Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

Chang, Jianhui, Wang, Yingying, Shao, Lijian, Laberge, Remi-Martin, Demaria, Marco, Campisi, Judith, Janakiraman, Krishnamurthy, Sharpless, Norman E +10 more·2016·Nature Medicine

DOI 10.1038/nm.4010

Cited by (257)

Items 201–257 of 257

Cellular senescence-mediated exacerbation of Duchenne muscular dystrophy
Sugihara, Hidetoshi, Teramoto, Naomi, Nakamura, Katsuyuki, Shiga, Takanori, Shirakawa, Taku, Matsuo, Masafumi, Ogasawara, Masashi, Nishino, Ichizo, Matsuwaki, Takashi, Nishihara, Masugi et al. · 2020 · Scientific Reports
Blocking negative effects of senescence in human skin fibroblasts with a plant extract
Lämmermann, Ingo, Terlecki-Zaniewicz, Lucia, Weinmüllner, Regina, Schosserer, Markus, Dellago, Hanna, de Matos Branco, André Dargen, Autheried, Dominik, Sevcnikar, Benjamin, Kleissl, Lisa, Berlin, Irina et al. · 2018 · npj Aging and Mechanisms of Disease
BRAFV600E-induced senescence drives Langerhans cell histiocytosis pathophysiology
Bigenwald, Camille, Le Berichel, Jessica, Wilk, C. Matthias, Chakraborty, Rikhia, Chen, Steven T., Tabachnikova, Alexandra, Mancusi, Rebecca, Abhyankar, Harshal, Casanova-Acebes, Maria, Laface, Ilaria et al. · 2021 · Nature Medicine
Cdkn1a transcript variant 2 is a marker of aging and cellular senescence.
López-Domínguez, José Alberto, Rodríguez-López, Sandra, Ahumada-Castro, Ulises, Desprez, Pierre-Yves, Konovalenko, Maria, Laberge, Remi-Martin, Cárdenas, César, Villalba, José Manuel, Campisi, Judith · 2021 · Aging
Musculoskeletal senescence: a moving target ready to be eliminated
Baar, Marjolein P, Perdiguero, Eusebio, Muñoz-Cánoves, Pura, de Keizer, Peter LJ · 2018 · Current Opinion in Pharmacology
Utilizing PROTAC technology to address the on-target platelet toxicity associated with inhibition of BCL-X <sub>L</sub>
Zhang, Xuan, Thummuri, Dinesh, He, Yonghan, Liu, Xingui, Zhang, Peiyi, Zhou, Daohong, Zheng, Guangrong · 2019 · Chemical Communications
Mitochondria and cellular senescence: Implications for musculoskeletal ageing
Habiballa, Leena, Salmonowicz, Hanna, Passos, João F. · 2019 · Free Radical Biology and Medicine
Cellular Senescence as a Therapeutic Target for Age-Related Diseases: A Review
Amaya-Montoya, Mateo, Pérez-Londoño, Agustín, Guatibonza-García, Valentina, Vargas-Villanueva, Andrea, Mendivil, Carlos O. · 2020 · Advances in Therapy
Efficacy and limitations of senolysis in atherosclerosis
Garrido, Abel Martin, Kaistha, Anuradha, Uryga, Anna K, Oc, Sebnem, Foote, Kirsty, Shah, Aarti, Finigan, Alison, Figg, Nichola, Dobnikar, Lina, Jørgensen, Helle et al. · 2022 · Cardiovascular Research
Senolytic activity of piperlongumine analogues: Synthesis and biological evaluation
Liu, Xingui, Wang, Yingying, Zhang, Xuan, Gao, Zhengya, Zhang, Suping, Shi, Peizhong, Zhang, Xin, Song, Lin, Hendrickson, Howard, Zhou, Daohong et al. · 2018 · Bioorganic & Medicinal Chemistry
Senescent cells suppress innate smooth muscle cell repair functions in atherosclerosis
Childs, Bennett G., Zhang, Cheng, Shuja, Fahad, Sturmlechner, Ines, Trewartha, Shawn, Velasco, Raul Fierro, Baker, Darren J., Li, Hu, van Deursen, Jan M. · 2021 · Nature Aging
Targeting senescent cells improves functional recovery after spinal cord injury
Paramos-de-Carvalho, Diogo, Martins, Isaura, Cristóvão, Ana Margarida, Dias, Ana Filipa, Neves-Silva, Dalila, Pereira, Telmo, Chapela, Diana, Farinho, Ana, Jacinto, António, Saúde, Leonor · 2021 · Cell Reports
