The circadian clock: pacemaker and tumour suppressor

Cancer immunoediting: from immunosurveillance to tumor escape

Dunn, G. P., Bruce, A. T., Ikeda, H., Old, L. J., & Schreiber, R. D. (2002) · Nature Immunology · doi:10.1038/ni1102-991 · Cited by 5,393

Coordination of circadian timing in mammals

Reppert, S. M., & Weaver, D. R. (2002) · Nature · doi:10.1038/nature00965 · Cited by 4,379

Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases

Johnson, G. L., & Lapadat, R. (2002) · Science · doi:10.1126/science.1072682 · Cited by 4,295

β-Catenin regulates expression of cyclin D1 in colon carcinoma cells

Tetsu, O., & McCormick, F. (1999) · Nature · doi:10.1038/18884 · Cited by 3,601

AP-1 as a regulator of cell life and death

Shaulian, E., & Karin, M. (2002) · Nature Cell Biology · doi:10.1038/ncb0502-e131 · Cited by 2,961

Melanopsin-Containing Retinal Ganglion Cells: Architecture, Projections, and Intrinsic Photosensitivity

Hattar, S., Liao, H.-W., Takao, M., Berson, D. M., & Yau, K.-W. (2002) · Science · doi:10.1126/science.1069609 · Cited by 2,734

Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus

Damiola, F., Le Minh, N., Preitner, N., Kornmann, B., Fleury-Olela, F., & Schibler, U. (2000) · Genes & Development · doi:10.1101/gad.183500 · Cited by 2,394

Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock

Panda, S., Antoch, M. P., Miller, B. H., Su, A. I., Schook, A. C., Straume, M., Schultz, P. G., Kay, S. A., Takahashi, J. S., & Hogenesch, J. B. (2002) · Cell · doi:10.1016/s0092-8674(02)00722-5 · Cited by 2,310

The Orphan Nuclear Receptor REV-ERBα Controls Circadian Transcription within the Positive Limb of the Mammalian Circadian Oscillator

Preitner, N., Damiola, F., Luis-Lopez-Molina, Zakany, J., Duboule, D., Albrecht, U., & Schibler, U. (2002) · Cell · doi:10.1016/s0092-8674(02)00825-5 · Cited by 2,198

Loss of a circadian adrenal corticosterone rhythm following suprachiasmatic lesions in the rat

Moore, R. Y., & Eichler, V. B. (1972) · Brain Research · doi:10.1016/0006-8993(72)90054-6 · Cited by 2,135

Regulation of estrogen receptor beta activity and implications in health and disease

Swedenborg, E., Power, K. A., Cai, W., Pongratz, I., & Rüegg, J. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0118-z · Cited by 69

A connection between MAPK pathways and circadian clocks

de Paula, R. M., Lamb, T. M., Bennett, L. D., & Bell‐Pedersen, D. (2008) · Cell Cycle · doi:10.4161/cc.7.17.6516 · Cited by 69

Circadian disruption and biomarkers of tumor progression in breast cancer patients awaiting surgery

Cash, E. D., Sephton, S. E., Chagpar, A. B., Spiegel, D., Rebholz, W. N., Zimmaro, L. A., Tillie, J. M., & Dhabhar, F. S. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.02.017 · Cited by 70

How to Achieve Fast Entrainment? The Timescale to Synchronization

Granada, A. E., & Herzel, H. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007057 · Cited by 68

Circadian genes and breast cancer susceptibility in rotating shift workers

Monsees, G. M., Kraft, P. L., Hankinson, S. E., Hunter, D. J., & Schernhammer, E. S. (2012) · International Journal of Cancer · doi:10.1002/ijc.27564 · Cited by 68

Association of shiftwork and immune cells among police officers from the Buffalo Cardio-Metabolic Occupational Police Stress study

Wirth, M. D., Andrew, M. E., Burchfiel, C. M., Burch, J. B., Fekedulegn, D. B., Hartley, T. A., Charles, L. E., & Violanti, J. M. (2017) · Chronobiology International · doi:10.1080/07420528.2017.1316732 · Cited by 73

