CoChat
Sign Up
Cited by 224Cannabis and Cannabinoid ResearchNeuroscience and Neuropharmacology ResearchNeural dynamics and brain function

Distinct timing in the activity of cannabinoid-sensitive and cannabinoid-insensitive basket cells

Open access
Glickfeld, Lindsey L, Scanziani, Massimo·2006·Nature Neuroscience
DOI 10.1038/nn1688PMC PMC3509385
Open this paper in CoChat — free account

Abstract

Cannabinoids are powerful modulators of inhibition, yet the precise spike timing of cannabinoid receptor (CB1R)-expressing inhibitory neurons in relation to other neurons in the circuit is poorly understood. Here we found that the spike timing of CB1R-expressing basket cells, a major target for cannabinoids in the rat hippocampus, was distinct from the other main group of basket cells, the CB1R-negative. Despite receiving the same afferent inputs, the synaptic and biophysical properties of the two cell types were tuned to detect different features of activity. CB1R-negative basket cells responded reliably and immediately to subtle and repetitive excitation. In contrast, CB1R-positive basket cells responded later and did not follow repetitive activity, but were better suited to integrate the consecutive excitation of independent afferents. This temporal separation in the activity of the two basket cell types generated distinct epochs of somatic inhibition that were differentially affected by endocannabinoids.

Integrity signals

Registry

Crossref · 10.1038/nn1688

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • As a result of slow facilitation, these interneurons (presumably SST-containing O-LM cells, BiCs and CB1R-positive CCK-containing cells) are engaged in a later inhibitory epoch reflecting an integration mode that drives distal dendritic inhibitory inputs proportional to spike rates late in the series.

    “As a result of slow facilitation, these interneurons [presumably SST-containing O-LM cells, BiCs and CB1R-positive CCK-containing cells (404)] are engaged in a later inhibitory epoch reflecting an integration mode that drives distal dendritic inhibitory inputs proportional to spike rates late in the series.”

    From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [404]

  • In most cortical networks, the dynamic between excitatory and inhibitory inputs is strongly modulated by short-term plasticity of the respective components, such that progressive changes in the excitation:inhibition ratio result in progressive degradation of the excitation and inhibition balance.

    “In most cortical networks, the dynamic between excitatory and inhibitory inputs is strongly modulated by the short-term plasticity properties of the respective components, such that progressive changes in the excitation:inhibition ratio results in a progressive degradation of the excitation and inhibition balance (372, 404).”

    From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [404]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Glickfeld, L. L., & Scanziani, M.
Affiliations
University of California San Diego (US)
Corresponding author
Scanziani, Massimo
ORCID
Venue
Nature Neuroscience
Publisher
Springer Science and Business Media LLC
Published
2006-04-30
Volume
9
Issue
6
Pages
807-815
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
DOI
10.1038/nn1688
PMC
PMC3509385
OpenAlex
W2119343718
Cited by
222
References
42
Citations by year
2026: 2 · 2025: 8 · 2024: 6 · 2023: 7 · 2022: 6 · 2021: 7 · 2020: 11 · 2019: 3 · 2018: 8 · 2017: 5 · 2016: 10 · 2015: 7 · 2014: 18 · 2013: 19 · 2012: 13
FWCI
9.20
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (5t32da007315-11)
  • National Institute of Mental Health (MH 70058, MH71401, R01MH071401, R01MH070058)
  • National Institute on Drug Abuse (T32-DA-007315, 5T32DA007315)
Topics
  • Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
CB1 receptor, basket cells, inhibitory interneurons, spike timing, hippocampus, endocannabinoids, somatic inhibition, synaptic integration, afferent input, inhibitory circuits
MeSH terms
Animals, Cannabinoids, Dendrites, Hippocampus, Interneurons, Male, Nerve Net, Neural Inhibition, Neural Pathways, Synaptic Transmission, Organ Culture Techniques, Reaction Time, Synapses, Time Factors, Rats, Wistar, Pyramidal Cells, Patch-Clamp Techniques, Excitatory Postsynaptic Potentials, Receptor, Cannabinoid, CB1, Cell Shape, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review