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Fatty acid carbon is essential for dNTP synthesis in endothelial cells
Open accessAbstract
The metabolism of endothelial cells during vessel sprouting remains poorly studied. Here we report that endothelial loss of CPT1A, a rate-limiting enzyme of fatty acid oxidation (FAO), causes vascular sprouting defects due to impaired proliferation, not migration, of human and murine endothelial cells. Reduction of FAO in endothelial cells did not cause energy depletion or disturb redox homeostasis, but impaired de novo nucleotide synthesis for DNA replication. Isotope labelling studies in control endothelial cells showed that fatty acid carbons substantially replenished the Krebs cycle, and were incorporated into aspartate (a nucleotide precursor), uridine monophosphate (a precursor of pyrimidine nucleoside triphosphates) and DNA. CPT1A silencing reduced these processes and depleted endothelial cell stores of aspartate and deoxyribonucleoside triphosphates. Acetate (metabolized to acetyl-CoA, thereby substituting for the depleted FAO-derived acetyl-CoA) or a nucleoside mix rescued the phenotype of CPT1A-silenced endothelial cells. Finally, CPT1 blockade inhibited pathological ocular angiogenesis in mice, suggesting a novel strategy for blocking angiogenesis.
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“Acetyl CoA from FAO is used for the TCA cycle as well as for aspartate and nucleotide synthesis.52”
From The multifaceted contributions of mitochondria to cellular metabolism (2018) · cites this paper as [52]
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Cites
Jaffe, E. A., Nachman, R., Becker, C. G., & Minick, C. (1973) · Journal of Clinical Investigation · doi:10.1172/jci107470 · Cited by 7,146
Basic and Therapeutic Aspects of Angiogenesis
Potente, M., Gerhardt, H., & Carmeliet, P. (2011) · Cell · doi:10.1016/j.cell.2011.08.039 · Cited by 2,771
Self-citationVisualizing Spatiotemporal Dynamics of Multicellular Cell-Cycle Progression
Sakaue-Sawano, A., Kurokawa, H., Morimura, T., Hanyu, A., Hama, H., Osawa, H., Kashiwagi, S., Fukami, K., Miyata, T., Miyoshi, H., et al. (2008) · Cell · doi:10.1016/j.cell.2007.12.033 · Cited by 2,194
The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation
Wang, R., Dillon, C. P., Shi, L. Z., Milasta, S., Carter, R., Finkelstein, D., McCormick, L. L., Fitzgerald, P., Chi, H., Munger, J., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.021 · Cited by 2,140
Carmeliet, P., Moons, L., Luttun, A., Vincenti, V., Compernolle, V., Mol, M. D., Wu, Y., Bono, F., Devy, L., Beck, H., et al. (2001) · Nature Medicine · doi:10.1038/87904 · Cited by 1,708
Self-citationRole of PFKFB3-Driven Glycolysis in Vessel Sprouting
Bock, K. D., Γεωργιάδου, Μ., Schoors, S., Kuchnio, A., Wong, B. W., Cantelmo, A. R., Quaegebeur, A., Ghesquière, B., Cauwenberghs, S., Eelen, G., et al. (2013) · Cell · doi:10.1016/j.cell.2013.06.037 · Cited by 1,591
Self-citationCancer metabolism: fatty acid oxidation in the limelight
Carracedo, A., Cantley, L. C., & Pandolfi, P. P. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3483 · Cited by 1,353
Ausprunk, D. H., & Folkman, J. (1977) · Microvascular Research · doi:10.1016/0026-2862(77)90141-8 · Cited by 1,290
The Notch Ligands Dll4 and Jagged1 Have Opposing Effects on Angiogenesis
Benedito, R., Roca, C., Sörensen, I., Adams, S., Gossler, A., Fruttiger, M., & Adams, R. H. (2009) · Cell · doi:10.1016/j.cell.2009.03.025 · Cited by 1,138
Recent molecular discoveries in angiogenesis and antiangiogenic therapies in cancer
Welti, J. C., Loges, S., Dimmeler, S., & Carmeliet, P. (2013) · Journal of Clinical Investigation · doi:10.1172/jci70212 · Cited by 601
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Sex‐specific, reciprocal regulation of ERα and miR‐22 controls muscle lipid metabolism in male mice
