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Diet, gut microbiota and immune responses
Abstract
The fields of immunology, microbiology, nutrition and metabolism are rapidly converging. Here we expand on a diet-microbiota model as the basis for the greater incidence of asthma and autoimmunity in developed countries.
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“the composition and products of intestinal microorganisms have a great influence on the immune response [3,4].”
From Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity (2021) · cites this paper as [4]
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“Moreover, deviations from the intestinal microbiota profile, which was established in youth, are associated with inflammatory bowel disease [87].”
From Evolution of the immune system in humans from infancy to old age (2015) · cites this paper as [87]
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“However, some other studies find benefits without achieving a significant improvement in composite indices to measure disease activity [81, 82].”
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“Nutrition in Immune-Metabolic Interactions The ‘‘diet hypothesis’’ suggests that dietary composition and feeding timing constitute a major factor contributing to immune regulation of metabolism (Maslowski and Mackay, 2011).”
BackgroundDietary modulation of the microbiome affects autoinflammatory disease
Lukens, J. R., Gurung, P., Vogel, P., Johnson, G. R., Carter, R. A., McGoldrick, D. J., Bandi, S. R., Calabrese, C. R., Walle, L. V., Lamkanfi, M., et al. (2014) · Nature · doi:10.1038/nature13788 · Cited by 314
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“biota [653] are two of many additional factors that warrant consideration in future studies that address the roles of ROS and NO in mediating the microvascular dysfunction that is associated with inflammation.”
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“Additional bacterial fermentation products such as polysaccharide A and peptidoglycan exert anti-inflammatory effects on the host immune system((87)).”
BackgroundWorld Gastroenterology Organisation Global Guidelines
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Metabolite-Sensing G Protein–Coupled Receptors—Facilitators of Diet-Related Immune Regulation
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Alterations in Intestinal Microbiota Correlate With Susceptibility to Type 1 Diabetes
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“Through similar mechanisms, a Western diet may also be involved in the global rise in the incidence of T1D observed in recent decades (47,53).”
BackgroundKonieczna, P., Groeger, D., Ziegler, M., Frei, R., Ferstl, R., Shanahan, F., Quigley, E. M. M., Kiely, B., Akdiş, C. A., & O’Mahony, L. (2011) · Gut · doi:10.1136/gutjnl-2011-300936 · Cited by 284
“short-chain fatty acids suggest that we may have previously underestimated the importance of the relationship between diet and the microbiota.(34) In addition, acetate production (following carbohydrate fermentation) by certain Bifidobacteria strains mediates protection from lethal Escherichia coli infection in mice.”
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“Furthermore, recent findings revealed that SCFAs alter the immune response through binding to G protein-coupled receptor, GPR43, which is expressed mainly on innate immune response and inflammatory cells (Maslowski & Mackay 2012).”
BackgroundGut microbiota and gastrointestinal health: current concepts and future directions
Aziz, Q., Doré, J., Emmanuel, A., Guarner, F., & Quigley, E. M. M. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12046 · Cited by 280
Ageing and gut microbes: Perspectives for health maintenance and longevity
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The nutrition‐gut microbiome‐physiology axis and allergic diseases
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“IBD is characterized by unresolved inflammation in the intestinal tract, which is controlled by a complex interplay of innate and adaptive immune mechanisms [35, 36].”
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“These resident bacteria play an essential role in normal digestive function, immune development, brain development and pathogenic defence [85,86].”
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“other environmental stressors that it encounters (Sansonetti, 2004; Crhanova et al., 2011; Maslowski and Mackay, 2011; Quintero-Fiho et al., 2012).”
BackgroundGut microbiota, host health, and polysaccharides
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“Butyrate is the main energy source for colonic epithelial cells (Maslowski and Mackay, 2011).”
InfluentialBacteroides and related species: The keystone taxa of the human gut microbiota
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Microbial ‘Old Friends’, immunoregulation and stress resilience
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“The nature of the microbiota profoundly affects immunoregulation [99].”
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Probiotic, prebiotic and synbiotic supplements in sturgeon aquaculture: a review
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“Improved growth performance is likely to be brought about by elevated digestive enzyme activities, possible improvements of intestine morphology or via prebiotic fermentation by endogenous gut microbes to produce SCFAs [51,56,61,62].”
Inside the Mucosal Immune System
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Food for thought: The role of nutrition in the microbiota-gut–brain axis
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“This ‘Westernization’ of diets together with sedentary lifestyles results in modifications to the gut microbiota, which may partially contribute to the higher incidences of chronic inflammatory disorders, such as cardiovascular disease, obesity, depression, allergies, diabetes and autoimmune disorders [16].”
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The gut microbiota and its role in the development of allergic disease: A wider perspective
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Metadata
- Authors
- Maslowski, K. M., & Mackay, C. R.
- Affiliations
- Garvan Institute of Medical Research (AU)
- Monash University (AU)
- Corresponding author
- Mackay, Charles R
- Venue
- Nature Immunology
- Published
- 2010-12-17
- Volume
- 12
- Issue
- 1
- Pages
- 5-9
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W1988821718
- Cited by
- 1,261
- References
- 29
- Citations by year
- 2026: 23 · 2025: 53 · 2024: 60 · 2023: 102 · 2022: 98 · 2021: 114 · 2020: 99 · 2019: 115 · 2018: 81 · 2017: 95 · 2016: 88 · 2015: 82 · 2014: 87 · 2013: 73 · 2012: 55
- FWCI
- 21.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- Helmholtz Centre for Ocean Research Kiel (GEOMAR) (acceptedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- diet, gut microbiota, immune response, asthma, autoimmunity, nutrition and immunity, host-microbe interactions, developed countries
- MeSH terms
- Animals, Clinical Trials as Topic, Diet, Humans, Inflammation, Signal Transduction, Models, Immunological, Immunity, Mucosal, Genetic Predisposition to Disease, Gastrointestinal Tract, Lipid Metabolism, Mice, Metagenome, Immunomodulation
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