The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Persistent cortical plasticity by upregulation of chondroitin 6-sulfation
Abstract
Cortical plasticity is most evident during a critical period in early life, but the mechanisms that restrict plasticity after the critical period are poorly understood. We found that a developmental increase in the 4-sulfation/6-sulfation (4S/6S) ratio of chondroitin sulfate proteoglycans (CSPGs), which are components of the brain extracellular matrix, leads to the termination of the critical period for ocular dominance plasticity in the mouse visual cortex. Condensation of CSPGs into perineuronal nets that enwrapped synaptic contacts on parvalbumin-expressing interneurons was prevented by cell-autonomous overexpression of chondroitin 6-sulfation, which maintains a low 4S/6S ratio. Furthermore, the increase in the 4S/6S ratio was required for the accumulation of Otx2, a homeoprotein that activates the development of parvalbumin-expressing interneurons, and for functional maturation of the electrophysiological properties of these cells. Our results indicate that the critical period for cortical plasticity is regulated by the 4S/6S ratio of CSPGs, which determines the maturation of parvalbumin-expressing interneurons.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“As a result, transgenic mice overexpressing C6ST--1 retain a juvenile level of ocular dominance plasticity even in adulthood (Miyata et al., 2012).”
From Casting a Wide Net: Role of Perineuronal Nets in Neural Plasticity (2016) · cites this paper as Miyata et al., 2012
In the citing paper
“Overall then, there is a substantial increase in the 4--sulfation/6-sulfation (C4S/C6S) ratio during brain development (Kitagawa et al., 1997;Miyata et al., 2012).”
From Casting a Wide Net: Role of Perineuronal Nets in Neural Plasticity (2016) · cites this paper as Miyata et al., 2012
In the citing paper
“Specifically, 6--O--sulfation is dominant in the juvenile brain to produce C6S, which is more permissive (Lin et al., 2011;Miyata et al., 2012)”
From Casting a Wide Net: Role of Perineuronal Nets in Neural Plasticity (2016) · cites this paper as Miyata et al., 2012
In the citing paper
“While chondroitin 4-sulphates (C4S) are inhibitory [5], chondroitin 6-sulphates (C6S) are more permissive to plasticity and regeneration [173, 174], and the balance between C6S and C4S regulates neuroplasticity.”
From The extracellular matrix and perineuronal nets in memory (2022) · cites this paper as [173]
In the citing paper
“The relative abundance of CS isomers incorporated into the CS-GAG chains has been linked to key biological functions within the brain including charged molecule diffusion (0S-CS (Nicholson & Hrabětová 2017)), neurocircuit plasticity (4S-CS and 6S-CS (Miyata et al. 2012; Yang et al. 2021)), glial scarring (4S6S-CS (Brown et al. 2012)), and neurite outgrowth (2S6S-CS (Shida et al. 2019; Clement et a”
From Perineuronal net deglycosylation associates with tauopathy‐induced gliosis and neurodegeneration (2024) · cites this paper as Miyata et al. 2012
In the citing paper
“Recent work suggests that microgliosis represents a potential mechanism driving PNN loss in models of neurodegeneration (Miyata et al. 2012; Miyata & Kitagawa 2016; Crapser et al. 2021)”
From Perineuronal net deglycosylation associates with tauopathy‐induced gliosis and neurodegeneration (2024) · cites this paper as Miyata et al. 2012
In the citing paper
“Second, PNN disruption prevents the persistent uptake of Otx2 homeoprotein into the enwrapped PV-cells required for their maintenance (27, 40, 41) (Fig. S3).”
From Prolonged Period of Cortical Plasticity upon Redox Dysregulation in Fast-Spiking Interneurons (2015) · cites this paper as [40]
In the citing paper
“Compromised PNNs prevent the persistent uptake of Otx2 homeoprotein into the enwrapped PV-cells needed for their maturation (including PNN maintenance itself) (27, 40, 41).”
From Prolonged Period of Cortical Plasticity upon Redox Dysregulation in Fast-Spiking Interneurons (2015) · cites this paper as [40]
In the citing paper
“This is further supported by the demonstration that the knock-out of specific sulfotranferases that modify the PNN structure interferes with Otx2 internalization and CP closure (Miyata et al., 2012)”
From Choroid-Plexus-Derived Otx2 Homeoprotein Constrains Adult Cortical Plasticity (2013) · cites this paper as Miyata et al., 2012
In the citing paper
“The model also stipulates that early sensory experience (sensory input) initiates expression of Otx2 binding sites on nascent PNNs (Beurdeley et al., 2012; Miyata et al., 2012), facilitating Otx2 import and opening a period of plasticity.”
