rossi, S. G., Rotundo, R. L., Spiegelman, B. M., & Moraes, C. T. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911570106 · Cited by 600
Self-citationRetractedBoström, P., Andersson, L. K., Vind, B. F., Håversen, L., Rutberg, M., Wickström, Y., Larsson, E. N. V., Jansson, P., Svensson, M. K. E., Brånemark, R., et al. (2010) · Diabetes · doi:10.2337/db09-1503 · Cited by 44
Self-citationRetractedA Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis
Puigserver, P., Wu, Z., Park, C. W., Graves, R., Wright, M., & Spiegelman, B. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81410-5 · Cited by 3,864
Self-citationLocating proteins in the cell using TargetP, SignalP and related tools
Emanuelsson, O., Brunak, S., von HEIJNE, G., & Nielsen, H. (2007) · Nature Protocols · doi:10.1038/nprot.2007.131 · Cited by 3,215
Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice
Seale, P., Conroe, H. M., Estall, J. L., Kajimura, S., Frontini, A., Ishibashi, J., Cohen, P., Cinti, S., & Spiegelman, B. M. (2010) · Journal of Clinical Investigation · doi:10.1172/jci44271 · Cited by 1,273
Self-citationNew role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure
Tseng, Y.-H., Kokkotou, E., Schulz, T. J., Huang, T. L., Winnay, J. N., Taniguchi, C. M., Tran, T. T., Suzuki, R., Espinoza, D. O., Yamamoto, Y., et al. (2008) · Nature · doi:10.1038/nature07221 · Cited by 1,099
The role of exercise and PGC1α in inflammation and chronic disease
Handschin, C., & Spiegelman, B. M. (2008) · Nature · doi:10.1038/nature07206 · Cited by 1,083
Self-citationSandri, M., Lin, J., Handschin, C., Yang, W., Arany, Z. P., Lecker, S. H., Goldberg, A. L., & Spiegelman, B. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607795103 · Cited by 974
Self-citationInitiation of myoblast to brown fat switch by a PRDM16–C/EBP-β transcriptional complex
Kajimura, S., Seale, P., Kubota, K., Lunsford, E., Frangioni, J. V., Gygi, S. P., & Spiegelman, B. M. (2009) · Nature · doi:10.1038/nature08262 · Cited by 703
Self-citationThe SCX/IMAC enrichment approach for global phosphorylation analysis by mass spectrometry
Villén, J., & Gygi, S. P. (2008) · Nature Protocols · doi:10.1038/nprot.2008.150 · Cited by 637
Self-citation
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Items 801–900 of 1,068
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Hattori, K., Naguro, I., Okabe, K., Funatsu, T., Furutani, S., Takeda, K., & Ichijo, H. (2016) · Nature Communications · doi:10.1038/ncomms11158 · Cited by 78
A new perspective of the hippocampus in the origin of exercise–brain interactions
Rendeiro, C., & Rhodes, J. S. (2018) · Brain Structure and Function · doi:10.1007/s00429-018-1665-6 · Cited by 78
Cerebrospinal fluid irisin correlates with amyloid‐β, BDNF, and cognition in Alzheimer's disease
Lourenco, M. V., Ribeiro, F. C., Sudo, F. K., Drummond, C., Assunção, N., Vanderborght, B., Tovar-Moll, F. F., Mattos, P., Felice, F. G. D., & Ferreira, S. T. (2020) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.12034 · Cited by 78
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Gutaj, P., Sibiak, R., Jankowski, M., Awdi, K., Bryl, R., Mozdziak, P. E., Kempisty, B., & Wender-Ożegowska, E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249408 · Cited by 78
From Obesity to Hippocampal Neurodegeneration: Pathogenesis and Non-Pharmacological Interventions
