Cited by 1,261Gut microbiota and healthAsthma and respiratory diseasesNutritional Studies and Diet

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Diet, gut microbiota and immune responses

Maslowski, Kendle M, Mackay, Charles R·2011·Nature Immunology

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Abstract

The fields of immunology, microbiology, nutrition and metabolism are rapidly converging. Here we expand on a diet-microbiota model as the basis for the greater incidence of asthma and autoimmunity in developed countries.

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Crossref · 10.1038/ni0111-5

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Background
Dietary pea fibre alters the microbial community and fermentation with increase in fibre degradation‐associated bacterial groups in the colon of pigs
Luo, Y., Chen, H., Yu, B., He, J., Zheng, P., Mao, X., Yu, J., Luo, J., Huang, Z., & Chen, D. (2017) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/jpn.12736 · Cited by 37
Kombuchas from Green and Black Tea Modulate the Gut Microbiota and Improve the Intestinal Health of Wistar Rats Fed a High-Fat High-Fructose Diet
Costa, M. A. D. C., Moreira, L. D. P. D., Duarte, V. D. S., Cardoso, R. R., José, V. P. B. D. S., da Silva, B. P., Grancieri, M., Corich, V., Giacomini, A., Bressan, J., et al. (2022) · Nutrients · doi:10.3390/nu14245234 · Cited by 40
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The aryl hydrocarbon receptor in innate T cell immunity
Stange, J., & Veldhoen, M. (2013) · Seminars in Immunopathology · doi:10.1007/s00281-013-0389-1 · Cited by 36
Modulation of growth performance, immunity, and disease resistance in narrow-clawed crayfish, Astacus leptodactylus leptodactylus (Eschscholtz, 1823) upon synbiotic feeding
Safari, O., & Paolucci, M. (2017) · Aquaculture · doi:10.1016/j.aquaculture.2017.05.049 · Cited by 34
A metagenomic study of the gut microbiome in PTB’S disease
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Immunological Function of Sphingosine 1-Phosphate in the Intestine
Kunisawa, J., & Kiyono, H. (2012) · Nutrients · doi:10.3390/nu4030154 · Cited by 34
“Thus, the intestinal immune system has to create harmonious immunological condition, and the disruption of the intestinal immune homeostasis leads to the development of allergic, inflammatory, and infectious diseases [1,2].”
Background
The Three Genetics (Nuclear DNA, Mitochondrial DNA, and Gut Microbiome) of Longevity in Humans Considered as Metaorganisms
Garagnani, P., Pirazzini, C., Giuliani, C., Candela, M., Brigidi, P., Sevini, F., Luiselli, D., Bacalini, M. G., Salvioli, S., Capri, M., et al. (2014) · BioMed Research International · doi:10.1155/2014/560340 · Cited by 38
“The influence of different cultural habits and lifestyle in the two populations considered is likely the major force underlying the observed differences [102], even if a “study effect” cannot be excluded [103].”
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Shaping the (auto)immune response in the gut: the role of intestinal immune regulation in the prevention of type 1 diabetes.
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Human microbiome, infections, and rheumatic disease
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“sulfasalazine) in the colon, suggesting a possible synergistic effect [67, 68].”
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Gut microbiota of the European Brown Hare (Lepus europaeus)
Stalder, G. L., Pinior, B., Zwirzitz, B., Loncaric, I., Jakupović, D., Vetter, S. G., Smith, S., Posautz, A., Hoelzl, F., Wagner, M., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-39638-9 · Cited by 33
Prebiotic effects in vitro of anthocyanins from the fruits of Lycium ruthenicum Murray on gut microbiota compositions of feces from healthy human and patients with inflammatory bowel disease
Peng, Y., Yan, Y., Wan, P., Chen, C., Chen, D., Zeng, X., & Cao, Y. (2021) · LWT · doi:10.1016/j.lwt.2021.111829 · Cited by 35
Probiotics and prebiotics in atopic dermatitis: Pros and cons (Review)
Fanfaret, I., Boda, D., Ion, L., Hosseyni, D., Leru, P. M., Ali, S., Corcea, S. L., & Bumbăcea, R. S. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.10811 · Cited by 38
“According to the diet‐microbiome hypothesis, changes in the Westernized diet that reflect a lower intake of fiber may result in alterations in the gut microbiome, followed by decreased production of immunomodulatory products, particularly SCFAs, which have anti‐inflammatory effects and contribute to the maintenance of…”
