Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

Chang, Jianhui, Wang, Yingying, Shao, Lijian, Laberge, Remi-Martin, Demaria, Marco, Campisi, Judith, Janakiraman, Krishnamurthy, Sharpless, Norman E +10 more·2016·Nature Medicine

Cited by (257)

Items 101–200 of 257

  1. High-Throughput Functional Genetic and Compound Screens Identify Targets for Senescence Induction in Cancer
    Wang, Liqin, Leite de Oliveira, Rodrigo, Wang, Cun, Fernandes Neto, João M., Mainardi, Sara, Evers, Bastiaan, Lieftink, Cor, Morris, Ben, Jochems, Fleur, Willemsen, Lisa et al. · 2017 · Cell Reports
  2. Cellular senescence: the sought or the unwanted?
    Sun, Yu, Coppé, Jean-Philippe, Lam, Eric W.-F. · 2018 · Trends in Molecular Medicine
  3. Elimination of Radiation-Induced Senescence in the Brain Tumor Microenvironment Attenuates Glioblastoma Recurrence
    Fletcher-Sananikone, Eliot, Kanji, Suman, Tomimatsu, Nozomi, Di Cristofaro, Luis Fernando Macedo, Kollipara, Rahul K., Saha, Debabrata, Floyd, John R., Sung, Patrick, Hromas, Robert, Burns, Terry C. et al. · 2021 · Cancer Research
  4. SASP: Tumor Suppressor or Promoter? Yes!
    Rao, Sonia G., Jackson, James G. · 2016 · Trends in Cancer
  5. A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells
    Wakita, Masahiro, Takahashi, Akiko, Sano, Osamu, Loo, Tze Mun, Imai, Yoshinori, Narukawa, Megumi, Iwata, Hidehisa, Matsudaira, Tatsuyuki, Kawamoto, Shimpei, Ohtani, Naoko et al. · 2020 · Nature Communications
  6. The Cancer SENESCopedia: A delineation of cancer cell senescence
    Jochems, Fleur, Thijssen, Bram, De Conti, Giulia, Jansen, Robin, Pogacar, Ziva, Groot, Kelvin, Wang, Liqin, Schepers, Arnout, Wang, Cun, Jin, Haojie et al. · 2021 · Cell Reports
  7. Endothelial senescence in vascular diseases: current understanding and future opportunities in senotherapeutics
    Han, Yeaeun, Kim, Sung Young · 2023 · Experimental & Molecular Medicine
  8. Cellular Senescence and Inflammaging in Age-Related Diseases
    Olivieri, Fabiola, Prattichizzo, Francesco, Grillari, Johannes, Balistreri, Carmela R. · 2018 · Mediators of Inflammation
  9. Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16high Cells In Vivo
    Omori, Satotaka, Wang, Teh-Wei, Johmura, Yoshikazu, Kanai, Tomomi, Nakano, Yasuhiro, Kido, Taketomo, Susaki, Etsuo A., Nakajima, Takuya, Shichino, Shigeyuki, Ueha, Satoshi et al. · 2020 · Cell Metabolism
  10. Vascular senescence in cardiovascular and metabolic diseases
    Katsuumi, Goro, Shimizu, Ippei, Yoshida, Yohko, Minamino, Tohru · 2018 · Frontiers in Cardiovascular Medicine
  11. Therapeutic interventions for aging: the case of cellular senescence
    Soto-Gamez, Abel, Demaria, Marco · 2017 · Drug Discovery Today
  12. Cellular Senescence in Postmitotic Cells: Beyond Growth Arrest
    Sapieha, Przemyslaw, Mallette, Frédérick A. · 2018 · Trends in Cell Biology
  13. Senescent cells: a therapeutic target for cardiovascular disease
    Childs, Bennett G., Li, Hu, van Deursen, Jan M. · 2018 · Journal of Clinical Investigation
  14. Immune Clearance of Senescent Cells to Combat Ageing and Chronic Diseases
    Song, Ping, An, Junqing, Zou, Ming-Hui · 2020 · Cells