Lee, T. H.-Y., & Yau, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010201 · Cited by 78
Feraco, A., Gorini, S., Armani, A., Camajani, E., Rizzo, M., & Caprio, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179327 · Cited by 78
The Emerging Role of Irisin in Cardiovascular Diseases
Fu, J., Li, F., Tang, Y., Cai, L., Zeng, C., Yang, Y., & Yang, J. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.121.022453 · Cited by 78
Brain metabolism in Alzheimer’s disease: biological mechanisms of exercise
Xu, L., Liu, R., Qin, Y., & Wang, T. (2023) · Translational Neurodegeneration · doi:10.1186/s40035-023-00364-y · Cited by 78
Jaberi, S., & Fahnestock, M. L. (2023) · Biomolecules · doi:10.3390/biom13111577 · Cited by 78
Diet quality and diet patterns in relation to circulating cardiometabolic biomarkers
Ko, B., Park, K., Shin, S., Zaichenko, L., Davis, C. R., Crowell, J. A., Joung, H., & Mantzoros, C. S. (2015) · Clinical Nutrition · doi:10.1016/j.clnu.2015.03.022 · Cited by 78
Resistance Exercise Training does not Affect Plasma Irisin Levels of Hemodialysis Patients
Moraes, C., Leal, V. D. O., Marinho, S. M., Barroso, S. G., Rocha, G. D. S., Boaventura, G. T., & Mafra, D. (2013) · Hormone and Metabolic Research · doi:10.1055/s-0033-1354402 · Cited by 78
Jang, H. B., Kim, H.-J., Kang, J., Park, S. I., Park, K., & Lee, H. (2017) · Metabolism · doi:10.1016/j.metabol.2017.05.007 · Cited by 78
Inflammation Markers in Type 2 Diabetes and the Metabolic Syndrome in the Pediatric Population
Reinehr, T., & Roth, C. L. (2018) · Current Diabetes Reports · doi:10.1007/s11892-018-1110-5 · Cited by 78
Shen, H., Huang, S.-Y., Kung, C.-W., Chen, S., Chen, Y., Cheng, P., Lam, K., & Lee, Y. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.02.001 · Cited by 78
Planella-Farrugia, C., Comas, F., Sabater, M., Moreno, M., Moreno‐Navarrete, J. M., Rovira, O., Ricart, W., & Fernández‐Real, J. M. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00871 · Cited by 77
Bone-to-Brain: A Round Trip in the Adaptation to Mechanical Stimuli
Gerosa, L., & Lombardi, G. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.623893 · Cited by 78
Faulk, C. D., Barks, A. K., Sánchez, B. N., Zhang, Z., Anderson, O. S., Peterson, K. E., & Dolinoy, D. C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104273 · Cited by 77
Belviranlı, M., Okudan, N., Kabak, B., Erdoğan, M., & Karanfılcı, M. (2016) · The Physician and Sportsmedicine · doi:10.1080/00913847.2016.1196125 · Cited by 77
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Zhang, Y., Song, H., Zhang, Y., Wu, F., Mu, Q., Jiang, M., Wang, F., Zhang, W., Li, L., Shao, L., et al. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.116.004031 · Cited by 77
Roles of Irisin in the Linkage from Muscle to Bone During Mechanical Unloading in Mice
Kawao, N., Moritake, A., Tatsumi, K., & Kaji, H. (2018) · Calcified Tissue International · doi:10.1007/s00223-018-0387-3 · Cited by 77
Jackson, T. C., & Kochanek, P. M. (2019) · Therapeutic Hypothermia and Temperature Management · doi:10.1089/ther.2019.0001 · Cited by 77
He, Z., Li, H., Han, X., Zhou, F., Du, J., Yang, Y., Xu, Q., Zhang, S., Zhang, S., Zhao, N., et al. (2020) · Bone · doi:10.1016/j.bone.2020.115573 · Cited by 76
Ma, C., Ding, H., Deng, Y., Liu, H., Xiong, X., & Yang, Y. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.620608 · Cited by 76
