The DOI matches its Crossref record; 36 of the 37 references it cites were found in a registry or an index.
Fatty acid carbon is essential for dNTP synthesis in endothelial cells
Open accessAbstract
The metabolism of endothelial cells during vessel sprouting remains poorly studied. Here we report that endothelial loss of CPT1A, a rate-limiting enzyme of fatty acid oxidation (FAO), causes vascular sprouting defects due to impaired proliferation, not migration, of human and murine endothelial cells. Reduction of FAO in endothelial cells did not cause energy depletion or disturb redox homeostasis, but impaired de novo nucleotide synthesis for DNA replication. Isotope labelling studies in control endothelial cells showed that fatty acid carbons substantially replenished the Krebs cycle, and were incorporated into aspartate (a nucleotide precursor), uridine monophosphate (a precursor of pyrimidine nucleoside triphosphates) and DNA. CPT1A silencing reduced these processes and depleted endothelial cell stores of aspartate and deoxyribonucleoside triphosphates. Acetate (metabolized to acetyl-CoA, thereby substituting for the depleted FAO-derived acetyl-CoA) or a nucleoside mix rescued the phenotype of CPT1A-silenced endothelial cells. Finally, CPT1 blockade inhibited pathological ocular angiogenesis in mice, suggesting a novel strategy for blocking angiogenesis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Acetyl CoA from FAO is used for the TCA cycle as well as for aspartate and nucleotide synthesis.52”
From The multifaceted contributions of mitochondria to cellular metabolism (2018) · cites this paper as [52]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Jaffe, E. A., Nachman, R., Becker, C. G., & Minick, C. (1973) · Journal of Clinical Investigation · doi:10.1172/jci107470 · Cited by 7,146
Basic and Therapeutic Aspects of Angiogenesis
Potente, M., Gerhardt, H., & Carmeliet, P. (2011) · Cell · doi:10.1016/j.cell.2011.08.039 · Cited by 2,771
Self-citationVisualizing Spatiotemporal Dynamics of Multicellular Cell-Cycle Progression
Sakaue-Sawano, A., Kurokawa, H., Morimura, T., Hanyu, A., Hama, H., Osawa, H., Kashiwagi, S., Fukami, K., Miyata, T., Miyoshi, H., et al. (2008) · Cell · doi:10.1016/j.cell.2007.12.033 · Cited by 2,194
The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation
Wang, R., Dillon, C. P., Shi, L. Z., Milasta, S., Carter, R., Finkelstein, D., McCormick, L. L., Fitzgerald, P., Chi, H., Munger, J., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.021 · Cited by 2,140
Carmeliet, P., Moons, L., Luttun, A., Vincenti, V., Compernolle, V., Mol, M. D., Wu, Y., Bono, F., Devy, L., Beck, H., et al. (2001) · Nature Medicine · doi:10.1038/87904 · Cited by 1,708
Self-citationRole of PFKFB3-Driven Glycolysis in Vessel Sprouting
Bock, K. D., Γεωργιάδου, Μ., Schoors, S., Kuchnio, A., Wong, B. W., Cantelmo, A. R., Quaegebeur, A., Ghesquière, B., Cauwenberghs, S., Eelen, G., et al. (2013) · Cell · doi:10.1016/j.cell.2013.06.037 · Cited by 1,591
Self-citationCancer metabolism: fatty acid oxidation in the limelight
Carracedo, A., Cantley, L. C., & Pandolfi, P. P. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3483 · Cited by 1,353
Ausprunk, D. H., & Folkman, J. (1977) · Microvascular Research · doi:10.1016/0026-2862(77)90141-8 · Cited by 1,290
The Notch Ligands Dll4 and Jagged1 Have Opposing Effects on Angiogenesis