From Choroid-Plexus-Derived Otx2 Homeoprotein Constrains Adult Cortical Plasticity (2013) · cites this paper as Miyata et al., 2012
In the citing paper
“where they form a reticular dendrosomatic structure around largely parvalbumin-expressing interneurons”
From Microglial depletion prevents extracellular matrix changes and striatal volume reduction in a model of Huntington's disease (2020) · cites this paper as Miyata et al., 2012
In the citing paper
“Chondroitin-4-sulfation (CS-4) and chondroitin-6 sulfation (CS-6) are the two most common sulfation patterns in the brain, with several variations depending on the position of the sulfation on the CS chains43, 44”
From Aggrecan and chondroitin-6-sulfate abnormalities in schizophrenia and bipolar disorder: a postmortem study on the amygdala (2015) · cites this paper as [43]
In the citing paper
“Numbers of CS chains and their patterns of sulfation fundamentally affect their functions, such as their ability to interact with other molecules including growth factors and cytokines.43”
From Aggrecan and chondroitin-6-sulfate abnormalities in schizophrenia and bipolar disorder: a postmortem study on the amygdala (2015) · cites this paper as [43]
In the citing paper
“Fourth, disruption of PNNs can alter the resting membrane potential of PV neurons (Miyata et al, 2012) and decrease the amplitudes of both inhibitory (Liu et al, 2013) and excitatory (Pyka et al, 2011) postsynaptic currents.”
From Reduced Labeling of Parvalbumin Neurons and Perineuronal Nets in the Dorsolateral Prefrontal Cortex of Subjects with Schizophrenia (2016) · cites this paper as Miyata et al, 2012
In the citing paper
“Several studies suggest that ECM components, including PNNs, are critical regulators of synaptic plasticity (Do et al, 2015;Miyata et al, 2012;Morishita et al, 2015).”
From Reduced Labeling of Parvalbumin Neurons and Perineuronal Nets in the Dorsolateral Prefrontal Cortex of Subjects with Schizophrenia (2016) · cites this paper as Miyata et al, 2012
In the citing paper
“For example, altered sulfation of N-acetylgalactosamine (GalNAc, a major disaccharide found in CSPGs) results in greatly reduced WFA labeling (Miyata et al, 2012).”
From Reduced Labeling of Parvalbumin Neurons and Perineuronal Nets in the Dorsolateral Prefrontal Cortex of Subjects with Schizophrenia (2016) · cites this paper as Miyata et al, 2012
In the citing paper
“Interestingly, it has been recently shown that a developmental increase in the 4-sulfation/6-sulfation (4S/6S) ratio of CSPGs has a role in the closure of the critical period for ocular dominance plasticity in the mouse visual cortex, and condensation of CSPGs into PNNs is prevented by cell-autonomous overexpression of chondroitin 6-sulfation, which maintains a low 4S/6S ratio (Miyata et al., 2012”
From The hyaluronan and proteoglycan link proteins: Organizers of the brain extracellular matrix and key molecules for neuronal function and plasticity (2015) · cites this paper as Miyata et al., 2012
In the citing paper
“Indeed, the maturation and phenotypic maintenance of PVI require incorporation of a non-cell autonomous homeobox protein, Otx2, through its affinity with PNN (Beurdeley et al., 2012; Miyata et al., 2012).”
From Redox dysregulation, neuroinflammation, and NMDA receptor hypofunction: A “central hub” in schizophrenia pathophysiology? (2016) · cites this paper as Miyata et al., 2012
In the citing paper
“Given the pivotal role of PVI, PNN, and myelin in regulating brain plasticity dynamics and active epochs (McGee et al., 2005; Miyata et al., 2012; Morishita and Hensch, 2008), the dysregulation of this “hub” could yield the slow emergence of clinical symptoms by altering the timing of key windows of critical period of brain plasticity (Morishita et al., 2010, abstract Neuroscience Meeting, 62.30).”