  15. Proteostasis in cardiac health and disease
    Henning, Robert H., Brundel, Bianca J. J. M. · 2017 · Nature Reviews Cardiology
  16. Senescent Cells: Emerging Targets for Human Aging and Age-Related Diseases
    Song, Shuling, Lam, Eric W.-F., Tchkonia, Tamara, Kirkland, James L., Sun, Yu · 2020 · Trends in Biochemical Sciences
  17. <scp>DNA</scp> damage and senescence in osteoprogenitors expressing Osx1 may cause their decrease with age
    Kim, Ha‐Neui, Chang, Jianhui, Shao, Lijian, Han, Li, Iyer, Srividhya, Manolagas, Stavros C., O'Brien, Charles A., Jilka, Robert L., Zhou, Daohong, Almeida, Maria · 2017 · Aging Cell
  18. Reducing Senescent Cell Burden in Aging and Disease
    Pignolo, Robert J., Passos, João F., Khosla, Sundeep, Tchkonia, Tamara, Kirkland, James L. · 2020 · Trends in Molecular Medicine
  19. The role of cellular senescence in ageing of the placenta
    Cox, Lynne S., Redman, Christopher · 2017 · Placenta
  20. Integrating cellular senescence with the concept of damage accumulation in aging: Relevance for clearance of senescent cells
    Ogrodnik, Mikolaj, Salmonowicz, Hanna, Gladyshev, Vadim N. · 2019 · Aging Cell
  21. Connecting aging biology and inflammation in the omics era
    Walker, Keenan A., Basisty, Nathan, Wilson, David M., Ferrucci, Luigi · 2022 · Journal of Clinical Investigation
  22. Sentinel <i>p16</i> <sup>INK4a+</sup> cells in the basement membrane form a reparative niche in the lung
    Reyes, Nabora S., Krasilnikov, Maria, Allen, Nancy C., Lee, Jin Young, Hyams, Ben, Zhou, Minqi, Ravishankar, Supriya, Cassandras, Monica, Wang, Chaoqun, Khan, Imran et al. · 2022 · Science
  23. Lipid (per) oxidation in mitochondria: an emerging target in the ageing process?
    Ademowo, O. S., Dias, H. K. I., Burton, D. G. A., Griffiths, H. R. · 2017 · Biogerontology
  24. Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis
    Stojanović, Stevan D, Fiedler, Jan, Bauersachs, Johann, Thum, Thomas, Sedding, Daniel G · 2020 · European Heart Journal
  25. Clearance of therapy‐induced senescent tumor cells by the senolytic ABT‐263 via interference with BCL‐X<sub>L</sub>–BAX interaction
    Saleh, Tareq, Carpenter, Valerie J., Tyutyunyk‐Massey, Liliya, Murray, Graeme, Leverson, Joel D., Souers, Andrew J., Alotaibi, Moureq R., Faber, Anthony C., Reed, Jason, Harada, Hisashi et al. · 2020 · Molecular Oncology
  26. Context-dependent effects of cellular senescence in cancer development.
    Lecot, Pacome, Alimirah, Fatouma, Desprez, Pierre-Yves, Campisi, Judith, Wiley, Christopher · 2016 · British Journal of Cancer
  27. A Novel Indication for Panobinostat as a Senolytic Drug in NSCLC and HNSCC
    Samaraweera, Leleesha, Adomako, Alfred, Rodriguez-Gabin, Alicia, McDaid, Hayley M. · 2017 · Scientific Reports
  28. Senescence in Wound Repair: Emerging Strategies to Target Chronic Healing Wounds
    Wilkinson, Holly N., Hardman, Matthew J. · 2020 · Frontiers in Cell and Developmental Biology
  29. Astrocyte senescence promotes glutamate toxicity in cortical neurons
    Limbad, Chandani, Oron, Tal Ronnen, Alimirah, Fatouma, Davalos, Albert R., Tracy, Tara E., Gan, Li, Desprez, Pierre-Yves, Campisi, Judith · 2020 · PLOS ONE