Benedito, R., Roca, C., Sörensen, I., Adams, S., Gossler, A., Fruttiger, M., & Adams, R. H. (2009) · Cell · doi:10.1016/j.cell.2009.03.025 · Cited by 1,138
Recent molecular discoveries in angiogenesis and antiangiogenic therapies in cancer
Welti, J. C., Loges, S., Dimmeler, S., & Carmeliet, P. (2013) · Journal of Clinical Investigation · doi:10.1172/jci70212 · Cited by 601
Self-citation
Flagged first, then by citations
1 of the 37 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 101–200 of 646
Draoui, N., de Zeeuw, P., & Carmeliet, P. (2017) · Open Biology · doi:10.1098/rsob.170219 · Cited by 143
Self-citationTang, M., Dong, X., Xiao, L., Tan, Z., Luo, X., Yang, L., Li, W., Shi, F., Li, Y., Zhao, L., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04730-y · Cited by 138
Shao, H., Mohamed, E., Xu, G. G., Waters, M. R., Jing, K., Ma, Y., Zhang, Y., Spiegel, S., Idowu, M. O., & Fang, X. (2015) · Oncotarget · doi:10.18632/oncotarget.6757 · Cited by 137
Uridine Metabolism and Its Role in Glucose, Lipid, and Amino Acid Homeostasis
Zhang, Y., Guo, S., Xie, C., & Fang, J. Q. (2020) · BioMed Research International · doi:10.1155/2020/7091718 · Cited by 129
Angiogenesis Revisited: An Overlooked Role of Endothelial Cell Metabolism in Vessel Sprouting
Vandekeere, S., Dewerchin, M. A., & Carmeliet, P. (2015) · Microcirculation · doi:10.1111/micc.12229 · Cited by 126
Self-citationZarkada, G., Howard, J. P., Xiao, X., Park, H., Bizou, M., Leclerc, S., Künzel, S. E., Boisseau, B., Li, J., Cagnone, G., et al. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.06.021 · Cited by 128
The Emerging Facets of Non-Cancerous Warburg Effect
Abdel‐Haleem, A. M., Lewis, N. E., Jamshidi, N., Mineta, K., Gao, X., & Gojobori, T. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00279 · Cited by 126
Visceral obesity and insulin resistance associate with CD36 deletion in lymphatic endothelial cells
Cifarelli, V., Appak‐Baskoy, S., Peche, V. S., Kluzak, A., Shew, T. M., Narendran, R., Pietka, K. M., Cella, M., Walls, C., Czepielewski, R. S., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23808-3 · Cited by 123
Vascular Normalization: A New Window Opened for Cancer Therapies
Yang, T., Xiao, H., Liu, X., Wang, Z., Zhang, Q., Wei, N., & Guo, X. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.719836 · Cited by 126
Modulation of endothelium function by fatty acids
Mallick, R., & Duttaroy, A. K. (2021) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-021-04260-9 · Cited by 129
Diet, lipids, and antitumor immunity
Prendeville, H., & Lynch, L. (2022) · Cellular and Molecular Immunology · doi:10.1038/s41423-021-00781-x · Cited by 126
Zhao, H., Dennery, P. A., & Yao, H. (2018) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00521.2017 · Cited by 116
Dual Roles of the AMP-Activated Protein Kinase Pathway in Angiogenesis
Li, Y., Sun, R., Zou, J., Ying, Y., & Luo, Z. (2019) · Cells · doi:10.3390/cells8070752 · Cited by 113
Diabetic Retinopathy: The Role of Mitochondria in the Neural Retina and Microvascular Disease
Miller, D. J., Cascio, M. A., & Rosca, M. G. (2020) · Antioxidants · doi:10.3390/antiox9100905 · Cited by 116
The Relationship Between Reactive Oxygen Species and Endothelial Cell Metabolism
Alhayaza, R., Haque, E., Karbasiafshar, C., Sellke, F. W., & Abid, M. R. (2020) · Frontiers in Chemistry · doi:10.3389/fchem.2020.592688 · Cited by 116
