Delivery materials for siRNA therapeutics

Atomic structure and chemistry of human serum albumin

He, X. M., & Carter, D. C. (1992) · Nature · doi:10.1038/358209a0 · Cited by 3,833

Factors affecting the clearance and biodistribution of polymeric nanoparticles

Alexis, F., Pridgen, E., Molnar, L. K., & Farokhzad, O. C. (2008) · Molecular Pharmaceutics · doi:10.1021/mp800051m · Cited by 3,699

Strategies in the design of nanoparticles for therapeutic applications

Petros, R. A., & DeSimone, J. M. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd2591 · Cited by 3,651

RNA interference

Hannon, G. J. (2002) · Nature · doi:10.1038/418244a · Cited by 3,651

Knocking down barriers: advances in siRNA delivery

Whitehead, K. A., Langer, R., & Anderson, D. G. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2742 · Cited by 3,115

Asymmetry in the Assembly of the RNAi Enzyme Complex

Schwarz, D. S., Hutvágner, G., Du, T., Xu, Z., Aronin, N., & Zamore, P. D. (2003) · Cell · doi:10.1016/s0092-8674(03)00759-1 · Cited by 2,922

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

Davis, M. E., Zuckerman, J. E., Choi, C. H. J., Seligson, D. B., Tolcher, A. W., Alabi, C. A., Yen, Y., Heidel, J. D., & Ribas, A. (2010) · Nature · doi:10.1038/nature08956 · Cited by 2,541

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

Soutschek, J., Akinc, A., Bramlage, B., Charissé, K., Constien, R., Donoghue, M., Elbashir, S. M., Geick, A., Hadwiger, P., Harborth, J., et al. (2004) · Nature · doi:10.1038/nature03121 · Cited by 2,206

Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface

Salvati, A., Pitek, A. S., Monopoli, M. P., Prapainop, K., Bombelli, F. B., Hristov, D. R., Kelly, P. M., Åberg, C., Mahon, E., & Dawson, K. A. (2013) · Nature Nanotechnology · doi:10.1038/nnano.2012.237 · Cited by 1,912

Phenotypic Heterogeneity of the Endothelium

Aird, W. C. (2007) · Circulation Research · doi:10.1161/01.res.0000255691.76142.4a · Cited by 1,824

The potential for targeted rewriting of epigenetic marks in COPD as a new therapeutic approach

Wu, D., Song, J., Bartel, S., Krauss‐Etschmann, S., Rots, M. G., & Hylkema, M. N. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.08.007 · Cited by 50

Efficient and targeted drug/siRNA co-delivery mediated by reversibly crosslinked polymersomes toward anti-inflammatory treatment of ulcerative colitis (UC)

Xu, X., Yang, W., Liang, Q., Shi, Y., Zhang, W., Wang, X., Meng, F., Zhong, Z., & Yin, L. (2019) · Nano Research · doi:10.1007/s12274-019-2274-2 · Cited by 49

Improving Tumor Accumulation of Aptamers by Prolonged Blood Circulation

Ding, D., Cai, Y., Lv, C., Li, J., & Tan, W. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.9b05878 · Cited by 49

Non-Coding RNAs and SARS-Related Coronaviruses

Henzinger, H., Barth, D. A., Klec, C., & Pichler, M. (2020) · Viruses · doi:10.3390/v12121374 · Cited by 49

Overcoming T Cell Exhaustion via Immune Checkpoint Modulation with a Dendrimer‐Based Hybrid Nanocomplex

Gao, Y., Ouyang, Z., Yang, C., Song, C., Jiang, C., Song, S., Shen, M., & Shi, X. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202100833 · Cited by 48

Advances and applications of RNA vaccines in tumor treatment

Yang, R., & Cui, J. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02141-5 · Cited by 48

Bolaamphiphiles as carriers for siRNA delivery: From chemical syntheses to practical applications

Gupta, K., Afonin, K. A., Viard, M., Herrero, V., Kasprzak, W. K., Kagiampakis, I., Kim, T., Koyfman, A. Y., Puri, A., Stepler, M., et al. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.06.041 · Cited by 48

Single-component self-assembled RNAi nanoparticles functionalized with tumor-targeting iNGR delivering abundant siRNA for efficient glioma therapy

An, S., Jiang, X., Shi, J., He, X., Li, J., Guo, Y., Zhang, Y., Ma, H., Lü, Y., & Jiang, C. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.02.084 · Cited by 48

Polynucleotides in cellular mimics: Coacervates and lipid vesicles

Vieregg, J., & Tang, T. ‐. D. (2016) · Current Opinion in Colloid & Interface Science · doi:10.1016/j.cocis.2016.09.004 · Cited by 49

Systemic Delivery of Folate-PEG siRNA Lipopolyplexes with Enhanced Intracellular Stability forIn VivoGene Silencing in Leukemia

Lee, D.-J., Kessel, E., Lehto, T., Liu, X., Yoshinaga, N., Padari, K., Chen, Y., Kempter, S., Uchida, S., Rädler, J. O., et al. (2017) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.7b00383 · Cited by 48

Engineered exosomes as drug and RNA co-delivery system: new hope for enhanced therapeutics?