Upregulation of circadian gene 'hClock' contribution to metastasis of colorectal cancer

Wang, Y.-P., Sun, N., Lü, C., Bei, Y.-B., Qian, R., & Hua, L. (2017) · International Journal of Oncology · doi:10.3892/ijo.2017.3987 · Cited by 69

ROR activation by Nobiletin enhances antitumor efficacy via suppression of IκB/NF-κB signaling in triple-negative breast cancer

Kim, E., Kim, Y.-J., Ji, Z., Kang, J. M., Wirianto, M., Paudel, K. R., Smith, J. A., Ono, K., Kim, J.-A., Eckel‐Mahan, K. L., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04826-5 · Cited by 67

Role of Sex Hormones in the Development and Progression of Hepatitis B Virus-Associated Hepatocellular Carcinoma

Montella, M., D'Arena, G. F., Crispo, A., Capunzo, M., Nocerino, F., Grimaldi, M., Barbieri, A., D’Ursi, A. M., Tecce, M. F., Amore, A., et al. (2015) · International Journal of Endocrinology · doi:10.1155/2015/854530 · Cited by 66

Deregulated expression of circadian clock and clock-controlled cell cycle genes in chronic lymphocytic leukemia

Rana, S., Munawar, M. A., Shahid, A., Malik, M., Ullah, H., Fatima, W., Mohsin, S., & Mahmood, S. (2013) · Molecular Biology Reports · doi:10.1007/s11033-013-2841-7 · Cited by 69

Circadian Disruption, Per3, and Human Cytokine Secretion

Guess, J., Burch, J. B., Ogoussan, K., Armstead, C. A., Zhang, H., Wagner, S., Hébert, J. R., Wood, P. A., Youngstedt, S. D., Hofseth, L. J., et al. (2009) · Integrative Cancer Therapies · doi:10.1177/1534735409352029 · Cited by 68

Circadian clock and cell cycle gene expression in mouse mammary epithelial cells and in the developing mouse mammary gland

Metz, R. P., Qu, X., Laffin, B., Earnest, D. J., & Porter, W. W. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20605 · Cited by 66

The use of sodium lamps to brightly illuminate mouse houses during their dark phases

McLennan, I. S., & Taylor-Jeffs, J. (2004) · Laboratory Animals · doi:10.1258/0023677041958927 · Cited by 66

Aberrant expression of Per1, Per2 and Per3 and their prognostic relevance in non-small cell lung cancer.

Liu, B., Xu, K., Jiang, Y., & Li, X. (2014) · Europe PMC (PubMed Central) · Cited by 66

Comparison of β-Adrenergic and Glucocorticoid Signaling on Clock Gene and Osteoblast-Related Gene Expressions in Human Osteoblast

Komoto, S., Kondo, H., Fukuta, O., & Togari, A. (2012) · Chronobiology International · doi:10.3109/07420528.2011.636496 · Cited by 65

Circadian regulation of epithelial functions in the intestine

Pácha, J., & Sumová, A. (2013) · Acta Physiologica · doi:10.1111/apha.12090 · Cited by 67

Circadian Disruption Accelerates Tumor Growth and Angio/Stromagenesis through a Wnt Signaling Pathway

Yasuniwa, Y., Izumi, H., Wang, K., Shimajiri, S., Sasaguri, Y., Kawai, K., Kasai, H., Shimada, T., Miyake, K., Kashiwagi, E., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015330 · Cited by 66

Altered expression of the clock gene machinery in kidney cancer patients

Mazzoccoli, G., Piepoli, A., Carella, M., Panza, A., Pazienza, V., Benegiamo, G., Palumbo, O., & Ranieri, E. (2011) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2011.11.007 · Cited by 65

Reduced Expression of PER3 Is Associated with Incidence and Development of Colon Cancer

