Delivery materials for siRNA therapeutics

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Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface

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Clinical Advances of siRNA-Based Nanotherapeutics for Cancer Treatment

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Engineering functional inorganic–organic hybrid systems: advances in siRNA therapeutics

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Remote loading of preencapsulated drugs into stealth liposomes

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Chemical and structural modifications of RNAi therapeutics

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Optimization of Mesenchymal Stromal Cell (MSC) Manufacturing Processes for a Better Therapeutic Outcome

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siRNA Delivery with Chitosan: Influence of Chitosan Molecular Weight, Degree of Deacetylation, and Amine to Phosphate Ratio on in Vitro Silencing Efficiency, Hemocompatibility, Biodistribution, and in Vivo Efficacy

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Engineering Nanoparticles for Targeted Delivery of Nucleic Acid Therapeutics in Tumor

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Achieving the Promise of Therapeutic Extracellular Vesicles: The Devil is in Details of Therapeutic Loading

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Lipid Delivery Systems for Nucleic-Acid-Based-Drugs: From Production to Clinical Applications

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Milk exosomes with enhanced mucus penetrability for oral delivery of siRNA

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A Systematic Study of Unsaturation in Lipid Nanoparticles Leads to Improved mRNA Transfection In Vivo

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α-Globin as a molecular target in the treatment of β-thalassemia

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Major degradable polycations as carriers for DNA and siRNA

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MFN2-related neuropathies: Clinical features, molecular pathogenesis and therapeutic perspectives

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Cross-kingdom RNA trafficking and environmental RNAi for powerful innovative pre- and post-harvest plant protection

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Stimuli-Responsive Polymer–Prodrug Hybrid Nanoplatform for Multistage siRNA Delivery and Combination Cancer Therapy

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Smart pH-responsive nanomedicines for disease therapy

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Nanomaterials for Therapeutic RNA Delivery

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Enhanced BBB permeability of osmotically active poly(mannitol-co-PEI) modified with rabies virus glycoprotein via selective stimulation of caveolar endocytosis for RNAi therapeutics in Alzheimer's disease

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Redox-responsive polyprodrug nanoparticles for targeted siRNA delivery and synergistic liver cancer therapy

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Visualization of self-delivering hydrophobically modified siRNA cellular internalization

Ly, S., Navaroli, D. M., Didiot, M.-C., Cardia, J., Pandarinathan, L., Alterman, J. F., Fogarty, K., Standley, C., Lifshitz, L. M., Bellve, K. D., et al. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkw1005 · Cited by 132

Conjugated Polymer Nanoparticles for Fluorescence Imaging and Sensing of Neurotransmitter Dopamine in Living Cells and the Brains of Zebrafish Larvae

Qian, C., Zhu, S., Feng, P., Chen, Y., Yu, J., Tang, X., Liu, Y., & Shen, Q. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b04987 · Cited by 133

Systemic Delivery of Bc12‐Targeting siRNA by DNA Nanoparticles Suppresses Cancer Cell Growth

Rahman, M. A., Wang, P., Zhao, Z., Wang, D., Nannapaneni, S., Zhang, C., Chen, Z., Griffith, C. C., Hurwitz, S. J., Chen, Z. G., et al. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201709485 · Cited by 132

Bioinspired Core–Shell Nanoparticles for Hydrophobic Drug Delivery

Yang, G., Liu, Y., Wang, H., Wilson, R. J., Hui, Y., Yu, L., Wibowo, D., Zhang, C., Whittaker, A. K., Middelberg, A. P. J., et al. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201908357 · Cited by 132

Nanoplatforms for mRNA Therapeutics

Meng, C., Chen, Z., Li, G., Welte, T., & Shen, H. (2021) · Advanced Therapeutics · doi:10.1002/adtp.202000099 · Cited by 130

mRNA nanomedicine: Design and recent applications

Kubiatowicz, L. J., Mohapatra, A., Krishnan, N., Fang, R. H., & Zhang, L. (2022) · Exploration · doi:10.1002/exp.20210217 · Cited by 131

Lipid carriers for mRNA delivery

Zhang, W., Jiang, Y., He, Y., Boucetta, H., Wu, J., Chen, Z., & He, W. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.11.026 · Cited by 134

Emerging roles for RNA-binding proteins as effectors and regulators of cardiovascular disease

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Injectable and protease-degradable hydrogel for siRNA sequestration and triggered delivery to the heart

Wang, L. L., Chung, J. J., Li, E. C., Uman, S., Atluri, P., & Burdick, J. A. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.07.004 · Cited by 129

