The gut microbiota: a major player in the toxicity of environmental pollutants?
Open accessAbstract
Exposure to environmental chemicals has been linked to various health disorders, including obesity, type 2 diabetes, cancer and dysregulation of the immune and reproductive systems, whereas the gastrointestinal microbiota critically contributes to a variety of host metabolic and immune functions. We aimed to evaluate the bidirectional relationship between gut bacteria and environmental pollutants and to assess the toxicological relevance of the bacteria-xenobiotic interplay for the host. We examined studies using isolated bacteria, faecal or caecal suspensions-germ-free or antibiotic-treated animals-as well as animals reassociated with a microbiota exposed to environmental chemicals. The literature indicates that gut microbes have an extensive capacity to metabolise environmental chemicals that can be classified in five core enzymatic families (azoreductases, nitroreductases, β-glucuronidases, sulfatases and β-lyases) unequivocally involved in the metabolism of >30 environmental contaminants. There is clear evidence that bacteria-dependent metabolism of pollutants modulates the toxicity for the host. Conversely, environmental contaminants from various chemical families have been shown to alter the composition and/or the metabolic activity of the gastrointestinal bacteria, which may be an important factor contributing to shape an individual's microbiotype. The physiological consequences of these alterations have not been studied in details but pollutant-induced alterations of the gut bacteria are likely to contribute to their toxicity. In conclusion, there is a body of evidence suggesting that gut microbiota are a major, yet underestimated element that must be considered to fully evaluate the toxicity of environmental contaminants.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The capacity of the gut microbiome to metabolize environmental chemicals is mediated by widely distributed enzymes such as beta-glucuronidases, azoreductases, and nitroreductases.
“The capacity of the gut microbiome to metabolize environmental chemicals is mediated by enzymes with a wide distribution such as b-glucoronidases, azoreductases, and nitroreductases, which are able to chemically transform a range of agents such as nitrotoluenes, pesticides, polychlorobiphenyls, azo dyes, and metals (Claus et al., 2016).”
From Gut reactions: Breaking down xenobiotic–microbiome interactions (2019) · cites this paper as Claus et al., 2016
Gut microbial enzymes can chemically transform nitrotoluenes, pesticides, polychlorobiphenyls, azo dyes, and metals.
“The capacity of the gut microbiome to metabolize environmental chemicals is mediated by enzymes with a wide distribution such as b-glucoronidases, azoreductases, and nitroreductases, which are able to chemically transform a range of agents such as nitrotoluenes, pesticides, polychlorobiphenyls, azo dyes, and metals (Claus et al., 2016).”
From Gut reactions: Breaking down xenobiotic–microbiome interactions (2019) · cites this paper as Claus et al., 2016
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624 · see citing works
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785 · see citing works
IARC Monographs on the Evaluation of Carcinogenic Risks to Humans
Zuckerman, A. J. (1995) · Journal of Clinical Pathology · doi:10.1136/jcp.48.7.691-a · Cited by 8,761 · see citing works
Human gut microbiome viewed across age and geography
Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815 · see citing works
A metagenome-wide association study of gut microbiota in type 2 diabetes
Qin, J., Li, Y., Cai, Z., Li, S., Zhu, J., Zhang, F., Liang, S., Zhang, W., Guan, Y., Shen, D., et al. (2012) · Nature · doi:10.1038/nature11450 · Cited by 6,762 · see citing works
The gut microbiota--masters of host development and physiology
Sommer, F., & Bäckhed, F. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro2974 · Cited by 3,681 · see citing works
IARC monographs on the evaluation of carcinogenic risks to humans
Hopkins, J. C. A. (1989) · Food and Chemical Toxicology · doi:10.1016/0278-6915(89)90054-9 · Cited by 2,868 · see citing works
The gut flora as a forgotten organ
O'Hara, A. M., & Shanahan, F. (2006) · The EMBO Reports · doi:10.1038/sj.embor.7400731 · Cited by 2,791 · see citing works
Artificial sweeteners induce glucose intolerance by altering the gut microbiota
Suez, J., Korem, T., Zeevi, D., Zilberman-Schapira, G., Thaiss, C. A., Maza, O., Israeli, D., Zmora, N., Gilad, S., Weinberger, A., et al. (2014) · Nature · doi:10.1038/nature13793 · Cited by 2,067 · cited 2× · see citing works
“103 These results suggest that human individuals feature a personalised response to arti fi cial sweeteners, possibly stemming from their differences in microbiota composition and function.”