  30. Paracrine roles of cellular senescence in promoting tumourigenesis
    Gonzalez-Meljem, Jose Mario, Apps, John Richard, Fraser, Helen Christina, Martinez-Barbera, Juan Pedro · 2018 · British Journal of Cancer
  31. Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition
    Crespo-Garcia, Sergio, Tsuruda, Pamela R., Dejda, Agnieszka, Ryan, Rathi D., Fournier, Frederik, Chaney, Shawnta Y., Pilon, Frederique, Dogan, Taner, Cagnone, Gael, Patel, Priyanka et al. · 2021 · Cell Metabolism
  32. Clearance of senescent cells during cardiac ischemia–reperfusion injury improves recovery
    Dookun, Emily, Walaszczyk, Anna, Redgrave, Rachael, Palmowski, Pawel, Tual‐Chalot, Simon, Suwana, Averina, Chapman, James, Jirkovsky, Eduard, Donastorg Sosa, Leticia, Gill, Eleanor et al. · 2020 · Aging Cell
  33. The World Goes Bats: Living Longer and Tolerating Viruses
    Gorbunova, Vera, Seluanov, Andrei, Kennedy, Brian K. · 2020 · Cell Metabolism
  34. Cellular senescence in the aging and diseased kidney
    Valentijn, F. A., Falke, L. L., Nguyen, T. Q., Goldschmeding, Roel · 2018 · Journal of Cell Communication and Signaling
  35. Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis
    Wiley, Christopher D., Sharma, Rishi, Davis, Sonnet S., Lopez-Dominguez, Jose Alberto, Mitchell, Kylie P., Wiley, Samantha, Alimirah, Fatouma, Kim, Dong Eun, Payne, Therese, Rosko, Andrew et al. · 2021 · Cell Metabolism
  36. Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging
    Robinson, Andria R., Yousefzadeh, Matthew J., Rozgaja, Tania A., Wang, Jin, Li, Xuesen, Tilstra, Jeremy S., Feldman, Chelsea H., Gregg, Siobhán Q., Johnson, Caroline H., Skoda, Erin M. et al. · 2018 · Redox Biology
  37. Galactose‐modified duocarmycin prodrugs as senolytics
    Guerrero, Ana, Guiho, Romain, Herranz, Nicolás, Uren, Anthony, Withers, Dominic J., Martínez‐Barbera, Juan Pedro, Tietze, Lutz F., Gil, Jesús · 2020 · Aging Cell
  38. Senescent cell turnover slows with age providing an explanation for the Gompertz law
    Karin, Omer, Agrawal, Amit, Porat, Ziv, Krizhanovsky, Valery, Alon, Uri · 2019 · Nature Communications
  39. The curcumin analog EF24 is a novel senolytic agent
    Li, Wen, He, Yonghan, Zhang, Rongping, Zheng, Guangrong, Zhou, Daohong · 2019 · Aging
  40. Discovery, development, and future application of senolytics: theories and predictions
    Wissler Gerdes, Erin O., Zhu, Yi, Tchkonia, Tamar, Kirkland, James L. · 2020 · The FEBS Journal
  41. Elimination of p19ARF-expressing cells enhances pulmonary function in mice
    Hashimoto, Michihiro, Asai, Azusa, Kawagishi, Hiroyuki, Mikawa, Ryuta, Iwashita, Yuji, Kanayama, Kazuki, Sugimoto, Kazushi, Sato, Tadashi, Maruyama, Mitsuo, Sugimoto, Masataka · 2016 · JCI Insight
  42. Targetable mechanisms driving immunoevasion of persistent senescent cells link chemotherapy-resistant cancer to aging
    Muñoz, Denise P., Yannone, Steven M., Daemen, Anneleen, Sun, Yu, Vakar-Lopez, Funda, Kawahara, Misako, Freund, Adam M., Rodier, Francis, Wu, Jennifer D., Desprez, Pierre-Yves et al. · 2019 · JCI Insight
  43. Senescence and senotherapeutics: a new field in cancer therapy