Photoactivatable Prodrug-Backboned Polymeric Nanoparticles for Efficient Light-Controlled Gene Delivery and Synergistic Treatment of Platinum-Resistant Ovarian Cancer

Zhang, Q., Kuang, G., He, S., Lu, H., Cheng, Y., Zhou, D., & Huang, Y. (2020) · Nano Letters · doi:10.1021/acs.nanolett.9b04981 · Cited by 129

microRNA-33 Regulates ApoE Lipidation and Amyloid-β Metabolism in the Brain

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Highly efficient siRNA delivery from core–shell mesoporous silica nanoparticles with multifunctional polymer caps

Möller, K., Müller, K., Engelke, H., Bräuchle, C., Wagner, E., & Bein, T. (2015) · Nanoscale · doi:10.1039/c5nr06246b · Cited by 133

Tumor Microenvironment-Responsive Multistaged Nanoplatform for Systemic RNAi and Cancer Therapy

Xu, X., Saw, P. E., Tao, W., Li, Y., Ji, X., Yu, M., Mahmoudi, M., Rasmussen, J., Ayyash, D., Zhou, Y., et al. (2017) · Nano Letters · doi:10.1021/acs.nanolett.7b01571 · Cited by 128

Customizable Lipid Nanoparticle Materials for the Delivery of siRNAs and mRNAs

Fenton, O. S., Kauffman, K. J., McClellan, R. L., Kaczmarek, J. C., Zeng, M. D., Andresen, J. L., Rhym, L. H., Heartlein, M. W., DeRosa, F., & Anderson, D. G. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201809056 · Cited by 129

DNA/RNA heteroduplex oligonucleotide for highly efficient gene silencing

Nishina, K., Piao, W., Yoshida‐Tanaka, K., Sujino, Y., Nishina, T., Yamamoto, T., Nitta, K., Yoshioka, K., Kuwahara, H., Yasuhara, H., et al. (2015) · Nature Communications · doi:10.1038/ncomms8969 · Cited by 128

Synthesis of siRNA nanoparticles to silence plaque-destabilizing gene in atherosclerotic lesional macrophages

Huang, X., Chuang, L. I. U., Kong, N., Xiao, Y., Yurdagul, A., Tabas, I. A., & Tao, W. (2022) · Nature Protocols · doi:10.1038/s41596-021-00665-4 · Cited by 126

Biomedical applications of mRNA nanomedicine

Xiong, Q., Lee, G. Y., Ding, J., Li, W., & Shi, J. (2018) · Nano Research · doi:10.1007/s12274-018-2146-1 · Cited by 125

Targeted fibrillar nanocarbon RNAi treatment of acute kidney injury

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A small molecule nanodrug consisting of amphiphilic targeting ligand–chemotherapy drug conjugate for targeted cancer therapy

Mou, Q., Ma, Y., Zhu, X., & Yan, D. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.03.037 · Cited by 126

Rational vaccinology with spherical nucleic acids

Wang, S., Qin, L., Yamankurt, G., Skakuj, K., Huang, Z. N., Chen, P., Dominguez, D., Lee, A., Zhang, B., & Mirkin, C. A. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1902805116 · Cited by 124

Delivering Nucleic‐Acid Based Nanomedicines on Biomaterial Scaffolds for Orthopedic Tissue Repair: Challenges, Progress and Future Perspectives

Raftery, R. M., Walsh, D. P., Castaño, I. M., Heise, A., Duffy, G. P., Cryan, S., & O’Brien, F. J. (2016) · Advanced Materials · doi:10.1002/adma.201505088 · Cited by 123

Imaging-guided delivery of RNAi for anticancer treatment

Wang, J., Mi, P., Lin, G., Wáng, Y. X. J., Liu, G., & Chen, X. S. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.01.008 · Cited by 123

Targeted delivery of siRNA to activated T cells via transferrin-polyethylenimine (Tf-PEI) as a potential therapy of asthma

Xie, Y., Kim, N. H., Nadithe, V., Schalk, D. L., Thakur, A. B., Kılıç, A., Lum, L. G., Bassett, D. J. P., & Merkel, O. M. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.03.029 · Cited by 125

Quantitative fluorescence spectroscopy and flow cytometry analyses of cell-penetrating peptides internalization pathways: optimization, pitfalls, comparison with mass spectrometry quantification

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Endosomal Escape and Cytosolic Penetration of Macromolecules Mediated by Synthetic Delivery Agents

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Binary Targeting of siRNA to Hematologic Cancer Cells In Vivo Using Layer‐by‐Layer Nanoparticles

Choi, K. Y., Correa, S., Min, J., Li, J., Roy, S., Laccetti, K. H., Dreaden, E. C., Kong, S. M., Heo, R., Roh, Y. H., et al. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201900018 · Cited by 120