Darfeuille-Michaud, A., Boudeau, J., Bulois, P., Neut, C., Glasser, A.-L., Barnich, N., Bringer, M.-A., Swidsinski, A., Beaugerie, L., & Colombel, J.-F. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.04.061 · Cited by 1,566 · see citing works
Unravelling the effects of the environment and host genotype on the gut microbiome
Spor, A., Koren, O., & Ley, R. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2540 · Cited by 1,509 · see citing works
The composition of the gut microbiota throughout life, with an emphasis on early life
Rodríguez, J. M., Murphy, K., Stanton, C., Ross, R. P., Kober, O. I., Juge, N., Avershina, E., Rudi, K., Narbad, A., Jenmalm, M. C., et al. (2015) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v26.26050 · Cited by 1,320 · see citing works
Computational Improvements Reveal Great Bacterial Diversity and High Metal Toxicity in Soil
Gans, J. D., Wolinsky, M., & Dunbar, J. (2005) · Science · doi:10.1126/science.1112665 · Cited by 1,210 · see citing works
Exposure to carcinogenic PAHs in the environment
Menzie, C. A., Potocki, B. B., & Santodonato, J. (1992) · Environmental Science & Technology · doi:10.1021/es00031a002 · Cited by 1,153 · see citing works
Altered profile of human gut microbiome is associated with cirrhosis and its complications
Bajaj, J. S., Heuman, D. M., Hylemon, P. B., Sanyal, A. J., White, M. B., Monteith, P., Noble, N. A., Unser, A. B., Daita, K., Fisher, A. R., et al. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2013.12.019 · Cited by 1,099 · see citing works
Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice
Le Roy, T., Llopis, M., Lepage, P., Bruneau, A., Rabot, S., Bevilacqua, C., Martin, P., Philippe, C., Walker, F., Bado, A., et al. (2013) · Gut · doi:10.1136/gutjnl-2012-303816 · Cited by 1,001 · see citing works
Endocrine Disruptors: From Endocrine to Metabolic Disruption
Casals-Casas, C., & Desvergne, B. (2011) · Annual Review of Physiology · doi:10.1146/annurev-physiol-012110-142200 · Cited by 902 · see citing works
Bäckhed, F., Fraser, C. M., Ringel, Y., Sanders, M. E., Sartor, R. B., Sherman, P. M., Versalovic, J., Young, V., & Finlay, B. B. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.10.012 · Cited by 836 · see citing works
Xenobiotics shape the physiology and gene expression of the active human gut microbiome
Maurice, C. F., Haiser, H. J., & Turnbaugh, P. J. (2013) · Cell · doi:10.1016/j.cell.2012.10.052 · Cited by 811 · see citing works
Chen, C.-J., Chen, C., Wu, M.-M., & Kuo, T.-L. (1992) · British Journal of Cancer · doi:10.1038/bjc.1992.380 · Cited by 773 · see citing works
Gut mucosal microbiome across stages of colorectal carcinogenesis
Nakatsu, G., Li, X., Zhou, H., Sheng, J., Wong, S. H., Wu, W. K. K., Ng, S. C., Tsoi, H., Dong, Y., Zhang, N., et al. (2015) · Nature Communications · doi:10.1038/ncomms9727 · Cited by 701 · see citing works
The gastrointestinal microbiota as a site for the biotransformation of drugs
Sousa, T., Paterson, R., Moore, V., Carlsson, A., Abrahamsson, B., & Basit, A. W. (2008) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2008.07.009 · Cited by 618 · see citing works
Lepage, P., Häsler, R., Spehlmann, M. E., Rehman, A., Žvirblienė, A., Begun, A., Ott, S. J., Kupčinskas, L., Dore, J. M., Raedler, A., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.04.011 · Cited by 592 · see citing works