    Myrianthopoulos, Vassilios, Evangelou, Konstantinos, Vasileiou, Panagiotis V.S., Cooks, Tomer, Vassilakopoulos, Theodoros P., Pangalis, Gerassimos A., Kouloukoussa, Myrsini, Kittas, Christos, Georgakilas, Alexandros G., Gorgoulis, Vassilis G. · 2019 · Pharmacology &amp; Therapeutics
  44. Hallmarks of progeroid syndromes: lessons from mice and reprogrammed cells
    Carrero, Dido, Soria-Valles, Clara, López-Otín, Carlos · 2016 · Disease Models &amp; Mechanisms
  45. COVID-19 and cellular senescence
    Schmitt, Clemens A., Tchkonia, Tamar, Niedernhofer, Laura J., Robbins, Paul D., Kirkland, James L., Lee, Soyoung · 2023 · Nature Reviews Immunology
  46. Metformin and Aging: A Review
    Glossmann, Hartmut H., Lutz, Oliver M.D. · 2019 · Gerontology
  47. An inducible p21-Cre mouse model to monitor and manipulate p21-highly-expressing senescent cells in vivo
    Wang, Binsheng, Wang, Lichao, Gasek, Nathan S., Zhou, Yueying, Kim, Taewan, Guo, Chun, Jellison, Evan R., Haynes, Laura, Yadav, Sumit, Tchkonia, Tamar et al. · 2021 · Nature Aging
  48. The role of cellular senescence and SASP in tumour microenvironment
    Takasugi, Masaki, Yoshida, Yuya, Hara, Eiji, Ohtani, Naoko · 2023 · The FEBS Journal
  49. Senescence as a therapeutically relevant response to CDK4/6 inhibitors
    Wagner, Verena, Gil, Jesús · 2020 · Oncogene
  50. Biomarkers to identify and isolate senescent cells
    Matjusaitis, Mantas, Chin, Greg, Sarnoski, Ethan Anders, Stolzing, Alexandra · 2016 · Ageing Research Reviews
  51. Single-cell senescence identification reveals senescence heterogeneity, trajectory, and modulators
    Tao, Wanyu, Yu, Zhengqing, Han, Jing-Dong J. · 2024 · Cell Metabolism
  52. Eliminating Senescent Cells Can Promote Pulmonary Hypertension Development and Progression
    Born, Emmanuelle, Lipskaia, Larissa, Breau, Marielle, Houssaini, Amal, Beaulieu, Delphine, Marcos, Elisabeth, Pierre, Remi, Do Cruzeiro, Marcio, Lefevre, Marine, Derumeaux, Genevieve et al. · 2023 · Circulation
  53. SILAC Analysis Reveals Increased Secretion of Hemostasis-Related Factors by Senescent Cells
    Wiley, Christopher D., Liu, Su, Limbad, Chandani, Zawadzka, Anna M., Beck, Jennifer, Demaria, Marco, Artwood, Robert, Alimirah, Fatouma, Lopez-Dominguez, Jose-Alberto, Kuehnemann, Chisaka et al. · 2019 · Cell Reports
  54. Role of the inflammation-autophagy-senescence integrative network in osteoarthritis
    Vinatier, Claire, Domínguez, Eduardo, Guicheux, Jerome, Caramés, Beatriz · 2018 · Frontiers in Physiology
  55. Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma
    Gonzalez-Meljem, Jose Mario, Haston, Scott, Carreno, Gabriela, Apps, John R., Pozzi, Sara, Stache, Christina, Kaushal, Grace, Virasami, Alex, Panousopoulos, Leonidas, Mousavy-Gharavy, Seyedeh Neda et al. · 2017 · Nature Communications
  56. The costs and benefits of senotherapeutics for human health
    Raffaele, Marco, Vinciguerra, Manlio · 2022 · The Lancet Healthy Longevity
  57. The chemistry of senescence
    Lozano-Torres, Beatriz, Estepa-Fernández, Alejandra, Rovira, Miguel, Orzáez, Mar, Serrano, Manuel, Martínez-Máñez, Ramón, Sancenón, Félix · 2019 · Nature Reviews Chemistry
