Delivery materials for siRNA therapeutics

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Gene Therapy Based on Nucleic Acid Nanostructure

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Antibody-siRNA conjugates (ARCs) using multifunctional peptide as a tumor enzyme cleavable linker mediated effective intracellular delivery of siRNA

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Blood cell-derived extracellular vesicles: diagnostic biomarkers and smart delivery systems

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Oral delivery of RNAi for cancer therapy

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Cationic Nanohydrogel Particles for Therapeutic Oligonucleotide Delivery

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Nanotechnology advances in pathogen- and host-targeted antiviral delivery: multipronged therapeutic intervention for pandemic control

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Development of Novel siRNA Therapeutics: A Review with a Focus on Inclisiran for the Treatment of Hypercholesterolemia

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Challenges and advances for glioma therapy based on inorganic nanoparticles

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Enhanced Gene Silencing through Human Serum Albumin-Mediated Delivery of Polyethylenimine-siRNA Polyplexes

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Self-assembled DNA nanostructures prepared by rolling circle amplification for the delivery of siRNA conjugates

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RNAi nanomaterials targeting immune cells as an anti-tumor therapy: the missing link in cancer treatment?

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Overcoming Immune Dysregulation with Immunoengineered Nanobiomaterials

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Tumor-Associated Fibronectin Targeted Liposomal Nanoplatform for Cyclophilin A siRNA Delivery and Targeted Malignant Glioblastoma Therapy

Saw, P. E., Zhang, A., Nie, Y., Zhang, L., Xu, Y., & Xu, X. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01194 · Cited by 39

Evolution of drug delivery system from viewpoint of controlled intracellular trafficking and selective tissue targeting toward future nanomedicine

Yamada, Y., Sato, Y., Nakamura, T., & Harashima, H. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.09.007 · Cited by 41

RNA Interference Nanotherapeutics for Treatment of Glioblastoma Multiforme

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Nano-based approaches in the development of antiviral agents and vaccines

Li, Y., Xiao, Y., Chen, Y., & Huang, K. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118761 · Cited by 39

Rational nanocarrier design towards clinical translation of cancer nanotherapy

Guo, D., Ji, X., & Luo, J. (2021) · Biomedical Materials · doi:10.1088/1748-605x/abe35a · Cited by 39

Calixarene‐Embedded Nanoparticles for Interference‐Free Gene–Drug Combination Cancer Therapy

Liu, Q., Zhang, T., Zheng, Y., Wang, C., Kang, Z., Zhao, Y., Chai, J., Li, H., Guo, D., Liu, Y., et al. (2021) · Small · doi:10.1002/smll.202006223 · Cited by 39

An indoleamine 2, 3-dioxygenase siRNA nanoparticle-coated and Trp2-displayed recombinant yeast vaccine inhibits melanoma tumor growth in mice

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Hydrogel Microspheres for Spatiotemporally Controlled Delivery of Rna and Silencing Gene Expression within Scaffold-Free Tissue Engineered ConstructsPreprint

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Biocompatible, chimeric peptide-condensed supramolecular nanoparticles for tumor cell-specific siRNA delivery and gene silencing

Wang, H., Chen, W., Xie, H., Wei, X., Yin, S., Zhou, L., Xu, X., & Zheng, S. (2014) · Chemical Communications · doi:10.1039/c4cc01061b · Cited by 38

pH-Responsive Nanometric Polydiacetylenic Micelles Allow for Efficient Intracellular siRNA Delivery

Ripoll, M., Neuberg, P., Kichler, A., Tounsi, N., Wagner, A., & Rémy, J.-S. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b09365 · Cited by 38

Administration Routes for Nano Drugs and Characterization of Nano Drug Loading

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Nanoparticle-siRNA: A Potential Strategy for Ovarian Cancer Therapy?