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Paoletti, I., & Coccurello, R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252413480 · Cited by 81
van den Beukel, J. C., Grefhorst, A., Quarta, C., Steenbergen, J., Mastroberardino, P. G., Lombès, M., Delhanty, P. J. D., Mazza, R., Pagotto, U., van der Lely, A. J., et al. (2014) · The FASEB Journal · doi:10.1096/fj.14-254839 · Cited by 76
The role of sex, adiposity, and gonadectomy in the regulation of irisin secretion
Zügel, M., Qiu, S., Laszlo, R., Bosnyák, E., Weigt, C., Müller, D. R., Diel, P. R., Steinacker, J. M., & Schümann, U. (2016) · Endocrine · doi:10.1007/s12020-016-0913-x · Cited by 76
Molecular mechanisms underlying metabolic syndrome: the expanding role of the adipocyte
Armani, A., Berry, A., Cirulli, F., & Caprio, M. (2017) · The FASEB Journal · doi:10.1096/fj.201601125rrr · Cited by 76
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Højlund, K., & Boström, P. (2013) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2013.04.002 · Cited by 76
Self-citationMuscle mitochondrial stress adaptation operates independently of endogenous FGF21 action
Ost, M., Coleman, V., Voigt, A., van Schothorst, E. M., Keipert, S., van der Stelt, I., Ringel, S., Graja, A., Ambrosi, T., Kipp, A. P., et al. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2015.11.002 · Cited by 75
De Gasperi, R., Hamidi, S., Harlow, L. M., Ksiezak-Reding, H., Bauman, W. A., & Cardozo, C. P. (2017) · Scientific Reports · doi:10.1038/s41598-017-13105-9 · Cited by 75
Chen, L., Chen, Y.-H., Cheng, K., Chien, T.-Y., Chan, C.-H., Tsao, S., & Huang, H.-Y. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.11.004 · Cited by 75
Frantz, E. D. C., Prodel, E., Bráz, I. D., Giori, I. G., Bargut, T. C. L., Magliano, D. C., & da Nóbrega, A. C. L. (2018) · Clinical Science · doi:10.1042/cs20180276 · Cited by 75
Wang, K., Song, F., Xu, K., Liu, Z., Han, S., Li, F., & Sun, Y. S. (2019) · Mediators of Inflammation · doi:10.1155/2019/1567179 · Cited by 75
Inoue, K., Fujie, S. J., Hasegawa, N., Horii, N., Uchida, M., Iemitsu, K., Sanada, K., Hamaoka, T., & Iemitsu, M. (2019) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2019-0602 · Cited by 76
Wang, Y., Dong, Z., Zhang, Z., Wang, Y., Yang, K., & Li, X. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/9911167 · Cited by 75
Mechanism and physical activities in bone-skeletal muscle crosstalk
Zhao, Z., Yan, K., Guan, Q., Guo, Q., & Zhao, C. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1287972 · Cited by 75
Biochemical Markers of Aging for Longitudinal Studies in Humans
Engelfriet, P. M., Jansen, E. H. J. M., Picavet, H. S. J., & Dollé, M. E. T. (2013) · Epidemiologic Reviews · doi:10.1093/epirev/mxs011 · Cited by 75
Bagheri, R., Rashidlamir, A., Ashtary‐Larky, D., Wong, A., Grubbs, B. F., Motevalli, M. S., Baker, J. S., Laher, I., & Zouhal, H. (2020) · European Journal of Applied Physiology · doi:10.1007/s00421-020-04332-6 · Cited by 75
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Hou, X. S., Zhang, Y., Li, W., Hu, A. J., Luo, C., Zhou, W., Hu, J. K., Daniele, S. G., Wang, J., Sheng, J., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03451-1 · Cited by 74
