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Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota
Open accessAbstract
Obesity is associated with low-grade chronic inflammation and intestinal dysbiosis. Ganoderma lucidum is a medicinal mushroom used in traditional Chinese medicine with putative anti-diabetic effects. Here, we show that a water extract of Ganoderma lucidum mycelium (WEGL) reduces body weight, inflammation and insulin resistance in mice fed a high-fat diet (HFD). Our data indicate that WEGL not only reverses HFD-induced gut dysbiosis—as indicated by the decreased Firmicutes-to-Bacteroidetes ratios and endotoxin-bearing Proteobacteria levels—but also maintains intestinal barrier integrity and reduces metabolic endotoxemia. The anti-obesity and microbiota-modulating effects are transmissible via horizontal faeces transfer from WEGL-treated mice to HFD-fed mice. We further show that high molecular weight polysaccharides (>300 kDa) isolated from the WEGL extract produce similar anti-obesity and microbiota-modulating effects. Our results indicate that G. lucidum and its high molecular weight polysaccharides may be used as prebiotic agents to prevent gut dysbiosis and obesity-related metabolic disorders in obese individuals.
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Metadata
- Authors
- Chang, C.-J., Lin, C.-S., Lu, C.-C., Martel, J., Ko, Y.-F., Ojcius, D. M., Tseng, S.-F., Wu, T.-R., Chen, Y.-Y. M., Young, J. D., & Lai, H.-C.
- Venue
- Nature Communications
- Published
- 2015-06-23
- Volume
- 6
- Issue
- 1
- Pages
- 7489-7489
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W1919048856
- Cited by
- 1,249
- References
- 30
- FWCI
- 24.19
- Type
- journal article
- Language
- en
- Open access
- gold
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