Cited by 1,800RNA Interference and Gene DeliveryNanoparticle-Based Drug DeliveryDendrimers and Hyperbranched Polymers

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Delivery materials for siRNA therapeutics

Kanasty, Rosemary, Dorkin, Joseph Robert, Vegas, Arturo, Anderson, Daniel·2013·Nature Materials

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Abstract

RNA interference (RNAi) has broad potential as a therapeutic to reversibly silence any gene. To achieve the clinical potential of RNAi, delivery materials are required to transport short interfering RNA (siRNA) to the site of action in the cells of target tissues. This Review provides an introduction to the biological challenges that siRNA delivery materials aim to overcome, as well as a discussion of the way that the most effective and clinically advanced classes of siRNA delivery systems, including lipid nanoparticles and siRNA conjugates, are designed to surmount these challenges. The systems that we discuss are diverse in their approaches to the delivery problem, and provide valuable insight to guide the design of future siRNA delivery materials.

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Authors: Kanasty, R., Dorkin, J. R., Vegas, A., & Anderson, D.
Affiliations: Koch Institute for Integrative Cancer Research At MIT (US)
Boston Children's Hospital (US)
Corresponding author: Anderson, Daniel
ORCID: Vegas, Arturo
Anderson, Daniel
Venue: Nature Materials
Publisher: Springer Science and Business Media LLC
Published: 2013-10-23
Volume: 12
Issue: 11
Pages: 967-977
ISSN: 1476-1122 (ISSN-L)
1476-4660
DOI: 10.1038/nmat3765
OpenAlex: W1995770815
Cited by: 1,800
References: 113
Citations by year: 2026: 77 · 2025: 103 · 2024: 111 · 2023: 138 · 2022: 139 · 2021: 148 · 2020: 159 · 2019: 129 · 2018: 164 · 2017: 151 · 2016: 183 · 2015: 179 · 2014: 114 · 2013: 4
FWCI: 15.04
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Materials (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
Keywords: siRNA delivery, RNA interference therapy, lipid nanoparticles, siRNA conjugates, gene silencing, drug delivery materials
MeSH terms: Animals, Drug Carriers, Humans, RNA, Small Interfering, Nanoparticles

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