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Anastasilakis, A. D., Koulaxis, D., Kefala, N., Pοlyzos, S. A., Upadhyay, J., Pagkalidou, E., Economou, F. I., Anastasilakis, C. D., & Mantzoros, C. S. (2017) · Metabolism · doi:10.1016/j.metabol.2017.05.002 · Cited by 74
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Prestes, J., da Cunha Nascimento, D., Tibana, R. A., Teixeira, T. G., Vieira, D. C. L., Tajra, V., de Farias, D. L., Silva, A. O., Funghetto, S. S., de Souza, V. C., et al. (2015) · AGE · doi:10.1007/s11357-015-9793-x · Cited by 73
Elevated skeletal muscle irisin precursor FNDC5 mRNA in obese OLETF rats
Roberts, M. D., Bayless, D. S., Jenkins, N. T., Padilla, J., Childs, T. E., Martin, J. S., Dalbo, V. J., Booth, F. W., Rector, R. S., & Laughlin, M. H. (2013) · Metabolism · doi:10.1016/j.metabol.2013.02.002 · Cited by 73
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Ye, X., Shen, Y., Ni, C., Ye, J., Xin, Y., Zhang, W., & Ren, Y. (2019) · Peptides · doi:10.1016/j.peptides.2019.170120 · Cited by 73
Li, H., Qin, S., Liang, Q., Xi, Y., Bo, W., Cai, M., & Tian, Z. (2021) · Biomedicines · doi:10.3390/biomedicines9060701 · Cited by 73
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Joung, K. E., Park, K., Zaichenko, L., Sahin-Efe, A., Thakkar, B., Brinkoetter, M. T., Usher, N., Warner, D. E., Davis, C. R., Crowell, J. A., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-3669 · Cited by 73
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Pourranjbar, M., Arabnejad, N., Naderipour, K., & Rafie, F. (2018) · Journal of Medicine and Life · doi:10.25122/jml-2018-0033 · Cited by 73
Muscle Irisin Response to Aerobic vs HIIT in Overweight Female Adolescents
Archundia-Herrera, C., Macias-Cervantes, M., Ruiz-Muñoz, B., Vargas-Ortiz, K., Kornhauser, C., & Perez-Vazquez, V. (2017) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-017-0302-5 · Cited by 72
Caloric restriction and exercise “mimetics”: ready for prime time
Handschin, C. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2015.11.009 · Cited by 72
New Insights Into the Comorbidity of Coronary Heart Disease and Depression
Wu, Y., Zhu, B., Chen, Z., Duan, J., Luo, A., Yang, L., & Yang, C. (2019) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2019.03.002 · Cited by 72
Canosa, L. F., & Bertucci, J. I. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.111029 · Cited by 72
Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans
Whittle, A. J., Jiang, M., Peirce, V. J., Relat, J., Virtue, S., Ebinuma, H., Fukamachi, I., Yamaguchi, T., Takahashi, M., Murano, T., et al. (2015) · Nature Communications · doi:10.1038/ncomms9951 · Cited by 72
Sarcopenia and risk of nonalcoholic fatty liver disease: A meta-analysis
Wijarnpreecha, K., Panjawatanan, P., Thongprayoon, C., Jaruvongvanich, V., & Ungprasert, P. (2018) · Saudi Journal of Gastroenterology · doi:10.4103/sjg.sjg_237_17 · Cited by 72
Stinkens, R., Brouwers, B., Jocken, J. W. E., Blaak, E. E., Teunissen-Beekman, K. F. M., Hesselink, M. K. C., van Baak, M. A., Schrauwen, P., & Goossens, G. H. (2018) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00496.2018 · Cited by 72
Irisin deficiency disturbs bone metabolism
Zhu, X., Li, X., Wang, X., Chen, T., Tao, F., Liu, C.-J., Tu, Q., Shen, G., & Chen, J. J. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29894 · Cited by 72
Myokines: a descriptive review