Nanoparticle-encapsulated siRNAs for gene silencing in the haematopoietic stem-cell niche

Krohn-Grimberghe, M., Mitchell, M. J., Schloss, M. J., Khan, O. F., Courties, G., Guimarães, P. P. G., Rohde, D., Cremer, S., Kowalski, P. S., Sun, Y., et al. (2020) · Nature Biomedical Engineering · doi:10.1038/s41551-020-00623-7 · Cited by 123

RGD engineered dendrimer nanotherapeutic as an emerging targeted approach in cancer therapy

Sheikh, A., Md, S., & Kesharwani, P. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.10.028 · Cited by 119

A review on current status of antiviral siRNA

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Robotics, microfluidics, nanotechnology and AI in the synthesis and evaluation of liposomes and polymeric drug delivery systems

Egorov, E., Pieters, C., Korach-Rechtman, H., Shklover, J., & Schroeder, A. (2021) · Drug Delivery and Translational Research · doi:10.1007/s13346-021-00929-2 · Cited by 118

Highly effective inhibition of lung cancer growth and metastasis by systemic delivery of siRNA via multimodal mesoporous silica-based nanocarrier

Chen, Y., Gu, H., Zhang, D. S., Fan, L., Liu, T., & Xia, W. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.09.003 · Cited by 117

Conjugated polymer nanomaterials for theranostics

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Nucleic acid nanoassembly-enhanced RNA therapeutics and diagnosis

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Advances and challenges in targeting IRF5, a key regulator of inflammation

Almuttaqi, H., & Udalova, I. A. (2018) · FEBS Journal · doi:10.1111/febs.14654 · Cited by 116

Redox‐Responsive Nanoparticle‐Mediated Systemic RNAi for Effective Cancer Therapy

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Homotypic Targeting Delivery of siRNA with Artificial Cancer Cells

Zhang, L., Deng, S., Zhang, Y., Peng, Q., Li, H., Wang, P., Fu, X., Lei, X., Qin, A., & Yu, X. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.201900772 · Cited by 115

Pharmacokinetics and biodistribution of recently-developed siRNA nanomedicines

Park, J., Park, J., Pei, Y., Xu, J., & Yeo, Y. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.12.004 · Cited by 114

Engineered Hydrogels for Local and Sustained Delivery of RNA‐Interference Therapies

Wang, L. L., & Burdick, J. A. (2016) · Advanced Healthcare Materials · doi:10.1002/adhm.201601041 · Cited by 114

Cross-Kingdom Small RNAs among Animals, Plants and Microbes

Zeng, J., Gupta, V. K., Jiang, Y., Yang, B. J., Gong, L., & Zhu, H. M. (2019) · Cells · doi:10.3390/cells8040371 · Cited by 119

Current RNA-based Therapeutics in Clinical Trials

Zhou, L., Qin, Z., Zhu, Y., He, Z., & Xu, T. (2019) · Current Gene Therapy · doi:10.2174/1566523219666190719100526 · Cited by 118

Multicomponent Supramolecular Polymers as a Modular Platform for Intracellular Delivery

Bakker, M. H., Lee, C. C., Meijer, E. W., Dankers, P. Y. W., & Albertazzi, L. (2016) · ACS Nano · doi:10.1021/acsnano.5b05383 · Cited by 113

Dendrimers Show Promise for siRNA and microRNA Therapeutics

Dzmitruk, V., Apartsin, E. K., Ihnatsyeu-Kachan, A., Abashkin, V., Shcharbin, D., & Bryszewska, M. J. (2018) · Pharmaceutics · doi:10.3390/pharmaceutics10030126 · Cited by 113

Systemic mRNA delivery to the lungs by functional polyester-based carriers

Yan, Y., Xiong, H., Zhang, X., Cheng, Q., & Siegwart, D. J. (2017) · Biomacromolecules · doi:10.1021/acs.biomac.7b01356 · Cited by 111

Quantitating Endosomal Escape of a Library of Polymers for mRNA Delivery

Jiang, Y., Qiao, L., Wang, Y., Xu, E., Ho, A. S. L., Singh, P., Wang, Y., Jiang, Z., Yang, F., Tietjen, G. T., et al. (2020) · Nano Letters · doi:10.1021/acs.nanolett.9b04426 · Cited by 111

Cellular uptake behaviour, photothermal therapy performance, and cytotoxicity of gold nanorods with various coatings

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Cell penetrating peptide-modified poly(lactic-co-glycolic acid) nanoparticles with enhanced cell internalization

Steinbach-Rankins, J. M., Seo, Y.-E., & Saltzman, W. M. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.11.029 · Cited by 111

