Differential regulation of central nervous system autoimmunity by TH1 and TH17 cells

Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

Harrington, L. E., Hatton, R. D., Mangan, P. R., Turner, H., Murphy, T. L., Murphy, K. M., & Weaver, C. T. (2005) · Nature Immunology · doi:10.1038/ni1254 · Cited by 4,742

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

Park, H., Li, Z., Yang, X. O., Chang, S. H., Nurieva, R., Wang, Y.-H., Wang, Y., Hood, L., Zhu, Z., Tian, Q., et al. (2005) · Nature Immunology · doi:10.1038/ni1261 · Cited by 4,265

Immunology of multiple sclerosis

Sospedra, M., & Martin, R. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115707 · Cited by 2,149

Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis

Agrawal, S., Anderson, P., Durbeej, M., van Rooijen, N., Ivars, F., Opdenakker, G., & Sorokin, L. M. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20051342 · Cited by 559

Regulatory T cells: mechanisms of differentiation and function

Josefowicz, S. Z., Lu, L.-F., & Rudensky, A. Y. (2012) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141623 · Cited by 2,866

C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE

Reboldi, A., Coisne, C., Baumjohann, D., Benvenuto, F., Bottinelli, D., Lira, S., Uccelli, A., Lanzavecchia, A., Engelhardt, B., & Sallusto, F. (2009) · Nature Immunology · doi:10.1038/ni.1716 · Cited by 1,206

Fate mapping of IL-17-producing T cells in inflammatory responses

Hirota, K., Duarte, J. H., Veldhoen, M., Hornsby, E., Li, Y., Cua, D. J., Ahlfors, H., Wilhelm, C., Tolaini, M., Menzel, U., et al. (2011) · Nature Immunology · doi:10.1038/ni.1993 · Cited by 1,176

Functional morphology of the blood–brain barrier in health and disease

Liebner, S., Dijkhuizen, R. M., Reiss, Y., Plate, K. H., Agalliu, D., & Constantin, G. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1815-1 · Cited by 872

Th1, Th17, and Th9 Effector Cells Induce Experimental Autoimmune Encephalomyelitis with Different Pathological Phenotypes

Jäger, A., Dardalhon, V., Sobel, R. A., Bettelli, E., & Kuchroo, V. K. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901906 · Cited by 783

The roles of IL‐17A in inflammatory immune responses and host defense against pathogens

Iwakura, Y., Nakae, S., Saijo, S., & Ishigame, H. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00699.x · Cited by 513

Th17 Cells Induce Ectopic Lymphoid Follicles in Central Nervous System Tissue Inflammation

Peters, A., Pitcher, L. A., Sullivan, J. M., Mitsdoerffer, M., Acton, S. E., Franz, B., Wucherpfennig, K., Turley, S., Carroll, M. C., Sobel, R. A., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.10.015 · Cited by 480

The experimental autoimmune encephalomyelitis (EAE) model of MS

(2014) · Handbook of Clinical Neurology · doi:10.1016/b978-0-444-52001-2.00008-x · Cited by 464

Ion channels and transporters in lymphocyte function and immunity

Feske, S., Skolnik, E. Y., & Prakriya, M. (2012) · Nature Reviews Immunology · doi:10.1038/nri3233 · Cited by 441

Neuroplastic changes in depression: A role for the immune system

Eyre, H., & Baune, B. T. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.03.019 · Cited by 319

Astrocyte-restricted ablation of interleukin-17-induced ACT1-mediated signaling ameliorates autoimmune encephalomyelitis

Kang, Z., Altuntas, C. Z., Gulen, M. F., Liu, C., Giltiay, N., Qin, H., Liu, L., Qian, W., Ransohoff, R. M., Bergmann, C., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.03.004 · Cited by 297

Silencing MicroRNA-155 Ameliorates Experimental Autoimmune Encephalomyelitis

Murugaiyan, G., Beynon, V., Mittal, A., Joller, N., & Weiner, H. L. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003952 · Cited by 289

Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation

Ryu, J. K., Petersen, M. A., Murray, S. G., Baeten, K. M., Meyer-Franke, A., Chan, J. P., Vagena, E., Bedard, C., Machado, M. R., Coronado, P. E. R., et al. (2015) · Nature Communications · doi:10.1038/ncomms9164 · Cited by 271

T cell responses in the central nervous system

Korn, T., & Kallies, A. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2016.144 · Cited by 268