Aerobic Glycolysis: Beyond Proliferation
Jones, W., & Bianchi, K. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00227 · Cited by 114
Asymmetric division coordinates collective cell migration in angiogenesis
Costa, G., Harrington, K., Lovegrove, H. E., Page, D. J., Chakravartula, S., Bentley, K., & Herbert, S. P. (2016) · Nature Cell Biology · doi:10.1038/ncb3443 · Cited by 110
Lee, L. Y.-H., Oldham, W. M., He, H., Wang, R., Mulhern, R., Handy, D. E., & Loscalzo, J. (2021) · Circulation · doi:10.1161/circulationaha.121.053960 · Cited by 108
Decoding tumor angiogenesis: pathways, mechanisms, and future directions in anti-cancer strategies
Liu, X., Zhang, J., Yi, T., Li, H., Tang, X., Liu, D., Wu, D., & Li, Y. (2025) · Biomarker Research · doi:10.1186/s40364-025-00779-x · Cited by 125
Metabolic control of the cell cycle
Kalucka, J. M., Missiaen, R., Γεωργιάδου, Μ., Schoors, S., Lange, C. M., Bock, K. D., Dewerchin, M. A., & Carmeliet, P. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1090068 · Cited by 107
Self-citationTCA Cycle Rewiring as Emerging Metabolic Signature of Hepatocellular Carcinoma
Todisco, S., Convertini, P., Iacobazzi, V., & Infantino, V. (2019) · Cancers · doi:10.3390/cancers12010068 · Cited by 105
Chen, J., Zou, L., Lu, G. X., Grinchuk, O. V., Fang, L., Ong, D. S. T., Taneja, R., Ong, C. N., & Shen, H. (2022) · Cell Discovery · doi:10.1038/s41421-022-00406-1 · Cited by 107
How Endothelial Cells Adapt Their Metabolism to Form Vessels in Tumors
Zecchin, A., Kalucka, J. M., Dubois, C., & Carmeliet, P. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01750 · Cited by 111
Self-citationTumor Endothelial Heterogeneity in Cancer Progression
Maishi, N., Annan, D. A., Kikuchi, H., Hida, Y., & Hida, K. (2019) · Cancers · doi:10.3390/cancers11101511 · Cited by 106
Metabolic Regulation of Cell Fate and Function
Ghosh-Choudhary, S. K., Liu, J., & Finkel, T. (2020) · Trends in Cell Biology · doi:10.1016/j.tcb.2019.12.005 · Cited by 109
Phototransduction Influences Metabolic Flux and Nucleotide Metabolism in Mouse Retina
Du, J., Rountree, A. M., Cleghorn, W. M., Contreras, L., Lindsay, K. J., Sadı́lek, M., Gu, H., Djukovic, D., Raftery, D., Satrústegui, J., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.698985 · Cited by 97
Shi, J., Fu, H., Jia, Z., He, K., Fu, L. N., & Wang, W. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.11.025 · Cited by 110
Central Role of Metabolism in Endothelial Cell Function and Vascular Disease
Bierhansl, L., Conradi, L., Treps, L., Dewerchin, M. A., & Carmeliet, P. (2017) · Physiology · doi:10.1152/physiol.00031.2016 · Cited by 107
Self-citationCassim, S., Raymond, V., Assadzadeh, L. D., Lapierre, P., & Bilodeau, M. (2018) · Cell Cycle · doi:10.1080/15384101.2018.1460023 · Cited by 101
Mitochondrial purine and pyrimidine metabolism and beyond
Wang, L. (2016) · Nucleosides Nucleotides & Nucleic Acids · doi:10.1080/15257770.2015.1125001 · Cited by 99
Briant, L. J. B., Dodd, M. S., Chibalina, M. V., Rorsman, N. J. G., Johnson, P., Carmeliet, P., Rorsman, P., & Knudsen, J. G. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.05.035 · Cited by 101
Self-citationEndothelial cell plasticity at the single-cell level
Pasut, A., Becker, L. M., Cuypers, A., & Carmeliet, P. (2021) · Angiogenesis · doi:10.1007/s10456-021-09797-3 · Cited by 100