Lü, K., Abo, R., Schlieper, K. A., Graffam, M. E., Levine, S. S., Wishnok, J. S., Swenberg, J. A., Tannenbaum, S. R., & Fox, J. G. (2014) · Environmental Health Perspectives · doi:10.1289/ehp.1307429 · Cited by 517 · see citing works
Metabolism of Foreign Compounds by Gastrointestinal Microorganisms
Scheline, R. R. (1973) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06622-0 · Cited by 517 · see citing works
Persistent organochlorinated pesticides and mechanisms of their toxicity
Mrema, E. J., Rubino, F. M., Brambilla, G., Moretto, A., Tsatsakis, A. M., & Colosio, C. (2012) · Toxicology · doi:10.1016/j.tox.2012.11.015 · Cited by 482 · see citing works
Reduction of polynitroaromatic compounds: the bacterial nitroreductases
Roldán, M. D., Pérez‐Reinado, E., del Castillo, F. J., et al. (2008) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2008.00107.x · Cited by 457 · see citing works
Tordoff, M. G., & Alleva, A. (1990) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/51.6.963 · Cited by 444 · see citing works
Nettleton, J. A., Lutsey, P. L., Wang, Y., Lima, J. A. C., Michos, E. D., & Jacobs, D. R. (2009) · Diabetes Care · doi:10.2337/dc08-1799 · Cited by 420 · see citing works
Altered Fecal Microbiota Composition Associated with Food Allergy in Infants
Ling, Z., Li, Z., Liu, X., Cheng, Y., Luo, Y., Tong, X., Li, Y., Wang, Y., Sun, J., Li, L., et al. (2014) · Applied and Environmental Microbiology · doi:10.1128/aem.00003-14 · Cited by 375 · see citing works
The University of Minnesota Biocatalysis/Biodegradation Database: improving public access
Gao, J., Ellis, L. B. M., & Wackett, L. P. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp771 · Cited by 347 · see citing works
Abou-Donia, M. B., EL-Masry, E. M., Abdel-Rahman, A. A., McLendon, R. E., & Schiffman, S. S. (2008) · Journal of Toxicology and Environmental Health · doi:10.1080/15287390802328630 · Cited by 342 · see citing works
Azoreductase activity of anaerobic bacteria isolated from human intestinal microflora
Rafii, F., Franklin, W., & Cerniglia, C. E. (1990) · Applied and Environmental Microbiology · doi:10.1128/aem.56.7.2146-2151.1990 · Cited by 340 · see citing works
Palmnäs, M. S. A., Cowan, T., Bomhof, M. R., Su, J., Reimer, R. A., Vogel, H. J., Hittel, D. S., & Shearer, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109841 · Cited by 337 · see citing works
Bosetti, C., Boffetta, P., & Vecchia, C. L. (2006) · Annals of Oncology · doi:10.1093/annonc/mdl172 · Cited by 306 · see citing works
Zhang, L., Nichols, R. G., Correll, J. B., Murray, I. A., Tanaka, N., Smith, P. B. W., Hubbard, T. D., Sebastian, A., Albert, I. U., Hatzakis, E., et al. (2015) · Environmental Health Perspectives · doi:10.1289/ehp.1409055 · Cited by 299 · see citing works
Exercise Attenuates PCB-Induced Changes in the Mouse Gut Microbiome
Choi, J. J., Eum, S. Y., Rampersaud, E., Daunert, S., Abreu, M. T., & Toborek, M. (2013) · Environmental Health Perspectives · doi:10.1289/ehp.1306534 · Cited by 298 · see citing works
Shehata, A. A., Schrödl, W., Aldin, A. A., et al. (2012) · Current Microbiology · doi:10.1007/s00284-012-0277-2 · Cited by 270 · see citing works
Methyl Sulfone and Hydroxylated Metabolites of Polychlorinated Biphenyls
Letcher, R. J., Klasson‐Wehler, E., & Bergman, Å. (2000) · Springer eBooks · doi:10.1007/3-540-48915-0_11 · Cited by 263 · see citing works
Human Colon Microbiota Transform Polycyclic Aromatic Hydrocarbons to Estrogenic Metabolites
