BMP-7 counteracts TGF-β1–induced epithelial-to-mesenchymal transition and reverses chronic renal injury

The basics of epithelial-mesenchymal transition

Kalluri, R., & Weinberg, R. A. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39104 · Cited by 10,196

Microenvironmental regulation of tumor progression and metastasis

Quail, D. F., & Joyce, J. A. (2013) · Nature Medicine · doi:10.1038/nm.3394 · Cited by 7,994

EMT: 2016

Nieto, M. A., Huang, R. Y.-J., Jackson, R. A., & Thiery, J. P. (2016) · Cell · doi:10.1016/j.cell.2016.06.028 · Cited by 4,492

Fibroblasts in cancer

Kalluri, R., & Zeisberg, M. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1877 · Cited by 4,538

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

Wynn, T. A., & Ramalingam, T. R. (2012) · Nature Medicine · doi:10.1038/nm.2807 · Cited by 3,541

TGF-β: the master regulator of fibrosis

Meng, X.-M., Nikolic-Paterson, D. J., & Lan, H. Y. (2016) · Nature Reviews Nephrology · doi:10.1038/nrneph.2016.48 · Cited by 3,528

Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

Friedman, S. L. (2008) · Physiological Reviews · doi:10.1152/physrev.00013.2007 · Cited by 2,842

Biomarkers for epithelial-mesenchymal transitions

Zeisberg, M., & Neilson, E. G. (2009) · Journal of Clinical Investigation · doi:10.1172/jci36183 · Cited by 2,299

Pathogenesis of Liver Fibrosis

Hernandez-Gea, V., & Friedman, S. L. (2011) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-011110-130246 · Cited by 1,809

Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development

Kang, H. M., Ahn, S. H., Choi, P., Ko, Y.-A., Han, S. H., Chinga, F., Park, A. S. D., Tao, J., Sharma, K., Pullman, J., et al. (2015) · Nature Medicine · doi:10.1038/nm.3762 · Cited by 1,555

Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix

Kim, K. K., Kugler, M. C., Wolters, P. J., Robillard, L., Galvez, M. G., Brumwell, A. N., Sheppard, D., & Chapman, H. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605669103 · Cited by 1,257

Cardiac fibrosis

Frangogiannis, N. G. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvaa324 · Cited by 1,229

New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure

Tseng, Y.-H., Kokkotou, E., Schulz, T. J., Huang, T. L., Winnay, J. N., Taniguchi, C. M., Tran, T. T., Suzuki, R., Espinoza, D. O., Yamamoto, Y., et al. (2008) · Nature · doi:10.1038/nature07221 · Cited by 1,099

Discovery of Endothelial to Mesenchymal Transition as a Source for Carcinoma-Associated Fibroblasts

Zeisberg, E. M., Potenta, S., Xie, L., Zeisberg, M., & Kalluri, R. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-3127 · Cited by 1,011

TGF-β signaling in health and disease

Massagué, J., & Sheppard, D. (2023) · Cell · doi:10.1016/j.cell.2023.07.036 · Cited by 890

Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-β as major players and therapeutic targets

Gressner, A. M., & Weiskirchen, R. (2006) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2006.tb00292.x · Cited by 718

Galectin-3 Expression and Secretion Links Macrophages to the Promotion of Renal Fibrosis

Henderson, N. C., Mackinnon, A. C., Farnworth, S. L., Kipari, T., Haslett, C., Iredale, J. P., Liu, F.-T., Hughes, J., & Sethi, T. (2008) · The American Journal of Pathology · doi:10.2353/ajpath.2008.070726 · Cited by 562

Development of TGF-β signalling inhibitors for cancer therapy

Yingling, J. M., Blanchard, K. L., & Sawyer, J. S. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1580 · Cited by 549

Smad3-Mediated Upregulation of miR-21 Promotes Renal Fibrosis

Zhong, X., Chung, A. C. K., Chen, H.-Y., Meng, X.-M., & Lan, H. Y. (2011) · Journal of the American Society of Nephrology · doi:10.1681/asn.2010111168 · Cited by 409

MicroRNAs in kidney physiology and disease

Trionfini, P., Benigni, A., & Remuzzi, G. (2015) · Nature Reviews Nephrology · doi:10.1038/nrneph.2014.202 · Cited by 353

Liver fibrosis: cellular mechanisms of progression and resolution

Henderson, N. C., & Iredale, J. P. (2007) · Clinical Science · doi:10.1042/cs20060242 · Cited by 270

Connective tissue growth factor: a fibrogenic master switch in fibrotic liver diseases

Gressner, O. A., & Gressner, A. M. (2008) · Liver International · doi:10.1111/j.1478-3231.2008.01826.x · Cited by 270

Pathophysiology of the Diabetic Kidney

Vallon, V., & Komers, R. (2011) · Comprehensive Physiology · doi:10.1002/cphy.c100049 · Cited by 259

Asbestos-induced lung diseases: an update

Kamp, D. W. (2009) · Translational Research · doi:10.1016/j.trsl.2009.01.004 · Cited by 251