Self-citationRodrigues, M. F., Obre, É., de Melo, F. H. M., dos Santos, G. C., Galina, A., Jasiulionis, M. G., Rossignol, R., Rumjanek, F. D., & Amoêdo, N. D. (2015) · Biochemical Journal · doi:10.1042/bj20150645 · Cited by 101
The pathobiology of polycystic kidney disease from a metabolic viewpoint
Menezes, L. F., & Germino, G. G. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0183-y · Cited by 96
Quaegebeur, A., Segura, I., Schmieder, R., Verdegem, D., Decimo, I., Bifari, F., Dresselaers, T., Eelen, G., Ghosh, D., Davidson, S. M., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.12.007 · Cited by 96
Self-citationFatty acid oxidation and photoreceptor metabolic needs
Fu, Z., Kern, T. S., Hellström, A., & Smith, L. E. H. (2020) · Journal of Lipid Research · doi:10.1194/jlr.tr120000618 · Cited by 98
Ushio‐Fukai, M., Ash, D., Nagarkoti, S., de Chantemèle, E. J. B., Fulton, D. J., & Fukai, T. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8161 · Cited by 99
Egnatchik, R. A., Brittain, E. L., Shah, A. T., Fares, W. H., Ford, H. J., Monahan, K., Kang, C., Kocurek, E. G., Shijun, Z., Luong, T., et al. (2016) · Pulmonary Circulation · doi:10.1086/690236 · Cited by 95
Ocaña, M. C., Martı́nez-Poveda, B., Quesada, A. R., & Medina, M. Á. (2018) · Medicinal Research Reviews · doi:10.1002/med.21511 · Cited by 92
Liu, W., Zhang, G., Wu, J., Zhang, Y., Liu, J., Luo, H., & Shao, L. (2020) · Journal of Nanobiotechnology · doi:10.1186/s12951-019-0570-3 · Cited by 91
Endothelial Cell Glucose Metabolism and Angiogenesis
Du, W., Ren, L., Hamblin, M. H., & Fan, Y. (2021) · Biomedicines · doi:10.3390/biomedicines9020147 · Cited by 92
Lu, Q., Yao, Y., Hu, Z., Hu, C., Song, Q., Ye, J., Xu, C., Wang, A. Z., Chen, Q., & Wang, Q. K. (2016) · PLoS Biology · doi:10.1371/journal.pbio.1002529 · Cited by 92
Homeostasis and transitional activation of regulatory T cells require c-Myc
Saravia, J., Zeng, H., Dhungana, Y., Blanco, D. B., Nguyen, T.-L. M., Chapman, N. M., Wang, Y., Kanneganti, A., Liu, S., Raynor, J. L., et al. (2020) · Science Advances · doi:10.1126/sciadv.aaw6443 · Cited by 87
Self-citationCapellades, J., Navarro, M., Samino, S., García‐Ramírez, M., Hernández, C., Simó, R., Vinaixa, M., & Yanes, Ó. (2015) · Analytical Chemistry · doi:10.1021/acs.analchem.5b03628 · Cited by 88
Impairment of Fatty Acid Oxidation in Alveolar Epithelial Cells Mediates Acute Lung Injury
Cui, H., Xie, N., Banerjee, S., Ge, J., Guo, S., & Liu, G. (2018) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2018-0152oc · Cited by 88
Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells
Stone, O. A., El-Brolosy, M. A., Wilhelm, K., Liu, X., Romão, A. M., Grillo, E., Lai, J. K. H., Günther, S., Jeratsch, S., Kuenne, C. T., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06406-8 · Cited by 91
Metabolism in the Tumor Microenvironment
Lau, A. N., & Heiden, M. G. V. (2019) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-030419-033333 · Cited by 92
Recent advances in anti-angiogenic nanomedicines for cancer therapy
Bhattarai, P., Hameed, S., & Dai, Z. (2018) · Nanoscale · doi:10.1039/c7nr09612g · Cited by 90
Mitochondrial respiration controls neoangiogenesis during wound healing and tumour growth
Schiffmann, L. M., Werthenbach, J. P., Heintges-Kleinhofer, F., Seeger, J., Fritsch, M., Günther, S., Willenborg, S., Brodesser, S., Lucas, C., Jüngst, C., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17472-2 · Cited by 76