de Wiele, T. V., Vanhaecke, L., Boeckaert, C., Peru, K. M., Headley, J. V., Verstraete, W., & Siciliano, S. D. (2004) · Environmental Health Perspectives · doi:10.1289/ehp.7259 · Cited by 248 · see citing works
Bladder Tumors in Rats Fed Cyclohexylamine or High Doses of a Mixture of Cyclamate and Saccharin
Price, J. M., Biava, C. G., Oser, B. L., Vogin, E. E., Steinfeld, J. L., & Ley, H. L. (1970) · Science · doi:10.1126/science.167.3921.1131 · Cited by 224 · see citing works
Arsenic Metabolism by Human Gut Microbiota upon in Vitro Digestion of Contaminated Soils
de Wiele, T. V., Gallawa, C. M., Kubachk, K. M., Creed, J. T., Basta, N. T., Dayton, E. A., Whitacre, S. D., Laing, G. D., & Bradham, K. D. (2010) · Environmental Health Perspectives · doi:10.1289/ehp.0901794 · Cited by 220 · see citing works
Toxicological significance of azo dye metabolism by human intestinal microbiota
Chen, H. (2012) · Frontiers in Bioscience-Elite · doi:10.2741/e400 · Cited by 218 · see citing works
Ecotoxicology inside the gut: impact of heavy metals on the mouse microbiome
Breton, J., Massart, S., Vandamme, P., De Brandt, E., Pot, B., & Foligné, B. (2013) · BMC Pharmacology and Toxicology · doi:10.1186/2050-6511-14-62 · Cited by 213 · see citing works
Developing a metagenomic view of xenobiotic metabolism
Haiser, H. J., & Turnbaugh, P. J. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2012.07.009 · Cited by 186 · cited 1× · see citing works
“…Turnbaugh recently pointed out the relevance of the bioremediation literature; particularly as concerns the metabolism of environmental chemicals: 20 a catalogue of microbial biocatalytic reactions on environmental pollutants currently lists almost 1,500 reactions carried out by 529…”
Do Interactions Between Gut Ecology and Environmental Chemicals Contribute to Obesity and Diabetes?
Snedeker, S. M., & Hay, A. G. (2011) · Environmental Health Perspectives · doi:10.1289/ehp.1104204 · Cited by 183 · see citing works
Gascón, M., Morales, E., Sunyer, J., & Vrijheid, M. (2013) · Environment International · doi:10.1016/j.envint.2012.11.005 · Cited by 174 · see citing works
Intestinal bacteria and ulcerative colitis.
Cummings, J. H., Macfarlane, G. T., & Macfarlane, S. (2003) · PubMed · Cited by 164 · see citing works
Melamine-Induced Renal Toxicity Is Mediated by the Gut Microbiota
Zheng, X., Zhao, A., Xie, G., Chi, Y., Zhao, L., Li, H., Wang, C., Bao, Y., Jia, W., Luther, M., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3005114 · Cited by 151 · see citing works
Dinitrotoluene: Acute Toxicity, Oncogenicity, Genotoxicity, and Metabolism
Rickert, D. E., Butterworth, B. E., Popp, J. A., et al. (1984) · Critical Reviews in Toxicology · doi:10.3109/10408448409003373 · Cited by 141 · see citing works
The metabolism of intense sweeteners
Renwick, A. G. C. (1986) · Xenobiotica · doi:10.3109/00498258609038983 · Cited by 139 · see citing works
Joly, C., Gay-Quéheillard, J., Léké, A., Chardon, K., Delanaud, S., Bach, V., & Khorsi-Cauet, H. (2013) · Environmental Science and Pollution Research · doi:10.1007/s11356-012-1283-4 · Cited by 135 · see citing works
Metabolism of 2,4′,5-Trichlorobiphenyl by the Mercapturic Acid Pathway
Bakke, J. E., Bergman, Å., & Larsen, G. L. (1982) · Science · doi:10.1126/science.6806905 · Cited by 134 · see citing works
Rafil, F., Franklin, W., Heflich, R. H., & Cerniglia, C. E. (1991) · Applied and Environmental Microbiology · doi:10.1128/aem.57.4.962-968.1991 · Cited by 133 · see citing works
