Cited by 1,261Gut microbiota and healthAsthma and respiratory diseasesNutritional Studies and Diet

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Diet, gut microbiota and immune responses

Maslowski, Kendle M, Mackay, Charles R·2011·Nature Immunology

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Abstract

The fields of immunology, microbiology, nutrition and metabolism are rapidly converging. Here we expand on a diet-microbiota model as the basis for the greater incidence of asthma and autoimmunity in developed countries.

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Crossref · 10.1038/ni0111-5

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Background
The Link Between Nutrition and Alzheimer’s Disease: From Prevention to Treatment
Martins, L. B., Silveira, A. L. M., & Teixeira, A. L. (2021) · Neurodegenerative Disease Management · doi:10.2217/nmt-2020-0023 · Cited by 26
Advancing and refining archaeological dental calculus research using multiomic frameworks
Wright, S., Dobney, K. M., & Weyrich, L. S. (2021) · STAR Science & Technology of Archaeological Research · doi:10.1080/20548923.2021.1882122 · Cited by 26
Oral Microbiota: A New Insight into Cancer Progression, Diagnosis and Treatment
Wang, X., Xu, H.-W., & Liu, N. (2023) · Phenomics · doi:10.1007/s43657-023-00124-y · Cited by 28
“The oral microbiota colonization also affected by diet (Maslowski and Mackay 2011; David et al. 2014b).”
Background
The effects of oats on the function of gut microflora in children with coeliac disease
Tjellström, B., Stenhammar, L., Sundqvist, T., Fälth‐Magnusson, K., Hollén, E., Magnusson, K., Norin, E. L., Midtvedt, T., & Högberg, L. (2014) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12707 · Cited by 24
Diet matters, particularly in pregnancy – Results from MoBa studies of maternal diet and pregnancy outcomes
Brantsæter, A. L., Haugen, M. A., Myhre, R., Sengpiel, V., Englund‐Ögge, L., Nilsen, R. M., Borgen, I., Duarte‐Salles, T., Papadopoulou, E., Vejrup, K., et al. (2014) · Norsk Epidemiologi · doi:10.5324/nje.v24i1-2.1805 · Cited by 23
“It has been indicated that these substances directly, or indirectly, through prompting a favourable gut microbiota, can have an impact on inflammation, blood pressure and blood lipids (81-83).”
Background
The microbiome and its impact on food allergy and atopic dermatitis in children
Łoś-Rychalska, E., Gołębiewski, M., Grzybowski, T., Rogalla-Ładniak, U., & Krogulska, A. (2020) · Advances in Dermatology and Allergology · doi:10.5114/ada.2019.90120 · Cited by 23
Effects of soluble dietary fiber from sweet potato dregs on the structures of intestinal flora in mice
Zhu, L., Gao, M., Li, H., Deng, Z., Zhang, B., & Fan, Y. (2021) · Food Bioscience · doi:10.1016/j.fbio.2021.100880 · Cited by 24
Potential Replacements for Antibiotic Growth Promoters in Poultry: Interactions at the Gut Level and Their Impact on Host Immunity
Swaggerty, C. L., Bortoluzzi, C., Lee, A., Eyng, C., Pont, G. C. D., & Kogut, M. H. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-85686-1_8 · Cited by 23
Sex disparate gut microbiome and metabolome perturbations precede disease progression in a mouse model of Rett syndrome
Neier, K. E., Grant, T. E., Palmer, R. L., Chappell, D., Hakam, S. M., Yasui, K. M., Rolston, M., Settles, M. L., Hunter, S. S., Madany, A. M., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-02915-3 · Cited by 26
High‐Salt Diet‐Induced Gastritis in C57BL/6 Mice is Associated with Microbial Dysbiosis and Alleviated by a Buckwheat Diet
Li, Y., Li, W., Wang, X., Ding, C., Liu, J., Li, Y., Li, W., & Sun, Y. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900965 · Cited by 25
An Integrated Multi-Disciplinary Perspective for Addressing Challenges of the Human Gut Microbiome
Shah, R., McKenzie, E. J., Rosin, M., Jadhav, S. R., Gondalia, S. V., Rosendale, D., & Beale, D. J. (2020) · Metabolites · doi:10.3390/metabo10030094 · Cited by 25
How host metabolism impacts on virus pathogenesis
Varanasi, S. K., & Rouse, B. T. (2017) · Current Opinion in Virology · doi:10.1016/j.coviro.2017.11.003 · Cited by 21
“This balance can influence numerous systemic diseases that include cancers, autoimmunity and allergies, as well as responses to infections and vaccines [24,25].”
Background
Components of heat-treated Helianthus annuus L. pectin inhibit tumor growth and promote immunity in a mouse CT26 tumor model
Guan, Y., Zhang, Z., Yu, X., Yan, J., Zhou, Y., Cheng, H., & Tai, G. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.07.001 · Cited by 22
Enhancing Checkpoint Inhibitor Therapy in Solid Tissue Cancers: The Role of Diet, the Microbiome & Microbiome-Derived Metabolites
Malczewski, A. B., Ketheesan, N., Coward, J. I. G., & Navarro, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.624434 · Cited by 22
High Sugar-Sweetened Beverage Consumption Is Associated with Increased Health Care Utilization in Patients with Inflammatory Bowel Disease: A Multiyear, Prospective Analysis