Interleukin-17 in chronic inflammatory neurological diseases

Milovanovic, J., Arsenijevic, A., Stojanovic, B., Kanjevac, T., Arsenijevic, D., Radosavljevic, G., Milovanovic, M., & Arsenijevic, N. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00947 · Cited by 250

Cell-specific and region-specific transcriptomics in the multiple sclerosis model: Focus on astrocytes

Itoh, N., Itoh, Y., Tassoni, A., Ren, E., Kaito, M., Ohno, A., Ao, Y., Farkhondeh, V., Johnsonbaugh, H., Burda, J., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1716032115 · Cited by 253

Experimental Autoimmune Encephalomyelitis (EAE) as Animal Models of Multiple Sclerosis (MS)

Glatigny, S., & Bettelli, E. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a028977 · Cited by 247

Pro-cognitive properties of T cells

Kipnis, J., Gadani, S., & Derecki, N. C. (2012) · Nature Reviews Immunology · doi:10.1038/nri3280 · Cited by 246

Neurological Disease as a Failure of Brain-Immune Crosstalk: The Multiple Faces of Neuroinflammation

Schwartz, M., & Deczkowska, A. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.08.001 · Cited by 246

CXCR7 influences leukocyte entry into the CNS parenchyma by controlling abluminal CXCL12 abundance during autoimmunity

Cruz-Orengo, L., Holman, D. W., Dorsey, D., Zhou, L., Zhang, P., Wright, M., McCandless, E. E., Patel, J. R., Luker, G. D., Littman, D. R., et al. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20102010 · Cited by 231

Act1 mediates IL-17-induced EAE pathogenesis selectively in NG2+ glial cells

Kang, Z., Wang, C., Zepp, J., Wu, L., Sun, K., Zhao, J., Chandrasekharan, U., DiCorleto, P. E., Trapp, B. D., Ransohoff, R. M., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3505 · Cited by 218

Amelioration of experimental autoimmune encephalomyelitis by probiotic mixture is mediated by a shift in T helper cell immune response

Kwon, H.-K., Kim, G.-C., Kim, Y., Hwang, W., Jash, A., Sahoo, A., Kim, J.-E., Nam, J. H., & Im, S.-H. (2013) · Clinical Immunology · doi:10.1016/j.clim.2013.01.001 · Cited by 212

Emerging tendency towards autoimmune process in major depressive patients: A novel insight from Th17 cells

Chen, Y., Jiang, T., Chen, P., Ouyang, J., Xu, G., Zeng, Z., & Sun, Y. (2011) · Psychiatry Research · doi:10.1016/j.psychres.2010.10.029 · Cited by 209

Pericytes regulate vascular immune homeostasis in the CNS

Török, O., Schreiner, B., Schaffenrath, J., Tsai, H.-C., Maheshwari, U., Stifter, S. A., Welsh, C., Amorim, A., Sridhar, S., Utz, S. G., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2016587118 · Cited by 166

Melanoma cell adhesion molecule identifies encephalitogenic T lymphocytes and promotes their recruitment to the central nervous system

Larochelle, C., Cayrol, R., Kebir, H., Alvarez, J. I., Lécuyer, M.-A., Ifergan, I., Viel, É., Bourbonnière, L., Beauseigle, D., Terouz, S., et al. (2012) · Brain · doi:10.1093/brain/aws212 · Cited by 145

β-Synuclein-reactive T cells induce autoimmune CNS grey matter degeneration

Lodygin, D., Hermann, M., Schweingruber, N., Flügel-Koch, C., Watanabe, T., Schlosser, C., Merlini, A., Körner, H., Chang, H.-F., Fischer, H. J., et al. (2019) · Nature · doi:10.1038/s41586-019-0964-2 · Cited by 140

Genome-wide association study of severity in multiple sclerosis

International Multiple Sclerosis Genetics Consortium, Briggs, F. B. S., Shao, X., Goldstein, B. A., Oksenberg, J. R., Barcellos, L. F., & De Jager, P. L. (2011) · Genes & Immunity · doi:10.1038/gene.2011.34 · Cited by 120

Transfer of Myelin-Reactive Th17 Cells Impairs Endogenous Remyelination in the Central Nervous System of Cuprizone-Fed Mice

Baxi, E. G., DeBruin, J., Tosi, D. M., Grishkan, I. V., Smith, M. D., Kirby, L. A., Strasburger, H. J., Fairchild, A. N., Calabresi, P. A., & Gocke, A. R. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.3817-14.2015 · Cited by 103