Schweisgut, J., Schutt, C., Wüst, S., Wietelmann, A., Ghesquière, B., Carmeliet, P., Dröse, S., Korach, K. S., Braun, T. W., & Boettger, T. (2017) · The EMBO Journal · doi:10.15252/embj.201695988 · Cited by 32
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Declercq, M., de Zeeuw, P., Conchinha, N. V., Geldhof, V., Ramalho, A. S., García‐Caballero, M., Brepoels, K., Ensinck, M. M., Carlon, M. S., Bird, M., et al. (2020) · European Respiratory Journal · doi:10.1183/13993003.00261-2020 · Cited by 32
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Santoro, M. M. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.08.002 · Cited by 32
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Armour, S. L., Frueh, A., Chibalina, M. V., Dou, H., Argemi‐Muntadas, L., Hamilton, A., Katzilieris‐Petras, G., Carmeliet, P., Davies, B., Möritz, T., et al. (2023) · Diabetes · doi:10.2337/db23-0056 · Cited by 31
Self-citationHamsanathan, S., Anthonymuthu, T., Han, S., Shinglot, H., Siefken, E., Sims, A., Sen, P., Pepper, H. L., Snyder, N. W., Bayir, H., et al. (2022) · Science Advances · doi:10.1126/sciadv.abl6083 · Cited by 30
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Zhang, S., Paccalet, A., Rohde, D., Cremer, S., Hulsmans, M., Lee, I., Mentkowski, K. I., Grune, J., Schloss, M. J., Honold, L., et al. (2023) · Nature Cardiovascular Research · doi:10.1038/s44161-023-00388-7 · Cited by 31
You, N., Liu, G., Yu, M., Chen, W., Fei, X., Sun, T., Han, M., Qin, Z., Wei, Z., & Wang, D. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2024.12.049 · Cited by 31
Huang, Z., Xu, B., Huang, X., Zhang, Y., Yu, M., Han, X., Song, L., Xia, Y., Zhou, Z., Wang, X., et al. (2019) · Nanotoxicology · doi:10.1080/17435390.2018.1537411 · Cited by 30
Faulkner, A., Lynam, E. G., Purcell, R. H., Jones, C. A., Lopez, C. A., Mary Board, Wagner, K., Wagner, N., Carr, C. A., & Wheeler-Jones, C. P. D. (2020) · Scientific Reports · doi:10.1038/s41598-020-63900-0 · Cited by 32
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Fatty acid oxidation facilitates DNA double-strand break repair by promoting PARP1 acetylation
Yang, S., Hwang, S., Kim, B.-J., Shin, S., Kim, M., & Jeong, S. M. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05968-w · Cited by 34
Wang, J., Zhao, R., Xu, S., Zhou, X., Cai, K., Chen, Y., Zhou, Z., Sun, X., Shi, Y., Wang, F., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-54407-7 · Cited by 32
Yoshinaga, A., Kajihara, N., Kukidome, D., Motoshima, H., Matsumura, T., Nishikawa, T., & Araki, E. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.8008 · Cited by 30
Natural Compounds as Metabolic Modulators of the Tumor Microenvironment
Dias, A. S., Helguero, L. A., Almeida, C. R., & Duarte, I. F. (2021) · Molecules · doi:10.3390/molecules26123494 · Cited by 31
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Stevens, R. P., Paudel, S. S., Johnson, S., Stevens, T., & Lee, J. (2021) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00131.2021 · Cited by 32
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Di, M., Zhang, Y., Zeng, R., Liu, X., Chen, W., Zhang, M., Zhang, C., Li, M., & Zhang, M. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.60302 · Cited by 32
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Mitchell, S. L., Ma, C., Scott, W. K., Agarwal, A., Pericak‐Vance, M. A., Haines, J. L., Jones, D. P., Uppal, K., & Brantley, M. A. (2021) · Cells · doi:10.3390/cells10113141 · Cited by 29
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Fu, Z., Nilsson, A., Hellström, A., & Smith, L. E. H. (2022) · eLife · doi:10.7554/elife.80550 · Cited by 30
Correction: Corrigendum: Fatty acid carbon is essential for dNTP synthesis in endothelial cells
Schoors, S., Brüning, U., Missiaen, R., Queiroz, K. C. S., Borgers, G., Elia, I., Zecchin, A., Cantelmo, A. R., Christen, S., Goveia, J., et al. (2015) · Nature · doi:10.1038/nature14624 · Cited by 28