Barbalho, S. M., Neto, E. V. P., Goulart, R. D. Á., Bechara, M. D., Chagas, E. F. B., Audi, M., Campos, L. M. G., Guiguer, É. L., Buchaim, R. L., Buchaim, D. V., et al. (2020) · The Journal of Sports Medicine and Physical Fitness · doi:10.23736/s0022-4707.20.10884-3 · Cited by 73
Wang, K., Li, F., Wang, C., Deng, Y., Cao, Z., Cui, Y., Xu, K., Ln, P., & Sun, Y. (2019) · Medical Science Monitor · doi:10.12659/msm.915331 · Cited by 71
Hadi, A., Arab, A., Hajianfar, H., Talaei, B., Miraghajani, M. S., Babajafari, S., Marx, W., & Tavakoly, R. (2020) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2020.102315 · Cited by 71
Liu, X., Liu, Y., Liu, J., Zhang, H., Shan, C., Guo, Y., Gong, X., Cui, M., Li, X., & Tang, M. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.382223 · Cited by 75
Regulation of brown adipocyte metabolism by myostatin/follistatin signaling
Singh, R., Braga, M., & Pervin, S. (2014) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2014.00060 · Cited by 71
Maternal serum and fetal cord blood irisin levels in gestational diabetes mellitus
Yüksel, M. A., Öncül, M., Tüten, A., İmamoğlu, M., Açıkgöz, A. S., Kücür, M., & Madazlı, R. (2014) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2013.12.025 · Cited by 71
Contraction and AICAR Stimulate IL-6 Vesicle Depletion From Skeletal Muscle Fibers In Vivo
Lauritzen, H. P. M. M., Brandauer, J., Schjerling, P., Koh, H., Treebak, J. T., Hirshman, M. F., Galbo, H., & Goodyear, L. J. (2013) · Diabetes · doi:10.2337/db12-1261 · Cited by 71
Jia, R., Luo, X.-Q., Wang, G., Lin, C. ‐., Qiao, H., Wang, N., Yao, T., Barclay, J. L., Whitehead, J. P., Luo, X., et al. (2016) · Acta Physiologica · doi:10.1111/apha.12688 · Cited by 71
Liu, X., Mujahid, H., Rong, B., Lu, Q., Zhang, W., Li, P., Li, N., Liang, E., Wang, Q., Tang, D., et al. (2017) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13360 · Cited by 71
Detection and quantitation of irisin in human cerebrospinal fluid by tandem mass spectrometry
Ruan, Q., Zhang, L., Ruan, J., Zhang, X., Chen, J., Ma, C., & Yu, Z. (2018) · Peptides · doi:10.1016/j.peptides.2018.03.013 · Cited by 71
Role of Perivascular Adipose Tissue in Health and Disease
Fernández‐Alfonso, M. S., Somoza, B., Tsvetkov, D., Kuczmanski, A., Dashwood, M. R., & Gil‐Ortega, M. (2017) · Comprehensive physiology · doi:10.1002/cphy.c170004 · Cited by 71
Relationship between circulating irisin levels and overweight/obesity: A meta-analysis
Jia, J., Yu, F., Wei, W., Yang, P., Zhang, R., Sheng, Y., & Shi, Y.-Q. (2019) · World Journal of Clinical Cases · doi:10.12998/wjcc.v7.i12.1444 · Cited by 71
Functional Relationship between Leptin and Nitric Oxide in Metabolism
Becerril, S., Rodrı́guez, A., Catalán, V., Ramírez, B., Unamuno, X., Portincasa, P., Gómez‐Ambrosi, J., & Frühbeck, G. (2019) · Nutrients · doi:10.3390/nu11092129 · Cited by 71
Amanat, S., Sinaei, E., Panji, M., MohammadporHodki, R., Bagheri-Hosseinabadi, Z., Asadimehr, H., Fararouei, M., & Dianatinasab, A. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.562895 · Cited by 70
Mambrini, S. P., Grillo, A., Colosimo, S., Zarpellon, F., Pozzi, G., Furlan, D., Amodeo, G., & Bertoli, S. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1426551 · Cited by 70
No evidence of white adipocyte browning after endurance exercise training in obese men