Aghamiri, S., Fallah-Mehrjardi, K., Shabani, S., Keshavarz‐Fathi, M., Kargar, S., & Rezaei, N. (2019) · Nanomedicine · doi:10.2217/nnm-2018-0379 · Cited by 38

Hyperbranched cationic polysaccharide derivatives for efficient siRNA delivery and diabetic wound healing enhancement

Lan, B., Wu, J., Li, N., Pan, C., Yan, L., Yang, C. H., Zhang, L., Yang, L., & Ren, M. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.03.164 · Cited by 38

Complexation of single stranded RNA with an ionizable lipid: an all-atom molecular dynamics simulation study

Rissanou, A. N., Ouranidis, A., & Karatasos, K. (2020) · Soft Matter · doi:10.1039/d0sm00736f · Cited by 38

Hybrid lipid self-assembling nanoparticles for brain delivery of microRNA

Campani, V., Zappavigna, S., Scotti, L., Abate, M., Porru, M., Leonetti, C., Caraglia, M., & Rosa, G. D. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119693 · Cited by 38

Cyclodextrins based delivery systems for macro biomolecules

Liu, J., Ding, X., Fu, Y., Xiang, C., Yuan, Y., Zhang, Y., & Yu, P. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.113105 · Cited by 39

Emerging roles for lncRNA-NEAT1 in colorectal cancer

Azizidoost, S., Ghaedrahmati, F., Anbiyaee, O., Ali, R. A., Cheraghzadeh, M., & Farzaneh, M. (2022) · Cancer Cell International · doi:10.1186/s12935-022-02627-6 · Cited by 39

Targeting and tracking mRNA lipid nanoparticles at the particle, transcript and protein level

Kang, D. D., Marks, A. R., Morlà‐Folch, J., Dong, Y., Brown, B. D., & Teunissen, A. J. P. (2025) · Nature Biomedical Engineering · doi:10.1038/s41551-025-01511-8 · Cited by 40

Evaluation of the physicochemical properties and the biocompatibility of polyethylene glycol-conjugated gold nanoparticles: A formulation strategy for siRNA delivery

Rahme, K., Guo, J., Holmes, J. D., & O’Driscoll, C. M. (2015) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2015.08.032 · Cited by 37

Chaperonin–Dendrimer Conjugates for siRNA Delivery

Nussbaumer, M. G., Duskey, J. T., Röther, M., Renggli, K., Chami, M., & Bruns, N. (2016) · Advanced Science · doi:10.1002/advs.201600046 · Cited by 38

Nanoengineered strategies for siRNA delivery: from target assessment to cancer therapeutic efficacy

Mishra, D. K., Balekar, N., & Mishra, P. K. (2017) · Drug Delivery and Translational Research · doi:10.1007/s13346-016-0352-5 · Cited by 37

Hydrazone-modulated peptides for efficient gene transfection

Louzao, I., García‐Fandiño, R., & Montenegro, J. (2017) · Journal of Materials Chemistry B · doi:10.1039/c7tb00179g · Cited by 37

Delivery of miRNA-Targeted Oligonucleotides in the Rat Striatum by Magnetofection with Neuromag®

de Almeida, S. S. T., Horst, C. H., Soto‐Sánchez, C., Fernández, E., & Titze‐de‐Almeida, R. (2018) · Molecules · doi:10.3390/molecules23071825 · Cited by 37

Multi-Drug/Gene NASH Therapy Delivery and Selective Hyperspectral NIR Imaging Using Chirality-Sorted Single-Walled Carbon Nanotubes

Hasan, M. T., Campbell, E., Sizova, O. S., Lyle, V., Akkaraju, G. R., Kirkpatrick, D. L., & Naumov, A. V. (2019) · Cancers · doi:10.3390/cancers11081175 · Cited by 38

Tooth Regeneration: Insights from Tooth Development and Spatial-Temporal Control of Bioactive Drug Release

Huang, D., Ren, J., Li, R., Guan, C., Feng, Z., Bao, B., Wang, W., & Zhou, C. (2019) · Stem Cell Reviews and Reports · doi:10.1007/s12015-019-09940-0 · Cited by 37

Double-Stranded RNAs in Plant Protection Against Pathogenic Organisms and Viruses in Agriculture

Morozov, S. Y., Solovyev, A. G., Kalinina, N. O., & Taliansky, M. E. (2019) · Acta Naturae · doi:10.32607/20758251-2019-11-4-13-21 · Cited by 37