Dietary supplementation of Chlorella vulgaris improved growth performance, immunity, intestinal microbiota and stress resistance of juvenile narrow clawed crayfish, Pontastacus leptodactylus Eschscholtz, 1823
Safari, O., Paolucci, M., & Motlagh, H. A. (2022) · Aquaculture · doi:10.1016/j.aquaculture.2022.738138 · Cited by 33
Synergistic Interaction of Low Salinity Stress With Vibrio Infection Causes Mass Mortalities in the Oyster by Inducing Host Microflora Imbalance and Immune Dysregulation
Li, X., Yang, B., Shi, C., Wang, H., Yu, R., Li, Q., & Liu, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.859975 · Cited by 37
Contribution of the microbiome for better phenotyping of people living with obesity
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Immune Modulating Capability of Two Exopolysaccharide-ProducingBifidobacteriumStrains in a Wistar Rat Model
Salazar, N., López, P., Garrido, P., Morán, J., Cabello, E., Gueimonde, M., Suárez, A., González, C., Reyes‐Gavilán, C. G. D. L., & Ruas‐Madiedo, P. (2014) · BioMed Research International · doi:10.1155/2014/106290 · Cited by 33
“In parallel to the direct interaction with immune cells of the host, the immunomodulation could also be achieved through intervention on the intestinal microbiota [18, 19].”
Background
The effect of microbial colonization on the host proteome varies by gastrointestinal location
Lichtman, J. S., Alsentzer, E., Jaffe, M., Sprockett, D., Masutani, E., Ikwa, E., Fragiadakis, G. K., Clifford, D., Huang, B. E., Sonnenburg, J. L., et al. (2016) · The ISME Journal · doi:10.1038/ismej.2015.187 · Cited by 32
“…of the gut microbiota has been implicated in several human diseases, including type 1 diabetes (Wen et al., 2008), obesity (Ley et al., 2006; Turnbaugh et al., 2006), asthma (Penders et al., 2007) and inflammatory bowel disease (Frank et al., 2007; Penders et al., 2007; Maslowski and Mackay, 2011).”
Background
Positive effects of replacing commercial feeds by fresh black soldier fly (Hermetia illucens) larvae in the diets of Pacific white shrimp (Litopenaeus vannamei): Immune enzyme, water quality, and intestinal microbiota
He, Y., Zhang, N., Wang, A., Wang, S., Che, Y., Huang, S., Yi, Q., Ma, Y., & Jiang, Y. (2022) · Frontiers in Marine Science · doi:10.3389/fmars.2022.987363 · Cited by 32
“Intestinal microbiota helps the host to digest indigestible feed components such as cellulose, and it also participates in the maturation of intestinal mucosa, immune response, and disease resistance (Maslowski and Mackay, 2011; Llewellyn et al., 2014).”
Background
Nutritional Influences on Epigenetic Programming
Palmer, D. J., Huang, R., Craig, J. M., & Prescott, S. L. (2014) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2014.07.003 · Cited by 31
Depth-Dependent Differences in Community Structure of the Human Colonic Microbiota in Health
Lavelle, A., Lennon, G., Docherty, N. G., Balfe, Á., Mulcahy, H. E., Doherty, G. A., O’Donoghue, D. P., Hyland, J. M., Shanahan, F., Sheahan, K. D., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078835 · Cited by 31
“Conversely, the potential role of the microbiota in the etiology of conditions such as allergy and asthma [6], inflammatory bowel disease [7], colorectal cancer [8], irritable bowel syndrome [9], obesity/metabolic syndrome [10] and even regulation of the gut brain axis [11], is highly topical, while a close link betwe…”
Dietary Keratan Sulfate from Shark Cartilage Modulates Gut Microbiota and Increases the Abundance of Lactobacillus spp.
Shang, Q., Li, Q., Zhang, M., Song, G., Shi, J., Jiang, H., Cai, C., Hao, J., Li, G., & Yu, G. (2016) · Marine Drugs · doi:10.3390/md14120224 · Cited by 32
Modulation of Gut Microbiota in Pathological States
Wang, Y., Wang, B., Wu, J., Jiang, X., Tang, H., & Nielsen, O. H. (2017) · Engineering · doi:10.1016/j.eng.2017.01.013 · Cited by 37
“Although gut microbes are phylogenetically conserved [8], the composition of human gut microbes can be affected by the host’s personal hygiene, diet, drug intake, and disease status throughout his or her life [9,10].”
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Intestinal Bacteria of Common Carp (Cyprinus carpio L.) as a Biological Control Agent for Aeromonas