  58. The Chromatin Landscape of Cellular Senescence
    Criscione, Steven W., Teo, Yee Voan, Neretti, Nicola · 2016 · Trends in Genetics
  59. NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health.
    SenNet Consortium, Writing Group, Lee, Patty J., Benz, Christopher C., Blood, Philip, Börner, Katy, Campisi, Judith, Chen, Feng, Daldrup-Link, Heike, De Jager, Phil et al. · 2022 · Nature Aging
  60. Identifying specific functional roles for senescence across cell types
    2024
  61. Targeting senescent cholangiocytes and activated fibroblasts with B‐cell lymphoma‐extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2−/− ) mice
    Moncsek, Anja, Al‐Suraih, Mohammed S., Trussoni, Christy E., O'Hara, Steven P., Splinter, Patrick L., Zuber, Camille, Patsenker, Eleonora, Valli, Piero V., Fingas, Christian D., Weber, Achim et al. · 2018 · Hepatology
  62. “Inflammaging” as a druggable target: a senescence-associated secretory phenotype-centered view of type 2 diabetes
    Prattichizzo, Francesco, De Nigris, Valeria, La Sala, Lucia, Procopio, Antonio Domenico, Olivieri, Fabiola, Ceriello, Antonio · 2016 · Oxidative Medicine and Cellular Longevity
  63. Disease drivers of aging
    Hodes, Richard J., Sierra, Felipe, Austad, Steven N., Epel, Elissa, Neigh, Gretchen N., Erlandson, Kristine M., Schafer, Marissa J., LeBrasseur, Nathan K., Wiley, Christopher, Campisi, Judith et al. · 2016 · Annals of the New York Academy of Sciences
  64. New Horizons: Novel Approaches to Enhance Healthspan Through Targeting Cellular Senescence and Related Aging Mechanisms
    Tchkonia, Tamar, Palmer, Allyson K, Kirkland, James L · 2021 · The Journal of Clinical Endocrinology &amp; Metabolism
  65. Role of Cellular Senescence in Type II Diabetes
    Narasimhan, Akilavalli, Flores, Rafael R, Robbins, Paul D, Niedernhofer, Laura J · 2021 · Endocrinology
  66. Oxidation resistance 1 is a novel senolytic target
    Zhang, Xin, Zhang, Suping, Liu, Xingui, Wang, Yingying, Chang, Jianhui, Zhang, Xuan, Mackintosh, Samuel G., Tackett, Alan J., He, Yonghan, Lv, Dongwen et al. · 2018 · Aging Cell
  67. The Senolytic Drug Navitoclax (ABT-263) Causes Trabecular Bone Loss and Impaired Osteoprogenitor Function in Aged Mice
    Sharma, Anuj K., Roberts, Rachel L., Benson, Reginald D., Pierce, Jessica L., Yu, Kanglun, Hamrick, Mark W., McGee-Lawrence, Meghan E. · 2020 · Frontiers in Cell and Developmental Biology
  68. Targeting Senescent Cells for a Healthier Aging: Challenges and Opportunities
    Song, Shuling, Tchkonia, Tamara, Jiang, Jing, Kirkland, James L., Sun, Yu · 2020 · Advanced Science
  69. The DNA Damage Response in Neurons: Die by Apoptosis or Survive in a Senescence-Like State?
    Fielder, Edward, von Zglinicki, Thomas, Jurk, Diana · 2017 · Journal of Alzheimer's Disease
  70. Conserved and novel functions of programmed cellular senescence during vertebrate development
    Davaapil, Hongorzul, Brockes, Jeremy P., Yun, Maximina H. · 2016 · Development
  71. Recent advances in the discovery of senolytics
    Zhang, Lei, Pitcher, Louise E., Prahalad, Vaishali, Niedernhofer, Laura J., Robbins, Paul D. · 2021 · Mechanisms of Ageing and Development
  72. Cell senescence contributes to tissue regeneration in zebrafish
    Da Silva‐Álvarez, Sabela, Guerra‐Varela, Jorge, Sobrido‐Cameán, Daniel, Quelle, Ana, Barreiro‐Iglesias, Antón, Sánchez, Laura, Collado, Manuel · 2020 · Aging Cell