Tsiloulis, T., Carey, A. L., Bayliss, J., Canny, B., Meex, R. C. R., & Watt, M. J. (2018) · International Journal of Obesity · doi:10.1038/ijo.2017.295 · Cited by 70
Continual evolution of type 2 diabetes: an update on pathophysiology and emerging treatment options
Cornell, S. A. (2015) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s67387 · Cited by 70
Diagnostic measures for sarcopenia and bone mineral density
Bijlsma, A. Y., Meskers, C. G. M., Molendijk, M. L., Westendorp, R. G. J., Sipilä, S., Stenroth, L., Sillanpää, E., McPhee, J. S., Jones, D. A., Narici, M. V., et al. (2013) · Osteoporosis International · doi:10.1007/s00198-013-2376-8 · Cited by 70
Bone-Muscle Mutual Interactions
Lara-Castillo, N., & Johnson, M. L. (2020) · Current Osteoporosis Reports · doi:10.1007/s11914-020-00602-6 · Cited by 70
Allicin‐induced host‐gut microbe interactions improves energy homeostasis
Zhang, C., He, X., Sheng, Y., Cui, Y., Xu, J., Zheng, S., Liu, J., Xu, W., Luo, Y., & Huang, K. (2020) · The FASEB Journal · doi:10.1096/fj.202001007r · Cited by 70
Colaianni, G., Errede, M., Sanesi, L., Notarnicola, A., Celi, M., Zerlotin, R., Storlino, G., Pignataro, P., Oranger, A., Pesce, V., et al. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4192 · Cited by 70
Zheng, S., Chen, N., Kang, X.-J., Hu, Y., & Shi, S. (2021) · Endocrine · doi:10.1007/s12020-021-02875-y · Cited by 70
Factors mediating exercise‐induced organ crosstalk
Sabaratnam, R., Wojtaszewski, J. F. P., & Højlund, K. (2022) · Acta Physiologica · doi:10.1111/apha.13766 · Cited by 70
Self-citationJia, S., Yang, Y., Bai, Y., Wei, Y., Zhang, H., Tian, Y., Liu, J., & Bai, L. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.797855 · Cited by 70
Rönn, T., Volkov, P., Tornberg, Å. B., Elgzyri, T., Hansson, O., Eriksson, K., Groop, P., & Ling, C. (2014) · Acta Physiologica · doi:10.1111/apha.12247 · Cited by 70
Huerta, A. E., Prieto-Hontoria, P. L., Fernández‐Galilea, M., Sáinź, N., Cuervo, M., Martínez, J. A., & Moreno-Aliaga, M. J. (2015) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-015-0400-5 · Cited by 70
Quintens, R., Singh, S., Lemaire, K., Bock, K. D., Granvik, M., Schraenen, A., Vroegrijk, I. O. C. M., Costa, V., Noten, P. V., Lambrechts, D., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056719 · Cited by 70
Lastra, G., & Manrique, C. M. (2015) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2015-0010 · Cited by 70
Winn, N. C., Grunewald, Z. I., Liu, Y., Heden, T. D., Nyhoff, L. M., & Kanaley, J. A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0170690 · Cited by 70
Metabolic Health—The Role of Adipo-Myokines
Gräf, C., & Ferrari, N. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20246159 · Cited by 70
The benefits of physical exercise for the health of the pancreatic β‐cell: a review of the evidence
Curran, M., Drayson, M. T., Andrews, R. C., Zoppi, C. C., Barlow, J. P., Solomon, T. P. J., & Narendran, P. (2020) · Experimental Physiology · doi:10.1113/ep088220 · Cited by 70
Bang, H. S., Seo, D. Y., Chung, Y. M., Oh, K.-M., Park, J. J., Arturo, F., Jeong, S.-H., Kim, N., & Han, J. (2014) · The Korean Journal of Physiology & Pharmacology · doi:10.4196/kjpp.2014.18.5.441 · Cited by 69
Nicolini, C., Michalski, B., Toepp, S. L., Turco, C. V., D'Hoine, T., Harasym, D., Gibala, M. J., Fahnestock, M., & Nelson, A. J. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.03.042 · Cited by 69