Chen, H., Yao, H., Chi, J., Li, C., Liu, Y., Jiayi, Y., Yu, J., Wang, J., Ruan, Y., Pi, J., et al. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1254356 · Cited by 48

Immune checkpoint inhibitors in cancer therapy: what lies beyond monoclonal antibodies?

Zamani, M. R., & Šácha, P. (2025) · Medical Oncology · doi:10.1007/s12032-025-02822-1 · Cited by 51

Aerosol Delivery of siRNA to the Lungs. Part 1: Rationale for Gene Delivery Systems

Youngren-Ortiz, S. R., Gandhi, N. S., España‐Serrano, L., & Chougule, M. B. (2015) · KONA Powder and Particle Journal · doi:10.14356/kona.2016014 · Cited by 49

Targetable micelleplex hydrogel for long-term, effective, and systemic siRNA delivery

Kim, Y., & Song, S. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.05.070 · Cited by 47

Oligonucleotide Therapy for Obstructive and Restrictive Respiratory Diseases

Liao, W., Dong, J., Peh, H. Y., Tan, L., Lim, K., Li, L., & Wong, W. S. F. (2017) · Molecules · doi:10.3390/molecules22010139 · Cited by 47

An injectable supramolecular self-healing bio-hydrogel with high stretchability, extensibility and ductility, and a high swelling ratio

Zhu, S., Wang, J., Yan, H., Wang, Y., Zhao, Y., Feng, B., Duan, K., & Weng, J. (2017) · Journal of Materials Chemistry B · doi:10.1039/c7tb01183k · Cited by 47

An RNA Origami Octahedron with Intrinsic siRNAs for Potent Gene Knockdown

Høiberg, H. C., Sparvath, S. M., Andersen, V. L., Kjems, J., & Andersen, E. S. (2018) · Biotechnology Journal · doi:10.1002/biot.201700634 · Cited by 48

Photostable and Biocompatible Fluorescent Silicon Nanoparticles for Imaging-Guided Co-Delivery of siRNA and Doxorubicin to Drug-Resistant Cancer Cells

Guo, D., Ji, X., Fei, P., Zhong, Y., Chu, B., Su, Y., & He, Y. (2019) · Nano-Micro Letters · doi:10.1007/s40820-019-0257-1 · Cited by 48

Leading RNA Interference Therapeutics Part 1: Silencing Hereditary Transthyretin Amyloidosis, with a Focus on Patisiran

Titze-de-Almeida, S. S., Brandão, P. R. D. P., Faber, I., & Titze‐de‐Almeida, R. (2019) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-019-00434-w · Cited by 49

Efficient and tumor-specific knockdown of MTDH gene attenuates paclitaxel resistance of breast cancer cells both in vivo and in vitro

Liu, Y., Tian, Y., Leong, W. S., Song, H., Yang, W., Wang, M., Wang, X., Kong, J., Shan, B., & Song, Z. (2018) · Breast Cancer Research · doi:10.1186/s13058-018-1042-7 · Cited by 47

Organ/Cell-Selective Intracellular Delivery of Biologics via N-Acetylated Galactosamine-Functionalized Polydisulfide Conjugates

Lu, J., Dai, Y., He, Y., Zhang, T., Zhang, J., Chen, X., Jiang, C., & Lu, H. (2024) · Journal of the American Chemical Society · doi:10.1021/jacs.3c11914 · Cited by 47

Live cell imaging of duplex siRNA intracellular trafficking

Hirsch, M., & Helm, M. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv307 · Cited by 46

Therapeutic Applications of Spherical Nucleic Acids

Barnaby, S. N., Sita, T. L., Petrosko, S. H., Stegh, A. H., & Mirkin, C. A. (2015) · Cancer treatment and research · doi:10.1007/978-3-319-16555-4_2 · Cited by 46