Heterochronic parabiosis regulates the extent of cellular senescence in multiple tissues
Yousefzadeh, Matthew J., Wilkinson, John E., Hughes, Brian, Gadela, Namrata, Ladiges, Warren C., Vo, Nam, Niedernhofer, Laura J., Huffman, Derek M., Robbins, Paul D. · 2020 · GeroScience
Therapeutic Potential of Senolytics in Cardiovascular Disease
Dookun, Emily, Passos, João F., Arthur, Helen M., Richardson, Gavin D. · 2022 · Cardiovascular Drugs and Therapy
Transcriptional repression of DNA repair genes is a hallmark and a cause of cellular senescence
Collin, Guillaume, Huna, Anda, Warnier, Marine, Flaman, Jean-Michel, Bernard, David · 2018 · Cell Death & Disease
Targeting senescent cells: possible implications for delaying skin aging: a mini-review
Velarde, Michael C., Demaria, Marco · 2016 · Gerontology
p16Ink4a and p21Cip1/Waf1 promote tumour growth by enhancing myeloid-derived suppressor cells chemotaxis
Okuma, Atsushi, Hanyu, Aki, Watanabe, Sugiko, Hara, Eiji · 2017 · Nature Communications
Untangling senescent and damage‐associated microglia in the aging and diseased brain
Ng, Pei Y., McNeely, Taylor L., Baker, Darren J. · 2023 · The FEBS Journal
Advancements in therapeutic drugs targeting of senescence
Zhu, Mingsheng, Meng, Ping, Ling, Xian, Zhou, Lili · 2020 · Therapeutic Advances in Chronic Disease
DOT1L modulates the senescence-associated secretory phenotype through epigenetic regulation of IL1A
Leon, Kelly E., Buj, Raquel, Lesko, Elizabeth, Dahl, Erika S., Chen, Chi-Wei, Tangudu, Naveen Kumar, Imamura-Kawasawa, Yuka, Kossenkov, Andrew V., Hobbs, Ryan P., Aird, Katherine M. · 2021 · Journal of Cell Biology
Fisetin as a Senotherapeutic Agent: Biopharmaceutical Properties and Crosstalk between Cell Senescence and Neuroprotection
Elsallabi, Osama, Patruno, Antonia, Pesce, Mirko, Cataldi, Amelia, Carradori, Simone, Gallorini, Marialucia · 2022 · Molecules
Cellular Senescence in Idiopathic Pulmonary Fibrosis
Kellogg, D. L., Kellogg, D. L., Musi, N., Nambiar, A. M. · 2021 · Current Molecular Biology Reports
BCL-XL expression is essential for human erythropoiesis and engraftment of hematopoietic stem cells
Afreen, Sehar, Bohler, Sheila, Müller, Alexandra, Demmerath, Eva-Maria, Weiss, Julia Miriam, Jutzi, Jonas Samuel, Schachtrup, Kristina, Kunze, Mirjam, Erlacher, Miriam · 2020 · Cell Death & Disease
Adipose tissue aging is regulated by an altered immune system
Zhang, Yi-Xiang, Ou, Min-Yi, Yang, Zi-Han, Sun, Yu, Li, Qing-Feng, Zhou, Shuang-Bai · 2023 · Frontiers in Immunology
Senescence and the Aging Immune System as Major Drivers of Chronic Kidney Disease
Schroth, Johannes, Thiemermann, Christoph, Henson, Siân M. · 2020 · Frontiers in Cell and Developmental Biology
Osteocyte Cellular Senescence
Farr, Joshua N., Kaur, Japneet, Doolittle, Madison L., Khosla, Sundeep · 2020 · Current Osteoporosis Reports
Restoration of hippocampal neural precursor function by ablation of senescent cells in the aging stem cell niche
Fatt, Michael P., Tran, Lina M., Vetere, Gisella, Storer, Mekayla A., Simonetta, Jaclin V., Miller, Freda D., Frankland, Paul W., Kaplan, David R. · 2022 · Stem Cell Reports
The Potential Role of Cellular Senescence in Non-Alcoholic Fatty Liver Disease
Engelmann, Cornelius, Tacke, Frank · 2022 · International Journal of Molecular Sciences
Multiparametric senescent cell phenotyping reveals targets of senolytic therapy in the aged murine skeleton
Doolittle, Madison L., Saul, Dominik, Kaur, Japneet, Rowsey, Jennifer L., Vos, Stephanie J., Pavelko, Kevin D., Farr, Joshua N., Monroe, David G., Khosla, Sundeep · 2023 · Nature Communications
