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Cited by 286

The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.

Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors

Open access
Kurashima, Yosuke, Amiya, Takeaki, Nochi, Tomonori, Fujisawa, Kumiko, Haraguchi, Takeshi, Iba, Hideo, Tsutsui, Hiroko, Sato, Shintaro, Nakajima, Sachiko, Iijima, Hideki, Kubo, Masato, Kunisawa, Jun, Kiyono, Hiroshi·2012·Nature Communications
DOI 10.1038/ncomms2023
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Abstract

Mast cells are known effector cells in allergic and inflammatory diseases, but their precise roles in intestinal inflammation remain unknown. Here we show that activation of mast cells in intestinal inflammation is mediated by ATP-reactive P2X7 purinoceptors. We find an increase in the numbers of mast cells expressing P2X7 purinoceptors in the colons of mice with colitis and of patients with Crohn's disease. Treatment of mice with a P2X7 purinoceptor-specific antibody inhibits mast cell activation and subsequent intestinal inflammation. Similarly, intestinal inflammation is ameliorated in mast cell-deficient KitW-sh/W-sh mice, and reconstitution with wild-type, but not P2x7−/− mast cells results in susceptibility to inflammation. ATP-P2X7 purinoceptor-mediated activation of mast cells not only induces inflammatory cytokines, but also chemokines and leukotrienes, to recruit neutrophils and subsequently exacerbate intestinal inflammation. These findings reveal the role of P2X7 purinoceptor-mediated mast cell activation in both the initiation and exacerbation of intestinal inflammation. Mast cells are mediators of type I allergic disease and inflammation. Here, Kurashimaet al. show that mast cells are increased in the colons of mice with colitis, and that activation of the cells and subsequent inflammation can be blocked by inhibition of the purinoceptor, P2X7.

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Metadata

Authors
Kurashima, Y., Amiya, T., Nochi, T., Fujisawa, K., Haraguchi, T., Iba, H., Tsutsui, H., Sato, S., Nakajima, S., Iijima, H., Kubo, M., Kunisawa, J., & Kiyono, H.
Venue
Nature Communications
Publisher
Springer Science and Business Media LLC
Published
2012-09-04
Volume
3
Issue
1
Pages
1034-1034
ISSN
2041-1723 (ISSN-L)
DOI
10.1038/ncomms2023
OpenAlex
W2089597910
Cited by
286
References
53
FWCI
13.28
Type
journal article
Language
en
Open access
hybrid

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