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Hematopoietic stem cell niche maintenance during homeostasis and regeneration
Open accessAbstract
The bone marrow niche has mystified scientists for many years, leading to widespread investigation to shed light into its molecular and cellular composition. Considerable efforts have been devoted toward uncovering the regulatory mechanisms of hematopoietic stem cell (HSC) niche maintenance. Recent advances in imaging and genetic manipulation of mouse models have allowed the identification of distinct vascular niches that have been shown to orchestrate the balance between quiescence, proliferation and regeneration of the bone marrow after injury. Here we highlight the recently discovered intrinsic mechanisms, microenvironmental interactions and communication with surrounding cells involved in HSC regulation, during homeostasis and in regeneration after injury and discuss their implications for regenerative therapy.
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Cites
Takahashi, K., & Yamanaka, S. (2006) · Cell · doi:10.1016/j.cell.2006.07.024 · Cited by 26,673
Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
Shalaby, F., Rossant, J., Yamaguchi, T. P., Gertsenstein, M., Wu, X.-F., Breitman, M. L., & Schuh, A. C. (1995) · Nature · doi:10.1038/376062a0 · Cited by 3,931
The bone marrow niche for haematopoietic stem cells
Morrison, S. J., & Scadden, D. T. (2014) · Nature · doi:10.1038/nature12984 · Cited by 2,451
Wnt proteins are lipid-modified and can act as stem cell growth factors
Willert, K., Brown, J. D., Danenberg, E., Duncan, A. W., Weissman, I. L., Reya, T., Yates, J. R., & Nusse, R. (2003) · Nature · doi:10.1038/nature01611 · Cited by 2,257
A role for Wnt signalling in self-renewal of haematopoietic stem cells
Reya, T., Duncan, A. W., Ailles, L., Domen, J., Scherer, D. C., Willert, K., Hintz, L., Nusse, R., & Weissman, I. L. (2003) · Nature · doi:10.1038/nature01593 · Cited by 2,159
Wilson, A., Laurenti, E., Oser, G., van der Wath, R. C., Blanco-Bose, W., Jaworski, M., Offner, S., Dunant, C. F., Eshkind, L., Bockamp, E., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.048 · Cited by 1,908
The ageing systemic milieu negatively regulates neurogenesis and cognitive function
Villeda, S. A., Luo, J., Mosher, K. I., Zou, B., Britschgi, M., Bieri, G., Stan, T. M., Fainberg, N., Ding, Z., Eggel, A., et al. (2011) · Nature · doi:10.1038/nature10357 · Cited by 1,763
FoxOs Are Critical Mediators of Hematopoietic Stem Cell Resistance to Physiologic Oxidative Stress
Tothova, Z., Kollipara, R., Huntly, B. J., Lee, B. H., Castrillon, D. H., Cullen, D. E., McDowell, E. P., Lazo-Kallanian, S., Williams, I. R., Sears, C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.01.003 · Cited by 1,562
Zhou, B. O., Yue, R., Murphy, M. M., Peyer, J. G., & Morrison, S. J. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.06.008 · Cited by 1,381
IFNα activates dormant haematopoietic stem cells in vivo
Essers, M. A. G., Offner, S., Blanco-Bose, W. E., Waibler, Z., Kalinke, U., Duchosal, M. A., & Trumpp, A. (2009) · Nature · doi:10.1038/nature07815 · Cited by 1,368
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Ambrosi, T. H., Scialdone, A., Graja, A., Gohlke, S., Jank, A.-M., Bocian, C., Woelk, L., Fan, H., Logan, D. W., Schürmann, A., et al. (2017) · Cell Stem Cell · doi:10.1016/j.stem.2017.02.009 · Cited by 856
Pietras, E. M., Mirantes-Barbeito, C., Fong, S., Loeffler, D., Kovtonyuk, L. V., Zhang, S., Lakshminarasimhan, R., Chin, C. P., Techner, J.-M., Will, B., et al. (2016) · Nature Cell Biology · doi:10.1038/ncb3346 · Cited by 689
Blood vessel formation and function in bone
Sivaraj, K. K., & Adams, R. H. (2016) · Development · doi:10.1242/dev.136861 · Cited by 441
Does niche competition determine the origin of tissue-resident macrophages?