Multiparametric senescent cell phenotyping reveals CD24 osteolineage cells as targets of senolytic therapy in the aged murine skeleton
Doolittle, Madison L., Saul, Dominik, Kaur, Japneet, Rowsey, Jennifer L., Vos, Stephanie J., Pavelko, Kevin D., Farr, Joshua N., Monroe, David G., Khosla, Sundeep · 2023
Chronic expression of p16INK4a in the epidermis induces Wnt-mediated hyperplasia and promotes tumor initiation
Azazmeh, Narmen, Assouline, Benjamin, Winter, Eitan, Ruppo, Shmuel, Nevo, Yuval, Maly, Alexander, Meir, Karen, Witkiewicz, Agnieszka K., Cohen, Jonathan, Rizou, Sophia V. et al. · 2020 · Nature Communications
p53 in Bronchial Club Cells Facilitates Chronic Lung Inflammation by Promoting Senescence
Sagiv, Adi, Bar-Shai, Amir, Levi, Naama, Hatzav, Miki, Zada, Lior, Ovadya, Yossi, Roitman, Lior, Manella, Gal, Regev, Ofer, Majewska, Julia et al. · 2018 · Cell Reports
The struggle of a good friend getting old: cellular senescence in viral responses and therapy
Kohli, Jaskaren, Veenstra, Iris, Demaria, Marco · 2021 · The EMBO Reports
Taking advantage of drug resistance, a new approach in the war on cancer
Wang, Liqin, Bernards, Rene · 2018 · Frontiers of Medicine
Sex-biased islet β cell dysfunction is caused by the MODY MAFA S64F variant by inducing premature aging and senescence in males
Walker, Emily M., Cha, Jeeyeon, Tong, Xin, Guo, Min, Liu, Jin-Hua, Yu, Sophia, Iacovazzo, Donato, Mauvais-Jarvis, Franck, Flanagan, Sarah E., Korbonits, Márta et al. · 2021 · Cell Reports
Senescence-induced cellular reprogramming drives cnidarian whole-body regeneration
Salinas-Saavedra, Miguel, Febrimarsa, Krasovec, Gabriel, Horkan, Helen R., Baxevanis, Andreas D., Frank, Uri · 2023 · Cell Reports
Rag1 immunodeficiency-induced early aging and senescence in zebrafish are dependent on chronic inflammation and oxidative stress
Novoa, Beatriz, Pereiro, Patricia, López‐Muñoz, Azucena, Varela, Mónica, Forn‐Cuní, Gabriel, Anchelin, Monique, Dios, Sonia, Romero, Alejandro, Martinez‐López, Alicia, Medina‐Gali, Regla María et al. · 2019 · Aging Cell
RANK links senescence to stemness in the mammary epithelia, delaying tumor onset but increasing tumor aggressiveness
Benítez, Sandra, Cordero, Alex, Santamaría, Patricia G., Redondo-Pedraza, Jaime, Rocha, Ana S., Collado-Solé, Alejandro, Jimenez, Maria, Sanz-Moreno, Adrian, Yoldi, Guillermo, Santos, Juliana C. et al. · 2021 · Developmental Cell
The Senolytic Drug Fisetin Attenuates Bone Degeneration in the Zmpste24−/− Progeria Mouse Model
Hambright, William S., Mu, Xiaodong, Gao, Xueqin, Guo, Ping, Kawakami, Yohei, Mitchell, John, Mullen, Michael, Nelson, Anna-Laura, Bahney, Chelsea, Nishimura, Haruki et al. · 2023 · Journal of Osteoporosis
Insights from In Vivo Studies of Cellular Senescence
Prieto, Luis I., Graves, Sara I., Baker, Darren J. · 2020 · Cells
Combining adoptive NK cell infusion with a dopamine-releasing peptide reduces senescent cells in aged mice
Bai, Zongke, Yang, Peiwei, Yu, Fan, Li, Zhong, Yao, Zheng, Martinez, Jean, Li, Mengwei, Xu, Hanmei · 2022 · Cell Death & Disease
A BDNF-TrkB autocrine loop enhances senescent cell viability
Anerillas, Carlos, Herman, Allison B., Munk, Rachel, Garrido, Amanda, Lam, Kwan-Wood Gabriel, Payea, Matthew J., Rossi, Martina, Tsitsipatis, Dimitrios, Martindale, Jennifer L., Piao, Yulan et al. · 2022 · Nature Communications
Murine mesenchymal cells that express elevated levels of the CDK inhibitor p16(Ink4a)<i>in vivo</i>are not necessarily senescent