Self-citationZeng, Y., Zhao, L., Zeng, K., Zhan, Z., Zhan, Z., Li, S., Zhan, H., Chai, P., Xie, C., Ding, S., et al. (2025) · Journal of Clinical Investigation · doi:10.1172/jci178550 · Cited by 27
Favara, D. M., Zois, C. E., Haider, S. A., Pires, E., Sheldon, H., McCullagh, J., Banham, A. H., & Harris, A. L. (2019) · Metabolites · doi:10.3390/metabo9120287 · Cited by 27
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Arbe, M. F., Agnetti, L., Breininger, E., Glikin, G. C., Finocchiaro, L. M. E., & Villaverde, M. S. (2020) · Translational Oncology · doi:10.1016/j.tranon.2020.100842 · Cited by 27
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Yang, B. X., Li, G., Liu, J., Li, X., Zhang, S., Sun, F., & Liu, W. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13122035 · Cited by 30
Wang, J., Xu, J., Zang, G., Zhang, T., Wu, Q., Zhang, H., Chen, Y., Wang, Y., Qin, W., Zhao, S., et al. (2022) · Research · doi:10.34133/2022/9839368 · Cited by 27
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Krejčı́, A., & Tennessen, J. M. (2017) · Development · doi:10.1242/dev.150573 · Cited by 27
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Kim, B., & Arany, Z. P. (2022) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041162 · Cited by 29
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Song, H., Guo, T., Zhao, Z., Wei, Y., Luo, H., Weng, W., Zhang, R., Zhong, M., Chen, C., Su, J., et al. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.06.006 · Cited by 26
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Li, G., Yao, Q., Liu, P., Zhang, H., Liu, Y., Li, S., Shi, Y., Li, Z., & Zhu, W. (2024) · MedComm · doi:10.1002/mco2.559 · Cited by 29
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Lovisa, S., & Kalluri, R. (2018) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.03.003 · Cited by 26
Jia, S., Bode, A. M., Chen, X., & Luo, X. (2024) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2024.189166 · Cited by 27
Lin, Z., Hua, G., & Hu, X. (2024) · Cancer Cell International · doi:10.1186/s12935-024-03481-4 · Cited by 31
Möller, J., Bhat, K., Riecken, K., Pörtner, R., Zeng, A., & Jandt, U. (2019) · Biotechnology and Bioengineering · doi:10.1002/bit.27124 · Cited by 25
Dallinga, M. G., Habani, Y. I., Schimmel, A. W. M., Dallinga‐Thie, G. M., Noorden, C. J. F. V., Klaassen, I., & Schlingemann, R. O. (2021) · Cells · doi:10.3390/cells10040926 · Cited by 25
Vascular Metabolism as Driver of Atherosclerosis: Linking Endothelial Metabolism to Inflammation
Dzobo, K. E., Hanford, K., & Kroon, J. (2021) · Immunometabolism · doi:10.20900/immunometab20210020 · Cited by 27
Wik, J. A., Phung, D., Kolan, S. S., Haraldsen, G., Skålhegg, B. S., & Fosse, J. H. (2021) · FEBS Open Bio · doi:10.1002/2211-5463.13174 · Cited by 25
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Tomita, Y., Usui‐Ouchi, A., Nilsson, A., Yang, J., Ko, M., Hellström, A., & Fu, Z. (2021) · Life · doi:10.3390/life11111119 · Cited by 25
Kulovic‐Sissawo, A., Tocantins, C., Diniz, M. S., Weiß, E., Steiner, A. J., Tokic, S., Madreiter‐Sokolowski, C. T., Pereira, S. P., & Hiden, U. (2024) · Biology · doi:10.3390/biology13020070 · Cited by 27
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Uldry, É., Faes, S., Demartines, N., & Dormond, O. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071401 · Cited by 27
Wang, J., Meng, S., Chen, Y., Wang, H., Hu, W., Liu, S., Huang, L., Xu, J., Li, Q., Wu, X., et al. (2025) · Redox Report · doi:10.1080/13510002.2025.2474897 · Cited by 25
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Din, Z. U., Cui, B., Wang, C., Zhang, X., Mehmood, A., Peng, F., & Liu, Q. (2024) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-024-04995-1 · Cited by 26