Sperry, J., Condro, M. C., Guo, L., Braas, D., VanderVeer-Harris, N., Kim, K. K. O., Pope, W. B., Divakaruni, A. S., Lai, A., Christofk, H. R., et al. (2020) · iScience · doi:10.1016/j.isci.2020.101453 · Cited by 88
Sadiku, P., Willson, J. A., Dickinson, R. S., Murphy, F. A., Harris, A. J., Lewis, A., Sammut, D., Mirchandani, A. S., Ryan, E. M., Watts, E., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci90848 · Cited by 92
Self-citationPatel, D., Menon, D., Bernfeld, E., Mroz, V., Kalan, S., Loayza, D., & Foster, D. A. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.710145 · Cited by 86
EndoDB: a database of endothelial cell transcriptomics data
Khan, S., Taverna, F., Rohlenová, K., Treps, L., Geldhof, V., de Rooij, L. P. M. H., Sokol, L., Pircher, A., Conradi, L., Kalucka, J. M., et al. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky997 · Cited by 86
Self-citationTargeting fatty acid metabolism in cancer and endothelial cells
Harjes, U., Kalucka, J. M., & Carmeliet, P. (2015) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2015.10.011 · Cited by 87
Self-citationInternational Journal of Scientific Research
Baruah, A., Das, S., Dutta, A., Das, B., Sharma, T., & Hazarika, M. (2025) · International Journal of Scientific Research · doi:10.15373/22778179 · Cited by 87
Angiogenesis in gynecological cancers and the options for anti-angiogenesis therapy
Yetkin-Arik, B., Kastelein, A. W., Klaassen, I., Jansen, C. H. J. R., Latul, Y. P., Vittori, M., Bırı, A., Kahraman, K., Griffioen, A. W., Amant, F. C., et al. (2020) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2020.188446 · Cited by 89
Role and therapeutic potential of dietary ketone bodies in lymph vessel growth
García‐Caballero, M., Zecchin, A., Souffreau, J., Truong, A.-C. K., Teuwen, L.-A. M. N., Vermaelen, W., Martín‐Pérez, R., de Zeeuw, P., Bouché, A., Vinckier, S., et al. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0087-y · Cited by 80
Self-citationShah, S., Carriveau, W. J., Li, J., Campbell, S. L., Kopinski, P. K., Lim, H., Daurio, N. A., Trefely, S., Won, K., Wallace, D. C., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.9666 · Cited by 85
Endothelial cell–cardiomyocyte crosstalk in diabetic cardiomyopathy
Wan, A., & Rodrigues, B. B. (2016) · Cardiovascular Research · doi:10.1093/cvr/cvw159 · Cited by 85
Pircher, A., Treps, L., Bodrug, N., & Carmeliet, P. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.08.011 · Cited by 84
Self-citationZhao, L., Liu, M., Sun, H., Yang, J., Huang, Y.-X., Huang, J., Lei, X. G., & Sun, L. (2023) · Science China Life Sciences · doi:10.1007/s11427-022-2226-1 · Cited by 82
Puchalska, P., Huang, X., Martin, S. E., Han, X., Patti, G. J., & Crawford, P. A. (2018) · iScience · doi:10.1016/j.isci.2018.10.029 · Cited by 79
Metabolic Signatures of Distinct Endothelial Phenotypes
Dumas, S. J., García‐Caballero, M., & Carmeliet, P. (2020) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2020.05.009 · Cited by 82
Self-citationVeitch, S., Njock, M., Chandy, M., Siraj, M. A., Chi, L., Mak, H., Yu, K., Rathnakumar, K., Perez-Romero, C. A., Chen, Z., et al. (2022) · Cardiovascular Diabetology · doi:10.1186/s12933-022-01458-z · Cited by 82
Navigating tumor angiogenesis: therapeutic perspectives and myeloid cell regulation mechanism