From Redox dysregulation, neuroinflammation, and NMDA receptor hypofunction: A “central hub” in schizophrenia pathophysiology? (2016) · cites this paper as Miyata et al., 2012
Citations
Cites
Efficient selection for high-expression transfectants with a novel eukaryotic vector
Niwa, H., Yamamura, K., & Miyazaki, J. (1991) · Gene · doi:10.1016/0378-1119(91)90434-d · Cited by 5,149
SINGLE-CELL RESPONSES IN STRIATE CORTEX OF KITTENS DEPRIVED OF VISION IN ONE EYE
Wiesel, T. N., & Hubel, D. H. (1963) · Journal of Neurophysiology · doi:10.1152/jn.1963.26.6.1003 · Cited by 2,628
Chondroitinase ABC promotes functional recovery after spinal cord injury
Bradbury, E. J., Moon, L. D. F., Popat, R. J., King, V. R., Bennett, G. S., Patel, P. N., Fawcett, J. W., & McMahon, S. B. (2002) · Nature · doi:10.1038/416636a · Cited by 2,357
Critical period plasticity in local cortical circuits
Hensch, T. K. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1787 · Cited by 2,323
Cortical inhibitory neurons and schizophrenia
Lewis, D. A., Hashimoto, T., & Volk, D. W. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1648 · Cited by 2,297
Reactivation of Ocular Dominance Plasticity in the Adult Visual Cortex
Pizzorusso, T., Medini, P., Berardi, N., Chierzi, S., Fawcett, J. W., & Maffei, L. (2002) · Science · doi:10.1126/science.1072699 · Cited by 1,679
Intrinsic firing patterns of diverse neocortical neurons
Connors, B. W., & Gutnick, M. J. (1990) · Trends in Neurosciences · doi:10.1016/0166-2236(90)90185-d · Cited by 1,440
A long, remarkable journey: Tangential migration in the telencephalon
Marín, Ó., & Rubenstein, J. L. R. (2001) · Nature reviews. Neuroscience · doi:10.1038/35097509 · Cited by 1,077
Local GABA Circuit Control of Experience-Dependent Plasticity in Developing Visual Cortex
Hensch, T. K., Fagiolini, M., Mataga, N., Stryker, M. P., Baekkeskov, S., & Kash, S. F. (1998) · Science · doi:10.1126/science.282.5393.1504 · Cited by 910
Experience-Dependent Plasticity of Binocular Responses in the Primary Visual Cortex of the Mouse
Gordon, J. A., & Stryker, M. P. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-10-03274.1996 · Cited by 885
Cited by
Sorted by citations
Critical periods in speech perception: New directions
Werker, J. F., & Hensch, T. K. (2015) · Annual Review of Psychology · doi:10.1146/annurev-psych-010814-015104 · Cited by 774
Balancing Plasticity/Stability Across Brain Development
Takesian, A. E., & Hensch, T. K. (2013) · Progress in Brain Research · doi:10.1016/b978-0-444-63327-9.00001-1 · Cited by 667
The roles of perineuronal nets and the perinodal extracellular matrix in neuronal function
Fawcett, J. W., Oohashi, T., & Pizzorusso, T. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0196-3 · Cited by 589
Perineuronal nets protect fast-spiking interneurons against oxidative stress
Cabungcal, J.-H., Steullet, P., Morishita, H., Kraftsik, R., Cuenod, M., Hensch, T. K., & Do, K. Q. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1300454110 · Cited by 512
Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex
Sipe, G. O., Lowery, Tremblay, M.-È., Kelly, E. A., Lamantia, C. E., & Majewska, A. K. (2016) · Nature Communications · doi:10.1038/ncomms10905 · Cited by 512
Biosynthesis and function of chondroitin sulfate
Mikami, T., & Kitagawa, H. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.06.006 · Cited by 526
Self-citationCasting a Wide Net: Role of Perineuronal Nets in Neural Plasticity
Sorg, B. A., Berretta, S., Blacktop, J. M., Fawcett, J. W., Kitagawa, H., Kwok, J. C. F., & Miquel, M. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.2351-16.2016 · Cited by 454
Self-citationTranscriptional Architecture of Synaptic Communication Delineates GABAergic Neuron Identity