Wang, X., Yan, D., Teng, M., Fan, J., Zhou, C., Li, D., Qiu, G., Sun, X., Li, T., Xing, T., et al. (2012) · Annals of Surgical Oncology · doi:10.1245/s10434-012-2279-5 · Cited by 67

The Circadian Clock Protein CRY1 Is a Negative Regulator of HIF-1α

Dimova, E. Y., Jakupović, M., Kubaichuk, K. I., Mennerich, D., Chi, T. F., Tamanini, F., Oklejewicz, M., Hänig, J., Byts, N., Mäkelä, K. A., et al. (2019) · iScience · doi:10.1016/j.isci.2019.02.027 · Cited by 66

Sirtuin-dependent clock control

Masri, S. (2015) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000219 · Cited by 63

The interaction between HIF-1 and AP-1 transcription factors in response to low oxygen

Laderoute, K. R. (2005) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2005.03.005 · Cited by 63

Shift work, circadian gene variants and risk of breast cancer

Grundy, A. L., Schuetz, J. M., Lai, A. S., Janoo-Gilani, R., Leach, S. R., Burstyn, I., Richardson, H., Brooks-Wilson, A. R., Spinelli, J. J., & Aronson, K. J. (2013) · Cancer Epidemiology · doi:10.1016/j.canep.2013.04.006 · Cited by 63

Spectral modulation attenuates molecular, endocrine, and neurobehavioral disruption induced by nocturnal light exposure

Rahman, S. A., Marcu, S., Shapiro, C. M., Brown, T. J., & Casper, R. F. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00597.2010 · Cited by 63

Effects of meal timing on tumor progression in mice

Wu, M. W., Li, X. M., Xian, L., & Lévi, F. (2004) · Life Sciences · doi:10.1016/j.lfs.2004.02.014 · Cited by 63

Why Life Oscillates – from a Topographical Towards a Functional Chronobiology

Moser, M., Frühwirth, M., Penter, R., & Winker, R. (2006) · Cancer Causes & Control · doi:10.1007/s10552-006-0015-9 · Cited by 62

A microphysiological system model of therapy for liver micrometastases

Clark, A. M., Wheeler, S., Taylor, D. P., Pillai, V. C., Young, C. L., Prantil‐Baun, R., Nguyen, T., Stolz, D. B., Borenstein, J. T., Lauffenburger, D. A., et al. (2014) · Experimental Biology and Medicine · doi:10.1177/1535370214532596 · Cited by 64

The effect of white light on normal and malignant murine melanocytes: A link between opsins, clock genes, and melanogenesis

de Assis, L. V. M., Moraes, M. N., Cruz‐Machado, S. D. S., & Castrucci, A. M. D. L. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2016.03.001 · Cited by 62

The MiR-135b–BMAL1–YY1 loop disturbs pancreatic clockwork to promote tumourigenesis and chemoresistance

Jiang, W., Zhao, S., Shen, J., Guo, L., Sun, Y., Zhu, Y., Ma, Z., Zhang, X., Hu, Y., Xiao, W., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-017-0233-y · Cited by 64

Of Mice and Women: Light as a Circadian Stimulus in Breast Cancer Research

Bullough, J. D., Rea, M. S., & Figueiro, M. G. (2006) · Cancer Causes & Control · doi:10.1007/s10552-005-0574-1 · Cited by 61

Role of Circadian Rhythms in Potassium Homeostasis

Gumz, M. L., & Rabinowitz, L. (2013) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2013.04.003 · Cited by 61

Hidden heterogeneity and circadian-controlled cell fate inferred from single cell lineages

Chakrabarti, S., Paek, A. L., Reyes, J. S., Lasick, K. A., Lahav, G., & Michor, F. (2018) · Nature Communications · doi:10.1038/s41467-018-07788-5 · Cited by 63

The Relationship between Circadian Rhythm and Cancer Disease

Munteanu, C., Turti, S., Achim, L., Muresan, R., Souca, M., Prifti, E., Mârza, S. M., & Papuc, I. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25115846 · Cited by 65