Yang, F., Lee, G., & Fan, Y. (2024) · Angiogenesis · doi:10.1007/s10456-024-09913-z · Cited by 90
The Heterogeneity of Lipid Metabolism in Cancer
Park, J. K., Coffey, N. J., Limoges, A., & Le, A. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-77736-8_3 · Cited by 80
MYCN-driven fatty acid uptake is a metabolic vulnerability in neuroblastoma
Tao, L., Mohammad, M. A., Milazzo, G., Moreno‐Smith, M., Patel, T. D., Zorman, B., Badachhape, A., Hernandez, B. E., Wolf, A. B., Zeng, Z., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31331-2 · Cited by 75
Multifaceted roles of mitochondria in wound healing and chronic wound pathogenesis
Hunt, M., Torres, M. S., Bachar-Wikström, E., & Wikström, J. D. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1252318 · Cited by 84
TFEB controls vascular development by regulating the proliferation of endothelial cells
Doronzo, G., Astanina, E., Corà, D., Chiabotto, G., Comunanza, V., Noghero, A., Neri, F., Puliafito, A., Primo, L., Spampanato, C., et al. (2018) · The EMBO Journal · doi:10.15252/embj.201798250 · Cited by 78
Antiangiogenic and tumour inhibitory effects of downregulating tumour endothelial FABP4
Harjes, U., Bridges, E., Gharpure, K. M., Roxanis, I., Sheldon, H., Miranda, F., Mangala, L. S., Pradeep, S., Lopez‐Berestein, G., Ahmed, A., et al. (2016) · Oncogene · doi:10.1038/onc.2016.256 · Cited by 78
Wong, B. W., Zecchin, A., García‐Caballero, M., & Carmeliet, P. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.03.021 · Cited by 78
Self-citationYu, Q., Tai, Y., Tang, Y. M., Zhao, J., Negi, V., Culley, M. K., Pilli, J., Sun, W., Brugger, K., Mayr, J. A., et al. (2019) · Circulation · doi:10.1161/circulationaha.118.035889 · Cited by 78
Becker, L. M., Chen, S.-H., Rodor, J., de Rooij, L. P. M. H., Baker, A. H., & Carmeliet, P. (2022) · Cardiovascular Research · doi:10.1093/cvr/cvac018 · Cited by 81
Self-citationAmoedo, N. D., Obre, E., & Rossignol, R. (2017) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2017.02.005 · Cited by 76
Alveolar cells under mechanical stressed niche: critical contributors to pulmonary fibrosis
Yang, J., Pan, X., Wang, L., & Yu, G. (2020) · Molecular Medicine · doi:10.1186/s10020-020-00223-w · Cited by 79
Endothelial SIRT3 regulates myofibroblast metabolic shifts in diabetic kidneys
Srivastava, S. P., Li, J., Takagaki, Y., Kitada, M., Goodwin, J. E., Kanasaki, K., & Koya, D. (2021) · iScience · doi:10.1016/j.isci.2021.102390 · Cited by 76
Khanna, D., Padilla, C. M., Tsoi, L. C., Nagaraja, V., Khanna, P. P., Tabib, T., Kahlenberg, J. M., Young, A., Huang, S., Gudjonsson, J. E., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.159566 · Cited by 76
Intracellular endothelial cell metabolism in vascular function and dysfunction
Citrin, K. M., Chaube, B., Fernandez-Hernando, C. F., & Suárez, Y. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.11.004 · Cited by 81
Yetkin-Arik, B., Vogels, I. M. C., Neyazi, N., van Duinen, V., Houtkooper, R. H., Noorden, C. J. F. V., Klaassen, I., & Schlingemann, R. O. (2019) · Scientific Reports · doi:10.1038/s41598-019-46503-2 · Cited by 75
MiR‐9‐5p protects from kidney fibrosis by metabolic reprogramming
Fierro‐Fernández, M., Miguel, V., Márquez‐Expósito, L., Nuevo‐Tapioles, C., Herrero, J. I., Blanco, E. M., Tituaña, J., Castillo, C., Cannata, P., Monsalve, M., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201901599rr · Cited by 74