Fine-tuned PEGylation of chitosan to maintain optimal siRNA-nanoplex bioactivity

Guţoaia, A., Schuster, L., Margutti, S., Laufer, S., Schlosshauer, B., Krastev, R., Stoll, D., & Hartmann, H. (2016) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2016.01.010 · Cited by 46

Tumoral gene silencing by receptor-targeted combinatorial siRNA polyplexes

Lee, D.-J., He, D., Kessel, E., Padari, K., Kempter, S., Lächelt, U., Rädler, J. O., Pooga, M., & Wagner, E. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.06.011 · Cited by 46

Deformable Discoidal Polymeric Nanoconstructs for the Precise Delivery of Therapeutic and Imaging Agents

Palange, A. L., Palomba, R., Rizzuti, I. F., Ferreira, M. F. M. M., & Decuzzi, P. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2017.02.012 · Cited by 46

Recent Advances in Nanomedicine and Survivin Targeting in Brain Cancers

Mazur, J., Roy, K., & Kanwar, J. R. (2017) · Nanomedicine · doi:10.2217/nnm-2017-0286 · Cited by 47

Neutralization of negative charges of siRNA results in improved safety and efficient gene silencing activity of lipid nanoparticles loaded with high levels of siRNA

Sato, Y., Matsui, H., Sato, R., & Harashima, H. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.06.017 · Cited by 46

Expert perspectives on potential environmental risks from nanomedicines and adequacy of the current guideline on environmental risk assessment

Mahapatra, I., Clark, J. R. A., Dobson, P. J., Owen, R., Lynch, I., & Lead, J. R. (2018) · Environmental Science Nano · doi:10.1039/c8en00053k · Cited by 47

Transfection by cationic gemini lipids and surfactants

Damen, M., Groenen, A., van Dongen, S. F. M., Nolte, R. J. M., Scholte, B. J., & Feiters, M. C. (2018) · MedChemComm · doi:10.1039/c8md00249e · Cited by 46

Design, mechanism, delivery and therapeutics of canonical and Dicer-substrate siRNA

Raja, M. A. G., Katas, H., & Amjad, M. W. (2019) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2018.12.005 · Cited by 46

Reactive Oxygen Species (ROS)-Degradable Polymeric Nanoplatform for Hypoxia-Targeted Gene Delivery: Unpacking DNA and Reducing Toxicity

Zhang, Y., Zhou, J., Ma, S., He, Y., Yang, J., & Gu, Z. (2019) · Biomacromolecules · doi:10.1021/acs.biomac.9b00054 · Cited by 46

A Multifunction Lipid-Based CRISPR-Cas13a Genetic Circuit Delivery System for Bladder Cancer Gene Therapy

Fan, J., Liu, Y., Liu, L., Huang, Y., Li, X., & Huang, W. (2019) · ACS Synthetic Biology · doi:10.1021/acssynbio.9b00349 · Cited by 46

Reductive Decationizable Block Copolymers for Stimuli-Responsive mRNA Delivery

Nuhn, L., Kaps, L., Diken, M., Schuppan, D., & Zentel, R. (2016) · Macromolecular Rapid Communications · doi:10.1002/marc.201600046 · Cited by 46

Engineered polymeric nanoparticles to guide the cellular internalization and trafficking of small interfering ribonucleic acids

Arnold, A. E., Czupiel, P., & Shoichet, M. S. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.02.019 · Cited by 46

The Role of Long Non-Coding RNAs in Thyroid Cancer

Peng, X., Zhang, K., Ma, L., Xu, J., & Chang, W. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00941 · Cited by 45

Fusogenic Coiled-Coil Peptides Enhance Lipid Nanoparticle-Mediated mRNA Delivery upon Intramyocardial Administration

Zeng, Y., Sentí, M. E., Labonia, M. C. I., Papadopoulou, P., Brans, M. A. D., Dokter, I., Fens, M. H. A. M., van Mil, A., Sluijter, J. P. G., Schiffelers, R. M., et al. (2023) · ACS Nano · doi:10.1021/acsnano.3c05341 · Cited by 48

Clustering Small Dendrimers into Nanoaggregates for Efficient DNA and siRNA Delivery with Minimal Toxicity

Liu, C., Shao, N., Wang, Y., & Cheng, Y. (2016) · Advanced Healthcare Materials · doi:10.1002/adhm.201500679 · Cited by 45

Diamond‐Nanoneedle‐Array‐Facilitated Intracellular Delivery and the Potential Influence on Cell Physiology