Paul, A., Crow, M., Raudales, R., He, M., Gillis, J., & Huang, Z. J. (2017) · Cell · doi:10.1016/j.cell.2017.08.032 · Cited by 421
Otx2 Binding to Perineuronal Nets Persistently Regulates Plasticity in the Mature Visual Cortex
Beurdeley, M., Spatazza, J., Lee, H. H. C., Sugiyama, S., Bernard, C., Di Nardo, A. A., Hensch, T. K., & Prochiantz, A. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0394-12.2012 · Cited by 398
Mauney, S. A., Athanas, K. M., Pantazopoulos, H., Shaskan, N., Passeri, E., Berretta, S., & Woo, T.-U. W. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.05.007 · Cited by 291
Encouraging an excitable brain state: mechanisms of brain repair in stroke
Joy, M. T., & Carmichael, S. T. (2020) · Nature reviews. Neuroscience · doi:10.1038/s41583-020-00396-7 · Cited by 300
Steullet, P., Cabungcal, J. H., Monin, A., Dwir, D., O'Donnell, P., Cuenod, M., & Do, K. Q. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2014.06.021 · Cited by 262
Targeting the neural extracellular matrix in neurological disorders
Soleman, S., Filippov, M. A., Dityatev, A., & Fawcett, J. W. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.08.050 · Cited by 244
Enwright, J. F., Sanapala, S., Foglio, A., Berry, R., Fish, K. N., & Lewis, D. A. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.24 · Cited by 223
Aggrecan Directs Extracellular Matrix-Mediated Neuronal Plasticity
Rowlands, D., Lensjø, K. K., Dinh, T., Yang, S., Andrews, M. R., Hafting, T., Fyhn, M., Fawcett, J. W., & Dick, G. (2018) · The Journal of Neuroscience · doi:10.1523/jneurosci.1122-18.2018 · Cited by 204
Mizumoto, S., Yamada, S., & Sugahara, K. (2015) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2015.06.004 · Cited by 202
Dyck, S. M., & Karimi‐Abdolrezaee, S. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.04.006 · Cited by 197
The extracellular matrix and perineuronal nets in memory
Fawcett, J. W., Fyhn, M., Jendelova, P., Kwok, J. C. F., Ruzicka, J., & Sorg, B. A. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01634-3 · Cited by 169
Choroid-Plexus-Derived Otx2 Homeoprotein Constrains Adult Cortical Plasticity
Spatazza, J., Lee, H. H. C., Di Nardo, A. A., Tibaldi, L., Joliot, A., Hensch, T. K., & Prochiantz, A. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.05.014 · Cited by 176
Miyata, S., & Kitagawa, H. (2017) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2017.06.010 · Cited by 171
Self-citationPantazopoulos, H., Markota, M., Jaquet, F., Ghosh, D., Wallin, A., Santos, A., Caterson, B., & Berretta, S. (2015) · Translational Psychiatry · doi:10.1038/tp.2014.128 · Cited by 153
Orlando, C., Ster, J., Gerber, U., Fawcett, J. W., & Raineteau, O. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.2406-12.2012 · Cited by 153
Krishnan, K., Wang, B.-S., Lu, J., Wang, L., Maffei, A., Cang, J., & Huang, Z. J. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1506499112 · Cited by 146
Do, K. Q., Cuenod, M., & Hensch, T. K. (2015) · Schizophrenia Bulletin · doi:10.1093/schbul/sbv065 · Cited by 158
Crapser, J. D., Ochaba, J., Soni, N., Reidling, J. C., Thompson, L. M., & Green, K. N. (2020) · Brain · doi:10.1093/brain/awz363 · Cited by 157
Burnside, E. R., & Bradbury, E. J. (2013) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12114 · Cited by 161
Berretta, S., Pantazopoulos, H., Markota, M., Brown, C., & Batzianouli, E. T. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2014.12.040 · Cited by 152
de Vivo, L., Landi, S., Panniello, M., Baroncelli, L., Chierzi, S., Mariotti, L., Spolidoro, M., Pizzorusso, T., Maffei, L., & Ratto, G. M. (2013) · Nature Communications · doi:10.1038/ncomms2491 · Cited by 148
Perineuronal nets in brain physiology and disease
