Cited by 1,261Gut microbiota and healthAsthma and respiratory diseasesNutritional Studies and Diet

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Diet, gut microbiota and immune responses

Maslowski, Kendle M, Mackay, Charles R·2011·Nature Immunology

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Abstract

The fields of immunology, microbiology, nutrition and metabolism are rapidly converging. Here we expand on a diet-microbiota model as the basis for the greater incidence of asthma and autoimmunity in developed countries.

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Crossref · 10.1038/ni0111-5

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“This adaptation is advantageous for Tibetan antelopes to survive and thrive in the harsh winter environment.”
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Causal analysis of the gut microbiota in differentiated thyroid carcinoma: a two-sample Mendelian randomization study
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Host-Microbiota Interactions and Their Importance in Promoting Growth and Resistance to Opportunistic Diseases in Salmonids
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Arthritis in space and time – To boldly go!
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“…to a healthy diet offers several major health benefits, including reduced mortality (Rao, 1989), improved immunological responses (Kau et al., 2011; Maslowski and Mackay, 2011) and reduced risk of coronary heart disease (Hu and Willett, 2002; Kushi et al., 1985) and cancer (Goodwin and Brodwick,…”
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Diamine oxidase levels in different chronic urticaria phenotypes
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“Several hypotheses which attempt to explain the rise of inflammatory conditions are generally related to different updates or versions of the hygiene hypothesis, where dietary features and microbiota diversity and composition are crucial.(20,21) Current guidelines are cautious when addressing the relationship of CU wi…”
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Innate lymphoid cells—key immune integrators of overall body homeostasis
Karagiannis, F., & Wilhelm, C. (2018) · Seminars in Immunopathology · doi:10.1007/s00281-018-0684-y · Cited by 9
“Indeed, dietary habits are now known to be major drivers of human diseases ranging from diabetes to inflammatory bowel disease and asthma [19, 20].”
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Unexplained inflammation in end‐stage kidney disease: Is the combination of enhanced gastrointestinal permeability and reticuloendothelial dysfunction its cause?
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Metabolomics and the Microbiome: Characterizing Molecular Diversity in Complex Microbial Communities
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Fatty is not that bad: feeding short-chain fatty acids to restrain autoimmunity
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Dynamic Interplay Between Microbiota and Mucosal Immunity in Early Shaping of Asthma and its Implication for the COVID-19 Pandemic
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Microbial Reprogramming Inhibits Western Diet-Associated Obesity
Poutahidis, T., Kleinewietfeld, M., Smillie, C. S., Levkovich, T., Perrotta, A., Bhela, S., Varian, B. J., Ibrahim, Y. M., Lakritz, J. R., Kearney, S. M., et al. (2014) · Apple Academic Press eBooks · doi:10.1201/b17254-6 · Cited by 8
Foods may modify responsiveness to cancer immune checkpoint blockers by altering both the gut microbiota and activation of estrogen receptors in immune cells
Hilakivi-Clarke, L. A., Verma, V., McDermott, M., Koak, P., & Andrade, F. D. O. (2022) · Frontiers in Microbiomes · doi:10.3389/frmbi.2022.1049688 · Cited by 7
The pediatric intestinal mucosal microbiome remains altered after clinical resolution of inflammatory and ischemic disease
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Identification of the Microbiota in the Aging Process
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Probiotics and Immune Response to Exercise
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Deciphering T Cell Dynamics in Alzheimer's Disease Pathogenesis: Insights and Implications
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“Diet acts as a powerful modulator of gut microbial composition and mucosal immune responses (84, 85).”
Learning Objectives for Weaving Evolutionary Thinking into Medical Education
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“…complex, plays a fundamental role in responding and adapting to the host environment, which supports host health and normal reproduction (Ley et al., 2008; Li et al., 2022), and supporting immune function and health maintenance (Bertino et al., 2022; Zhao et al., 2013; Maslowski and Mackay, 2011).”
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Authors: Maslowski, K. M., & Mackay, C. R.
Affiliations: Garvan Institute of Medical Research (AU)
Monash University (AU)
Corresponding author: Mackay, Charles R
ORCID: Maslowski, Kendle M
Mackay, Charles R
Venue: Nature Immunology
Publisher: Springer Science and Business Media LLC
Published: 2010-12-17
Volume: 12
Issue: 1
Pages: 5-9
ISSN: 1529-2908 (ISSN-L)
1529-2916
DOI: 10.1038/ni0111-5
OpenAlex: W1988821718
Cited by: 1,261
References: 29
Citations by year: 2026: 23 · 2025: 53 · 2024: 60 · 2023: 102 · 2022: 98 · 2021: 114 · 2020: 99 · 2019: 115 · 2018: 81 · 2017: 95 · 2016: 88 · 2015: 82 · 2014: 87 · 2013: 73 · 2012: 55
FWCI: 21.25
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Immunology (publishedVersion)
PubMed (publishedVersion)
Helmholtz Centre for Ocean Research Kiel (GEOMAR) (acceptedVersion)
University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords: diet, gut microbiota, immune response, asthma, autoimmunity, nutrition and immunity, host-microbe interactions, developed countries
MeSH terms: Animals, Clinical Trials as Topic, Diet, Humans, Inflammation, Signal Transduction, Models, Immunological, Immunity, Mucosal, Genetic Predisposition to Disease, Gastrointestinal Tract, Lipid Metabolism, Mice, Metagenome, Immunomodulation

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