Altered Circadian Expression of Cytokines and Cytolytic Factors in Splenic Natural Killer Cells of Per1 −/− Mutant Mice

Logan, R. W., Wynne, O., Levitt, D., Price, D., & Sarkar, D. K. (2013) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2012.0092 · Cited by 59

Circadian Phase Resetting via Single and Multiple Control Targets

Bagheri, N., Stelling, J., & Doyle, F. J. (2008) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000104 · Cited by 58

Rescue chemotherapy using multidrug chronomodulated hepatic arterial infusion for patients with heavily pretreated metastatic colorectal cancer

Bouchahda, M., Adam, R. A., Giacchetti, S., Castaing, D., Brézault, C., Hauteville, D., Innominato, P. F., Focan, C., Machover, D., & Lévi, F. (2009) · Cancer · doi:10.1002/cncr.24549 · Cited by 58

Circadian clock gene Per2 downregulation in non‑small cell lung cancer is associated with tumour progression and metastasis

Xiang, R., Cui, Y., Wang, Y., Xie, T., Yang, X., Wang, Z., Li, J., & Li, Q. (2018) · Oncology Reports · doi:10.3892/or.2018.6704 · Cited by 58

Approaches to the Pharmacological Management of Jet Lag

Arendt, J. (2018) · Drugs · doi:10.1007/s40265-018-0973-8 · Cited by 59

Release of extraction-resistant mRNA in stationary phase Saccharomyces cerevisiae produces a massive increase in transcript abundance in response to stress

Aragon, A. D., Quiñones, G., Thomas, E. V., Roy, S., & Werner‐Washburne, M. (2006) · Genome biology · doi:10.1186/gb-2006-7-2-r9 · Cited by 56

Molecular overlap of fly circadian rhythms and human pancreatic cancer

Pogue-Geile, K. L., Lyons‐Weiler, J., & Whitcomb, D. C. (2006) · Cancer Letters · doi:10.1016/j.canlet.2005.11.049 · Cited by 55

Polymorphisms in circadian genes, night work and breast cancer: Results from the GENICA study

Rabstein, S., Harth, V., Justenhoven, C., Pesch, B., Plöttner, S., Heinze, E., Lotz, A., Baisch, C., Schiffermann, M., Brauch, H. B., et al. (2014) · Chronobiology International · doi:10.3109/07420528.2014.957301 · Cited by 55

The Clinical Biology of Cystic Fibrosis Transmembrane Regulator Protein

Liou, T. G. (2018) · CHEST Journal · doi:10.1016/j.chest.2018.10.006 · Cited by 55

Temporal Gradient in the Clock Gene and Cell-Cycle Checkpoint KinaseWee1Expression along the Gut

Polidarová, L., Soták, M., Sládek, M., Pácha, J., & Sumová, A. (2009) · Chronobiology International · doi:10.1080/07420520902924889 · Cited by 54

A Timeless Link Between Circadian Patterns and Disease

Mazzoccoli, G., Laukkanen, M. O., Vinciguerra, M., Colangelo, T., & Colantuoni, V. (2015) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2015.11.007 · Cited by 55

Identification of an estrogen-regulated circadian mechanism necessary for breast acinar morphogenesis

Rossetti, S., Corlazzoli, F., Gregorski, A., Azmi, N. H. A., & Sacchi, N. (2012) · Cell Cycle · doi:10.4161/cc.21946 · Cited by 53

The impact of low-dose carcinogens and environmental disruptors on tissue invasion and metastasis

Ochieng, J., Nangami, G. N., Ogunkua, O., Miousse, I. R., Koturbash, I., Odero-Marah, V., McCawley, L. J., Nangia‐Makker, P., Ahmed, N., Luqmani, Y., et al. (2015) · Carcinogenesis · doi:10.1093/carcin/bgv034 · Cited by 54

Shift work, chronodisruption and cancer?—the IARC 2007 challenge for research and prevention and 10 theses from the Cologne Colloquium 2008

