Cited by 117Gut microbiota and healthNutrition, Genetics, and DiseaseNutritional Studies and Diet

The role of the gut microbiome in predicting response to diet and the development of precision nutrition models. Part II: results

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Hughes, Riley L, Kable, Mary E, Marco, Maria, Keim, Nancy L·2019·Advances in Nutrition

Abstract

The gut microbiota is increasingly implicated in the health and metabolism of its human host. The host's diet is a major component influencing the composition and function of the gut microbiota, and mounting evidence suggests that the composition and function of the gut microbiota influence the host's metabolic response to diet. This effect of the gut microbiota on personalized dietary response is a growing focus of precision nutrition research and may inform the effort to tailor dietary advice to the individual. Because the gut microbiota has been shown to be malleable to some extent, it may also allow for therapeutic alterations of the gut microbiota in order to alter response to certain dietary components. This article is the second in a 2-part review of the current research in the field of precision nutrition incorporating the gut microbiota into studies investigating interindividual variability in response to diet. Part I reviews the methods used by researchers to design and carry out such studies as well as analyze the results subsequently obtained. Part II reviews the findings of these studies and discusses the gaps in our current knowledge and directions for future research. The studies reviewed provide the current understanding in this field of research and a foundation from which we may build, utilizing and expanding upon the methods and results they present to inform future studies.

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  • A relatively stable microbiota might benefit from a stable diet, whereas an unstable microbiota could mean a flexible response to dietary intervention and constant re-evaluation of the optimal diet.

    “Thus, a relatively stable microbiota might benefit from a stable diet, whereas an unstable microbiota could mean a flexible response to dietary intervention and constant re-evaluation of the optimal diet (506).”

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  1. Zou H, Wang D, Ren H, Fang C, Shi Z, Zhang P, Chen P, Wang J, Yang H, Cai K, et al. Nonobese subjects of Bacteroides and Prevotella enterotypes responded differentially to calorie restriction intervention. bioRxiv 2019:514596.
  2. De Filippo C, Cavalieri D, Di Paola M, Ramazzotti M, Poullet JB, Massart S, Collini S, Pieraccini G, Lionetti P. Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proc Natl Acad Sci USA 2010;107(33): 14691-6.
  3. Hamer HM, Jonkers D, Venema K, Vanhoutvin S, Troost F, Brummer RJ. The role of butyrate on colonic function. Aliment Pharmacol Ther 2008;27(2):104-19.

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Authors
Hughes, R. L., Kable, M. E., Marco, M., & Keim, N. L.
Affiliations
  • University of California, Davis (US)
  • Agricultural Research Service (US)
Corresponding author
Keim, Nancy L
Venue
Advances in Nutrition
Publisher
Elsevier BV
Published
2019-11
Volume
10
Issue
6
Pages
979-998
ISSN
  • 2156-5376 (ISSN-L)
  • 2161-8313
OpenAlex
W2949601029
Cited by
117
References
139
Citations by year
2026: 17 · 2025: 25 · 2024: 16 · 2023: 14 · 2022: 15 · 2021: 14 · 2020: 15 · 2019: 1
FWCI
3.72
Type
journal article
Language
en
Open access
Locations
  • Advances in Nutrition (publishedVersion, public-domain)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • University of California Innovation Institute for Food and Health
  • Agricultural Research Service (2032-51530-022-00D, 2032-53000-001-00D)
  • Arcadia Biosciences and Ardent Mills
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords
gut microbiota, personalized nutrition, interindividual variability, diet-microbiome interactions, personalized dietary advice
MeSH terms
Gastrointestinal Microbiome, Fermented Foods, Bacteria, Energy Intake, Diet, Dietary Fiber, Humans, Nutritional Status, Caloric Restriction, Biomedical Research, Nutrition Therapy, Nutritional Sciences, Metabolomics, Precision Medicine, Epigenomics

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