Browning of white adipose tissue after a burn injury promotes hepatic steatosis and dysfunction
Abdullahi, A., Samadi, O., Auger, C., Kanagalingam, T., Boehning, D. F., Bi, S., & Jeschke, M. G. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-2103-2 · Cited by 69
Chen, X., Sun, K., Zhao, S., Geng, T., Fan, X., Sun, S., Zheng, M., & Jin, Q. (2020) · Cytokine · doi:10.1016/j.cyto.2020.155292 · Cited by 69
Regulation of tissue crosstalk by skeletal muscle-derived myonectin and other myokines
Seldin, M. M., & Wong, G. W. (2012) · Adipocyte · doi:10.4161/adip.20877 · Cited by 69
Han, S.-F., Jiao, J., Zhang, W., Xu, J., Zhang, W., Chun-ling, F., & Qin, L. (2016) · Nutrition · doi:10.1016/j.nut.2016.05.006 · Cited by 69
Immune Modulation of Brown(ing) Adipose Tissue in Obesity
van den Berg, S. M., van Dam, A. D., Rensen, P. C. N., de Winther, M. P. J., & Lutgens, E. (2016) · Endocrine Reviews · doi:10.1210/er.2016-1066 · Cited by 69
Metadata
- Authors
- Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., Kajimura, S., Zingaretti, M. C., Vind, B. F., Tu, H., Cinti, S., Højlund, K., Gygi, S. P., & Spiegelman, B. M.
- Affiliations
- Harvard University (US)
- Brigham and Women's Hospital (US)
- University of California, San Francisco (US)
- Marche Polytechnic University (IT)
- Odense University Hospital (DK)
- LakePharma (United States) (US)
- Corresponding author
- Spiegelman, Bruce M.
- ORCID
- Venue
- Nature
- Published
- 2012-01
- Volume
- 481
- Issue
- 7382
- Pages
- 463-468
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3522098
- OpenAlex
- W2085397620
- Cited by
- 4,810
- References
- 26
- Citations by year
- 2026: 309 · 2025: 347 · 2024: 361 · 2023: 392 · 2022: 453 · 2021: 408 · 2020: 393 · 2019: 331 · 2018: 318 · 2017: 294 · 2016: 275 · 2015: 292 · 2014: 283 · 2013: 229 · 2012: 120
- FWCI
- 198.16
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- University of Southern Denmark Research Portal (University of Southern Denmark) (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- RePEc: Research Papers in Economics (submittedVersion)
- Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
- Scholarworks@UNIST (Ulsan National Institute of Science and Technology) (submittedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (K99DK087853, DK54477, R56DK054477, R01DK031405, DK-31405, R01DK061562, R01DK054477, R37DK031405)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- irisin, FNDC5, PGC-1α, myokines, brown adipose tissue browning, white adipose tissue, thermogenesis, UCP1, physical activity, energy expenditure, obesity, glucose homeostasis, type 2 diabetes, metabolic disease treatment
- MeSH terms
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Uncoupling Protein 1, Animals, Adipose Tissue, Brown, Cells, Cultured, Energy Metabolism, Gene Expression Regulation, Hormones, Humans, Insulin Resistance, Ion Channels, Mice, Inbred BALB C, Mice, Transgenic, Obesity, Physical Conditioning, Animal, Plasma, Transcription Factors, Exercise, Trans-Activators, Culture Media, Conditioned, Adipocytes, Cell Respiration, Thermogenesis, Models, Animal, Mitochondrial Proteins, Muscle Cells, Intracellular Signaling Peptides and Proteins, Subcutaneous Fat, Mice, Adipose Tissue, White
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