Bioresorbable silicon electronics for transient spatiotemporal mapping of electrical activity from the cerebral cortex
Open accessAbstract
Bioresorbable silicon electronics technology offers unprecedented opportunities to deploy advanced implantable monitoring systems that eliminate risks, cost and discomfort associated with surgical extraction. Applications include postoperative monitoring and transient physiologic recording after percutaneous or minimally invasive placement of vascular, cardiac, orthopaedic, neural or other devices. We present an embodiment of these materials in both passive and actively addressed arrays of bioresorbable silicon electrodes with multiplexing capabilities, which record in vivo electrophysiological signals from the cortical surface and the subgaleal space. The devices detect normal physiologic and epileptiform activity, both in acute and chronic recordings. Comparative studies show sensor performance comparable to standard clinical systems and reduced tissue reactivity relative to conventional clinical electrocorticography (ECoG) electrodes. This technology offers general applicability in neural interfaces, with additional potential utility in treatment of disorders where transient monitoring and modulation of physiologic function, implant integrity and tissue recovery or regeneration are required.
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Various electrodes with different materials, shapes, and characteristics can be placed on or in the brain, peripheral nerves, and muscles to record ECoG, LFP, ENG, and EMG respectively.
“Various electrodes, with different materials, shapes, and characteristics, can be places on or in the human brain, peripheral nerves, and muscles to record ECoG,[300] LFP,[301] ENG[302] and EMG[303] respectively.”
From Flexible Electronics and Devices as Human–Machine Interfaces for Medical Robotics (2022) · cites this paper as [300]
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- Authors
- Yu, K. J., Kuzum, D., Hwang, S.-W., Kim, B. H., Juul, H., Kim, N. H., Won, S. M., Chiang, K., Trumpis, M., Richardson, A. G., Cheng, H., Fang, H., Thompson, M., Bink, H., Talos, D., Seo, K. J., Lee, H. N., Kang, S.-K., Kim, J.-H., Lee, J. Y., Huang, Y., Jensen, F. E., Dichter, M. A., Lucas, T. H., Viventi, J., Litt, B., & Rogers, J. A.
- Affiliations
- University of Illinois Urbana-Champaign (US)
- University of California San Diego (US)
- Korea University (KR)
- University of Pennsylvania (US)
- Duke University (US)
- Pennsylvania State University (US)
- Northwestern University (US)
- Corresponding author
- Litt, Brian
- Rogers, John A.
- ORCID
- Venue
- Nature Materials
- Published
- 2016-04-18
- Volume
- 15
- Issue
- 7
- Pages
- 782-791
- ISSN
- 1476-1122 (ISSN-L)
- 1476-4660
- PMC
- PMC4919903
- OpenAlex
- W2342159388
- Cited by
- 523
- References
- 51
- Citations by year
- 2026: 38 · 2025: 41 · 2024: 65 · 2023: 52 · 2022: 46 · 2021: 61 · 2020: 57 · 2019: 54 · 2018: 60 · 2017: 38 · 2016: 11
- FWCI
- 30.48
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Materials (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- University of Pennsylvania Health System
- Defense Advanced Research Projects Agency
- National Institute of Neurological Disorders and Stroke (T32NS043126, T32NS091006)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Engineering › Biomedical Engineering › Analog and Mixed-Signal Circuit Design
- Physical Sciences › Engineering › Biomedical Engineering › Wireless Body Area Networks
- Keywords
- implanted electrodes, electrocorticography, cerebral cortex, epileptiform activity, neural interfaces, tissue reaction, postoperative monitoring
- MeSH terms
- Animals, Brain Mapping, Cerebral Cortex, Electrodes, Implanted, Silicon, Absorbable Implants, Rats, Brain Waves
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