Targeted galectin-7 inhibition with ultrasound microbubble targeted gene therapy as a sole therapy to prevent acute rejection following heart transplantation in a Rodent model

Wang, Z., Jiang, S., Li, S., Yu, W., Chen, J., Yu, D., Chen, Z., Li, Y., Kang, K., Wang, R., et al. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120366 · Cited by 37

Pure DNA scaffolded drug delivery systems for cancer therapy

Aliouat, H., Peng, Y., Waseem, Z., Wang, S., & Zhou, W. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121532 · Cited by 37

Stimulating TAM-mediated anti-tumor immunity with mannose-decorated nanoparticles in ovarian cancer

Glass, E. B., Hoover, A., Bullock, K. K., Madden, M. Z., Reinfeld, B. I., Harris, W., Parker, D., Hufnagel, D. H., Crispens, M. A., Khabele, D., et al. (2022) · BMC Cancer · doi:10.1186/s12885-022-09612-2 · Cited by 37

Hydrogels Based on Polyelectrolyte Complexes: Underlying Principles and Biomedical Applications

Sim, B., Chang, J. J., Lin, Q., Wong, J. H. M., Ow, V., Leow, Y., Wong, Y. J., Boo, Y. J., Goh, R. Z. R., & Loh, X. J. (2024) · Biomacromolecules · doi:10.1021/acs.biomac.4c01240 · Cited by 38

Perfluorocarbon-based nanomedicine: emerging strategy for diagnosis and treatment of diseases

Zhang, T., Zhang, Q., Tian, J., Xing, J., Guo, W., & Liang, X. (2018) · MRS Communications · doi:10.1557/mrc.2018.49 · Cited by 37

Characterization of Cationic Bolaamphiphile Vesicles for siRNA Delivery into Tumors and Brain

Kim, T., Viard, M., Afonin, K. A., Gupta, K., Popov, M., Salotti, J., Johnson, P. F., Linder, C., Heldman, E., & Shapiro, B. A. (2020) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2020.02.011 · Cited by 36

Bioengineered siRNA-Based Nanoplatforms Targeting Molecular Signaling Pathways for the Treatment of Triple Negative Breast Cancer: Preclinical and Clinical Advancements

Hattab, D., & Bakhtiar, A. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12100929 · Cited by 36

Engineering Multifunctional RNAi Nanomedicine To Concurrently Target Cancer Hallmarks for Combinatorial Therapy

Liu, Y., Ji, X., Tong, W. W. L., Askhatova, D., Yang, T., Cheng, H., Wang, Y. Z., & Shi, J. (2017) · Angewandte Chemie · doi:10.1002/ange.201710144 · Cited by 36

Development of amino acid-modified biodegradable lipid nanoparticles for siRNA delivery

Patel, P., Fetse, J., Lin, C., Guo, Y., Hasan, M. R., Nakhjiri, M., Zhao, Z., Jain, A., & Cheng, K. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.09.065 · Cited by 37

Cationic and hydrolysable branched polymers by RAFT for complexation and controlled release of dsRNA

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Liposomal Nanostructures for Drug Delivery in Gastrointestinal Cancers

Das, M., & Huang, L. (2018) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.118.254797 · Cited by 37

Non-viral nucleic acid delivery approach: A boon for state-of-the-art gene delivery

Sahu, K. K., Pradhan, M., Singh, D., Singh, M. R., & Yadav, D. K. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.104152 · Cited by 36

Nanotechnology-based delivery systems to overcome drug resistance in cancer

Patel, H. H., Li, J., Bo, L., Mehta, R., Ashby, C. R., Wang, S., Cai, W., & Chen, Z. (2024) · Medical Review · doi:10.1515/mr-2023-0058 · Cited by 38

Multicompartment Polyion Complex Micelles Based on Triblock Polypept(o)ides Mediate Efficient siRNA Delivery to Cancer‐Associated Fibroblasts for Antistromal Therapy of Hepatocellular Carcinoma

Schneider, P. M., Zhang, H., Simić, L., Dai, Z., Schrörs, B., Akilli‐Öztürk, Ö., Jian, L., Durak, F., Schunke, J., Bolduan, V., et al. (2024) · Advanced Materials · doi:10.1002/adma.202404784 · Cited by 36