Erren, T. C., Morfeld, P., Stork, J., Knauth, P., von Mülmann, M. J., Breitstadt, R., Müller, U., Emmerich, M., & Piekarski, C. (2009) · Scandinavian Journal of Work Environment & Health · doi:10.5271/sjweh.1303 · Cited by 53

Experimental chronic jet lag promotes growth and lung metastasis of Lewis lung carcinoma in C57BL/6 mice

Chen, Z. (2012) · Oncology Reports · doi:10.3892/or.2012.1688 · Cited by 52

The Circadian Clock Drives Mast Cell Functions in Allergic Reactions

Christ, P., Sowa, A. S., Froy, O., & Lorentz, A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01526 · Cited by 53

Circadian clock genes and risk of fatal prostate cancer

Markt, S. C., Valdimarsdóttir, U. A., Shui, I. M., Sigurðardóttir, L. G., Rider, J. R., Tamimi, R. M., Batista, J. L., Haneuse, S., Flynn‐Evans, E. E., Lockley, S. W., et al. (2014) · Cancer Causes & Control · doi:10.1007/s10552-014-0478-z · Cited by 56

The Pathophysiologic Role of Disrupted Circadian and Neuroendocrine Rhythms in Breast Carcinogenesis

Ball, L. J., Palesh, O. G., & Kriegsfeld, L. J. (2016) · Endocrine Reviews · doi:10.1210/er.2015-1133 · Cited by 54

Sustainability of coral reefs are affected by ecological light pollution in the Gulf of Aqaba/Eilat

Rosenberg, Y., Doniger, T., & Levy, O. (2019) · Communications Biology · doi:10.1038/s42003-019-0548-6 · Cited by 52

Non-circadian aspects of BHLHE40 cellular function in cancer

Kiss, Z., Mudryj, M. M., & Ghosh, P. (2020) · Genes & Cancer · doi:10.18632/genesandcancer.201 · Cited by 53

Nr1d1, an Important Circadian Pathway Regulatory Gene, Is Suppressed By Cigarette Smoke in Murine Lungs

Vasu, V. T., Cross, C. E., & Gohil, K. (2009) · Integrative Cancer Therapies · doi:10.1177/1534735409352027 · Cited by 52

Does “Clock” Matter in Prostate Cancer?

Zhu, Y. L., Zheng, T., Stevens, R. G., Zhang, Y., & Boyle, P. (2006) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-05-0631 · Cited by 52

Integrative Approaches to the Treatment of Cancer

O’Brien, K., Ried, K., Binjemain, T., & Sali, A. (2022) · Cancers · doi:10.3390/cancers14235933 · Cited by 51

Circadian clock organization in the retina: From clock components to rod and cone pathways and visual function

Bhoi, J. D., Goel, M., Ribelayga, C., & Mangel, S. C. (2022) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2022.101119 · Cited by 51

From quiescence to proliferation: Cdk oscillations drive the mammalian cell cycle

Gérard, C., & Goldbeter, A. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00413 · Cited by 52

Molecular Targets for Small-Molecule Modulators of Circadian Clocks

He, B., & Chen, Z. (2016) · Current Drug Metabolism · doi:10.2174/1389200217666160111124439 · Cited by 52

The anti-tumorigenic activity of A2M—A lesson from the naked mole-rat

Kurz, S., Thieme, R., Amberg, R., Groth, M., Jahnke, H., Pieroh, P., Horn, L., Kolb, M., Huse, K., Platzer, M., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0189514 · Cited by 51

Activation of Rev-erbα attenuates lipopolysaccharide-induced inflammatory reactions in human endometrial stroma cells via suppressing TLR4-regulated NF-κB activation

Zhao, W., Cui, L., Huang, X., Wang, S., Li, D., Li, L., Sun, Y., & Du, M. (2019) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmz078 · Cited by 51