  73. Senolytics for Cancer Therapy: Is All that Glitters Really Gold?
    Carpenter, Valerie J., Saleh, Tareq, Gewirtz, David A. · 2021 · Cancers
  74. Small-molecule MDM2 antagonists attenuate the senescence-associated secretory phenotype
    Wiley, Christopher D., Schaum, Nicholas, Alimirah, Fatouma, Lopez-Dominguez, Jose Alberto, Orjalo, Arturo V., Scott, Gary, Desprez, Pierre-Yves, Benz, Christopher, Davalos, Albert R., Campisi, Judith · 2018 · Scientific Reports
  75. Senotherapeutics: targeting senescence in idiopathic pulmonary fibrosis
    Merkt, Wolfgang, Bueno, Marta, Mora, Ana L., Lagares, David · 2020 · Seminars in Cell &amp; Developmental Biology
  76. Mouse Models to Disentangle the Hallmarks of Human Aging
    Folgueras, Alicia R., Freitas-Rodríguez, Sandra, Velasco, Gloria, López-Otín, Carlos · 2018 · Circulation Research
  77. ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging
    Zhao, Jing, Zhang, Lei, Lu, Aiping, Han, Yingchao, Colangelo, Debora, Bukata, Christina, Scibetta, Alex, Yousefzadeh, Matthew J., Li, Xuesen, Gurkar, Aditi U. et al. · 2020 · Aging
  78. Effects of intermittent senolytic therapy on bone metabolism in postmenopausal women: a phase 2 randomized controlled trial
    Farr, Joshua N., Atkinson, Elizabeth J., Achenbach, Sara J., Volkman, Tammie L., Tweed, Amanda J., Vos, Stephanie J., Ruan, Ming, Sfeir, Jad, Drake, Matthew T., Saul, Dominik et al. · 2024 · Nature Medicine
  79. Discovery of PROTAC BCL-XL degraders as potent anticancer agents with low on-target platelet toxicity
    Zhang, Xuan, Thummuri, Dinesh, Liu, Xingui, Hu, Wanyi, Zhang, Peiyi, Khan, Sajid, Yuan, Yaxia, Zhou, Daohong, Zheng, Guangrong · 2020 · European Journal of Medicinal Chemistry
  80. Senescence, brain inflammation, and oligomeric tau drive cognitive decline in Alzheimer's disease: Evidence from clinical and preclinical studies
    Gaikwad, Sagar, Senapati, Sudipta, Haque, Md. Anzarul, Kayed, Rakez · 2024 · Alzheimer's &amp; Dementia
  81. Systemic induction of senescence in young mice after single heterochronic blood exchange
    Jeon, Ok Hee, Mehdipour, Melod, Gil, Tae-Hwan, Kang, Minha, Aguirre, Nicholas W., Robinson, Zachery R., Kato, Cameron, Etienne, Jessy, Lee, Hyo Gyeong, Alimirah, Fatouma et al. · 2022 · Nature Metabolism
  82. Oncogene-induced senescence: From biology to therapy
    Zhu, Haoran, Blake, Shaun, Kusuma, Frances K, Pearson, Richard B, Kang, Jian, Chan, Keefe T · 2020 · Mechanisms of Ageing and Development
  83. Osteoclasts protect bone blood vessels against senescence through the angiogenin/plexin-B2 axis
    Liu, Xiaonan, Chai, Yu, Liu, Guanqiao, Su, Weiping, Guo, Qiaoyue, Lv, Xiao, Gao, Peisong, Yu, Bin, Ferbeyre, Gerardo, Cao, Xu et al. · 2021 · Nature Communications
  84. Long-term platinum-based drug accumulation in cancer-associated fibroblasts promotes colorectal cancer progression and resistance to therapy
    Linares, Jenniffer, Sallent-Aragay, Anna, Badia-Ramentol, Jordi, Recort-Bascuas, Alba, Méndez, Ana, Manero-Rupérez, Noemí, Re, Daniele Lo, Rivas, Elisa I., Guiu, Marc, Zwick, Melissa et al. · 2023 · Nature Communications
  85. Impact of Senescent Cell Subtypes on Tissue Dysfunction and Repair: Importance and Research Questions
    Tripathi, Utkarsh, Misra, Avanish, Tchkonia, Tamar, Kirkland, James L. · 2021 · Mechanisms of Ageing and Development
  86. Targeting senescent cells for a healthier longevity: the roadmap for an era of global aging
    Sun, Yu, Li, Qingfeng, Kirkland, James L · 2022 · Life Medicine