Frescas, David, Hall, Brandon M., Strom, Evguenia, Virtuoso, Lauren P., Gupta, Mahima, Gleiberman, Anatoli S., Rydkina, Elena, Balan, Vitaly, Vujcic, Slavoljub, Chernova, Olga B. et al. · 2017 · Cell Cycle
Context‐dependent roles of cellular senescence in normal, aged, and disease states
Moiseeva, Victoria, Cisneros, Andrés, Cobos, Aina Calls, Tarrega, Aida Beà, Oñate, Claudia Santos, Perdiguero, Eusebio, Serrano, Antonio L., Muñoz‐Cánoves, Pura · 2023 · The FEBS Journal
HMGB2 holds the key to the senescence-associated secretory phenotype
Guerrero, Ana, Gil, Jesús · 2016 · Journal of Cell Biology
Out with the old, in with the new: senescence in development
Czarkwiani, Anna, Yun, Maximina H · 2018 · Current Opinion in Cell Biology
Senescence in aging and disorders of the central nervous system
Swenson, Barbara L., Meyer, Charlton F., Bussian, Tyler J., Baker, Darren J. · 2019 · Translational Medicine of Aging
A Novel Quantitative Method for the Detection of Lipofuscin, the Main By-Product of Cellular Senescence, in Fluids
Rizou, Sophia V., Evangelou, Konstantinos, Myrianthopoulos, Vassilios, Mourouzis, Iordanis, Havaki, Sophia, Athanasiou, Aikaterini, Vasileiou, Panagiotis V. S., Margetis, Aggelos, Kotsinas, Athanassios, Kastrinakis, Nikolaos G. et al. · 2019 · Methods in Molecular Biology
Obesity, Senescence, and Senolytics
Chaib, Selim, Tchkonia, Tamara, Kirkland, James L. · 2021 · Handbook of Experimental Pharmacology
Early ageing after cytotoxic treatment for testicular cancer and cellular senescence: Time to act
Lubberts, Sjoukje, Meijer, Coby, Demaria, Marco, Gietema, Jourik A. · 2020 · Critical Reviews in Oncology/Hematology
Stress-induced cellular senescence contributes to chronic inflammation and cancer progression.
KOBASHIGAWA, SHINKO, M. SAKAGUCHI, YOSHIHIKO, MASUNAGA, SHINICHIRO, MORI, EIICHIRO · 2019 · Thermal Medicine
A Fully-Automated Senescence Test (FAST) for the high-throughput quantification of senescence-associated markers
Neri, Francesco, Takajjart, Selma N., Lerner, Chad A., Desprez, Pierre-Yves, Schilling, Birgit, Campisi, Judith, Gerencser, Akos A. · 2024 · GeroScience
p21 facilitates chronic lung inflammation via epithelial and endothelial cells
Levi, Naama, Papismadov, Nurit, Majewska, Julia, Roitman, Lior, Wigoda, Noa, Eilam, Raya, Tsoory, Michael, Rotkopf, Ron, Ovadya, Yossi, Akiva, Hagay et al. · 2023 · Aging
Vascular Senescence: A Potential Bridge Between Physiological Aging and Neurogenic Decline
Rojas-Vázquez, Sara, Blasco-Chamarro, Laura, López-Fabuel, Irene, Martínez-Máñez, Ramón, Fariñas, Isabel · 2021 · Frontiers in Neuroscience
Comparative analysis of senolytic drugs reveals mitochondrial determinants of efficacy and resistance
Wakita, Masahiro, Ito, Koyu, Fujii, Kaho, Sakamoto, Dai, Mikawa, Takumi, Sugawara, Sho, Zhou, Xiangyu, Park, Jeong Hoon, Miyagawa, Hideka, Motooka, Daisuke et al. · 2026 · Nature Aging
Senescent cell heterogeneity and responses to senolytic treatment are related to cell cycle status during senescence induction
Neri, Francesco, Zheng, Shuyuan, Watson, Mark A., Desprez, Pierre-Yves, Gerencser, Akos A., Campisi, Judith, Wirtz, Denis, Wu, Pei-Hsun, Schilling, Birgit · 2025 · Aging
Uncovering the signatures of aging and senescence in the human dorsolateral prefrontal cortex
Sloan, Nicholas X., Mares, Jason, Daly, Aidan C., Grier, Shaunice, Haq, Imdadul, Jackson, Christopher A., Barretto, Natalie, Casel, Obadele, Kang, Kristy, Khiste, Shruti et al. · 2026 · Cell Genomics