Toxicological significance of azo dye metabolism by human intestinal microbiota
Feng, J. (2011) · Frontiers in Bioscience-Elite · doi:10.2741/400 · Cited by 123 · see citing works
A survey of EPA/OPP and open literature on selected pesticide chemicals
Dearfield, K. L., McCarroll, N., Protzel, A., et al. (1999) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/s1383-5742(99)00019-8 · Cited by 123 · see citing works
The effect of gut microbiota on drug metabolism
Kang, M. J., Kim, H. G., Kim, J. S., Oh, D. G., Um, Y. J., Seo, C. S., Han, J. W., Cho, H. J., Kim, G. H., Jeong, T. C., et al. (2013) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2013.807798 · Cited by 120 · see citing works
Park, H. Y., Hertz‐Picciotto, I., Šovčíková, E., Kočan, A., Drobná, B., & Trnovec, T. (2010) · Environmental Health · doi:10.1186/1476-069x-9-51 · Cited by 118 · see citing works
Glyphosate suppresses the antagonistic effect of Enterococcus spp. on Clostridium botulinum
Krüger, M., Shehata, A. A., Schrödl, W., et al. (2013) · Anaerobe · doi:10.1016/j.anaerobe.2013.01.005 · Cited by 114 · see citing works
A Critical Review of the Literature on Nitrobenzene Toxicity
Beauchamp, R. O., Irons, R. D., Rickert, D. E., et al. (1982) · Critical Reviews in Toxicology · doi:10.3109/10408448209089848 · Cited by 110 · see citing works
Sudan azo dyes and Para Red degradation by prevalent bacteria of the human gastrointestinal tract
Xu, H., Heinze, T. M., Paine, D. D., Cerniglia, C. E., & Chen, H. (2009) · Anaerobe · doi:10.1016/j.anaerobe.2009.06.007 · Cited by 108 · see citing works
Xu, H., Heinze, T. M., Chen, S., Cerniglia, C. E., & Chen, H. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.01410-07 · Cited by 108 · see citing works
Kim, K.-S., Lee, Y., Kim, S. G., et al. (2013) · Chemosphere · doi:10.1016/j.chemosphere.2013.09.066 · Cited by 102 · see citing works
The role of the gut flora in the metabolism of cyclamate
Drasar, B. S., Renwick, A. G., & Williams, R. T. (1972) · Biochemical Journal · doi:10.1042/bj1290881 · Cited by 98 · see citing works
Respiratory involvement in polychlorinated biphenyls poisoning
Shigematsu, N., Ishimaru, S., Saito, R., et al. (1978) · Environmental Research · doi:10.1016/0013-9351(78)90146-9 · Cited by 97 · see citing works
Conversion of p , p ′-DDT to p , p ′-DDD by Intestinal Flora of the Rat
Mendel, J. L., & Walton, M. S. (1966) · Science · doi:10.1126/science.151.3717.1527 · Cited by 95 · see citing works
Fazeli, M., Hassanzadeh, P., & Alaei, S. (2010) · Human & Experimental Toxicology · doi:10.1177/0960327110369821 · Cited by 93 · see citing works
Rowland, I., DAVIES, M. J., & Evans, J. G. (1980) · Archives of Environmental Health An International Journal · doi:10.1080/00039896.1980.10667485 · Cited by 92 · see citing works
Factors Affecting Metabolic Activity of the Intestinal Microflora
Rowland, I. R. (1988) · Drug Metabolism Reviews · doi:10.3109/03602538808994135 · Cited by 84 · see citing works
The fate of cyclamate in man and other species
Renwick, A. G. C., & Williams, R. T. (1972) · Biochemical Journal · doi:10.1042/bj1290869 · Cited by 83 · see citing works
Food intolerance at adulthood after perinatal exposure to the endocrine disruptor bisphenol A
Ménard, S., Guzylack‐Piriou, L., Leveque, M., Braniste, V., Lencina, C., Naturel, M., Moussa, L., Sekkal, S., Harkat, C., Gaultier, E., et al. (2014) · The FASEB Journal · doi:10.1096/fj.14-255380 · Cited by 80 · see citing works