Acute in Vivo Toxicity Mitigation of PEI-Coated Maghemite Nanoparticles Using Controlled Oxidation and Surface Modifications toward siRNA Delivery

Israel, L. L., Lellouche, E., Ostrovsky, S., Yarmiayev, V., Bechor, M., Michaeli, S., & Lellouche, J. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b02743 · Cited by 35

Optimization of a cationic liposome-based gene delivery system for the application of miR-145 in anticancer therapeutics

Tao, J., Ding, W., Che, X., Chen, Y., CHEN, F., CHEN, X.-D., Ye, X., & Xiong, S. (2016) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2016.2530 · Cited by 35

Dioscin strengthens the efficiency of adriamycin in MCF-7 and MCF-7/ADR cells through autophagy induction: More than just down-regulation of MDR1

Wang, C., Huo, X., Wang, L., Meng, Q., Liu, Z., Liu, Q., Sun, H., Sun, P., Peng, J., & Liu, K. (2016) · Scientific Reports · doi:10.1038/srep28403 · Cited by 35

Synthesis and Evaluation of Parenchymal Retention and Efficacy of a Metabolically Stable O-Phosphocholine-N-docosahexaenoyl-l-serine siRNA Conjugate in Mouse Brain

Nikan, M., Osborn, M. F., Coles, A. H., Biscans, A., Godinho, B. M. D. C., Haraszti, R. A., Sapp, E., Echeverria, D., DiFiglia, M., Aronin, N., et al. (2017) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.7b00226 · Cited by 35

mRNA Delivery Using Bioreducible Lipidoid Nanoparticles Facilitates Neural Differentiation of Human Mesenchymal Stem Cells

Zhao, X., Glass, Z., Chen, J., Yang, L., Kaplan, D. L., & Xu, Q. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.202000938 · Cited by 36

Structural Optimization of Polymeric Carriers to Enhance the Immunostimulatory Activity of Molecularly Defined RIG-I Agonists

Jacobson, M. E., Becker, K. W., Palmer, C. R., Pastora, L. E., Fletcher, R. B., Collins, K. A., Fedorova, O., Duvall, C. L., Pyle, A. M., & Wilson, J. T. (2020) · ACS Central Science · doi:10.1021/acscentsci.0c00568 · Cited by 35

mRNA delivery via non-viral carriers for biomedical applications

Shuai, Q., Zhu, F., Zhao, M., & Yan, Y. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.121020 · Cited by 35

Surface-mediated delivery of siRNA from fibrin hydrogels for knockdown of the BMP-2 binding antagonist noggin

Kowalczewski, C. J., & Saul, J. M. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.07.045 · Cited by 35

A galactose-functionalized dendritic siRNA-nanovector to potentiate hepatitis C inhibition in liver cells

Lakshminarayanan, A., Reddy, B. U., Raghav, N., Ravi, V. K., Kumar, A., Maiti, P. K., Sood, A. K., Jayaraman, N., & Das, S. (2015) · Nanoscale · doi:10.1039/c5nr02898a · Cited by 35

Functionalized siRNA-chitosan nanoformulations promote triple-negative breast cancer cell death via blocking the miRNA-21/AKT/ERK signaling axis: in-silico and in vitro studies

Abdulmalek, S. A., Saleh, A. M., Shahin, Y. R., & Azab, E. F. E. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-03068-w · Cited by 34

Efficient Cellular Knockdown Mediated by siRNA Nanovectors of Gemini Cationic Lipids Having Delocalizable Headgroups and Oligo-Oxyethylene Spacers

Martínez‐Negro, M., Kumar, K., Barrán-Berdón, A. L., Datta, S., Kondaiah, P., Junquera, E., Bhattacharya, S., & Aicart, E. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b08823 · Cited by 34

Polymer-based nanocarriers for therapeutic nucleic acids delivery

Yuan, W., & Li, H. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-46143-6.00014-2 · Cited by 34

Molecular engineering of dendrimer nanovectors for siRNA delivery and gene silencing

Cao, Y., Liu, X., & Peng, L. (2017) · Frontiers of Chemical Science and Engineering · doi:10.1007/s11705-017-1623-5 · Cited by 35