Epithelial-mesenchymal transition: From molecular mechanisms, redox regulation to implications in human health and disease

Cannito, S., Novo, E., di Bonzo, L. V., Busletta, C., Colombatto, S., & Parola, M. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2737 · Cited by 239

Yap/Taz deletion in Gli(+) cell-derived myofibroblasts attenuates fibrosis

Liang, M., Yu, M., Xia, R., Song, K., Wang, J., Luo, J., Chen, G., & Cheng, J. (2017) · Journal of the American Society of Nephrology · doi:10.1681/asn.2015121354 · Cited by 169

Animal models of intestinal fibrosis: new tools for the understanding of pathogenesis and therapy of human disease

Rieder, F., Kessler, S., Sans, M., & Fiocchi, C. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00059.2012 · Cited by 135

BMPs functionally replace Klf4 and support efficient reprogramming of mouse fibroblasts by Oct4 alone

Chen, J., Liu, J., Yang, J., Chen, Y., Chen, J., Ni, S., Song, H., Zeng, L., Ding, K., & Pei, D. (2011) · Cell Research · doi:10.1038/cr.2010.172 · Cited by 124

Bone morphogenetic protein 7 (BMP7) reverses obesity and regulates appetite through a central mTOR pathway

Townsend, K. L., Suzuki, R., Huang, T. L., Jing, E., Schulz, T. J., Lee, K., Taniguchi, C. M., Espinoza, D. O., McDougall, L. E., Zhang, H., et al. (2012) · The FASEB Journal · doi:10.1096/fj.11-199067 · Cited by 105

Epithelial-to-mesenchymal transition and chronic allograft tubulointerstitial fibrosis

Bedi, S., Vidyasagar, A., & Djamali, A. (2008) · Transplantation Reviews · doi:10.1016/j.trre.2007.09.004 · Cited by 100

A small population of liver endothelial cells undergoes endothelial-to-mesenchymal transition in response to chronic liver injury

Ribera, J., Pauta, M., Melgar-Lesmes, P., Córdoba, B., Bosch, A., Calvo, M., Rodrigo-Torres, D., Sancho-Bru, P., Mira, A., Jiménez, W., et al. (2017) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00428.2016 · Cited by 64

Ultrasound triggered topical delivery of Bmp7 mRNA for white fat browning induction via engineered smart exosomes

Guo, Y., Wan, Z., Zhao, P., Wei, M., Liu, Y., Bu, T., Sun, W., Li, Z., & Yuan, L. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-01145-3 · Cited by 60

The effects of polydeoxyribonucleotide on wound healing and tissue regeneration: a systematic review of the literature

Colangelo, M. T., Galli, C., & Guizzardi, S. (2020) · Regenerative Medicine · doi:10.2217/rme-2019-0118 · Cited by 59

Bone morphogenetic proteins and growth differentiation factors as drug targets in cardiovascular and metabolic disease

Tobin, J. F., & Celeste, A. J. (2006) · Drug Discovery Today · doi:10.1016/j.drudis.2006.03.016 · Cited by 50

Nephrocan, a Novel Member of the Small Leucine-rich Repeat Protein Family, Is an Inhibitor of Transforming Growth Factor-β Signaling

Mochida, Y., Parisuthiman, D., Kaku, M., Hanai, J.-I., Sukhatme, V. P., & Yamauchi, M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604787200 · Cited by 34

Candidate rejuvenating factor GDF11 and tissue fibrosis: friend or foe?

Frohlich, J., & Vinciguerra, M. (2020) · GeroScience · doi:10.1007/s11357-020-00279-w · Cited by 28

Pharmacological induction of hypoxia-inducible transcription factor ARNT attenuates chronic kidney failure

Tampe, B., Tampe, D., Nyamsuren, G., Klöpper, F., Rapp, G., Kauffels, A., Lorf, T., Zeisberg, E. M., Müller, G. A., Kalluri, R., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci89632 · Cited by 24

BMP7-Loaded Human Umbilical Cord Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Ameliorate Liver Fibrosis by Targeting Activated Hepatic Stellate Cells

Zhu, D., Sun, Z., Wei, J., Zhang, Y., An, W., Lin, Y., & Li, X. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s450284 · Cited by 17

Mesenchymal‐like pancreatic cancer cells harbor specific genomic alterations more frequently than their epithelial‐like counterparts

Sinha, A., Cherba, D., Bartlam, H., Lenkiewicz, E., Evers, L., Barrett, M. T., & Haab, B. B. (2014) · Molecular Oncology · doi:10.1016/j.molonc.2014.04.007 · Cited by 11

Modulation of phosphatase of regenerating liver-1 within placental mesenchymal stem cells instigates the transition between epithelial-to-mesenchymal transition and mesenchymal-to-epithelial transition subsequent to hepatic fibrosis

Kim, J. Y., Park, H., Park, S. Y., Kim, S. H., Lim, J. Y., Lee, K. S., Bae, S. H., & Kim, G. J. (2025) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2024.0741 · Cited by 7