Zhu, X. A., Yuen, M., Yan, L., Zhang, Z., Ai, F., Yang, Y., Yu, K. N., Zhu, G., Zhang, W., & Chen, X. (2016) · Advanced Healthcare Materials · doi:10.1002/adhm.201500990 · Cited by 46

Targeted delivery of CXCR4-siRNA by scFv for HER2+ breast cancer therapy

Jiang, K., Li, J., Yin, J., Ma, Q., Yan, B., Zhang, X., Wang, L., Wang, L., Liu, T., Zhang, Y., et al. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.04.030 · Cited by 46

Targeted si-RNA with liposomes and exosomes (extracellular vesicles): How to unlock the potential

Antimisiaris, S. G., Mourtas, S., & Παπαδιά, Κ. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.01.056 · Cited by 46

Tuned Density of Anti-Tissue Factor Antibody Fragment onto siRNA-Loaded Polyion Complex Micelles for Optimizing Targetability into Pancreatic Cancer Cells

Min, H. S., Kim, H. J., Ahn, J., Naito, M., Hayashi, K., Toh, K., Kim, B. S., Matsumura, Y., Kwon, I. C., Miyata, K., et al. (2018) · Biomacromolecules · doi:10.1021/acs.biomac.8b00507 · Cited by 45

Systemic siRNA delivery to tumors by cell-penetrating α-helical polypeptide-based metastable nanoparticles

Liu, Y., Song, Z., Zheng, N., Nagasaka, K., Yin, L., & Cheng, J. (2018) · Nanoscale · doi:10.1039/c8nr03976c · Cited by 45

Nucleic Acid Nanomedicines in Phase II/III Clinical Trials: Translation of Nucleic Acid Therapies for Reprogramming Cells

Herrera, V. L. M., Colby, A. H., Ruiz‐Opazo, N., Coleman, D. G., & Grinstaff, M. W. (2018) · Nanomedicine · doi:10.2217/nnm-2018-0122 · Cited by 45

Efficient and Innocuous Delivery of Small Interfering RNA to Microglia Using an Amphiphilic Dendrimer Nanovector

Ellert‐Miklaszewska, A., Ochocka, N., Maleszewska, M., Ding, L., Laurini, E., Jiang, Y., Roura, A.-J., Giorgio, S., Gielniewski, B., Pricl, S., et al. (2019) · Nanomedicine · doi:10.2217/nnm-2019-0176 · Cited by 50

Advances in siRNA delivery strategies for the treatment of MDR cancer

Subhan, M. A., Attia, S. A., & Torchilin, V. P. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119337 · Cited by 46

Nanotechnology-enabled gene delivery for cancer and other genetic diseases

Jiang, T., Gonzalez, K. M., Cordova, L. E., & Lu, J. (2023) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2023.2200246 · Cited by 45

Strategy for selecting nanotechnology carriers to overcome immunological and hematological toxicities challenging clinical translation of nucleic acid-based therapeutics

Dobrovolskaia, M. A., & McNeil, S. E. (2015) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2015.1042857 · Cited by 44

Uptake Mechanism and Direct Translocation of a New CPP for siRNA Delivery

Ran, P., Xu, W., Ding, Y., Lu, S., & Chen, P. (2016) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.6b00030 · Cited by 44

DNA micelles as nanoreactors: efficient DNA functionalization with hydrophobic organic molecules

Trinh, T., Chidchob, P., Bazzi, H. S., & Sleiman, H. F. (2016) · Chemical Communications · doi:10.1039/c6cc04970b · Cited by 44

Nanotechnology in Healthcare: Applications and Challenges

Patel, S., & Nanda, R. (2015) · Medicinal Chemistry · doi:10.4172/2161-0444.1000312 · Cited by 44

Gold nanorod embedded large-pore mesoporous organosilica nanospheres for gene and photothermal cooperative therapy of triple negative breast cancer

Ni, Q., Teng, Z., Dang, M., Tian, Y., Zhang, Y., Huang, P., Su, X., Lu, N., Yang, Z., Tian, W., et al. (2016) · Nanoscale · doi:10.1039/c6nr07598c · Cited by 44

Chemical modulation of siRNA lipophilicity for efficient delivery

Tai, W. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.06.022 · Cited by 45

Lipid‐Modified Aminoglycosides for mRNA Delivery to the Liver

Yu, X., Liu, S., Cheng, Q., Wei, T., Lee, S. M., Zhang, D., & Siegwart, D. J. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.201901487 · Cited by 46