Liu, B., Yi, D., Li, S., Ramirez, K., Xia, X., Cao, Y., Zhao, H., Tripathi, A., Qiu, S., Kala, M., et al. (2025) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.124.321173 · Cited by 24
Yang, Y., Yang, Q., Luo, S., Zhang, Y., Lian, C., He, H., Zeng, J., & Zhang, G. (2022) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.63.1.28 · Cited by 24
Zhu, Y., Dun, H., Li, Y., Terada, Y., Shriver, L. P., Patti, G. J., Kreisel, D., Gelman, A. E., & Wong, B. W. (2022) · JCI Insight · doi:10.1172/jci.insight.151596 · Cited by 24
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Likhite, N., Yadav, V., Milliman, E. J., Sopariwala, D. H., Lorca, S., Narayana, N. P., Sheth, M., Reineke, E. L., Giguère, V., & Narkar, V. A. (2019) · Molecular and Cellular Biology · doi:10.1128/mcb.00411-18 · Cited by 24
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Camacho, J. E., Arnalich, F., Anciones, B., Peña, J. M., Gil, Á., Barbado, F. J., Puig, J. G., & Vázquez, J. J. (1985) · PubMed · Cited by 24
Pirri, D., Tian, S., Ayllón, B. T., Irving, S. E., Donati, F., Allen, S. P., Mammoto, T., Vilahur, G., Kabir, L., Bennett, J., et al. (2024) · Circulation Research · doi:10.1161/circresaha.123.324054 · Cited by 23
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Miguel, V., Tituaña, J., Herrero Meseguer, J. I., Herrero Rodríguez, L., Serra i Cucurull, D., Cuevas-Delgado, P., Barbas, C., Rodríguez Puyol, D., Márquez‐Expósito, L., Ruiz‐Ortega, M., et al. (2021) · Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) · Cited by 23
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Luo, X., Zou, W., Wei, Z., Yu, S., Zhao, Y., Wu, Y., Wang, A., & Lu, Y. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109167 · Cited by 25
Faulkner, A., Tamiato, A., Cathery, W., Rampin, A., Caravaggi, C. M. F., Jover, E., Allen, S., Mellor, H., Hauton, D., Heather, L. C., et al. (2020) · Diabetologia · doi:10.1007/s00125-020-05230-4 · Cited by 23
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Craige, S. M., Kaur, G., Bond, J. M., Caliz, A. D., Kant, S., & Keaney, J. F. (2024) · Antioxidants and Redox Signaling · doi:10.1089/ars.2024.0706 · Cited by 24
Yue, F., Gu, L., Qiu, J., Oprescu, S. N., Beckett, L. M., Ellis, J. M., Donkin, S. S., & Kuang, S. (2025) · The EMBO Journal · doi:10.1038/s44318-025-00397-1 · Cited by 25
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Flach, R. J. R., DiStefano, M. T., Danai, L. V., Senol-Cosar, O., Yawe, J. C., Kelly, M., Menendez, L. G., & Czech, M. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00037.2017 · Cited by 22
Schoonjans, C. A., Mathieu, B., Joudiou, N., Zampieri, L. X., Brusa, D., Sonveaux, P., Féron, O., & Gallez, B. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9103308 · Cited by 22
Bei, Y., Tia, B., Li, Y., Guo, Y., Deng, S., Huang, R., Zeng, H., Li, R., Wang, G., & Dai, J. (2021) · BioMed Research International · doi:10.1155/2021/9066938 · Cited by 22
Geric, I., Tyurina, Y. Y., Krysko, O., Krysko, D. V., de Schryver, E., Kagan, V. E., Veldhoven, P. P. V., Baes, M. I., & Verheijden, S. (2017) · Immunology · doi:10.1111/imm.12844 · Cited by 22
Self-citationJiao, S., Tang, B., Wang, Y., Li, C., Zeng, Z., Cui, L., Zhang, X., Shao, M., Guo, D., & Wang, Q. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01414 · Cited by 22
Ma, X., Wu, W., Hara, M., Zhou, J., Panzarin, C., Schafer, C. M., Griffin, C. T., Cai, J., Ma, J., & Takahashi, Y. (2024) · Communications Biology · doi:10.1038/s42003-024-06773-7 · Cited by 22
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Merchant, S., Paul, A., Reyes, A., Cassidy, D., Leach, A., Kim, D., Muh, S., Grabowski, G., Hoxhaj, G., Zhao, Z., et al. (2024) · Cell stem cell · doi:10.1016/j.stem.2024.11.014 · Cited by 22
Rodríguez‐Rodríguez, R., Baena, M., Zagmutt, S., Paraiso, W. K. D., Reguera, A. C., Fadó, R., & Casals, N. (2025) · Pharmacological Reviews · doi:10.1016/j.pharmr.2025.100051 · Cited by 22