Environmental carcinogens and large bowel cancer
Renwick, A. G. C., & Drašar, B. S. (1976) · Nature · doi:10.1038/263234a0 · Cited by 77 · see citing works
The impact of gut microbes in allergic diseases
Russell, S., & Finlay, B. B. (2012) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e3283573017 · Cited by 74 · see citing works
Negri, E., Bosetti, C., Fattore, E., & Vecchia, C. L. (2003) · European Journal of Cancer Prevention · doi:10.1097/00008469-200312000-00010 · Cited by 71 · see citing works
Hansen, S., Strøm, M., Olsen, S. F., Maslova, E., Rantakokko, P., Hannu, K., Rytter, D., Bech, B. H., Hansen, L. V., & Halldorsson, T. I. (2013) · Environmental Health Perspectives · doi:10.1289/ehp.1206397 · Cited by 71 · see citing works
Michalke, K., Schmidt, A., Huber, B., Meyer, J., Sulkowski, M., Hirner, A. V., Boertz, J., Mosel, F., Dammann, P., Hilken, G., et al. (2008) · Applied and Environmental Microbiology · doi:10.1128/aem.02933-07 · Cited by 67 · see citing works
Steroids in Germfree and Conventional Rats
Eriksson, H., & Gustafsson, J.-Α. (1970) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1970.tb00919.x · Cited by 67 · see citing works
The requirement of the gut flora in nitrobenzene-induced methemoglobinemia in rats
Reddy, B. G., Pohl, L. R., & Krishna, G. (1976) · Biochemical Pharmacology · doi:10.1016/0006-2952(76)90507-4 · Cited by 65 · see citing works
In vivo metabolism and genotoxic effects of nitrated polycyclic aromatic hydrocarbons.
Möller, L. (1994) · Environmental Health Perspectives · doi:10.1289/ehp.102-1566915 · Cited by 62 · see citing works
Metabolism of Methylmercuric Chloride by the Gastro-Intestinal Flora of the Rat
Rowland, I., DAVIES, M. J., & GRASSO, P. (1978) · Xenobiotica · doi:10.3109/00498257809060381 · Cited by 61 · see citing works
Dierickx, P. J. (1999) · Cell Biology and Toxicology · doi:10.1023/a:1007619919336 · Cited by 60 · see citing works
Williams, J. R., Grantham, P. H., Marsh, H. H., et al. (1970) · Biochemical Pharmacology · doi:10.1016/0006-2952(70)90338-2 · Cited by 59 · see citing works
Doolittle, D. J., Sherrill, J. M., & Butterworth, B. E. (1983) · PubMed · Cited by 58 · see citing works
In vitro metabolism of inorganic arsenic by the gastro‐intestinal microflora of the rat
Rowland, I., & DAVIES, M. J. (1981) · Journal of Applied Toxicology · doi:10.1002/jat.2550010508 · Cited by 55 · see citing works
Bakke, J. E., & Gustafsson, J.-Α. (1984) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(84)90532-7 · Cited by 53 · see citing works
Claus, S. P., & Swann, J. R. (2013) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-030212-182612 · Cited by 53 · see citing works
Self-citationMetabolism of Propachlor by the Germfree Rat
Bakke, J. E., Gustafsson, J.-Α., & Gustafsson, B. E. (1980) · Science · doi:10.1126/science.7433983 · Cited by 51 · see citing works
Bakke, J. E., Struble, C. B., Gustafsson, J.-Α., et al. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.3.668 · Cited by 51 · see citing works
Hirayama, K. (2000) · Carcinogenesis · doi:10.1093/carcin/21.11.2105 · Cited by 51 · see citing works
Metabolism and excretion of 2,4-[14C]dinitrotoluene in conventional and axenic Fischer-344 rats
Rickert, D. E., Long, R. M., Krakowka, S. G., et al. (1981) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(81)90312-4 · Cited by 49 · see citing works
