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Diet, gut microbiota and immune responses
Abstract
The fields of immunology, microbiology, nutrition and metabolism are rapidly converging. Here we expand on a diet-microbiota model as the basis for the greater incidence of asthma and autoimmunity in developed countries.
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“the composition and products of intestinal microorganisms have a great influence on the immune response [3,4].”
From Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity (2021) · cites this paper as [4]
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“Moreover, deviations from the intestinal microbiota profile, which was established in youth, are associated with inflammatory bowel disease [87].”
From Evolution of the immune system in humans from infancy to old age (2015) · cites this paper as [87]
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“It is known that diet not only influences the composition of the intestinal microbiota but also that the microbiota and its products have an effect on the host [48,49].”
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“…surfaces such as skin or intestinal epithelium, and production of excrements that interact with host immune cells (Balic et al., 2004; Brosschot & Reynolds, 2018; Cayrol & Girard, 2014; Cervi et al., 2004; Massacand et al., 2009; Scharsack et al., 2013; Segura et al., 2007; Ziegler & Artis, 2010).”
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“For nutrition and energy metabolism, the gut microbiota provides beneficial functions including nutrient absorption, vitamin synthesis, digestion of fiber [133], and regulation of weight and nutrition [134,135].”
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“Western diet, rich in protein and fat have emerged as important factors contributing to the increased incidence of obesity (650 million people worldwide and 100 million in USA) and inflammatory diseases, including MS in developed countries (12, 13).”
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Healthy components of coffee processing by-products
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Temperature dependence of parasitic infection and gut bacterial communities in bumble bees
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“Microbial symbionts can compete with parasites for space and resources, stimulate host immunity and produce allelopathic chemicals that inhibit parasite growth (Maslowski and Mackay, 2010; Spor et al., 2011).”
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Food-producing animals and their health in relation to human health
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“Short chain fatty acids in feces, one of the main microbial metabolites, are critically significant for immunoregulation and the maintenance of the gut and overall health (Fukuda et al. 2011; Maslowski and Mackay 2011; Peng et al. 2009).”
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The Role of the Gut Microbiome and Microbial Dysbiosis in Common Skin Diseases
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“Maslovsky and Macay, in their study, announced that the gut microflora contributes to the higher incidence of autoimmune diseases in developed countries [140].”
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“Fermentable fiber is metabolized by intestinal bacteria to short-chain fatty acids, which mediate a pro-inflammatory state via inhibition of nuclear factor [19].”
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“Recent studies have shown that diet influences gut microbiota 33 composition and activity (4), and that this in turn may influence brain function, including depressive 34 illness (5, 6).”
Background
Metadata
- Authors
- Maslowski, K. M., & Mackay, C. R.
- Affiliations
- Garvan Institute of Medical Research (AU)
- Monash University (AU)
- Corresponding author
- Mackay, Charles R
- Venue
- Nature Immunology
- Published
- 2010-12-17
- Volume
- 12
- Issue
- 1
- Pages
- 5-9
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W1988821718
- Cited by
- 1,261
- References
- 29
- Citations by year
- 2026: 23 · 2025: 53 · 2024: 60 · 2023: 102 · 2022: 98 · 2021: 114 · 2020: 99 · 2019: 115 · 2018: 81 · 2017: 95 · 2016: 88 · 2015: 82 · 2014: 87 · 2013: 73 · 2012: 55
- FWCI
- 21.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- Helmholtz Centre for Ocean Research Kiel (GEOMAR) (acceptedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- diet, gut microbiota, immune response, asthma, autoimmunity, nutrition and immunity, host-microbe interactions, developed countries
- MeSH terms
- Animals, Clinical Trials as Topic, Diet, Humans, Inflammation, Signal Transduction, Models, Immunological, Immunity, Mucosal, Genetic Predisposition to Disease, Gastrointestinal Tract, Lipid Metabolism, Mice, Metagenome, Immunomodulation
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