Impact of modified ribose sugars on nucleic acid conformation and function

Evich, M. G., Spring‐Connell, A. M., & Germann, M. W. (2017) · Heterocyclic Communications · doi:10.1515/hc-2017-0056 · Cited by 34

Targeted Delivery of siRNA with pH-Responsive Hybrid Gold Nanostars for Cancer Treatment

Zhu, H., Liu, W., Cheng, Z., Yao, K., Yang, Y. M., Xu, B., & Su, G. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18102029 · Cited by 34

Noncovalent tagging of siRNA with steroids for transmembrane delivery

Tai, W., & Gao, X. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.02.007 · Cited by 34

An Overview of RNA-Based Scaffolds for Osteogenesis

Damiati, L. A., & El-Messeiry, S. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.682581 · Cited by 35

Specific Silencing of Microglial Gene Expression in the Rat Brain by Nanoparticle-Based Small Interfering RNA Delivery

Guo, S., Cázarez‐Márquez, F., Jiao, H., Foppen, E., Korpel, N. L., Grootemaat, A. E., Liv, N., Gao, Y., van der Wel, N. N., Zhou, B., et al. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c22434 · Cited by 35

Current state of, prospects for, and obstacles to mRNA vaccine development

Aljabali, A. A. A., Bashatwah, R. M., Obeid, M. A., Mishra, V., Mishra, Y., Serrano‐Aroca, Á., Lundstrom, K. H., & Tambuwala, M. M. (2022) · Drug Discovery Today · doi:10.1016/j.drudis.2022.103458 · Cited by 35

MIR4435-2HG in exosomes promotes gastric carcinogenesis by inducing M2 polarization in macrophages

Li, C., Chen, Z., Gao, J., Tang, T., Zhou, L., Zhang, G., Zhang, D., Shen, C., Guo, L., & Fu, T. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1017745 · Cited by 34

Effect of nano-scale curvature on the intrinsic blood coagulation system

Kushida, T., Saha, K., Subramani, C., Nandwana, V., & Rotello, V. M. (2014) · Nanoscale · doi:10.1039/c4nr04128c · Cited by 34

Progress in Self-assembling Peptide-based Nanomaterials for Biomedical Applications

Yu, C., Huang, W. T., Li, Z., Lei, X., He, D., & Sun, L. (2015) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026615666150701114527 · Cited by 34

Ion Channels in the Eye

Giblin, J. P., Comes, N., Strauß, O., & Gasull, X. (2015) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2015.11.006 · Cited by 34

Nanotherapy silencing the interleukin‐8 gene produces regression of prostate cancer by inhibition of angiogenesis

Aalinkeel, R., Nair, B. B., Chen, C., Mahajan, S. D., Reynolds, J. L., Zhang, H., Sun, H., Sykes, D. E., Chadha, K. C., Turowski, S. G., et al. (2016) · Immunology · doi:10.1111/imm.12618 · Cited by 34

Matrix metalloproteases-responsive nanomaterials for tumor targeting diagnosis and treatment

Xiong, J., & Gao, H. (2017) · Journal of Microencapsulation · doi:10.1080/02652048.2017.1343873 · Cited by 34

A Crosslinked Nucleic Acid Nanogel for Effective siRNA Delivery and Antitumor Therapy

Ding, F., Mou, Q., Ma, Y., Pan, G., Guo, Y., Tong, G., Choi, C. H. J., Zhu, X., & Zhang, C. (2018) · Angewandte Chemie · doi:10.1002/ange.201711242 · Cited by 33

Contaminating transfection complexes can masquerade as small extracellular vesicles and impair their delivery of RNA

McCann, J. L., Sosa‐Miranda, C. D., Guo, H., Reshke, R., Savard, A., Buzatto, A. Z., Taylor, J. A., Li, L., & Gibbings, D. (2022) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12220 · Cited by 36

Oligonucleotide conjugates – Candidates for gene silencing therapeutics

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Effective and Specific Gene Silencing of Epidermal Growth Factor Receptors Mediated by Conjugated Oxaborole and Galactose-Based Polymers

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