Cited by 24Neurological Disease Mechanisms and TreatmentsAlzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Glucagon-Like Peptide-2 Receptor is Involved in Spatial Cognitive Dysfunction in Rats After Chronic Cerebral Hypoperfusion

Xie, Yan-Chun, Yao, Zhao-Hui, Yao, Xiao-Li, Pan, Jian-Zhen, Zhang, Shao-Feng, Zhang, Yong, Hu, Ji-Chang·2018·Journal of Alzheimer's Disease

Abstract

Chronic cerebral hypoperfusion (CCH) affects the aging population and especially patients with neurodegenerative diseases, such as Alzheimer's disease or Parkinson's disease. CCH is closely related to the cognitive dysfunction in these diseases. Glucagon-like peptide-2 receptor (GLP2R) mRNA and protein are highly expressed in the gut and in hippocampal neurons. This receptor is involved in the regulation of food intake and the control of energy balance and glucose homeostasis. The present study employed behavioral techniques, electrophysiology, western blotting, immunohistochemistry, quantitative real time polymerase chain reaction (qRT-PCR), and Golgi staining to investigate whether the expression of GLP2R changes after CCH and whether GLP2R is involved in cognitive impairment caused by CCH. Our findings show that CCH significantly decreased hippocampal GLP2R mRNA and protein levels. GLP2R upregulation could prevent CCH-induced cognitive impairment. It also improved the CCH-induced impairment of long-term potentiation and long-term depression. Additionally, GLP2R modulated after CCH the AKT-mTOR-p70S6K pathway in the hippocampus. Moreover, an upregulation of the GLP2R increased the neurogenesis in the dentate gyrus, neuronal activity, and density of dendritic spines and mushroom spines in hippocampal neurons. Our findings reveal the involvement of GLP2R via a modulation of the AKT-mTOR-p70S6K pathway in the mechanisms underlying CCH-induced impairments of spatial learning and memory. We suggest that the GLP2R and the AKT-mTOR-p70S6K pathway in the hippocampus are promising targets to treat cognition deficits in CCH.

Integrity signals

Registry

Crossref · 10.3233/jad-180782

Cites

85 of 85 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Xie, Y.-C., Yao, Z.-H., Yao, X.-L., Pan, J.-Z., Zhang, S.-F., Zhang, Y., & Hu, J.-C.
Affiliations
  • Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, China
  • Department of Geriatrics, Renmin Hospital of Wuhan University, Wuhan, China
  • Zhengzhou Central Hospital (CN)
  • Renmin Hospital of Wuhan University (CN)
  • Department of Pathology, Renmin Hospital of Wuhan University, Wuhan, China
Venue
Journal of Alzheimer's Disease
Published
2018-12-12
Volume
66
Issue
4
Pages
1559-1576
ISSN
  • 1387-2877 (ISSN-L)
  • 1875-8908
OpenAlex
W2901051078
Cited by
24
References
85
Citations by year
2026: 3 · 2024: 1 · 2023: 1 · 2022: 5 · 2021: 5 · 2020: 6 · 2019: 3
FWCI
1.57
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Alzheimer s Disease (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
chronic cerebral hypoperfusion
MeSH terms
Glucagon-Like Peptide-2 Receptor, Animals, Brain Ischemia, Disease Models, Animal, Hippocampus, Male, Neuronal Plasticity, Neurons, Phosphorylation, Signal Transduction, Up-Regulation, Rats, Sprague-Dawley, Dendritic Spines, Proto-Oncogene Proteins c-akt, Rats, TOR Serine-Threonine Kinases, Spatial Memory, Spatial Learning

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review