Testa, D., Prochiantz, A., & Nardo, A. A. D. (2018) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2018.09.011 · Cited by 153
Chondroitin sulfates and their binding molecules in the central nervous system
Djerbal, L., Lortat-Jacob, H., & Kwok, J. (2017) · Glycoconjugate Journal · doi:10.1007/s10719-017-9761-z · Cited by 144
Rapid transformation of Chlamydomonas reinhardtii without cell-wall removal
Yamano, T., Iguchi, H., & Fukuzawa, H. (2013) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2012.12.020 · Cited by 142
Wingert, J. C., & Sorg, B. A. (2021) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2021.673210 · Cited by 129
Brain ageing changes proteoglycan sulfation, rendering perineuronal nets more inhibitory
Foscarin, S., Raha-Chowdhury, R., Fawcett, J. W., & Kwok, J. C. F. (2017) · Aging · doi:10.18632/aging.101256 · Cited by 139
Dzyubenko, E., Gottschling, C., & Faissner, A. (2016) · Neural Plasticity · doi:10.1155/2016/5214961 · Cited by 134
Oohashi, T., Edamatsu, M., Bekku, Y., & Carulli, D. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.09.010 · Cited by 131
Cuénod, M., Steullet, P., Cabungcal, J.-H., Dwir, D., Khadimallah, I., Klauser, P., Conus, P., & Kim, Q. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01374-w · Cited by 134
An Extracellular Perspective on CNS Maturation: Perineuronal Nets and the Control of Plasticity
Carulli, D., & Verhaagen, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052434 · Cited by 136
In Sickness and in Health: Perineuronal Nets and Synaptic Plasticity in Psychiatric Disorders
Pantazopoulos, H., & Berretta, S. (2015) · Neural Plasticity · doi:10.1155/2016/9847696 · Cited by 128
Sigal, Y. M., Bae, H., Bogart, L. J., Hensch, T. K., & Zhuang, X. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1817222116 · Cited by 118
Morawski, M., Reinert, T., Meyer-Klaucke, W., Wagner, F. E., Tröger, W., Reinert, A., Jäger, C., Brückner, G., & Arendt, T. (2015) · Scientific Reports · doi:10.1038/srep16471 · Cited by 116
“GAG-ing with the neuron”: The role of glycosaminoglycan patterning in the central nervous system
Smith, P. D., Coulson‐Thomas, V. J., Foscarin, S., Kwok, J. C. F., & Fawcett, J. W. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.08.004 · Cited by 114
Cerebellar plasticity and associative memories are controlled by perineuronal nets
Carulli, D., Broersen, R., de Winter, F., Muir, E. M., Mešković, M., de Waal, M., de Vries, S., Boele, H.-J., Canto, C. B., De Zeeuw, C. I., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1916163117 · Cited by 110
Chloride Dysregulation, Seizures, and Cerebral Edema: A Relationship with Therapeutic Potential
Glykys, J. C., Dzhala, V. I., Egawa, K., Kahle, K. T., Delpire, E. J., & Staley, K. J. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.03.006 · Cited by 112
Tewari, B. P., Chaunsali, L., Prim, C. E., & Sontheimer, H. W. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.1022754 · Cited by 115
Lupori, L., Totaro, V., Cornuti, S., Ciampi, L., Carrara, F., Grilli, E., Viglione, A., Tozzi, F., Putignano, E., Mazziotti, R. M., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112788 · Cited by 113
Involvement of cortical fast-spiking parvalbumin-positive basket cells in epilepsy
Jiang, X., Lachance, M., & Rossignol, E. (2016) · Progress in brain research · doi:10.1016/bs.pbr.2016.04.012 · Cited by 101
Otx2-PNN interaction to regulate cortical plasticity
Bernard, C., & Prochiantz, A. (2016) · Neural Plasticity · doi:10.1155/2016/7931693 · Cited by 102
Miller, G. M., & Hsieh‐Wilson, L. C. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.08.015 · Cited by 101
MECP2 regulates cortical plasticity underlying a learned behaviour in adult female mice