Yim, Y.-J., Seo, J., Kang, S.-I., et al. (2007) · Archives of Environmental Contamination and Toxicology · doi:10.1007/s00244-007-9044-y · Cited by 48 · see citing works
Nakamura, I., Hosokawa, K., Tamura, H., et al. (1977) · Bulletin of Environmental Contamination and Toxicology · doi:10.1007/bf01685974 · Cited by 47 · see citing works
Möller, L., Corrie, M., Midtvedt, T., et al. (1988) · Carcinogenesis · doi:10.1093/carcin/9.5.823 · Cited by 46 · see citing works
Metabolism of 2,4-dinitrotoluene by intestinal microorganisms from rat, mouse, and man
Guest, D., Schnell, S. R., Rickert, D. E., et al. (1982) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(82)90335-0 · Cited by 43 · see citing works
Persistent environmental pollutants and couple fecundity: an overview
Louis, G. M. B. (2013) · Reproduction · doi:10.1530/rep-13-0472 · Cited by 43 · see citing works
The new intense sweetener Acesulfame K
Lipinski, G. V. R. (1985) · Food Chemistry · doi:10.1016/0308-8146(85)90120-7 · Cited by 42 · see citing works
Role of intestinal microflora in xenobiotic‐induced toxicity
Jeong, H. G., Kang, M. J., Kim, H. G., Oh, D. G., Kim, J. S., Lee, S., & Jeong, T. C. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200461 · Cited by 42 · see citing works
Levin, A. A., & Dent, J. G. (1982) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(25)07912-7 · Cited by 41 · see citing works
Brandt, I., Klasson‐Wehler, E., Rafter, J. J., et al. (1982) · Toxicology Letters · doi:10.1016/0378-4274(82)90251-x · Cited by 39 · see citing works
Methyl Mercury Decomposition in Mice Treated with Antibiotics
Seko, Y., Miura, T., Takahashi, M., et al. (1981) · Acta Pharmacologica et Toxicologica · doi:10.1111/j.1600-0773.1981.tb00903.x · Cited by 29 · see citing works
Gut bacteria and the metabolism of cyclamate in the rat
Renwick, A. G. C., & Williams, R. T. (1969) · Biochemical Journal · doi:10.1042/bj1140078pa · Cited by 28 · see citing works
Diaz-Bone, R. A., Hollmann, M. W., Wuerfel, O., et al. (2009) · Journal of Analytical Atomic Spectrometry · doi:10.1039/b822968f · Cited by 27 · see citing works
Entero-bacterial Formation of Cyclohexylamine in Rats Ingesting Cyclamate
Bickel, M. H., Burkard, B., Meier-strasser, E., et al. (1974) · Xenobiotica · doi:10.3109/00498257409052106 · Cited by 26 · see citing works
Haschek, W. M., Rousseaux, C. G., Wallig, M. A., et al. (2022) · International Journal of Toxicology · doi:10.1177/10915818221099126 · Cited by 23 · see citing works
Metabolic adaptation of rat faecal microflora to cyclamate in vitro
Mallett, A. K., Rowland, I., Bearne, C. A., et al. (1985) · Food and Chemical Toxicology · doi:10.1016/0278-6915(85)90048-1 · Cited by 22 · see citing works
Gustafsson, J.-Α., Rafter, J. J., Bakke, J. E., & Gustafsson, B. E. (1981) · Nutrition and Cancer · doi:10.1080/01635588109513687 · Cited by 20 · see citing works
Philbert, M. A., Gray, A. J., & Connors, T. A. (1987) · Toxicology Letters · doi:10.1016/0378-4274(87)90013-0 · Cited by 18 · see citing works
The Metabolism of Some Xenobiotics in Germ-Free and Conventional Rats
Macholz, R. M., Kujawa, M., Schulze, J., et al. (1985) · Archives of toxicology. Supplement · doi:10.1007/978-3-642-69928-3_77 · Cited by 10 · see citing works
Rowland, I. (1988) · Elsevier eBooks · doi:10.1016/b978-0-12-599920-5.50013-3 · Cited by 5 · see citing works
The carcinogenic activity of 2-acetaminofluorene; effects of concentration and duration of exposure.