Ahsan, M., Koutroumpakis, F., Rivers, C. R., Wilson, A. S., Johnston, E. R., Hashash, J. G., Barrie, A. M., Alchoufete, T., Babichenko, D., Tang, G., et al. (2022) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2022.01.001 · Cited by 24
Gut microbiota in alopecia areata
Brzychcy, K., Dróźdż, I., Skoczylas, S., Płoszaj, T., Sobolewska-Sztychny, D., Skibińska, M., Narbutt, J., & Lesiak, A. (2022) · Advances in Dermatology and Allergology · doi:10.5114/ada.2022.120453 · Cited by 25
“A recent study by Maslowski and Mackay [22] looked at microbiota as the basis for increased incidence of autoimmune conditions in developed countries.”
Background
Diet and the anti-inflammatory effect of heat shock proteins.
van Eden, W. (2014) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530314666140922145333 · Cited by 17
The microbiome and inborn errors of metabolism: Why we should look carefully at their interplay?
Colonetti, K., Roesch, L. F. W., & Schwartz, I. V. D. (2018) · Genetics and Molecular Biology · doi:10.1590/1678-4685-gmb-2017-0235 · Cited by 22
“, 2006) and influencing the immune and inflammatory responses (Maslowski and Mackay, 2011; Tremaroli and Bäckhed, 2012; LopezLegarrea et al., 2014).”
Background
Elevated fecal calprotectin levels are associated with severity of atopic dermatitis in children
Seo, S., Ahn, S. H., Ri, S., Yoon, Y., Byeon, J. H., Kim, S., Yoon, W., & Yoo, Y. (2017) · Asian Pacific Journal of Allergy and Immunology · doi:10.12932/ap-100317-0044 · Cited by 22
“25 Altered gut microbiota and subsequently reduced production in SCFA can be implicated in children with AD.”
Background
Gender specific differences of immune competence in the sea cucumber Apostichopus japonicus before and after spawning
Jiang, J., Zhao, Z., Pan, Y., Dong, Y., Gao, S., Li, S., Wang, C., Yang, H., Lin, S., & Zhou, Z. (2019) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2019.04.051 · Cited by 22
Effect of Berberine from Coptis chinensis on Apoptosis of Intestinal Epithelial Cells in a Mouse Model of Ulcerative Colitis: Role of Endoplasmic Reticulum Stress
Shen, Y., Liu, Y., Wang, Z., Xianli, R., Li, S., Ni, S., & Zhong, J. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/3784671 · Cited by 22
“Body weight was measured at regular intervals daily, fecal traits were examined in parallel with fecal occult blood tests, and the disease activity index (DAI) was scored as previously described [12].”
BackgroundMethod
Gut-microbiota-on-a-chip: an enabling field for physiological research
Trujillo-de Santiago, G., Lobo-Zegers, M. J., Montes-Fonseca, S. L., Zhang, Y. S., & Alvarez, M. M. (2018) · Microphysiological Systems · doi:10.21037/mps.2018.09.01 · Cited by 43
“By contrast, the composition of the microbiome of any single individual (4,20,49) is significantly influenced by multiple environmental factors (13,29,55), including diet and exposure to food additives (56) and drugs (i.”
Background
Diversity of intestinal microbiota in infancy and the risk of allergic disease in childhood
Storrø, O., Avershina, E., & Rudi, K. (2013) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0b013e328360968b · Cited by 21
The Role of Metabolite-Sensing G Protein-Coupled Receptors in Inflammation and Metabolic Disease
Recio, C., Lucy, D., Iveson, P., Iqbal, A. J., Valaris, S., Wynne, G. M., Russell, A. J., Choudhury, R. P., O’Callaghan, C. A., Monaco, C. G., et al. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7168 · Cited by 22
“Maslowski et al. (101, 102) showed that mice lacking GPR43 presented exacerbated inﬂammation (more PMN recruitment and chemotaxis, higher ROS production, and increased expression levels of key inﬂammatory mediators such as CXCL1 or TNF-a ) in dextran sulfate sodium (DSS)-induced colitis, indicating that the GPR43-depe…”
Influential
Qi‐Deficiency Related Increases in Disease Susceptibility Are Potentially Mediated by the Intestinal Microbiota
Ma, K., Chen, J., Kuang, L., Bi, J., Cheng, J., Li, F., Sun, X., Nie, X., Liu, Y., Luo, R., et al. (2018) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2018/1304397 · Cited by 21
Xylanase supplementation in plant protein‐enriched diets improves growth performance by optimizing the intestinal microflora and enhancing the intestinal immune function in grass carp grow‐out ( Ctenopharyngodon idella )
Jin, Y., Zhou, X., Jiang, W., Wu, P., Liu, Y., Jiang, J., Zeng, Y., Kuang, S., Tang, L. Y., Zhang, Y., et al. (2020) · Aquaculture Nutrition · doi:10.1111/anu.13038 · Cited by 21
A Purified Glucomannan Oligosaccharide from Amorphophallus konjac Improves Colonic Mucosal Barrier Function via Enhancing Butyrate Production and Histone Protein H3 and H4 Acetylation
Cui, H., Zhu, X., Wang, Z., Fang, J., & Yuan, T. (2021) · Journal of Natural Products · doi:10.1021/acs.jnatprod.0c01125 · Cited by 21
