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Allergic host defences

Palm, Noah W., Rosenstein, Rachel K., Medzhitov, Ruslan·2012·Nature
DOI 10.1038/nature11047PMC PMC3596087
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  1. Anthony, R. M., Rutitzky, L. I., Urban, J. F., Jr, Stadecker, M. J. & Gause, W. C. Protective immune mechanisms in helminth infection. Nature Rev. Immunol. 7, 975–987 (2007) · DOI · Paper page
  2. Spits, H. & Di Santo, J. P. The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling. Nature Immunol. 12, 21–27 (2011) · DOI
  3. McKerrow, J. H., Caffrey, C., Kelly, B., Loke, P. & Sajid, M. Proteases in parasitic diseases. Annu. Rev. Pathol. 1, 497–536 (2006) · DOI
  4. Profet, M. The function of allergy: immunological defense against toxins. Q. Rev. Biol. 66, 23–62 (1991)This review outlines the ‘toxin hypothesis’, which proposes that allergic responses provide a defence against environmental toxins and carcinogens. · DOI · Paper page
  5. Burton, O. T. & Oettgen, H. C. Beyond immediate hypersensitivity: evolving roles for IgE antibodies in immune homeostasis and allergic diseases. Immunol. Rev. 242, 128–143 (2011) · DOI
  6. Harris, N. & Gause, W. C. To B or not to B: B cells and the Th2-type immune response to helminths. Trends Immunol. 32, 80–88 (2011) · DOI · Paper page
  7. Aalberse, R. C. Structural biology of allergens. J. Allergy Clin. Immunol. 106, 228–238 (2000) · DOI
  8. Higginbotham, R. D. Mast cells and local resistance to Russell’s viper venom. J. Immunol. 95, 867–875 (1965)This is the first demonstration of a beneficial role for mast cells in the detoxification of venoms and protection from the noxious effects of envenomation. · DOI · Paper page
  9. Higginbotham, R. D. & Karnella, S. The significance of the mast cell response to bee venom. J. Immunol. 106, 233–240 (1971) · DOI · Paper page
  10. Fry, B. G. et al. Early evolution of the venom system in lizards and snakes. Nature 439, 584–588 (2006) · DOI
  11. Fry, B. G. et al. The toxicogenomic multiverse: convergent recruitment of proteins into animal venoms. Annu. Rev. Genomics Hum. Genet. 10, 483–511 (2009) · DOI
  12. Müller, U. R. Insect venoms. Chem. Immunol. Allergy 95, 141–156 (2010) · DOI
  13. Metz, M. et al. Mast cells can enhance resistance to snake and honeybee venoms. Science 313, 526–530 (2006)This paper provides definitive evidence that mast cells enhance resistance to envenomation by detoxifying venom components. · DOI · Paper page
  14. Matthews, K. R. Controlling and coordinating development in vector-transmitted parasites. Science 331, 1149–1153 (2011) · DOI
  15. Müller-Doblies, U. U. et al. Feeding by the tick, Ixodes scapularis, causes CD4+ T cells responding to cognate antigen to develop the capacity to express IL-4. Parasite Immunol. 29, 485–499 (2007) · DOI
  16. Wada, T. et al. Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks. J. Clin. Invest. 120, 2867–2875 (2010)This paper demonstrates that basophils are critical for IgE-dependent acquired resistance to tick feeding. · DOI · Paper page
  17. Schuijt, T. J., Hovius, J. W., van der Poll, T., van Dam, A. P. & Fikrig, E. Lyme borreliosis vaccination: the facts, the challenge, the future. Trends Parasitol. 27, 40–47 (2011) · DOI
  18. Loukas, A. et al. Vaccinomics for the major blood feeding helminths of humans. OMICS 15, 567–577 (2011) · DOI
  19. Thorpe, S. C., Murdoch, R. D. & Kemeny, D. M. The effect of the castor bean toxin, ricin, on rat IgE and IgG responses. Immunology 68, 307–311 (1989)
  20. Chawla, A., Repa, J. J., Evans, R. M. & Mangelsdorf, D. J. Nuclear receptors and lipid physiology: opening the X-files. Science 294, 1866–1870 (2001) · DOI · Paper page
  21. Li, J. & Uetrecht, J. P. The danger hypothesis applied to idiosyncratic drug reactions. Handb. Exp. Pharmacol. 196, 493–509 (2010) · DOI
  22. Palm, N. W. & Medzhitov, R. Immunostimulatory activity of haptenated proteins. Proc. Natl Acad. Sci. USA 106, 4782–4787 (2009) · DOI
  23. Kalish, R. S. & Askenase, P. W. Molecular mechanisms of CD8+ T cell-mediated delayed hypersensitivity: implications for allergies, asthma, and autoimmunity. J. Allergy Clin. Immunol. 103, 192–199 (1999) · DOI
  24. Kondo, H., Ichikawa, Y. & Imokawa, G. Percutaneous sensitization with allergens through barrier-disrupted skin elicits a Th2-dominant cytokine response. Eur. J. Immunol. 28, 769–779 (1998) · DOI
