Cited by 241Neuroscience and Neural EngineeringNeural dynamics and brain functionUndergraduate Neuroscience Education and Research

Next-generation interfaces for studying neural function

Open access
Frank, James A., Antonini, Marc-Joseph, Anikeeva, Polina·2019·Nature Biotechnology

Abstract

Monitoring and modulating the diversity of signals used by neurons and glia in a closed-loop fashion is necessary to establish causative links between biochemical processes within the nervous system and observed behaviors. As developments in neural-interface hardware strive to keep pace with rapid progress in genetically encoded and synthetic reporters and modulators of neural activity, the integration of multiple functional features becomes a key requirement and a pressing challenge in the field of neural engineering. Electrical, optical and chemical approaches have been used to manipulate and record neuronal activity in vivo, with a recent focus on technologies that both integrate multiple modes of interaction with neurons into a single device and enable bidirectional communication with neural circuits with enhanced spatiotemporal precision. These technologies not only are facilitating a greater understanding of the brain, spinal cord and peripheral circuits in the context of health and disease, but also are informing the development of future closed-loop therapies for neurological, neuro-immune and neuroendocrine conditions.

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Crossref · 10.1038/s41587-019-0198-8

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139 of 139 references verified0 citation errors · 0 not checkable

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  • Passive neural interfaces have proved effective as bioelectronic therapies in managing neurological and psychiatric disorders, as well as treatments for sensory and motor dysfunctions.

    “Passive neural interfaces have proved as effective bioelectronic therapies in managing neurological and psychiatric disorders, as well as treatments for sensory and motor dysfunctions [1].”

    From Active Neural Interface Circuits and Systems for Selective Control of Peripheral Nerves: A Review (2024) · cites this paper as [1]

    The Abstract (page unavailable) says implanted electrical stimulation devices are used to treat neurological disorders, supporting that part of the claim. But the Conclusions and perspective section describes therapies for psychiatric conditions as something future insights will inform, while the Multi-modal interaction section reports restored locomotion only in rodents after spinal cord injury. Our copy does not establish that passive interfaces have proved effective across psychiatric, sensory, and motor dysfunctions. (LLM, conf=0.86)

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Research works printed but not linked: 9

  1. [120]Jeong J-W Wireless Optofluidic Systems for Programmable In Vivo Pharmacology and Optogenetics. Cell 162, 662– 674 (2015). 26189679 PMC4525768
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Authors
Frank, J. A., Antonini, M.-J., & Anikeeva, P.
Affiliations
McGovern Institute for Brain Research (US)
Corresponding author
Anikeeva, Polina
Venue
Nature Biotechnology
Published
2019-08-12
Volume
37
Issue
9
Pages
1013-1023
ISSN
  • 0733-222X (ISSN-L)
  • 1087-0156
  • 1546-1696
OpenAlex
W2968558827
Cited by
241
References
139
Citations by year
2026: 21 · 2025: 39 · 2024: 30 · 2023: 47 · 2022: 36 · 2021: 36 · 2020: 30 · 2019: 2
FWCI
3.45
Type
journal article
Language
en
Open access
Locations
  • Nature Biotechnology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (5R01NS086804)
  • U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (1R01MH111872)
  • National Science Foundation (EEC-1028725, DMR-1419807)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Undergraduate Neuroscience Education and Research
Keywords
neural interfaces, optogenetics, genetically encoded reporters, neural circuits, closed-loop therapy
MeSH terms
Brain, Diagnostic Techniques, Neurological, Electric Stimulation, Humans, Nerve Net, Neurons

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