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Degradation of the ABA co-receptor ABI1 by PUB12/13 U-box E3 ligases

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Kong, Lingyao, Cheng, Jinkui, Zhu, Yujuan, Ding, Yanglin, Meng, Jingjing, Chen, Zhizhong, Xie, Qi, Guo, Yan, Li, Jigang, Yang, Shuhua, Gong, Zhizhong·2015·Nature Communications

DOI 10.1038/ncomms9630

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Abstract

Clade A protein phosphatase 2Cs (PP2Cs) are abscisic acid (ABA) co-receptors that block ABA signalling by inhibiting the downstream protein kinases. ABA signalling is activated after PP2Cs are inhibited by ABA-bound PYR/PYL/RCAR ABA receptors (PYLs) in Arabidopsis. However, whether these PP2Cs are regulated by other factors remains unknown. Here, we report that ABI1 (ABA-INSENSITIVE 1) can interact with the U-box E3 ligases PUB12 and PUB13, but is ubiquitinated only when it interacts with ABA receptors in an in vitro assay. A mutant form of ABI1-1 that is unable to interact with PYLs is more stable than the wild-type protein. Both ABI1 degradation and all tested ABA responses are reduced in pub12 pub13 mutants compared with the wild type. Introducing the abi1-3 loss-of-function mutation into pub12 pub13 mutant recovers the ABA-insensitive phenotypes of the pub12 pub13 mutant. We thus uncover an important regulatory mechanism for regulating ABI1 levels by PUB12 and PUB13.

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Clough, S. J., & Bent, A. F. (1998) · The Plant Journal · doi:10.1046/j.1365-313x.1998.00343.x · Cited by 21,934
Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation
Trapnell, C., Williams, B. A., Pertea, G., Mortazavi, A., Kwan, G., van Baren, M. J., Salzberg, S. L., Wold, B. J., & Pachter, L. (2010) · Nature Biotechnology · doi:10.1038/nbt.1621 · Cited by 15,556
TopHat: discovering splice junctions with RNA-Seq
Trapnell, C., Pachter, L., & Salzberg, S. L. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp120 · Cited by 11,617
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Park, S.-Y., Fung, P., Nishimura, N., Jensen, D. R., Fujii, H., Zhao, Y., Lumba, S., Santiago, J., Rodrigues, A., Chow, T.-F. F., et al. (2009) · Science · doi:10.1126/science.1173041 · Cited by 2,974
Regulators of PP2C Phosphatase Activity Function as Abscisic Acid Sensors
Ma, Y., Szostkiewicz, I., Korte, A., Moes, D., Yang, Y., Christmann, A., & Grill, E. (2009) · Science · doi:10.1126/science.1172408 · Cited by 2,459
Calcium channels activated by hydrogen peroxide mediate abscisic acid signalling in guard cells
Pei, Z.-M., Murata, Y., Benning, G., Thomine, S., Klüsener, B., Allen, G. J., Grill, E., & Schroeder, J. I. (2000) · Nature · doi:10.1038/35021067 · Cited by 2,109
Firefly Luciferase Complementation Imaging Assay for Protein-Protein Interactions in Plants
Chen, H., Zou, Y., Shang, Y., Lin, H., Wang, Y., Cai, R., Tang, X., & Zhou, J.-M. (2008) · Plant Physiology · doi:10.1104/pp.107.111740 · Cited by 1,525
In vitro reconstitution of an abscisic acid signalling pathway
Fujii, H., Chinnusamy, V., Rodrigues, A., Rubio, S., Antoni, R., Park, S.-Y., Cutler, S. R., Sheen, J., Rodriguez, P. L., & Zhu, J.-K. (2009) · Nature · doi:10.1038/nature08599 · Cited by 1,351
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Geiger, D., Scherzer, S., Mumm, P., Stange, A., Marten, I., Bauer, H., Ache, P., Matschi, S., Liese, A., Al-Rasheid, K. A. S., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912021106 · Cited by 903
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Leung, J., Bouvier-Durand, M., Morris, P.-C., Guerrier, D., Chefdor, F., & Giraudat, J. (1994) · Science · doi:10.1126/science.7910981 · Cited by 767
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Melcher, K., Ng, L.-M., Zhou, X. E., Soon, F.-F., Xu, Y., Suino-Powell, K. M., Park, S.-Y., Weiner, J. J., Fujii, H., Chinnusamy, V., et al. (2009) · Nature · doi:10.1038/nature08613 · Cited by 731
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Authors: Kong, L., Cheng, J., Zhu, Y., Ding, Y., Meng, J., Chen, Z., Xie, Q., Guo, Y., Li, J., Yang, S., & Gong, Z.
Venue: Nature Communications
Publisher: Springer Science and Business Media LLC
Published: 2015-10-20
Volume: 6
Issue: 1
Pages: 8630-8630
ISSN: 2041-1723 (ISSN-L)
DOI: 10.1038/ncomms9630
OpenAlex: W2254998690
Cited by: 316
References: 55
FWCI: 22.60
Type: journal article
Language: en
Open access: gold

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Degradation of the ABA co-receptor ABI1 by PUB12/13 U-box E3 ligases

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