Cited by 185Motor Control and AdaptationVisual perception and processing mechanismsNeural and Behavioral Psychology Studies

A cognitive signal for the proactive timing of action in macaque LIP

Maimon, Gaby, Assad, John A·2006·Nature Neuroscience

Abstract

Natural movements often occur without any immediate external event to cause them. In contrast to reactive movements, which are directly triggered by external cues, it is less clear how these proactive actions are initiated or when they will be made. We found that single neurons in the macaque's lateral intraparietal area (LIP) exhibit gradual firing rate elevations that reach a consistent value--which may correspond to a threshold--at the time of proactive, but not reactive, arm movements. This activity differs from sensory- and motor-related activity recorded in nearby cortical areas and could provide an internal trigger for action when abrupt external triggers in the visual input are unavailable.

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Crossref · 10.1038/nn1716

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  • A time-dependent rise of firing rate in LIP and elsewhere has been interpreted as a representation of elapsed time in the form of a hazard rate or anticipation function.

    “A time-dependent rise of firing rate in LIP and elsewhere has been interpreted as a representation of elapsed time in the form of a hazard rate or anticipation function 12,33–35.”

    From Decision-making with multiple alternatives (2008) · cites this paper as [35]

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Authors
Maimon, G., & Assad, J. A.
Affiliations
Harvard University (US)
Corresponding author
Assad, John A
Venue
Nature Neuroscience
Published
2006-06-04
Volume
9
Issue
7
Pages
948-955
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
OpenAlex
W1981330394
Cited by
185
References
38
Citations by year
2026: 6 · 2025: 6 · 2024: 6 · 2023: 8 · 2022: 10 · 2021: 8 · 2020: 11 · 2019: 6 · 2018: 8 · 2017: 8 · 2016: 11 · 2015: 11 · 2014: 13 · 2013: 13 · 2012: 9
FWCI
5.18
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Science Foundation
  • McKnight Endowment Fund for Neuroscience
  • National Eye Institute (R01EY012106, EY12106)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
proactive behavior, lateral intraparietal area, action timing, arm movement, single-unit activity, macaque
MeSH terms
Action Potentials, Animals, Behavior, Animal, Cognition, Macaca mulatta, Male, Models, Neurological, Movement, Neurons, Parietal Lobe, Photic Stimulation, Psychomotor Performance, Sensory Thresholds, Time Factors, Time Perception, Logistic Models

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