  87. The senotherapeutic drug ABT-737 disrupts aberrant p21 expression to restore liver regeneration in adult mice
    Ritschka, Birgit, Knauer-Meyer, Tania, Gonçalves, Daniel Sampaio, Mas, Alba, Plassat, Jean-Luc, Durik, Matej, Jacobs, Hugues, Pedone, Elisa, Di Vicino, Umberto, Cosma, Maria Pia et al. · 2020 · Genes &amp; Development
  88. Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions
    Ho, Theodore T., Dellorusso, Paul V., Verovskaya, Evgenia V., Bakker, Sietske T., Flach, Johanna, Smith, Lucas K., Ventura, Patrick B., Lansinger, Olivia M., Hérault, Aurélie, Zhang, Si Yi et al. · 2021 · Journal of Experimental Medicine
  89. Targeting YAP-mediated HSC death susceptibility and senescence for treatment of liver fibrosis
    Du, Kuo, Maeso-Díaz, Raquel, Oh, Seh Hoon, Wang, Ergang, Chen, Tianyi, Pan, Christopher, Xiang, Kun, Dutta, Rajesh Kumar, Wang, Xiao-Fan, Chi, Jen-Tsan et al. · 2023 · Hepatology
  90. Cellular senescence in gastrointestinal diseases: from pathogenesis to therapeutics
    Frey, Nina, Venturelli, Sascha, Zender, Lars, Bitzer, Michael · 2018 · Nature Reviews Gastroenterology &amp; Hepatology
  91. Aged murine hematopoietic stem cells drive aging-associated immune remodeling
    Leins, Hanna, Mulaw, Medhanie, Eiwen, Karina, Sakk, Vadim, Liang, Ying, Denkinger, Michael, Geiger, Hartmut, Schirmbeck, Reinhold · 2018 · Blood
  92. Skeletal muscle aging, cellular senescence, and senotherapeutics: current knowledge and future directions
    Englund, Davis A., Zhang, Xu, Aversa, Zaira, LeBrasseur, Nathan K. · 2021 · Mechanisms of Ageing and Development
  93. Hsp90 inhibitors as senolytic drugs to extend healthy aging
    Fuhrmann-Stroissnigg, Heike, Niedernhofer, Laura J., Robbins, Paul D. · 2018 · Cell Cycle
  94. SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response
    Tsuji, Shunya, Minami, Shohei, Hashimoto, Rina, Konishi, Yusuke, Suzuki, Tatsuya, Kondo, Tamae, Sasai, Miwa, Torii, Shiho, Ono, Chikako, Shichinohe, Shintaro et al. · 2022 · Nature Aging
  95. Cellular Senescence Contributes to Large Elastic Artery Stiffening and Endothelial Dysfunction With Aging: Amelioration With Senolytic Treatment
    Clayton, Zachary S., Rossman, Matthew J., Mahoney, Sophia A., Venkatasubramanian, Ravinandan, Maurer, Grace S., Hutton, David A., VanDongen, Nicholas S., Greenberg, Nathan T., Longtine, Abigail G., Ludwig, Katelyn R. et al. · 2023 · Hypertension
  96. Can blocking inflammation enhance immunity during aging?
    Chambers, Emma S., Akbar, Arne N. · 2020 · Journal of Allergy and Clinical Immunology
  97. Senescent hepatic stellate cells promote liver regeneration through IL-6 and ligands of CXCR2
    Cheng, Naiyuan, Kim, Ki-Hyun, Lau, Lester F. · 2022 · JCI Insight
  98. Non-cell autonomous effects of the senescence-associated secretory phenotype in cancer therapy.
    Saleh, Tareq, Tyutynuk-Massey, Liliya, Cudjoe, Emmanuel K., Idowu, Michael O., Landry, Joseph W., Gewirtz, David A. · 2018 · Frontiers in Oncology
  99. Detection of senescence using machine learning algorithms based on nuclear features
    Duran, Imanol, Pombo, Joaquim, Sun, Bin, Gallage, Suchira, Kudo, Hiromi, McHugh, Domhnall, Bousset, Laura, Barragan Avila, Jose Efren, Forlano, Roberta, Manousou, Pinelopi et al. · 2024 · Nature Communications
  100. Is exercise a senolytic medicine? A systematic review
    Chen, Xiang‐Ke, Yi, Zhen‐Ni, Wong, Gordon Tin‐Chun, Hasan, Kazi Md. Mahmudul, Kwan, Joseph Shiu‐Kwong, Ma, Alvin Chun‐Hang, Chang, Raymond Chuen‐Chung · 2021 · Aging Cell