Mulyani, Y., Aryantha, N., Suhandono, S., & Pancoro, A. (2018) · Journal of Pure and Applied Microbiology · doi:10.22207/jpam.12.2.18 · Cited by 32
The Effect of Gluten-Free Diet on Health and the Gut Microbiota Cannot Be Extrapolated from One Population to Others
García-Mazcorro, J. F., Noratto, G. D., & Remes-Troche, J. M. (2018) · Nutrients · doi:10.3390/nu10101421 · Cited by 33
“From all microbial niches in the body, the digestive tract has received the mostattention in part due to its role in health and immunity [2].”
Background
New insights on atherosclerosis: A cross-talk between endocannabinoid systems with gut microbiota
Moludi, J., Alizadeh, M., Yagin, N. L., Pasdar, Y., Nachvak, S. M., Abdollahzad, H., & Tabaei, A. S. (2018) · Journal of Cardiovascular and Thoracic Research · doi:10.15171/jcvtr.2018.21 · Cited by 32
Mediterranean diet: the missing link between gut microbiota and inflammatory diseases
Bifulco, M. (2015) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2015.81 · Cited by 32
Immunoregulatory Intestinal Microbiota and COVID-19 in Patients with Type Two Diabetes: A Double-Edged Sword
Petakh, P., Kamyshna, I. I., Nykyforuk, A., Yao, R., Imbery, J. F., Oksenych, V., Korda, M. M., & Kamyshnyi, O. (2022) · Viruses · doi:10.3390/v14030477 · Cited by 33
The Skin Microbiome in Atopic Dermatitis and Its Relationship to Emollients
Lynde, C. W., Andriessen, A., Bertucci, V., McCuaig, C. C., Skotnicki, S., Weinstein, M., Wiseman, M., & Zip, C. M. (2015) · Journal of Cutaneous Medicine and Surgery · doi:10.1177/1203475415605498 · Cited by 32
“Under unfavorable conditions, an altered community of microbes can arise on the skin, leading to conditions of dysbiosis.(7,8) Both interactions between microbes and between a microbe and the host can promote disease.”
Background
Fasting-mimicking diet remodels gut microbiota and suppresses colorectal cancer progression
Luo, M., Wang, Q., Sun, Y., Jiang, Y., Wang, Q., Gu, Y., Hu, Z., Chen, Q., Xu, J., Chen, S., et al. (2024) · npj Biofilms and Microbiomes · doi:10.1038/s41522-024-00520-w · Cited by 35
Alcohol and dietary factors associate with gut integrity and inflammation in HIV ‐infected adults
Webel, A. R., Sattar, A., Funderburg, N., Kinley, B., Longenecker, C. T., Labbato, D. E., Alam, S. K., & McComsey, G. (2016) · HIV Medicine · doi:10.1111/hiv.12442 · Cited by 31
Prolonged Absence of Mechanoluminal Stimulation in Human Intestine Alters the Transcriptome and Intestinal Stem Cell Niche
Wieck, M. M., Schlieve, C. R., Thornton, M. E., Fowler, K. L., Isani, M. A., Grant, C. N., Hilton, A. E., Hou, X., Grubbs, B. H., Frey, M. R., et al. (2017) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2016.12.008 · Cited by 31
“Up-regulated genes also were involved in xenobiotic responses and there is evidence that the microbiome is a major contributor to epithelial integrity and homeostasis.(76,77) We previously studied whether there was a difference in the pediatric microbiome between fed and unfed intestine.”
Background
Bifidobacterium breve UCC2003 Employs Multiple Transcriptional Regulators To Control Metabolism of Particular Human Milk Oligosaccharides
James, K., Motherway, M. O., Penno, C., O'Brien, R. L., & van Sinderen, D. (2018) · Applied and Environmental Microbiology · doi:10.1128/aem.02774-17 · Cited by 31
Determination of berberine-upregulated endogenous short-chain fatty acids through derivatization by 2-bromoacetophenone
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The Effect of a Planetary Health Diet on the Human Gut Microbiome: A Descriptive Analysis
Rehner, J., Schmartz, G. P., Kramer, T., Keller, V., Keller, A., & Becker, S. L. (2023) · Nutrients · doi:10.3390/nu15081924 · Cited by 31
Perinatal nutrition: How to take care of the gut microbiota?
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“Dietary strategies have been described to modulate either the gut microbiota composition or the metabolic/immunological activity [20,21].”
Background
Feeding Pasteurized Waste Milk to Preweaned Dairy Calves Changes Fecal and Upper Respiratory Tract Microbiota
Maynou, G., Chester-Jones, H., Bach, À., & Terré, M. (2019) · Frontiers in Veterinary Science · doi:10.3389/fvets.2019.00159 · Cited by 30
Impact of Dietary Patterns on H. pylori Infection and the Modulation of Microbiota to Counteract Its Effect. A Narrative Review
Rueda‐Robles, A., Rubio‐Tomás, T., Plaza‐Díaz, J., & Álvarez‐Mercado, A. I. (2021) · Pathogens · doi:10.3390/pathogens10070875 · Cited by 31