Association of Dietary Prebiotic Consumption with Reduced Risk of Alzheimer’s Disease in a Multiethnic Population
Gu, Y., Nishikawa, M., Brickman, A. M., Manly, J. J., Schupf, N., & Mayeux, R. P. (2021) · Current Alzheimer Research · doi:10.2174/1567205019666211222115142 · Cited by 25
Association between dietary inflammatory index scores and the increased disease activity of rheumatoid arthritis: a cross-sectional study
Nayebi, A., Soleimani, D., Mostafaei, S., Elahi, N., Pahlavani, N., Bagheri, A., Elahi, H., Mahmoudi, M., & Nachvak, S. M. (2022) · Nutrition Journal · doi:10.1186/s12937-022-00805-w · Cited by 20
“Diet is a modifiable environmental factor that plays an important role in regulating inflammation and immune function [8].”
Background
Potential of Akkermansia muciniphila and its outer membrane proteins as therapeutic targets for neuropsychological diseases
Zhang, F., & Wang, D. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1191445 · Cited by 23
“SCFAs have several beneficial effects including maintaining epithelial barrier function, diminishing oxidative DNA damage, regulating cytokine production, promoting anti-inflammation, and stimulating immune functions (Maslowski and Mackay, 2011) and metabolic health (Muller et al.”
Background
Diet-induced shifts in the gut microbiota influence anastomotic healing in a murine model of colonic surgery
Boatman, S. M., Kaiser, T., Nalluri, H., Khan, M. H., Dietz, M. A., Kohn, J. F., Johnson, A. J., Gaertner, W. B., Staley, C. M., & Jahansouz, C. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2283147 · Cited by 24
“15,16 17–20 Microbial compositional shifts dominated by a collagenolytic strain of Enterococcus faecalis , which is associated with impaired tissue healing, have been demonstrated in mice fed an obesogenic diet, leading to increased rates of AL.”
Background
Inflammatory bowel disease: beyond the boundaries of the bowel
Actis, G. C., Rosina, F., & Mackay, I. R. (2011) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/egh.11.23 · Cited by 21
Feeding immunity: skepticism, delicacies and delights
Veldhoen, M., & Veiga‐Fernandes, H. (2015) · Nature Immunology · doi:10.1038/ni.3100 · Cited by 20
New Perspectives in Clostridium difficile Disease Pathogenesis
Monaghan, T. M. (2015) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2014.11.007 · Cited by 22
Amino acids modulates the intestinal proteome associated with immune and stress response in weaning pig
Ren, M., Liu, C., Zeng, X., Yue, L., Mao, X., Qiao, S., & Wang, J. (2014) · Molecular Biology Reports · doi:10.1007/s11033-014-3225-3 · Cited by 21
“Gut development is of critical importance for piglets to optimize growth because of its various functions in nutrient digestion and absorption, and selective barrier protection from pathogens and toxins [1, 2].”
Background
Spatial quorum sensing modelling using coloured hybrid Petri nets and simulative model checking
Gilbert, D., Monika Heiner, A., Ghanbar, L., & Chodak, J. (2019) · BMC Bioinformatics · doi:10.1186/s12859-019-2690-z · Cited by 21
Proceedings of the 2014 A.S.P.E.N. Research Workshop
Alverdy, J. C., Gilbert, J. A., DeFazio, J. R., Sadowsky, M. J., Chang, E. B., Morowitz, M. J., & Teitelbaum, D. H. (2013) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607113517904 · Cited by 21
Starving the Gut: A Deficit of Butyrate in the Intestinal Ecosystem of Children With Intestinal Failure
Dowhaniuk, J. K., Szamosi, J. C., Chorlton, S. D., Owens, J., Mileski, H., Clause, R., Pernica, J. M., Bowdish, D. M. E., Surette, M. G., & Ratcliffe, E. M. (2019) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.1715 · Cited by 20
Microbiota Changes Due to Grape Seed Extract Diet Improved Intestinal Homeostasis and Decreased Fatness in Parental Broiler Hens
Grandhaye, J., Douard, V., Rodriguez‐Mateos, A., Xu, Y., Cheok, A., Riva, A., Guabiraba, R., Zemb, O., Philippe, C., Monnoye, M., et al. (2020) · Microorganisms · doi:10.3390/microorganisms8081141 · Cited by 23
“GSE can also modify the microbiota composition [26].”
Effect of dietary encapsulated organic salts (Na‐acetate, Na‐butyrate, Na‐lactate and Na‐propionate) on growth performance, haemolymph, antioxidant and digestive enzyme activities and gut microbiota of juvenile narrow clawed crayfish, Astacus leptodactylus leptodactylus Eschscholtz, 1823
Safari, O., Paolucci, M., & Motlagh, H. A. (2020) · Aquaculture Nutrition · doi:10.1111/anu.13167 · Cited by 20
Targeting the perinatal diet to modulate the gut microbiota increases dietary variety and prebiotic and probiotic food intakes: results from a randomised controlled trial
Dawson, S. L., Mohebbi, M., Craig, J. M., Dawson, P., Clarke, G. A., Tang, M. L. K., & Jacka, F. N. (2020) · Public Health Nutrition · doi:10.1017/s1368980020003511 · Cited by 21
“In humans, the gut microbiota respond rapidly to dietary change (12,13) and are related to health and disease (14,15) .”