Endothelial cell metabolism in cardiovascular physiology and disease
Pasut, A., Lama, E., Van Craenenbroeck, A. H., Kroon, J., & Carmeliet, P. (2025) · Nature Reviews Cardiology · doi:10.1038/s41569-025-01162-x · Cited by 74
Self-citationMa, Y., Wang, W., Devarakonda, T., Zhou, H., Wang, X., Salloum, F. N., Spiegel, S., & Fang, X. (2020) · Scientific Reports · doi:10.1038/s41598-020-58334-7 · Cited by 74
Angiocrine polyamine production regulates adiposity
Monelli, E., Villacampa, P., Zabala‐Letona, A., Martínez-Romero, A., Llena, J., Beiroa, D., Gouveia, L., Chivite, Í., Zagmutt, S., Gama-Pérez, P., et al. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00544-6 · Cited by 76
The Role of Lipid Metabolism for Neural Stem Cell Regulation
Knobloch, M. (2017) · Brain Plasticity · doi:10.3233/bpl-160035 · Cited by 78
How glucose, glutamine and fatty acid metabolism shape blood and lymph vessel development
Teuwen, L.-A. M. N., Geldhof, V., & Carmeliet, P. (2017) · Developmental Biology · doi:10.1016/j.ydbio.2017.12.001 · Cited by 75
Self-citationIssitt, T., Bosseboeuf, E., de Winter, N., Dufton, N., Gestri, G., Senatore, V., Chikh, A., RANDI, A. M., & Raimondi, C. (2018) · iScience · doi:10.1016/j.isci.2018.12.005 · Cited by 74
Neutrophil trapping and nexocytosis, mast cell-mediated processes for inflammatory signal relay
Mihlan, M., Wissmann, S., Gavrilov, A., Kaltenbach, L., Britz, M., Franke, K., Hummel, B., Imle, A., Suzuki, R., Stecher, M., et al. (2024) · Cell · doi:10.1016/j.cell.2024.07.014 · Cited by 75
Self-citationMetabolic Reprogramming in Tumor Endothelial Cells
García‐Caballero, M., Sokol, L., Cuypers, A., & Carmeliet, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911052 · Cited by 72
Self-citationFasting reshapes tissue-specific niches to improve NK cell-mediated anti-tumor immunity
Delconte, R. B., Owyong, M., Santosa, E. K., Srpan, K., Sheppard, S., McGuire, T. J., Abbasi, A. J., Díaz-Salazar, C., Chun, J. J. M., Rogatsky, I., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.05.021 · Cited by 73
Yao, H., Gong, J., Peterson, A. L., Lu, X., Zhang, P., & Dennery, P. A. (2018) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2018-0335oc · Cited by 71
Citric Acid: A Nexus Between Cellular Mechanisms and Biomaterial Innovations
Xu, H. F., Yan, S., Gerhard, E. M., Xie, D., Liu, X., Zhang, B., Shi, D., Ameer, G. A., & Yang, J. Y. (2024) · Advanced Materials · doi:10.1002/adma.202402871 · Cited by 74
Initiation of acute graft-versus-host disease by angiogenesis
Riesner, K., Shi, Y., Jacobi, A., Kräter, M., Kalupa, M., McGearey, A., Mertlitz, S., Cordes, S., Schrezenmeier, J., Mengwasser, J., et al. (2017) · Blood · doi:10.1182/blood-2016-08-736314 · Cited by 71
Single-Cell Transcriptomics Reveals Endothelial Plasticity During Diabetic Atherogenesis
Zhao, G., Lu, H., Liu, Y., Zhao, Y., Zhu, T., Garcia-Barrio, M. T., Chen, Y. E., & Zhang, J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.689469 · Cited by 67
Ketone body oxidation increases cardiac endothelial cell proliferation
Weis, E., Puchalska, P., Nelson, A. B., Taylor, J., Moll, I., Hasan, S. S., Dewenter, M., Hagenmueller, M., Fleming, T. H., Poschet, G., et al. (2022) · EMBO Molecular Medicine · doi:10.15252/emmm.202114753 · Cited by 67