Circadian genesPer1andPer2increase radiosensitivity of gliomain vivo

Zhanfeng, N., Li, Y., Fei, Z., Hao, S., Guangxing, L., & Hechun, X. (2015) · Oncotarget · doi:10.18632/oncotarget.3179 · Cited by 50

A sub-pathway-based approach for identifying drug response principal network

Chen, X., Xu, J., Huang, B., Li, J., Wu, X., Ma, L., Jia, X., Bian, X., Tan, F., Liu, L., et al. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq714 · Cited by 50

Cancer Clocks Out for Lunch: Disruption of Circadian Rhythm and Metabolic Oscillation in Cancer

Altman, B. J. (2016) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2016.00062 · Cited by 54

CircadiOmics: circadian omic web portal

Ceglia, N., Liu, Y., Chen, S., Agostinelli, F., Eckel‐Mahan, K. L., Sassone‐Corsi, P., & Baldi, P. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky441 · Cited by 49

Chronotype and Breast Cancer Risk in a Cohort of US Nurses

Ramin, C. A., Devore, E. E., Pierre-Paul, J., Duffy, J. F., Hankinson, S. E., & Schernhammer, E. S. (2013) · Chronobiology International · doi:10.3109/07420528.2013.809359 · Cited by 49

Symptom clusters in cancer patients and their relation to EGFR ligand modulation of the circadian axis.

Rich, T. A. (2007) · PubMed · Cited by 49

Day-to-day dynamics of associations between sleep, napping, fatigue, and the cortisol diurnal rhythm in women diagnosed as having breast cancer

Tell, D., Mathews, H. L., & Janusek, L. W. (2014) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000097 · Cited by 48

Night work and breast cancer estrogen receptor status – results from the German GENICA study

Rabstein, S., Harth, V., Pesch, B., Pallapies, D., Lotz, A., Justenhoven, C., Baisch, C., Schiffermann, M., Haas, S., Fischer, H., et al. (2013) · Scandinavian Journal of Work Environment & Health · doi:10.5271/sjweh.3360 · Cited by 49

Cyclin-dependent Kinase 5 (Cdk5) Regulates the Function of CLOCK Protein by Direct Phosphorylation

Kwak, Y., Jeong, J., Lee, S., Park, Y.-U., Lee, S., Han, D.-H., Kim, J., Ohshima, T., Mikoshiba, K., Suh, Y., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.494856 · Cited by 48

Molecular Regulation of Circadian Chromatin

Zhu, Q., & Belden, W. J. (2020) · Journal of Molecular Biology · doi:10.1016/j.jmb.2020.01.009 · Cited by 47

Recent advances in modulators of circadian rhythms: an update and perspective

Huang, S., Jiao, X., Lu, D., Pei, X., Qi, D., & Li, Z. (2020) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2020.1772249 · Cited by 50

Correlation of the risk of breast cancer and disruption of the circadian rhythm (Review)

Leonardi, G. C., Rapisarda, V., Marconi, A., Scalisi, A., Catalano, F., Proietti, L., Travali, S., Libra, M., & Fenga, C. (2012) · Oncology Reports · doi:10.3892/or.2012.1839 · Cited by 51

Health consequences of shift work and implications for structural design

Figueiro, M. G., & White, R. D. (2013) · Journal of Perinatology · doi:10.1038/jp.2013.7 · Cited by 48

Circadian clock circuitry in colorectal cancer

Mazzoccoli, G. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i15.4197 · Cited by 47

A Common Origin: Signaling Similarities in the Regulation of the Circadian Clock and DNA Damage Responses

Uchida, Y., Hirayama, J., & Nishina, H. (2010) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.33.535 · Cited by 48

Alterations of Circadian Clockworks During Differentiation and Apoptosis of Rat Ovarian Cells

Chu, G., Yoshida, K., Narahara, S., Uchikawa, M., Kawamura, M., Yamauchi, N., Xi, Y., Shigeyoshi, Y., Hashimoto, S., & Hattori, M. (2011) · Chronobiology International · doi:10.3109/07420528.2011.589933 · Cited by 50