Local release of siRNA using polyplex-loaded thermosensitive hydrogels

Fliervoet, L. A. L., Zhang, H., van Groesen, E., Fortuin, K., Duin, N. J. C. B., Remaut, K., Schiffelers, R. M., Hennink, W. E., & Vermonden, T. (2020) · Nanoscale · doi:10.1039/d0nr03147j · Cited by 44

Targeted nanomedicines for the treatment of bone disease and regeneration

Ordikhani, F., Zandi, N., Mazaheri, M., Luther, G. A., Ghovvati, M., Akbarzadeh, A., & Annabi, N. (2020) · Medicinal Research Reviews · doi:10.1002/med.21759 · Cited by 45

Targeted delivery systems of siRNA based on ionizable lipid nanoparticles and cationic polymer vectors

Yao, Z., Liu, T., Wang, J., Fu, Y., Zhao, J., Wang, X., Li, Y., Yang, X., & He, Z. (2025) · Biotechnology Advances · doi:10.1016/j.biotechadv.2025.108546 · Cited by 43

Micro-/nano-electroporation for active gene delivery

Yang, Z., Chang, L., Chiang, C., & Lee, L. J. (2015) · Current Pharmaceutical Design · doi:10.2174/1381612821666151027152121 · Cited by 43

Polymers modified with double-tailed fluorous compounds for efficient DNA and siRNA delivery

He, B., Wang, Y., Shao, N., Chang, H., & Cheng, Y. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.04.037 · Cited by 43

Advanced Strategies in Immune Modulation of Cancer Using Lipid-Based Nanoparticles

Mizrahy, S., Hazan‐Halevy, I., Landesman‐Milo, D., Ng, B. D., & Peer, D. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00069 · Cited by 44

Development of Cationic Quaternary Ammonium Sulfonamide Amino Lipids for Nucleic Acid Delivery

Miller, J. B., Kós, P., Tieu, V., Zhou, K., & Siegwart, D. J. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b15982 · Cited by 43

Structurally modulated codelivery of siRNA and Argonaute 2 for enhanced RNA interference

Li, J., Wu, C., Wang, W., He, Y., Elkayam, E., Joshua‐Tor, L., & Hammond, P. T. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1719565115 · Cited by 43

Reactive Oxygen Species (ROS)-Responsive Charge-Switchable Nanocarriers for Gene Therapy of Metastatic Cancer

Xiang, J., Liu, X., Zhou, Z., Zhu, D., Zhou, Q., Piao, Y., Jiang, L., Tang, J., Liu, X., & Shen, Y. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b13291 · Cited by 43

Synthetic miR-143 Exhibited an Anti-Cancer Effect via the Downregulation of K-RAS Networks of Renal Cell Cancer Cells In Vitro and In Vivo

Takai, T., Tsujino, T., Yoshikawa, Y., Inamoto, T., Sugito, N., Kuranaga, Y., Heishima, K., Soga, T., Hayashi, K., Miyata, K., et al. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2019.03.004 · Cited by 43

Targeting siRNA in colorectal cancer therapy: Nanotechnology comes into view

Aghamiri, S., Jafarpour, A., Malekshahi, Z. V., Gomari, M. M., & Negahdari, B. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28281 · Cited by 43

Mechanism of Dissociation Kinetics in Polyelectrolyte Complex Micelles

Wu, H., Ting, J., & Tirrell, M. (2020) · Macromolecules · doi:10.1021/acs.macromol.9b01814 · Cited by 43

RNA interference therapeutics targeting angiotensinogen ameliorate preeclamptic phenotype in rodent models

Haase, N., Foster, D. J., Cunningham, M., Bercher, J., Nguyen, T. M., Shulga‐Morskaya, S., Milstein, S., Shaikh, S., Rollins, J., Golić, M., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci99417 · Cited by 45

Increasing Angiogenesis Factors in Hypoxic Diabetic Wound Conditions by siRNA Delivery: Additive Effect of LbL-Gold Nanocarriers and Desloratadine-Induced Lysosomal Escape

Shaabani, E., Sharifiaghdam, M., Lammens, J., Keersmaecker, H. D., Vervaet, C., Beer, T. D., Motevaseli, E., Ghahremani, M. H., Mansouri, P., Smedt, S. C. D., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179216 · Cited by 43

Cationic Vesicles Based on Amphiphilic Pillar[5]arene Capped with Ferrocenium: A Redox‐Responsive System for Drug/siRNA Co‐Delivery