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Trotta, R., Rivis, S., Zhao, S., Orban, M., Cafarello, S. T., Charatsidou, I., Poźniak, J., Dehairs, J., Vanheer, L., Pulido-Vicuña, C. A., et al. (2025) · Cancer Discovery · doi:10.1158/2159-8290.cd-24-0415 · Cited by 21
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Hong, S., Shin, J., Aldokhayyil, M., Brown, M. D., & Park, J. (2022) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000289 · Cited by 21
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Hyroššová, P., Milošević, M., Škoda, J., Vachtenheim, J., Jr., Rohlena, J., & Rohlenová, K. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1046630 · Cited by 23
Zhang, L., Li, S., Li, L., Chen, Z., & Yang, Y. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.8270 · Cited by 21
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Verhoeven, J., Baelen, J., Agrawal, M., & Agostinis, P. (2021) · FEBS Letters · doi:10.1002/1873-3468.14087 · Cited by 20
Chang, J., Gong, J., Rizal, S., Peterson, A. L., Chang, J., Yao, C., Dennery, P. A., & Yao, H. (2022) · Respiratory Research · doi:10.1186/s12931-022-02135-1 · Cited by 20
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Shi, Y., Huang, X., Zeng, Y., Zhai, M., Yao, H., Liu, C., Li, B., Gong, S., Yu, Q., Zhuang, J., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.103013 · Cited by 21
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Xu, S., Liao, J., Liu, B., Zhang, C., & Xu, X. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09588-1 · Cited by 20
Tang, K., Huang, C., Huang, Z., Wang, Z., & Tan, N. (2025) · Cardiovascular Diabetology · doi:10.1186/s12933-025-02638-3 · Cited by 23
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Subudhi, S., Lee, S., & Jain, R. K. (2026) · Cell · doi:10.1016/j.cell.2026.03.016 · Cited by 29
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Metadata
- Authors
- Schoors, S., Bruning, U., Missiaen, R., Queiroz, K. C. S., Borgers, G., Elia, I., Zecchin, A., Cantelmo, A. R., Christen, S., Goveia, J., Heggermont, W., Goddé, L., Vinckier, S., Van Veldhoven, P. P., Eelen, G., Schoonjans, L., Gerhardt, H., Dewerchin, M., Baes, M., De Bock, K., Ghesquière, B., Lunt, S. Y., Fendt, S.-M., & Carmeliet, P.
- Affiliations
- KU Leuven (BE)
- Universitair Ziekenhuis Leuven (BE)
- Max Delbrück Center (DE)
- Michigan State University (US)
- Corresponding author
- Fendt, Sarah-Maria
- Carmeliet, Peter
- ORCID
- Venue
- Nature
- Published
- 2015-04-01
- Volume
- 520
- Issue
- 7546
- Pages
- 192-197
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC4413024
- OpenAlex
- W2075209047
- Cited by
- 646
- References
- 37
- Citations by year
- 2026: 50 · 2025: 65 · 2024: 78 · 2023: 39 · 2022: 66 · 2021: 55 · 2020: 68 · 2019: 45 · 2018: 61 · 2017: 55 · 2016: 43 · 2015: 19
- FWCI
- 19.61
- Type
- journal article
- Language
- en
- Update notices
- correction (2015-08-05)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
- Lirias (KU Leuven) (submittedVersion, other-oa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- fatty acid oxidation, CPT1A, endothelial cells, angiogenesis, vessel sprouting, de novo nucleotide synthesis, dNTP synthesis, aspartic acid, uridine monophosphate, acetyl-CoA, TCA cycle, endothelial cell proliferation, pathological angiogenesis, retinopathy of prematurity, ocular angiogenesis
- MeSH terms
- Adenosine Triphosphate, Animals, Blood Vessels, Carbon, Carnitine O-Palmitoyltransferase, Citric Acid Cycle, Disease Models, Animal, DNA, Fatty Acids, Glucose, Humans, Neovascularization, Pathologic, Nucleotides, Oxidation-Reduction, Retinopathy of Prematurity, Acetic Acid, Gene Silencing, Endothelial Cells, Cell Line, Tumor, Cell Proliferation, Mice, Human Umbilical Vein Endothelial Cells
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