Krishnan, K., Lau, B. Y. B., Ewall, G., Huang, Z. J., & Shea, S. D. (2017) · Nature Communications · doi:10.1038/ncomms14077 · Cited by 105
Perineuronal nets and schizophrenia: The importance of neuronal coatings
Bitanihirwe, B. K. Y., & Woo, T.-U. W. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.03.018 · Cited by 95
Neural ECM molecules in synaptic plasticity, learning, and memory
Senkov, O., Anđjus, P. R., Radenović, L., Soriano, E., & Dityatev, A. E. (2014) · Progress in brain research · doi:10.1016/b978-0-444-63486-3.00003-7 · Cited by 96
Prolonged Period of Cortical Plasticity upon Redox Dysregulation in Fast-Spiking Interneurons
Morishita, H., Cabungcal, J.-H., Chen, Y., Do, K. Q., & Hensch, T. K. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.12.026 · Cited by 92
Bozzelli, P. L., Alaiyed, S., Kim, E., Villapol, S., & Conant, K. E. (2018) · Neural Plasticity · doi:10.1155/2018/5735789 · Cited by 93
Santiago, A. N., Lim, K. Y., Opendak, M., Sullivan, R. M., & Aoki, C. (2018) · Journal of Comparative Neurology · doi:10.1002/cne.24522 · Cited by 87
Cortical plasticity induced by transplantation of embryonic somatostatin or parvalbumin interneurons
Tang, Y., Stryker, M. P., Álvarez-Buylla, A., & Espinosa, J. S. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1421844112 · Cited by 88
Nabel, E. M., & Morishita, H. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00146 · Cited by 85
A Sweet Talk: The Molecular Systems of Perineuronal Nets in Controlling Neuronal Communication
Spijker, H. M. V. ‘., & Kwok, J. C. F. (2017) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2017.00033 · Cited by 89
Enzymatic Synthesis of Homogeneous Chondroitin Sulfate Oligosaccharides
Li, J., Su, G., & Liu, J. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201705638 · Cited by 85
Directing Neuronal Signaling through Cell-Surface Glycan Engineering
Pulsipher, A., Griffin, M. E., Stone, S. E., Brown, J. M., & Hsieh‐Wilson, L. C. (2014) · Journal of the American Chemical Society · doi:10.1021/ja5005174 · Cited by 83
Mizumoto, S., Fongmoon, D., & Sugahara, K. (2012) · Glycoconjugate Journal · doi:10.1007/s10719-012-9463-5 · Cited by 84
Genetic Otx2 mis-localization delays critical period plasticity across brain regions
Lee, H. H. C., Bernard, C., Ye, Z., Acampora, D., Simeone, A., Prochiantz, A., Di Nardo, A. A., & Hensch, T. K. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.1 · Cited by 82
Izumikawa, T., Sato, B., & Kitagawa, H. (2014) · Scientific Reports · doi:10.1038/srep03701 · Cited by 79
Self-citationMirzadeh, Z., Alonge, K. M., Cabrales, E., Herranz‐Pérez, V., Scarlett, J. M., Brown, J. M., Hassouna, R., Matsen, M. E., Hồng, N. T., García‐Verdugo, J. M., et al. (2019) · Nature Metabolism · doi:10.1038/s42255-018-0029-0 · Cited by 82
Circadian Rhythms of Perineuronal Net Composition
Pantazopoulos, H., Gisabella, B., Rexrode, L., Benefield, D., Yıldız, E., Seltzer, P., Valeri, J., Chelini, G., Reich, A., Ardelt, M., et al. (2020) · eNeuro · doi:10.1523/eneuro.0034-19.2020 · Cited by 77
Regulation of Perineuronal Nets in the Adult Cortex by the Activity of the Cortical Network
Devienne, G. F., Picaud, S., Cohen, I., Piquet, J., Tricoire, L., Testa, D., Nardo, A. A. D., Rossier, J., Cauli, B., & Lambolez, B. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.0434-21.2021 · Cited by 92
Where no synapses go: gatekeepers of circuit remodeling and synaptic strength
Mironova, Y. A., & Giger, R. J. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.04.003 · Cited by 78
Identification of a critical sulfation in chondroitin that inhibits axonal regeneration
Pearson, C. S., Mencio, C. P., Barber, A. C., Martin, K. R., & Geller, H. M. (2018) · eLife · doi:10.7554/elife.37139 · Cited by 75
