Common medial frontal mechanisms of adaptive control in humans and rodents
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In this report we describe how common brain networks within the medial frontal cortex (MFC) facilitate adaptive behavioral control in rodents and humans. We demonstrate that after errors, low-frequency oscillations below 12 Hz are modulated over the midfrontal cortex in humans and within the prelimbic and anterior cingulate regions of the MFC in rats. These oscillations were phase locked between the MFC and motor areas in both rats and humans. In rats, single neurons that encoded prior behavioral outcomes were phase coherent with low-frequency field oscillations, particularly after errors. Inactivating the medial frontal regions in rats led to impaired behavioral adjustments after errors, eliminated the differential expression of low-frequency oscillations after errors and increased low-frequency spike-field coupling within the motor cortex. Our results describe a new mechanism for behavioral adaptation through low-frequency oscillations and elucidate how medial frontal networks synchronize brain activity to guide performance.
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MFTP serves as a neural marker of EF related to conflict and performance monitoring, with sources at least partly in the dorsomedial PFC.
“The second, mediofrontal theta power (MFTP), is a neural correlate of EF that indexes conflict and performance monitoring. MFTP has been shown in both human and animal models to reflect a readout of neural oscillations arising, at least in part, from the dorsomedial PFC (Cavanagh & Frank, 2014; Narayanan et al., 2013).”
From Family-based care buffers the stress sensitizing effect of early deprivation on executive functioning difficulties in adolescence (2023) · cites this paper as Narayanan et al., 2013
Mediofrontal theta oscillations reflect a more direct readout of a neural mechanism supporting cognitive control.
“Mediofrontal theta (4−8 Hz) oscillations reflect a more direct readout of a neural mechanism supporting cognitive control”
From Adolescent cognitive control and mediofrontal theta oscillations are disrupted by neglect: Associations with transdiagnostic risk for psychopathology in a randomized controlled trial (2020) · cites this paper as Narayanan et al., 2013
The causal role of mediofrontal theta oscillations in synchronizing brain regions to support cognitive control has been demonstrated in both humans and rodents.
“the causal role of mediofrontal theta oscillations in synchronizing brain regions to support cognitive control has been demonstrated in both humans and rodents (Herrmann et al., 2016; Narayanan et al., 2013)”
From Adolescent cognitive control and mediofrontal theta oscillations are disrupted by neglect: Associations with transdiagnostic risk for psychopathology in a randomized controlled trial (2020) · cites this paper as Narayanan et al., 2013
Event-related mediofrontal theta power has a well-defined role as a neural mechanism supporting cognitive control across mammalian species.
“event-related mediofrontal theta power has a well-defined role as a neural mechanism supporting cognitive control across mammalian species (Cavanagh and Frank, 2014), including rodents (Narayanan et al., 2013), non-human primates (Tsujimoto et al., 2006; Womelsdorf et al., 2010) and humans (Cavanagh et al., 2009)”
From Adolescent cognitive control and mediofrontal theta oscillations are disrupted by neglect: Associations with transdiagnostic risk for psychopathology in a randomized controlled trial (2020) · cites this paper as Narayanan et al., 2013
A homolog of rodent mediofrontal theta can be non-invasively recorded via EEG scalp electrodes over mediofrontal cortex in humans.
“A homolog of rodent mediofrontal theta can be non-invasively recorded via EEG scalp electrodes over mediofrontal cortex in humans (Narayanan et al., 2013)”
From Adolescent cognitive control and mediofrontal theta oscillations are disrupted by neglect: Associations with transdiagnostic risk for psychopathology in a randomized controlled trial (2020) · cites this paper as Narayanan et al., 2013
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- Authors
- Narayanan, N. S., Cavanagh, J. F., Frank, M. J., & Laubach, M.
- Affiliations
- University of Iowa (US)
- Brown University (US)
- Yale University (US)
- Corresponding author
- Laubach, Mark
- Venue
- Nature Neuroscience
- Published
- 2013-10-20
- Volume
- 16
- Issue
- 12
- Pages
- 1888-1895
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC3840072
- OpenAlex
- W2163919991
- Cited by
- 267
- References
- 44
- Citations by year
- 2026: 9 · 2025: 11 · 2024: 17 · 2023: 18 · 2022: 22 · 2021: 35 · 2020: 14 · 2019: 19 · 2018: 24 · 2017: 25 · 2016: 24 · 2015: 20 · 2014: 26 · 2013: 2
- FWCI
- 13.16
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Figshare (submittedVersion, cc-by)
- American University Research Archive
- Funders
- Brown University
- National Institutes of Health (5r01mh080066-10)
- National Institute on Aging (P01AG030004)
- National Institute of Mental Health (R01-MH080066, MH080066-01)
- National Institute of Neurological Disorders and Stroke (K08NS078100)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- adaptive control, anterior cingulate cortex, medial frontal cortex, low-frequency oscillations, phase locking, time estimation, prelimbic cortex, motor cortex, neural oscillations, cross-species comparison, rats, human
- MeSH terms
- Acoustic Stimulation, Adaptation, Physiological, Animals, Brain Mapping, Conditioning, Operant, Electroencephalography, Female, Frontal Lobe, Humans, Male, Reaction Time, Time Perception, Rats, Long-Evans, Rats, Young Adult, Brain Waves
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