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Diet, gut microbiota and immune responses
Abstract
The fields of immunology, microbiology, nutrition and metabolism are rapidly converging. Here we expand on a diet-microbiota model as the basis for the greater incidence of asthma and autoimmunity in developed countries.
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“the composition and products of intestinal microorganisms have a great influence on the immune response [3,4].”
From Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity (2021) · cites this paper as [4]
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“Moreover, deviations from the intestinal microbiota profile, which was established in youth, are associated with inflammatory bowel disease [87].”
From Evolution of the immune system in humans from infancy to old age (2015) · cites this paper as [87]
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Microbiota effects on cancer: From risks to therapies
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“…thought to be owing to an epigenetic mechanism or to the activation of SCFA receptors leading to anti-inflammatory effects, anti-microbial effects, and to a decreased intestinal barrier leakiness (Forsythe and Kunze, 2013; Ganapathy et al., 2013; Maslowski and Mackay, 2011; Singh et al., 2014).”
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“Various GPCR receptors are able to bind the various SCFAs with different affinity (8, 37).”
BackgroundInfluentialGradual Changes of Gut Microbiota in Weaned Miniature Piglets
Hu, J. P., Nie, Y., Chen, J., Zhang, Y., Wang, Z., Fan, Q., & Yan, X. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01727 · Cited by 201
“Growing evidences have linked gut microbial alterations to diets (Maslowski and Mackay, 2011; Doré and Blottière, 2015).”
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“The cause of the microbiota imbalance (dysbiosis) of unhealthy individuals across age and geography has been mainly correlated with dietary habits (Turnbaugh et al., 2008; De Filippo et al., 2010; Muegge et al., 2011; Wu et al., 2011; Arumugam et al., 2011; Menni et al., 2017).”
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“A link has been discovered between the functionality of the host immune system and the early-life gut microbiota composition [20,21,22].”
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The Human Gut Microbiota and Undernutrition
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“Although the impact of microbial metabolites and some nutrients on the immune system has been described (15, 43), the logic of this mode of host-microbial communication has been unclear.”
BackgroundBeneficial Effect of Intestinal Fermentation of Natural Polysaccharides
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“Certain gut bacteria degrade polysaccharides into short-chain fatty acids (SCFAs), mainly including acetate, propionate and butyrate.”
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“Recent work suggests a direct link between specific gut microbiota composition in early life and the subsequent predisposition to a number of important human diseases [19–25].”
BackgroundProbiotic Microbes Sustain Youthful Serum Testosterone Levels and Testicular Size in Aging Mice
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“Like in mammals, the intestinal microbiota of fish plays important role in host metabolism, nutrition, immunity, and health of fish [25,26].”
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“It is well known that dietary changes lead to an alteration in intestinal microbial composition, which has a profound influence on responses of the host immune system [for a recent review see (Maslowski & Mackay, 2011)].”
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“There is increasing evidence that the immune response is shaped by factors that include how the host establishes a stable ecosystem with a large cohort of accompanying bacteria (4-7).”
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“However, Verrucomicrobia, actinobacteria, and Bacteroidetes are considered ‘good’ bacteria due to their contribution to intestinal health and glucose homeostasis [26], host resistance to infective disease [27], and the production of favorable metabolites such as short-chain fatty acids (SCFAs), known to reduce inflamm…”
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“67 This lack of fiber is implicated in the etiology of Western diseases (15, 23, 24), which may in 68 part be tied to the effects of low fiber consumption on microbial SCFA production and SCFA 69 signaling (15, 25-29).”
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“, 2012) have raised questions about whether the microbiota we currently define as normal have been shaped by recent influences of modern Western diet, hygiene, antibiotic exposure, and lifestyle (Maslowski and Mackay, 2011).”