Authors: Maslowski, K. M., & Mackay, C. R.
Affiliations: Garvan Institute of Medical Research (AU)
Monash University (AU)
Corresponding author: Mackay, Charles R
ORCID: Maslowski, Kendle M
Mackay, Charles R
Venue: Nature Immunology
Publisher: Springer Science and Business Media LLC
Published: 2010-12-17
Volume: 12
Issue: 1
Pages: 5-9
ISSN: 1529-2908 (ISSN-L)
1529-2916
DOI: 10.1038/ni0111-5
OpenAlex: W1988821718
Cited by: 1,261
References: 29
Citations by year: 2026: 23 · 2025: 53 · 2024: 60 · 2023: 102 · 2022: 98 · 2021: 114 · 2020: 99 · 2019: 115 · 2018: 81 · 2017: 95 · 2016: 88 · 2015: 82 · 2014: 87 · 2013: 73 · 2012: 55
FWCI: 21.25
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Immunology (publishedVersion)
PubMed (publishedVersion)
Helmholtz Centre for Ocean Research Kiel (GEOMAR) (acceptedVersion)
University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords: diet, gut microbiota, immune response, asthma, autoimmunity, nutrition and immunity, host-microbe interactions, developed countries
MeSH terms: Animals, Clinical Trials as Topic, Diet, Humans, Inflammation, Signal Transduction, Models, Immunological, Immunity, Mucosal, Genetic Predisposition to Disease, Gastrointestinal Tract, Lipid Metabolism, Mice, Metagenome, Immunomodulation

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