Morikawa, S., Ikegaya, Y., Narita, M., & Tamura, H. (2017) · Scientific Reports · doi:10.1038/srep46024 · Cited by 74
Chondroitin Sulfate Is Required for Onset and Offset of Critical Period Plasticity in Visual Cortex
Hou, X., Yoshioka, N., Tsukano, H., Sakai, A., Miyata, S., Watanabe, Y., Yanagawa, Y., Sakimura, K., Takeuchi, K., Kitagawa, H., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-04007-x · Cited by 83
Self-citationChondroitin 6-sulphate is required for neuroplasticity and memory in ageing
Yang, S., Gigout, S., Molinaro, A., Naito-Matsui, Y., Hilton, S., Foscarin, S., Nieuwenhuis, B., Tan, C. L., Verhaagen, J., Pizzorusso, T., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01208-9 · Cited by 70
Self-citationThe tetrapartite synapse: a key concept in the pathophysiology of schizophrenia
Chelini, G., Pantazopoulos, H., Durning, P. T., & Berretta, S. (2018) · European Psychiatry · doi:10.1016/j.eurpsy.2018.02.003 · Cited by 73
Miyata, S., & Kitagawa, H. (2016) · Neural Plasticity · doi:10.1155/2016/1305801 · Cited by 70
Self-citationThe Chemorepulsive Protein Semaphorin 3A and Perineuronal Net-Mediated Plasticity
de Winter, F., Kwok, J. C. F., Fawcett, J. W., Vo, T. T., Carulli, D., & Verhaagen, J. (2016) · Neural Plasticity · doi:10.1155/2016/3679545 · Cited by 84
Mechanisms for modulation of neural plasticity and axon regeneration by chondroitin sulphate
Miyata, S., & Kitagawa, H. (2014) · The Journal of Biochemistry · doi:10.1093/jb/mvu067 · Cited by 73
Self-citationHomeoprotein Signaling in the Developing and Adult Nervous System
Prochiantz, A., & Nardo, A. A. D. (2015) · Neuron · doi:10.1016/j.neuron.2015.01.019 · Cited by 85
Miyata, S., Nadanaka, S., Igarashi, M., & Kitagawa, H. (2018) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2018.00003 · Cited by 68
Self-citationNadanaka, S., Kinouchi, H., & Kitagawa, H. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.814509 · Cited by 68
Self-citationFlexible Roles for Proteoglycan Sulfation and Receptor Signaling
Yu, P., Pearson, C. S., & Geller, H. M. (2018) · Trends in Neurosciences · doi:10.1016/j.tins.2017.10.005 · Cited by 67
Astroglial Scarring and Seizures
Robel, S. (2016) · The Neuroscientist · doi:10.1177/1073858416645498 · Cited by 64
Yang, S., Hilton, S., Alves, J. N., Saksida, L. M., Bussey, T., Matthews, R. T., Kitagawa, H., Spillantini, M. G., Kwok, J. C. F., & Fawcett, J. W. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.08.002 · Cited by 61
Self-citationThe role of human natural killer-1 (HNK-1) carbohydrate in neuronal plasticity and disease
Morise, J., Takematsu, H., & Oka, S. (2017) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2017.06.025 · Cited by 63
Alonge, K. M., Mirzadeh, Z., Scarlett, J. M., Logsdon, A. F., Brown, J. M., Cabrales, E., Chan, C. K., Kaiyala, K. J., Bentsen, M. A., Banks, W. A., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-00275-6 · Cited by 63
The “Loss” of Perineuronal Nets in Alzheimer's Disease: Missing or Hiding in Plain Sight?
Scarlett, J. M., Hu, S. J., & Alonge, K. M. (2022) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2022.896400 · Cited by 61
Perineuronal Net Dynamics in the Pathophysiology of Epilepsy
Chaunsali, L., Tewari, B. P., & Sontheimer, H. W. (2021) · Epiliepsy currents/Epilepsy currents · doi:10.1177/15357597211018688 · Cited by 60
Spatazza, J., Lullo, E. D., Joliot, A., Dupont, E., Moya, K. L., & Prochiantz, A. (2013) · Pharmacological Reviews · doi:10.1124/pr.112.006577 · Cited by 78
Hirono, M., Watanabe, S., Karube, F., Fujiyama, F., Kawahara, S., Nagao, S., Yanagawa, Y., & Misonou, H. (2018) · The Journal of Neuroscience · doi:10.1523/jneurosci.3238-17.2018 · Cited by 53
Cortical maps: a role for astrocytes?