Chang, Y., Yang, K., Peng, W., Huang, S., Pei, Y., Zhao, W. M., & Pei, Z. (2014) · Angewandte Chemie · doi:10.1002/ange.201407272 · Cited by 43

Development of in silico methodology for siRNA lipid nanoparticle formulations

Gao, H., Kan, S., Ye, Z., Feng, Y., Jin, L., Zhang, X., Deng, J., Chan, G., Hu, Y., Wang, Y., et al. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.136310 · Cited by 43

Systemic siRNA Nanoparticle-Based Drugs Combined with Radiofrequency Ablation for Cancer Therapy

Ahmed, M., Kumar, G., Navarro, G., Wang, Y., Gourevitch, S., Moussa, M., Rozenblum, N., Levchenko, T. S., Galun, E., Torchilin, V. P., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0128910 · Cited by 42

Biomimetic nanoparticles for siRNA delivery in the treatment of leukaemia

Guo, J., Cahill, M. R., McKenna, S. L., & O’Driscoll, C. M. (2014) · Biotechnology Advances · doi:10.1016/j.biotechadv.2014.08.007 · Cited by 44

Biodegradable nanoparticle-mediated K-ras down regulation for pancreatic cancer gene therapy

Yang, C., Hu, R., Anderson, T., Wang, Y., Lin, G., Law, W., Lin, W.-J., Nguyen, Q. T., Toh, H. T., Yoon, H. S., et al. (2015) · Journal of Materials Chemistry B · doi:10.1039/c4tb01623h · Cited by 43

NANOMEDICINE: will it offer possibilities to overcome multiple drug resistance in cancer?

Friberg, S. G., & Nyström, A. M. (2016) · Journal of Nanobiotechnology · doi:10.1186/s12951-016-0172-2 · Cited by 43

Screening of efficient siRNA carriers in a library of surface-engineered dendrimers

Liu, H., Chang, H., Lv, J., Jiang, C., Li, Z., Wang, F., Wang, H., Wang, M., Liu, C., Wang, X., et al. (2016) · Scientific Reports · doi:10.1038/srep25069 · Cited by 43

The pH-Triggered Triblock Nanocarrier Enabled Highly Efficient siRNA Delivery for Cancer Therapy

Du, L., Zhou, J., Meng, L., Wang, X., Wang, C., Huang, Y., Zheng, S., Deng, L., Cao, H., Liang, Z., et al. (2017) · Theranostics · doi:10.7150/thno.20297 · Cited by 44

Controlling miRNA-like off-target effects of an siRNA with nucleobase modifications

Suter, S. R., Ball‐Jones, A. A., Mumbleau, M. M., Valenzuela, R., Ibarra‐Soza, J. M., Owens, H., Fisher, A. J., & Beal, P. A. (2017) · Organic & Biomolecular Chemistry · doi:10.1039/c7ob02654d · Cited by 42

Immunogenicity Testing of Lipidoids In Vitro and In Silico: Modulating Lipidoid-Mediated TLR4 Activation by Nanoparticle Design

de Groot, A. M., Thanki, K., Gangloff, M., Falkenberg, E., Zeng, X., Bijnen, D. C. J. V., van Eden, W., Franzyk, H., Nielsen, H. M., Broere, F., et al. (2018) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2018.02.003 · Cited by 42

Strategies for improving the safety and RNAi efficacy of noncovalent peptide/siRNA nanocomplexes

Wang, J., Chen, G., Liu, N., Han, X., Zhao, F. H., Zhang, L., & Chen, P. (2022) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2022.102638 · Cited by 42

Regulation of vascular smooth muscle cell autophagy by DNA nanotube-conjugated mTOR siRNA

You, Z., Qian, H., Wang, C., He, B., Yan, J., Mao, C., & Wang, G. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.07.015 · Cited by 42

MicroRNA target prediction using thermodynamic and sequence curves

Ghoshal, A., Shankar, R., Bagchi, S., Grama, A. Y., & Chaterji, S. (2015) · BMC Genomics · doi:10.1186/s12864-015-1933-2 · Cited by 41

Multifunctional nucleic acid nanostructures for gene therapies

Liu, J., Wang, Z., Zhao, S., & Ding, B. (2018) · Nano Research · doi:10.1007/s12274-018-2093-x · Cited by 41

Promising Applications of AIEgens in Animal Models

He, B., Situ, B., Zhao, Z., & Zheng, L. (2019) · Small Methods · doi:10.1002/smtd.201900583 · Cited by 41

An ionizable supramolecular dendrimer nanosystem for effective siRNA delivery with a favorable safety profile

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