Suppression of angiopoietin-like 4 reprograms endothelial cell metabolism and inhibits angiogenesis
Chaube, B., Citrin, K. M., Sahraei, M., Singh, A. K., de Urturi, D. S., Ding, W., Pierce, R. W., Raaisa, R., CARDONE, R. L., Kibbey, R. G., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-43900-0 · Cited by 73
TNF-α induces acyl-CoA synthetase 3 to promote lipid droplet formation in human endothelial cells
Jung, H. S., Shimizu‐Albergine, M., Shen, X., Kramer, F., Shao, D., Vivekanandan‐Giri, A., Pennathur, S., Tian, R., Kanter, J. E., & Bornfeldt, K. (2019) · Journal of Lipid Research · doi:10.1194/jlr.ra119000256 · Cited by 66
Meçe, O., Houbaert, D., Sassano, M. L., Durré, T., Maes, H., Schaaf, M. B. E., More, S., Ganne, M., García‐Caballero, M., Borri, M., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30490-6 · Cited by 68
Self-citationBlood-brain barrier-supported neurogenesis in healthy and diseased brain
Пожиленкова, Е. А., Lopatina, O. L., Komleva, Y. K., Salmin, V. V., & Salmina, A. B. (2017) · Reviews in the Neurosciences · doi:10.1515/revneuro-2016-0071 · Cited by 66
The influence of endothelial metabolic reprogramming on the tumor microenvironment
Kane, K. M., Edwards, D. N., & Chen, J. (2024) · Oncogene · doi:10.1038/s41388-024-03228-5 · Cited by 72
Rochette, L., Méloux, A., Rigal, E., Zeller, M., Malka, G., Cottin, Y., & Vergely, C. (2019) · Calcified Tissue International · doi:10.1007/s00223-019-00573-6 · Cited by 66
Metadata
- Authors
- Schoors, S., Bruning, U., Missiaen, R., Queiroz, K. C. S., Borgers, G., Elia, I., Zecchin, A., Cantelmo, A. R., Christen, S., Goveia, J., Heggermont, W., Goddé, L., Vinckier, S., Van Veldhoven, P. P., Eelen, G., Schoonjans, L., Gerhardt, H., Dewerchin, M., Baes, M., De Bock, K., Ghesquière, B., Lunt, S. Y., Fendt, S.-M., & Carmeliet, P.
- Affiliations
- KU Leuven (BE)
- Universitair Ziekenhuis Leuven (BE)
- Max Delbrück Center (DE)
- Michigan State University (US)
- Corresponding author
- Fendt, Sarah-Maria
- Carmeliet, Peter
- ORCID
- Venue
- Nature
- Published
- 2015-04-01
- Volume
- 520
- Issue
- 7546
- Pages
- 192-197
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC4413024
- OpenAlex
- W2075209047
- Cited by
- 646
- References
- 37
- Citations by year
- 2026: 50 · 2025: 65 · 2024: 78 · 2023: 39 · 2022: 66 · 2021: 55 · 2020: 68 · 2019: 45 · 2018: 61 · 2017: 55 · 2016: 43 · 2015: 19
- FWCI
- 19.61
- Type
- journal article
- Language
- en
- Update notices
- correction (2015-08-05)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
- Lirias (KU Leuven) (submittedVersion, other-oa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- fatty acid oxidation, CPT1A, endothelial cells, angiogenesis, vessel sprouting, de novo nucleotide synthesis, dNTP synthesis, aspartic acid, uridine monophosphate, acetyl-CoA, TCA cycle, endothelial cell proliferation, pathological angiogenesis, retinopathy of prematurity, ocular angiogenesis
- MeSH terms
- Adenosine Triphosphate, Animals, Blood Vessels, Carbon, Carnitine O-Palmitoyltransferase, Citric Acid Cycle, Disease Models, Animal, DNA, Fatty Acids, Glucose, Humans, Neovascularization, Pathologic, Nucleotides, Oxidation-Reduction, Retinopathy of Prematurity, Acetic Acid, Gene Silencing, Endothelial Cells, Cell Line, Tumor, Cell Proliferation, Mice, Human Umbilical Vein Endothelial Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