Ulcerative colitis: molecular insights and intervention therapy
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Editorial: Gut Health: The New Paradigm in Food Animal Production
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“The gut microbiota confers health benefits to the host, including aiding in the digestion and absorption of nutrients, contributing to the construction of the intestinal epithelial barrier, the development and function of the host immune system, and competing with pathogenic microbes to prevent their harmful propagati…”
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“Having a profound impact on the overall human immune status, perturbations of the intestinal microbiota have been implicated in the development and progression of inflammatory diseases, such as inflammatory bowel diseases (IBD), autoimmune disorders, allergy and type II diabetes [12,13].”
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“…fibers is known to induce long-term changes in the gut microbiome that are associated with low production of beneficial microbial metabolites, i.e., short-chain fatty acids (SCFAs) such as acetate, propionate, and butyrate involved in the modulation of host immune and inflammatory health status 2 .”
BackgroundMicrobial Reprogramming Inhibits Western Diet-Associated Obesity
Poutahidis, T., Kleinewietfeld, M., Smillie, C., Levkovich, T., Perrotta, A., Bhela, S., Varian, B. J., Ibrahim, Y. M., Lakritz, J. R., Kearney, S. M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068596 · Cited by 164
“Westernized diets are also low in vitamin D, a nutrient that normally works together with IL-10 to enforce immune tolerance and protect against inflammatory disorders [61–63] and some types of cancer [64].”
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“Different dietary regimens have convincingly been shown to influence the composition of the intestinal microbiota (35, 37, 38) and are suggested to modulate the clinical phenotype of a number of inflammatory and non-inflammatory conditions (39).”
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“Diet, gut microbiota, and immune responses are probable explanations for the expanding incidence of inflammatory/immune diseases such as asthma, type 1 diabetes, and IBD in people living in developed countries (119).”
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Alteration in the Gut Microbiota Provokes Susceptibility to Tuberculosis
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“Recently, various reports signify that the gut microbes can modulate, tune, and tame the host immune response (3).”
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“These diets are associated with lower levels of short-chain fatty acids (SCFAs), produced by the microbiota, leading to inflammation [19].”
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BackgroundThe role of Akkermansia muciniphila in obesity, diabetes and atherosclerosis
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BackgroundInfluentialPortrait of an immunoregulatory bifidobacterium
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“…of the neonatal gut where decreased diversity and stability of microbial populations could promote disruption of key processes involved in host metabolism, immune function, and neurodevelopment (Round and Mazmanian, 2009; Nicholson et al., 2012; Maslowski and Mackay, 2011; Cryan and Dinan, 2012).”
BackgroundEvolution of Vertebrate Immunity
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BackgroundDietary Folic Acid Promotes Survival of Foxp3+ Regulatory T Cells in the Colon
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Metadata
- Authors
- Maslowski, K. M., & Mackay, C. R.
- Affiliations
- Garvan Institute of Medical Research (AU)
- Monash University (AU)
- Corresponding author
- Mackay, Charles R
- Venue
- Nature Immunology
- Published
- 2010-12-17
- Volume
- 12
- Issue
- 1
- Pages
- 5-9
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W1988821718
- Cited by
- 1,261
- References
- 29
- Citations by year
- 2026: 23 · 2025: 53 · 2024: 60 · 2023: 102 · 2022: 98 · 2021: 114 · 2020: 99 · 2019: 115 · 2018: 81 · 2017: 95 · 2016: 88 · 2015: 82 · 2014: 87 · 2013: 73 · 2012: 55
- FWCI
- 21.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- Helmholtz Centre for Ocean Research Kiel (GEOMAR) (acceptedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- diet, gut microbiota, immune response, asthma, autoimmunity, nutrition and immunity, host-microbe interactions, developed countries
- MeSH terms
- Animals, Clinical Trials as Topic, Diet, Humans, Inflammation, Signal Transduction, Models, Immunological, Immunity, Mucosal, Genetic Predisposition to Disease, Gastrointestinal Tract, Lipid Metabolism, Mice, Metagenome, Immunomodulation
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