Transcriptomics and proteomics reveal a cooperation between interferon and T-helper 17 cells in neuromyelitis optica

Agasing, A. M., Wu, Q., Khatri, B., Borisow, N., Ruprecht, K., Brandt, A. U., Gawde, S., Kumar, G., Quinn, J. L., Ko, R. M., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16625-7 · Cited by 98

T Cells Specifically Targeted to Amyloid Plaques Enhance Plaque Clearance in a Mouse Model of Alzheimer's Disease

Fisher, Y., Nemirovsky, A., Baron, R., & Monsonego, A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010830 · Cited by 83

Adoptive transfer of cytokine‐induced immunomodulatory adult microglia attenuates experimental autoimmune encephalomyelitis in DBA/1 mice

Zhang, X., Lund, H., Mia, S., Parsa, R., & Harris, R. A. (2014) · Glia · doi:10.1002/glia.22643 · Cited by 78

Plasma levels of IL-23 and IL-17 before and after antidepressant treatment in patients with major depressive disorder

Kim, J.-W., Kim, Y.-K., Hwang, J.-A., Yoon, H.-K., Ko, Y.-H., Han, C., Lee, H.-J., Ham, B.-J., & Lee, H. S. (2013) · Psychiatry Investigation · doi:10.4306/pi.2013.10.3.294 · Cited by 77

Association Between Serum MicroRNAs and Magnetic Resonance Imaging Measures of Multiple Sclerosis Severity

Regev, K., Healy, B. C., Khalid, F., Paul, A., Chu, R., Tauhid, S., Tummala, S., Diaz-Cruz, C., Raheja, R., Mazzola, M. A., et al. (2017) · JAMA Neurology · doi:10.1001/jamaneurol.2016.5197 · Cited by 68

Helminth infection in populations undergoing epidemiological transition: a friend or foe?

Wiria, A. E., Djuardi, Y., Supali, T., Sartono, E., & Yazdanbakhsh, M. (2012) · Seminars in Immunopathology · doi:10.1007/s00281-012-0358-0 · Cited by 54

Innate immune responses in central nervous system inflammation

Finsen, B., & Owens, T. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.05.030 · Cited by 50

Caveolin-1 Is Critical for Lymphocyte Trafficking into Central Nervous System during Experimental Autoimmune Encephalomyelitis

Wu, H., Deng, R., Chen, X., Wong, W. C., Chen, H., Gao, L., Nie, Y., Wu, W., & Shen, J. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.3734-15.2016 · Cited by 49

Janus‐like effects of type I interferon in autoimmune diseases

Axtell, R. C., & Raman, C. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01131.x · Cited by 47

Celastrol suppresses experimental autoimmune encephalomyelitis via MAPK/SGK1-regulated mediators of autoimmune pathology

Venkatesha, S. H., & Moudgil, K. D. (2019) · Inflammation Research · doi:10.1007/s00011-019-01219-x · Cited by 36

Methylprednisolone inhibits IFN-γ and IL-17 expression and production by cells infiltrating central nervous system in experimental autoimmune encephalomyelitis

Miljković, Ž., Momčilović, M., Miljković, D., & Mostarica-Stojković, M. (2009) · Journal of Neuroinflammation · doi:10.1186/1742-2094-6-37 · Cited by 35

IL-17 Exerts Anti-Apoptotic Effect via miR-155-5p Downregulation in Experimental Autoimmune Encephalomyelitis

Ksiazek-Winiarek, D., Szpakowski, P., Turniak, M., Szemraj, J., & Glabinski, A. (2017) · Journal of Molecular Neuroscience · doi:10.1007/s12031-017-0981-2 · Cited by 26

Identification of an Epitope from Adenine Nucleotide Translocator 1 That Induces Inflammation in Heart in A/J Mice

Basavalingappa, R. H., Massilamany, C., Krishnan, B., Gangaplara, A., Kang, G., Khalilzad-Sharghi, V., Han, Z., Othman, S., Li, Q., Riethoven, J.-J., et al. (2016) · The American Journal of Pathology · doi:10.1016/j.ajpath.2016.08.005 · Cited by 17

The Alzheimer’s Disease–Associated Protein BACE1 Modulates T Cell Activation and Th17 Function

Hernandez-Mir, G., Raphael, I., Revu, S., Poholek, C. H., Avery, L., Hawse, W. F., Kane, L. P., & McGeachy, M. J. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1800363 · Cited by 14