Guilliams, M., & Scott, C. L. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.42 · Cited by 409
Fetal monocytes and the origins of tissue-resident macrophages
Hoeffel, G., & Ginhoux, F. (2018) · Cellular Immunology · doi:10.1016/j.cellimm.2018.01.001 · Cited by 401
Osteoblasts remotely supply lung tumors with cancer-promoting SiglecF high neutrophils
Engblom, C., Pfirschke, C., Zilionis, R., Da Silva Martins, J., Bos, S. A., Courties, G., Rickelt, S., Severe, N., Baryawno, N., Faget, J., et al. (2017) · Science · doi:10.1126/science.aal5081 · Cited by 389
Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche
Maryanovich, M., Zahalka, A. H., Pierce, H., Pinho, S., Nakahara, F., Asada, N., Wei, Q., Wang, X., Ciero, P., Xu, J., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0030-x · Cited by 389
Self-citationHayakawa, Y., Ariyama, H., Stancikova, J., Sakitani, K., Asfaha, S., Renz, B. W., Dubeykovskaya, Z. A., Shibata, W., Wang, H., Westphalen, C. B., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.10.003 · Cited by 328
Cellular and epigenetic drivers of stem cell ageing
Ermolaeva, M., Neri, F., Ori, A., & Rudolph, K. L. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0020-3 · Cited by 272
Myeloid cell contributions to cardiovascular health and disease
Nahrendorf, M. (2018) · Nature Medicine · doi:10.1038/s41591-018-0064-0 · Cited by 258
Xue, C., Shen, Y., Li, X., Li, B., Zhao, S., Gu, J., Chen, Y., Ma, B., Wei, J., Han, Q., et al. (2018) · Stem Cells and Development · doi:10.1089/scd.2017.0296 · Cited by 232
Liu, J., Liu, Z., Pang, Y., & Zhou, H. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01343-7 · Cited by 219
Gnani, D., Crippa, S., della Volpe, L., Rossella, V., Conti, A., Lettera, E., Rivis, S., Ometti, M., Fraschini, G., Bernardo, M. E., et al. (2019) · Aging Cell · doi:10.1111/acel.12933 · Cited by 188
Dong, F., Hao, S., Zhang, S., Zhu, C., Cheng, H., Yang, Z., Hamey, F. K., Wang, X., Gao, A., Wang, F., et al. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-0512-1 · Cited by 121
Bowles, A. C., Kouroupis, D., Willman, M. A., Perucca Orfei, C., Agarwal, A., & Correa, D. (2020) · Stem Cells · doi:10.1002/stem.3196 · Cited by 120
Neural regulation of bone and bone marrow
Maryanovich, M., Takeishi, S., & Frenette, P. S. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a031344 · Cited by 114
Self-citationHennrich, M. L., Romanov, N., Horn, P., Jaeger, S., Eckstein, V., Steeples, V., Ye, F., Ding, X., Poisa-Beiro, L., Lai, M. C., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06353-4 · Cited by 101
Nahrendorf, M., & Swirski, F. K. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehv453 · Cited by 95
Jung, H., Kim, D. O., Byun, J.-E., Kim, W. S., Kim, M. J., Song, H. Y., Kim, Y. K., Kang, D.-K., Park, Y.-J., Kim, T.-D., et al. (2016) · Nature Communications · doi:10.1038/ncomms13674 · Cited by 81
Id1 Ablation Protects Hematopoietic Stem Cells from Stress-Induced Exhaustion and Aging
Singh, S. K., Singh, S., Gadomski, S., Sun, L., Pfannenstein, A., Magidson, V., Chen, X., Kozlov, S., Tessarollo, L., Klarmann, K. D., et al. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.06.001 · Cited by 78
Cosentino, M., Marino, F., & Maestroni, G. J. M. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00302 · Cited by 63
Stress and non-stress roles of inflammatory signals during HSC Emergence and maintenance
Clapes, T., Lefkopoulos, S., & Trompouki, E. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00487 · Cited by 62
Mohamad, S. F., Xu, L., Ghosh, J., Childress, P. J., Abeysekera, I., Himes, E. R., Wu, H., Alvarez, M. B., Davis, K. M., Aguilar-Perez, A., et al. (2017) · Blood Advances · doi:10.1182/bloodadvances.2017011304 · Cited by 56
Bone marrow inflammation in haematological malignancies
de Jong, M. M. E., Chen, L., Raaijmakers, M. H. G. P., & Cupedo, T. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-01003-x · Cited by 54
Blood on the tracks: hematopoietic stem cell-endothelial cell interactions in homing and engraftment
Perlin, J. R., Sporrij, A., & Zon, L. I. (2017) · Journal of Molecular Medicine · doi:10.1007/s00109-017-1559-8 · Cited by 52
Strategies for elevating hematopoietic stem cells expansion and engraftment capacity
Derakhshani, M., Abbaszadeh, H., Movassaghpour, A. A., Mehdizadeh, A., Ebrahimi-Warkiani, M., & Yousefi, M. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116598 · Cited by 28
Mantelmacher, F. D., Fishman, S., Cohen, K., Pasmanik Chor, M., Yamada, Y., Zvibel, I., & Varol, C. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601441 · Cited by 27
Deletion of the Imprinted Gene Grb10 Promotes Hematopoietic Stem Cell Self-Renewal and Regeneration
Yan, X., Himburg, H. A., Pohl, K., Quarmyne, M., Tran, E., Zhang, Y., Fang, T., Kan, J., Chao, N. J., Zhao, L., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.10.025 · Cited by 25
Roles of angiopoietin-like proteins in regulation of stem cell activity
Kadomatsu, T., & Oike, Y. (2019) · The Journal of Biochemistry · doi:10.1093/jb/mvz005 · Cited by 23
Arai, F., Stumpf, P. S., Ikushima, Y. M., Hosokawa, K., Roch, A., Lutolf, M. P., Suda, T., & MacArthur, B. D. (2020) · Cell Systems · doi:10.1016/j.cels.2020.11.004 · Cited by 19
Acute Myeloid Leukaemia Drives Metabolic Changes in the Bone Marrow Niche
Maynard, R. S., Hellmich, C., Bowles, K. M., & Rushworth, S. A. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.924567 · Cited by 17
Immunity, stem cells, and aging
Devaraj, E., Anbalagan, M., Ileng Kumaran, R., & Bhaskaran, N. (2021) · Stem Cells and Aging · doi:10.1016/b978-0-12-820071-1.00006-2 · Cited by 8
Metadata
- Authors
- Mendelson, A., & Frenette, P. S.
- Venue
- Nature Medicine
- Published
- 2014-08
- Volume
- 20
- Issue
- 8
- Pages
- 833-846
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2052730253
- Cited by
- 792
- References
- 35
- FWCI
- 46.74
- Type
- journal article
- Language
- en
- Open access
- green
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