Systemic delivery of mRNA and DNA to the lung using polymer-lipid nanoparticles

Kaczmarek, J. C., Patel, A. K., Rhym, L. H., Palmiero, U. C., Bhat, B., Heartlein, M. W., DeRosa, F., & Anderson, D. G. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120966 · Cited by 110

Biodegradable Amino-Ester Nanomaterials for Cas9 mRNA Delivery in Vitro and in Vivo

Zhang, X., Li, B., Luo, X., Zhao, W., Jiang, J., Zhang, C., Gao, M., Chen, X., & Dong, Y. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b08163 · Cited by 107

Mastering Dendrimer Self‐Assembly for Efficient siRNA Delivery: From Conceptual Design to In Vivo Efficient Gene Silencing

Chen, C., Posocco, P., Liu, X., Cheng, Q., Laurini, E., Zhou, J., Liu, C., Wang, Y., Tang, J., Col, V. D., et al. (2016) · Small · doi:10.1002/smll.201503866 · Cited by 109

Lipid Nanovesicles by Microfluidics: Manipulation, Synthesis, and Drug Delivery

Liu, C., Feng, Q., & Sun, J. (2018) · Advanced Materials · doi:10.1002/adma.201804788 · Cited by 107

Lipid nanocarriers for microRNA delivery

Scheideler, M., Vidaković, I., & Prassl, R. (2019) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2019.104837 · Cited by 111

Improved Nucleic Acid Therapy with Advanced Nanoscale Biotechnology

Weng, Y., Huang, Q., Li, C., Yang, Y., Wang, X., Yu, J., Huang, Y., & Liang, X. (2019) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2019.12.004 · Cited by 110

Correlating the Structure and Gene Silencing Activity of Oligonucleotide-Loaded Lipid Nanoparticles Using Small-Angle X-ray Scattering

Hammel, M., Fan, Y., Sarode, A., Byrnes, A. E., Zang, N., Kou, P., Nagapudi, K., Leung, D., Hoogenraad, C. C., Chen, T., et al. (2023) · ACS Nano · doi:10.1021/acsnano.3c01186 · Cited by 107

Tumor acidity-sensitive linkage-bridged block copolymer for therapeutic siRNA delivery

Xu, C., Zhang, H., Sun, C., Liu, Y., Shen, S., Yang, X., Zhu, Y., & Wang, J. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.02.031 · Cited by 106

Fluorine-Doped Cationic Carbon Dots for Efficient Gene Delivery

Zuo, G., Xie, A., Pan, X., Su, T., Li, J., & Dong, W. (2018) · ACS Applied Nano Materials · doi:10.1021/acsanm.8b00521 · Cited by 108

Aptamer-Based Targeted Protein Degradation

Liu, Y., Qian, X., Ran, C., Li, L., Fu, T., Su, D., Xie, S., & Tan, W. (2023) · ACS Nano · doi:10.1021/acsnano.2c10379 · Cited by 110

Gold Nanoparticle Approach to the Selective Delivery of Gene Silencing in Cancer—The Case for Combined Delivery?

Mendes, R. G. P. R., Fernandes, A. R., & Baptista, P. V. (2017) · Genes · doi:10.3390/genes8030094 · Cited by 105

Rapid Synthesis of a Lipocationic Polyester Library via Ring-Opening Polymerization of Functional Valerolactones for Efficacious siRNA Delivery

Hao, J., Kós, P., Zhou, K., Miller, J. B., Xue, L., Yan, Y., Xiong, H., Elkassih, S. A., & Siegwart, D. J. (2015) · Journal of the American Chemical Society · doi:10.1021/jacs.5b03429 · Cited by 104

Highly specific delivery of siRNA to hepatocytes circumvents endothelial cell-mediated lipid nanoparticle-associated toxicity leading to the safe and efficacious decrease in the hepatitis B virus

Sato, Y., Matsui, H., Yamamoto, N., Sato, R., Munakata, T., Kohara, M., & Harashima, H. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.09.044 · Cited by 104

Construction of a Biomimetic Magnetosome and Its Application as a SiRNA Carrier for High‐Performance Anticancer Therapy

Zhang, F., Zhao, L., Wang, S., Yang, J., Lu, G., Luo, N., Gao, X., Ma, G., Xie, H., & Wei, W. (2017) · Advanced Functional Materials · doi:10.1002/adfm.201703326 · Cited by 104

Polycation Architecture and Assembly Direct Successful Gene Delivery: Micelleplexes Outperform Polyplexes via Optimal DNA Packaging

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The Progress and Promise of RNA Medicine─An Arsenal of Targeted Treatments

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