DeEds, F., & Rh, W. (1946) · PubMed · Cited by 1 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Letcher, R. J., Klasson-Wehler, E. & Bergman, A. in New Types of Persistent Halogenated Compounds (ed. Paasivirta J.) 315–359 (Springer-Verlag, 2000).
- Rowland, I. R. in Role of the Gut Flora in Toxicity and Cancer (ed. Rowland, I. R.) 207–226 (Academic Press, 1988).
Cited by
Sorted by citations
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286 · see citing works
Chemical transformation of xenobiotics by the human gut microbiota
Koppel, N., Maini Rekdal, V., & Balskus, E. P. (2017) · Science · doi:10.1126/science.aag2770 · Cited by 1,080 · see citing works
Development of the gut microbiota in infancy and its impact on health in later life
Tanaka, M., & Nakayama, J. (2017) · Allergology International · doi:10.1016/j.alit.2017.07.010 · Cited by 639 · see citing works
Gut reactions: Breaking down xenobiotic–microbiome interactions
Clarke, G., Sandhu, K. V., Griffin, B. T., Dinan, T. G., Cryan, J. F., & Hyland, N. P. (2019) · Pharmacological Reviews · doi:10.1124/pr.118.015768 · Cited by 319 · see citing works
Batch effects removal for microbiome data via conditional quantile regression
Ling, W., Lu, J., Zhao, N., Lulla, A., Plantinga, A. M., Fu, W., Zhang, A., Liu, H., Song, H., Li, Z., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33071-9 · Cited by 136 · see citing works
Links between Dietary Protein Sources, the Gut Microbiota, and Obesity
Madsen, L., Myrmel, L. S., Fjære, E., Liaset, B., & Kristiansen, K. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.01047 · Cited by 110 · see citing works
Prospective views for whey protein and/or resistance training against age-related sarcopenia
Liao, Y., Peng, Z., Chen, L., Zhang, Y., Cheng, Q., Nüssler, A. K., Bao, W., Liu, L., & Yang, W. (2019) · Aging and Disease · doi:10.14336/ad.2018.0325 · Cited by 68 · see citing works
Prescott, S. L., Wegienka, G., Logan, A. C., & Katz, D. L. (2018) · BioPsychoSocial Medicine · doi:10.1186/s13030-018-0126-z · Cited by 53 · see citing works
- Authors
- Claus, S. P., Guillou, H., & Ellero-Simatos, S.
- Affiliations
- University of Reading (GB)
- Toxicologie Alimentaire (FR)
- Venue
- npj Biofilms and Microbiomes
- Published
- 2016-05-04
- Volume
- 2
- Issue
- 1
- Pages
- 16003-16003
- ISSN
- 2055-5008 (ISSN-L)
- PMC
- PMC5515271
- OpenAlex
- W2345411160
- Cited by
- 678
- References
- 110
- Citations by year
- 2026: 54 · 2025: 69 · 2024: 80 · 2023: 63 · 2022: 84 · 2021: 94 · 2020: 90 · 2019: 56 · 2018: 54 · 2017: 31 · 2016: 3
- FWCI
- 4.34
- Type
- journal article
- Language
- en
- Update notices
- erratum (2017-06-22)
- Open access
- gold
- doi.org
- Locations
- npj Biofilms and Microbiomes (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- CentAUR (University of Reading) (acceptedVersion)
- HAL (submittedVersion, other-oa)
- Funders
- European Commission
- Institut National de la Recherche Agronomique
- Conseil Régional Midi-Pyrénées
- Medical Research Council (MR/M004945/1)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Physical Sciences › Environmental Science › Pollution › Microbial bioremediation and biosurfactants
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
- Keywords
- gut microbiota, environmental pollutants, xenobiotic metabolism, azoreductase, nitroreductase, beta-glucuronidase, sulfatase, beta-lyase, host toxicity, germ-free animals, cecal microbiota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
