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Diet, gut microbiota and immune responses
Abstract
The fields of immunology, microbiology, nutrition and metabolism are rapidly converging. Here we expand on a diet-microbiota model as the basis for the greater incidence of asthma and autoimmunity in developed countries.
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“the composition and products of intestinal microorganisms have a great influence on the immune response [3,4].”
From Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity (2021) · cites this paper as [4]
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“Moreover, deviations from the intestinal microbiota profile, which was established in youth, are associated with inflammatory bowel disease [87].”
From Evolution of the immune system in humans from infancy to old age (2015) · cites this paper as [87]
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“This strongly supports the hypothesis of Maslowski & Mackay(32) who hypothesised that SCFA bind to the GPR43 receptor, which causes the down-regulation of pro-inflammatory cytokines.”
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“Microbiota-derived SCFAs, including butyrate, have well established anti-inflammatory properties [36] and in mice have been shown to promote the integrity of the blood brain barrier [37].”
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“It has been reported that SCFA show anti-inflammatory properties (Maslowski and Mackay, 2011).”
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“Specifically, microbe-derived short chain fatty acids regulate host physiology and immune function via gutexpressed receptors [81,120], suggesting a complementary mode of action.”
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“(GPR109A), 43 (GPR43) and by inhibition of histone deacetylases (HDACs) on circulating leukocytes [46].”
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“Newly established routes linking nutrition, intestinal microbiota, and immunity [36] can now also be considered.”
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“In addition to their direct immunomodulatory effects these nutrients also appear to modulate the microbiome, and relative deficiencies are implicated in the rising rates of immune and inflammatory diseases in general [116, 117].”
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“However, gut microbiota (the assemblage of microorganisms in the gut) has been shown to play a pivotal role in gut energy metabolism.(20)”
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“Furthermore, an important immune regulatory role played by the microbiota is linked to its ability to produce short chain fatty acids (SCFAs), in particular butyrate (Turnbaugh et al., 2009; Maslowski and Mackay, 2011).”
BackgroundMicrobiota intestinal en la salud y la enfermedad
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“Furthermore, paralleling the hygiene hypothesis, a “diet hypothesis” has been proposed to explain the differential incidence of allergic and chronic inflammatory diseases among countries with a similar cleanliness in the environment but with remarkable different diets (162).”
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Metadata
- Authors
- Maslowski, K. M., & Mackay, C. R.
- Affiliations
- Garvan Institute of Medical Research (AU)
- Monash University (AU)
- Corresponding author
- Mackay, Charles R
- Venue
- Nature Immunology
- Published
- 2010-12-17
- Volume
- 12
- Issue
- 1
- Pages
- 5-9
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W1988821718
- Cited by
- 1,261
- References
- 29
- Citations by year
- 2026: 23 · 2025: 53 · 2024: 60 · 2023: 102 · 2022: 98 · 2021: 114 · 2020: 99 · 2019: 115 · 2018: 81 · 2017: 95 · 2016: 88 · 2015: 82 · 2014: 87 · 2013: 73 · 2012: 55
- FWCI
- 21.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- Helmholtz Centre for Ocean Research Kiel (GEOMAR) (acceptedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- diet, gut microbiota, immune response, asthma, autoimmunity, nutrition and immunity, host-microbe interactions, developed countries
- MeSH terms
- Animals, Clinical Trials as Topic, Diet, Humans, Inflammation, Signal Transduction, Models, Immunological, Immunity, Mucosal, Genetic Predisposition to Disease, Gastrointestinal Tract, Lipid Metabolism, Mice, Metagenome, Immunomodulation
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