López-Hidalgo, M. A., & Schummers, J. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.11.001 · Cited by 59
Koike, T., Izumikawa, T., Tamura, J., & Kitagawa, H. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.03.024 · Cited by 58
Self-citationOTX2 Signals from the Choroid Plexus to Regulate Adult Neurogenesis
Planques, A., Moreira, V. O., Dubreuil, C., Prochiantz, A., & Nardo, A. A. D. (2019) · eNeuro · doi:10.1523/eneuro.0262-18.2019 · Cited by 60
Incubation of depression: ECM assembly and parvalbumin interneurons after stress
Spijker, S., Koskinen, M.-K., & Riga, D. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.07.015 · Cited by 55
Decoding perineuronal net glycan sulfation patterns in the Alzheimer's disease brain
Logsdon, A. F., Francis, K. L., Richardson, N. E., HU, S. J. W., Faber, C. L., Phan, B. A., Nguyen, V., Setthavongsack, N., Banks, W. A., Woltjer, R. L., et al. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12451 · Cited by 56
Human genetic disorders and knockout mice deficient in glycosaminoglycan
Mizumoto, S., Yamada, S., & Sugahara, K. (2014) · BioMed Research International · doi:10.1155/2014/495764 · Cited by 54
Diurnal changes in perineuronal nets and parvalbumin neurons in the rat medial prefrontal cortex
Harkness, J. H., Gonzalez, A. E., Bushana, P. N., Jorgensen, E. T., Hegarty, D. M., Nardo, A. A. D., Prochiantz, A., Wisor, J. P., Aicher, S. A., Brown, T. E., et al. (2021) · Brain Structure and Function · doi:10.1007/s00429-021-02229-4 · Cited by 55
Mapping pathologic circuitry in schizophrenia
Glausier, J. R., & Lewis, D. A. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63639-3.00025-6 · Cited by 53
Yu, Z., Chen, N., Hu, D., Chen, W., Yuan, Y., Meng, S., Zhang, W., Lu, L., Han, Y., & Shi, J. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00004 · Cited by 52
Ryu, Y., Iwashita, M., Lee, W., Uchimura, K., & Kosodo, Y. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.709620 · Cited by 51
Liu, C., Fan, L., Xing, J., Wang, Q., Lin, C., Liu, C., Deng, X., Ning, C., Zhou, L., Rong, L., et al. (2019) · Biomaterials Science · doi:10.1039/c8bm01363b · Cited by 52
Ribic, A., Crair, M. C., & Biederer, T. (2019) · Cell Reports · doi:10.1016/j.celrep.2018.12.069 · Cited by 51
Proteoglycan Sulphation in the Function of the Mature Central Nervous System
Fawcett, J. W., & Kwok, J. C. F. (2022) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2022.895493 · Cited by 50
Involvement of chondroitin 6-sulfation in temporal lobe epilepsy
Yutsudo, N., & Kitagawa, H. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.07.009 · Cited by 50
Self-citation
Metadata
- Authors
- Miyata, S., Komatsu, Y., Yoshimura, Y., Taya, C., & Kitagawa, H.
- Affiliations
- Kobe Pharmaceutical University (JP)
- Research Institute of Environmental Medicine, Nagoya University (JP)
- National Institutes of Natural Sciences (JP)
- Tokyo Metropolitan Institute of Medical Science (JP)
- Corresponding author
- Kitagawa, Hiroshi
- Venue
- Nature Neuroscience
- Published
- 2012-01-15
- Volume
- 15
- Issue
- 3
- Pages
- 414-422
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2078474557
- Cited by
- 365
- References
- 49
- Citations by year
- 2026: 19 · 2025: 22 · 2024: 23 · 2023: 22 · 2022: 23 · 2021: 38 · 2020: 36 · 2019: 25 · 2018: 25 · 2017: 26 · 2016: 18 · 2015: 28 · 2014: 28 · 2013: 26 · 2012: 6
- FWCI
- 13.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University Research Committee, Emory University
- Japan Society for the Promotion of Science (21390025, 23110003)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- chondroitin sulfate proteoglycans, ocular dominance plasticity, critical period, visual cortex, parvalbumin interneurons, perineuronal nets, extracellular matrix, Otx2, interneuron maturation, cortical plasticity
- MeSH terms
- Carbohydrate Sulfotransferases, Action Potentials, Age Factors, Amphetamines, Animals, Animals, Newborn, Astrocytes, Bacterial Proteins, Cells, Cultured, Chlorocebus aethiops, Chondroitin Sulfates, Humans, Functional Laterality, Luminescent Proteins, Mice, Transgenic, Nerve Tissue Proteins, Neuronal Plasticity, Parvalbumins, Chondroitin Sulfate Proteoglycans, Sensory Deprivation, Time Factors, Visual Cortex, Visual Pathways, Sulfotransferases, Up-Regulation, Electroporation, Patch-Clamp Techniques, Gene Expression Regulation, Developmental, Receptors, N-Acetylglucosamine, Plant Lectins, Vesicular Glutamate Transport Protein 2, Mice, Otx Transcription Factors, Aggrecans, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