  25. Bernstein, J. A. et al. Health effects of air pollution. J. Allergy Clin. Immunol. 114, 1116–1123 (2004) · DOI
  26. Thomas, W. R., Hales, B. J. & Smith, W. A. Structural biology of allergens. Curr. Allergy Asthma Rep. 5, 388–393 (2005) · DOI
  27. Karp, C. L. Guilt by intimate association: what makes an allergen an allergen? J. Allergy Clin. Immunol. 125, 955–960 (2010) · DOI
  28. Trompette, A. et al. Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein. Nature 457, 585–588 (2009) · DOI
  29. Eisenbarth, S. C. et al. Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen. J. Exp. Med. 196, 1645–1651 (2002) · DOI
  30. Finkelman, F. D. et al. Interleukin-4- and interleukin-13-mediated host protection against intestinal nematode parasites. Immunol. Rev. 201, 139–155 (2004) · DOI · Paper page
  31. Moro, K. et al. Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells. Nature 463, 540–544 (2010)References 34–37 describe the discovery of novel classes of ILCs that produce type 2 cytokines in response to IL-25 and IL-33. · DOI
  32. Neill, D. R. et al. Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity. Nature 464, 1367–1370 (2010) · DOI · Paper page
  33. Price, A. E. et al. Systemically dispersed innate IL-13-expressing cells in type 2 immunity. Proc. Natl Acad. Sci. USA 107, 11489–11494 (2010) · DOI
  34. Saenz, S. A. et al. IL25 elicits a multipotent progenitor cell population that promotes TH2 cytokine responses. Nature 464, 1362–1366 (2010) · DOI
  35. Zhao, W. & Hu, Z. The enigmatic processing and secretion of interleukin-33. Cell. Mol. Immunol. 7, 260–262 (2010) · DOI
  36. Hsu, C. L., Neilsen, C. V. & Bryce, P. J. IL-33 is produced by mast cells and regulates IgE-dependent inflammation. PLoS ONE 5, e11944 (2010) · DOI
  37. Ziegler, S. F. & Artis, D. Sensing the outside world: TSLP regulates barrier immunity. Nature Immunol. 11, 289–293 (2010) · DOI
  38. Soumelis, V. et al. Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nature Immunol. 3, 673–680 (2002) · DOI
  39. Liu, Y. J. Thymic stromal lymphopoietin: master switch for allergic inflammation. J. Exp. Med. 203, 269–273 (2006) · DOI · Paper page
  40. Fahy, J. V. & Dickey, B. F. Airway mucus function and dysfunction. N. Engl. J. Med. 363, 2233–2247 (2010) · DOI
  41. Jeffry, J., Kim, S. & Chen, Z. F. Itch signaling in the nervous system. Physiology (Bethesda) 26, 286–292 (2011)
  42. Raap, U., Stander, S. & Metz, M. Pathophysiology of itch and new treatments. Curr. Opin. Allergy Clin. Immunol. 11, 420–427 (2011) · DOI
  43. Monticelli, L. A. et al. Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus. Nature Immunol. 12, 1045–1054 (2011) · DOI
  44. Allen, J. E. & Wynn, T. A. Evolution of Th2 immunity: a rapid repair response to tissue destructive pathogens. PLoS Pathog. 7, e1002003 (2011)In this review, the authors propose that the T H 2 response evolved to function as a tissue repair response to damage caused by helminths. · DOI
  45. Zenewicz, L. A. & Flavell, R. A. Recent advances in IL-22 biology. Int. Immunol. 23, 159–163 (2011) · DOI
  46. Ikutani, M. et al. Identification of innate IL-5-producing cells and their role in lung eosinophil regulation and antitumor immunity. J. Immunol. 188, 703–713 (2012) · DOI
  47. Bartemes, K. R. e. t. a. l. IL-33-responsive Lineage−CD25+CD44hi lymphoid cells mediate innate type 2 immunity and allergic inflammation in the lungs. J. Immunol. 188, 1503–1513 (2011) · DOI · Paper page
  48. Martinez, F. O., Helming, L. & Gordon, S. Alternative activation of macrophages: an immunologic functional perspective. Annu. Rev. Immunol. 27, 451–483 (2009) · DOI · Paper page
  49. Sokol, C. L., Barton, G. M., Farr, A. G. & Medzhitov, R. A mechanism for the initiation of allergen-induced T helper type 2 responses. Nature Immunol. 9, 310–318 (2008) · DOI
  50. Reese, T. A. et al. Chitin induces accumulation in tissue of innate immune cells associated with allergy. Nature 447, 92–96 (2007) · DOI
  51. Schmidt, M. et al. Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel. Nature Immunol. 11, 814–819 (2010) · DOI
  52. Shreffler, W. G. et al. The major glycoprotein allergen from Arachis hypogaea, Ara h 1, is a ligand of dendritic cell-specific ICAM-grabbing nonintegrin and acts as a Th2 adjuvant in vitro . J. Immunol. 177, 3677–3685 (2006) · DOI