Robust synchronization of the cell cycle and the circadian clock through bidirectional coupling

Yan, J., & Goldbeter, A. (2019) · Journal of The Royal Society Interface · doi:10.1098/rsif.2019.0376 · Cited by 47

The clock protein period 2 synchronizes mitotic expansion and decidual transformation of human endometrial stromal cells

Muter, J., Lucas, E. S., Chan, Y., Brighton, P. J., Moore, J. D., Lacey, L., Quenby, S. M., Lam, E. W. ‐., & Brosens, J. J. (2015) · The FASEB Journal · doi:10.1096/fj.14-267195 · Cited by 48

Circadian clock pathway genes associated with colorectal cancer risk and prognosis

Gu, D., Li, S., Ben, S., Du, M., Chu, H., Zhang, Z., Wang, M., Zhang, Z., & Chen, J. (2018) · Archives of Toxicology · doi:10.1007/s00204-018-2251-7 · Cited by 46

Deletion of clock gene Bmal1 impaired the chondrocyte function due to disruption of the HIF1α-VEGF signaling pathway

Ma, Z., Jin, X., Qian, Z., Li, F., Xu, M., Zhang, Y., Kang, X., Li, H., Gao, X. Y., Zhao, L., et al. (2019) · Cell Cycle · doi:10.1080/15384101.2019.1620572 · Cited by 46

Association between CLOCK, PER3 and CCRN4L with non-small cell lung cancer in Brazilian patients

Couto, P. P., de Miranda, D. M., Vieira, R. N., Vilhena, A., Marco, L. A. D., & Bastos‐Rodrigues, L. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.2224 · Cited by 46

Circadian Rhythms in the CNS and Peripheral Clock Disorders: Function of Clock Genes: Influence of Medication for Bronchial Asthma on Circadian Gene

Burioka, N., Fukuoka, Y., Takata, M., Endo, M., Miyata, M., Chikumi, H., Tomita, K., Kodani, M., Touge, H., Takeda, K., et al. (2007) · Journal of Pharmacological Sciences · doi:10.1254/jphs.fmj06003x4 · Cited by 45

Expression of Clock Genes in Patients with Colorectal Cancer

Karantanos, T., Theodoropoulos, G. E., Gazouli, M., Vaiopoulou, A., Karantanou, C., Lymberi, M., & Pektasides, D. (2013) · The International Journal of Biological Markers · doi:10.5301/jbm.5000033 · Cited by 45

Overexpression of the clock gene Per2 suppresses oral squamous cell carcinoma progression by activating autophagy via the PI3K/AKT/mTOR pathway

Liu, H., Gong, X., & Yang, K. (2020) · Journal of Cancer · doi:10.7150/jca.42771 · Cited by 45

ERK-mediated TIMELESS expression suppresses G2/M arrest in colon cancer cells

Neilsen, B. K., Frodyma, D. E., McCall, J. L., Fisher, K. W., & Lewis, R. E. (2019) · PLoS ONE · doi:10.1371/journal.pone.0209224 · Cited by 44

Circadian Expression of Clock- and Tumor Suppressor Genes in Human Oral Mucosa

Zieker, D., Jenne, I., Koenigsrainer, I., Zdichavsky, M., Nieselt, K., Buck, K., Zieker, J., Beckert, S., Glatzle, J., Spanagel, R., et al. (2010) · Cellular Physiology and Biochemistry · doi:10.1159/000320547 · Cited by 44

Circadian Time-Dependent Tumor Suppressor Function of Period Genes

Yang, X., Wood, P. A., Ansell, C. M., & Hrushesky, W. J. M. (2009) · Integrative Cancer Therapies · doi:10.1177/1534735409352083 · Cited by 45

Sleep Disruption and Cancer: Chicken or the Egg?