Authors: Maslowski, K. M., & Mackay, C. R.
Affiliations: Garvan Institute of Medical Research (AU)
Monash University (AU)
Corresponding author: Mackay, Charles R
ORCID: Maslowski, Kendle M
Mackay, Charles R
Venue: Nature Immunology
Publisher: Springer Science and Business Media LLC
Published: 2010-12-17
Volume: 12
Issue: 1
Pages: 5-9
ISSN: 1529-2908 (ISSN-L)
1529-2916
DOI: 10.1038/ni0111-5
OpenAlex: W1988821718
Cited by: 1,261
References: 29
Citations by year: 2026: 23 · 2025: 53 · 2024: 60 · 2023: 102 · 2022: 98 · 2021: 114 · 2020: 99 · 2019: 115 · 2018: 81 · 2017: 95 · 2016: 88 · 2015: 82 · 2014: 87 · 2013: 73 · 2012: 55
FWCI: 21.25
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Immunology (publishedVersion)
PubMed (publishedVersion)
Helmholtz Centre for Ocean Research Kiel (GEOMAR) (acceptedVersion)
University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords: diet, gut microbiota, immune response, asthma, autoimmunity, nutrition and immunity, host-microbe interactions, developed countries
MeSH terms: Animals, Clinical Trials as Topic, Diet, Humans, Inflammation, Signal Transduction, Models, Immunological, Immunity, Mucosal, Genetic Predisposition to Disease, Gastrointestinal Tract, Lipid Metabolism, Mice, Metagenome, Immunomodulation

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Diet, gut microbiota and immune responses

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