  53. Phillips, C., Coward, W. R., Pritchard, D. I. & Hewitt, C. R. Basophils express a type 2 cytokine profile on exposure to proteases from helminths and house dust mites. J. Leukoc. Biol. 73, 165–171 (2003) · DOI
  54. Dudler, T. et al. A link between catalytic activity, IgE-independent mast cell activation, and allergenicity of bee venom phospholipase A2. J. Immunol. 155, 2605–2613 (1995) · DOI
  55. Steinfelder, S. et al. The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1). J. Exp. Med. 206, 1681–1690 (2009) · DOI
  56. Idzko, M. et al. Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells. Nature Med. 13, 913–919 (2007) · DOI
  57. Oyoshi, M. K., Larson, R. P., Ziegler, S. F. & Geha, R. S. Mechanical injury polarizes skin dendritic cells to elicit a TH2 response by inducing cutaneous thymic stromal lymphopoietin expression. J. Allergy Clin. Immunol. 126, 976–984 (2010) · DOI
  58. Navarro-Zorraquino, M. et al. Determination of the immunoglobulin E postoperative variation as a measure of surgical injury. World J. Surg. 25, 585–591 (2001) · DOI
  59. Kavaliers, M., Choleris, E., Agmo, A. & Pfaff, D. W. Olfactory-mediated parasite recognition and avoidance: linking genes to behavior. Horm. Behav. 46, 272–283 (2004) · DOI
  60. Tizzano, M. et al. Nasal chemosensory cells use bitter taste signaling to detect irritants and bacterial signals. Proc. Natl Acad. Sci. USA 107, 3210–3215 (2010) · DOI
  61. Rivière, S., Challet, L., Fluegge, D., Spehr, M. & Rodriguez, I. Formyl peptide receptor-like proteins are a novel family of vomeronasal chemosensors. Nature 459, 574–577 (2009) · DOI
  62. Bessac, B. F. & Jordt, S. E. Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control. Physiology (Bethesda) 23, 360–370 (2008)
  63. Bertrand, P. P. & Bertrand, R. L. Serotonin release and uptake in the gastrointestinal tract. Auton. Neurosci. 153, 47–57 (2010) · DOI
  64. Siegel, S. & Kreutzer, R. Pavlovian conditioning and multiple chemical sensitivity. Environ. Health Perspect. 105 (suppl. 2). 521–526 (1997)
  65. Mackenzie, M. Rose cold. Historical document. Ann. Allergy 19, 298–304 (1961)
  66. MacKenzie, J. N. The production of the so-called “rose cold” by means of an artificial rose. Am. J. Med. Sci. 91, 45–47 (1896)
  67. Justesen, D. R., Braun, E. W., Garrison, R. G. & Pendleton, R. B. Pharmacological differentiation of allergic and classically conditioned asthma in the guinea pig. Science 170, 864–866 (1970) · DOI
  68. Cara, D. C., Conde, A. A. & Vaz, N. M. Immunological induction of flavor aversion in mice. Braz. J. Med. Biol. Res. 27, 1331–1341 (1994)
  69. Cara, D. C., Conde, A. A. & Vaz, N. M. Immunological induction of flavour aversion in mice. II. Passive/adoptive transfer and pharmacological inhibition. Scand. J. Immunol. 45, 16–20 (1997) · DOI
  70. Zarzana, E. C., Basso, A. S., Costa-Pinto, F. A. & Palermo-Neto, J. Pharmacological manipulation of immune-induced food aversion in rats. Neuroimmunomodulation 16, 19–27 (2009) · DOI
  71. Lang, P. M., Moalem-Taylor, G., Tracey, D. J., Bostock, H. & Grafe, P. Activity-dependent modulation of axonal excitability in unmyelinated peripheral rat nerve fibers by the 5-HT(3) serotonin receptor. J. Neurophysiol. 96, 2963–2971 (2006) · DOI
  72. Costa-Pinto, F. A., Basso, A. S. & Russo, M. Role of mast cell degranulation in the neural correlates of the immediate allergic reaction in a murine model of asthma. Brain Behav. Immun. 21, 783–790 (2007) · DOI
  73. Costa-Pinto, F. A., Basso, A. S., Britto, L. R., Malucelli, B. E. & Russo, M. Avoidance behavior and neural correlates of allergen exposure in a murine model of asthma. Brain Behav. Immun. 19, 52–60 (2005) · DOI
  74. Mirotti, L., Castro, J., Costa-Pinto, F. A. & Russo, M. Neural pathways in allergic inflammation. J. Allergy (Cairo) 2010, 491928 (2010)This review covers the literature describing allergy-mediated avoidance behaviours.
  75. Zacharia, B. E. & Sherman, P. Atopy, helminths, and cancer. Med. Hypotheses 60, 1–5 (2003) · DOI

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Metadata

Authors
Palm, N. W., Rosenstein, R. K., & Medzhitov, R.
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
2012-04
Volume
484
Issue
7395
Pages
465-472
ISSN
  • 0028-0836
  • 1476-4687
DOI
10.1038/nature11047
PMC
PMC3596087
Cited by
352
References
11
Language
en
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