Berisha, A., Shutkind, K., & Borniger, J. C. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.856235 · Cited by 44

Direct Transcriptional Control of a p38 MAPK Pathway by the Circadian Clock in Neurospora crassa

Lamb, T. M., Goldsmith, C. S., Bennett, L. D., Finch, K. E., & Bell‐Pedersen, D. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027149 · Cited by 41

Circadian (De)regulation in Head and Neck Squamous Cell Carcinoma

Rahman, S., Pavelić, S. K., & Markova-Car, E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112662 · Cited by 41

BMAL1 Knockdown Leans Epithelial–Mesenchymal Balance toward Epithelial Properties and Decreases the Chemoresistance of Colon Carcinoma Cells

Zhang, Y., Devocelle, A., Desterke, C., de Souza, L. E. B., Hadadi, É., Acloque, H., Foudi, A., Xiang, Y., Ballesta, A., Chang, Y., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105247 · Cited by 41

Melatonin in animal models

Pévet, P. (2003) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2003.5.4/ppevet · Cited by 41

The Symphony of Life [Chronobiological Investigations]

Moser, M., Frühwirth, M., & Kenner, T. (2008) · IEEE Engineering in Medicine and Biology Magazine · doi:10.1109/memb.2007.907365 · Cited by 41

Communication between circadian clusters: The key to a plastic network

Beckwith, E. J., & Ceriani, M. F. (2015) · FEBS Letters · doi:10.1016/j.febslet.2015.08.017 · Cited by 40

Inherited variation in circadian rhythm genes and risks of prostate cancer and three other cancer sites in combined cancer consortia

Gu, F., Zhang, H., Hyland, P. L., Berndt, S. I., Gapstur, S. M., Wheeler, W., Amos, C. I., Bezieau, S., Bickeböller, H., Brenner, H., et al. (2017) · International Journal of Cancer · doi:10.1002/ijc.30883 · Cited by 43

Chronotype and postmenopausal breast cancer risk among women in the California Teachers Study

Hurley, S. E., Goldberg, D. E., Behren, J. V., DeHart, J. C., Wang, S., & Reynolds, P. (2019) · Chronobiology International · doi:10.1080/07420528.2019.1658113 · Cited by 40

Preventive and curative effect of melatonin on mammary carcinogenesis induced by dimethylbenz[a]anthracene in the female Sprague–Dawley rat

Lenoir, V., Canonico, M., Perrin, M.-H., Martin, A., Scholler, R., & Kerdelhué, B. (2005) · Breast Cancer Research · doi:10.1186/bcr1031 · Cited by 40

The Impact of HIF1α on the Per2 Circadian Rhythm in Renal Cancer Cell Lines

Okabe, T., Kumagai, M., Nakajima, Y., Shirotake, S., Kodaira, K., Oyama, M., Ueno, M., & Ikeda, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109693 · Cited by 39

The Effect of Light Exposure at Night (LAN) on Carcinogenesis via Decreased Nocturnal Melatonin Synthesis

Giudice, A., Crispo, A., Grimaldi, M., Polo, A., Bimonte, S., Capunzo, M., Amore, A., D'Arena, G. F., Cerino, P., Budillon, A., et al. (2018) · Molecules · doi:10.3390/molecules23061308 · Cited by 40

The days and nights of cancer cells.

Canaple, L., Kakizawa, T., & Laudet, V. (2003) · PubMed · Cited by 108

The tumour suppressing role of the circadian clock

Davis, K. T., Roden, L. C., Leaner, V. D., & van der Watt, P. J. (2019) · IUBMB Life · doi:10.1002/iub.2005 · Cited by 36

Circadian rhythm and its role in malignancy

Rana, S., & Mahmood, S. (2010) · Journal of Circadian Rhythms · doi:10.1186/1740-3391-8-3 · Cited by 113

Circadian Disruption as a Driver of Carcinogenesis: Advances in Mechanistic Understanding

Jiao, D. (2025) · MedScien · doi:10.61173/xghg2k98

Circadian Clock, Cell Division, and Cancer: From Molecules to Organism

Shostak, A. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040873 · Cited by 169