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The circadian clock: pacemaker and tumour suppressor
Abstract
The circadian rhythms are daily oscillations in various biological processes that are regulated by an endogenous clock. Disruption of these rhythms has been associated with cancer in humans. One of the cellular processes that is regulated by circadian rhythm is cell proliferation, which often shows asynchrony between normal and malignant tissues. This asynchrony highlights the importance of the circadian clock in tumour suppression in vivo and is one of the theoretical foundations for cancer chronotherapy. Investigation of the mechanisms by which the circadian clock controls cell proliferation and other cellular functions might lead to new therapeutic targets.
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“The circadian system and its prime marker, melatonin, are considered to have antitumor effects through multiple pathways, including antioxidant activity, anti-inflammatory effects, and immune enhancement.33-37”
From Total and Cause-Specific Mortality of U.S. Nurses Working Rotating Night Shifts (2015) · cites this paper as [35]
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Metadata
- Authors
- Fu, L., & Lee, C. C.
- Affiliations
- Baylor College of Medicine (US)
- Corresponding author
- Lee, Cheng Chi
- Venue
- Nature reviews. Cancer
- Published
- 2003-05-01
- Volume
- 3
- Issue
- 5
- Pages
- 350-361
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W1997364930
- Cited by
- 678
- References
- 200
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 16 · 2023: 25 · 2022: 25 · 2021: 21 · 2020: 26 · 2019: 33 · 2018: 42 · 2017: 36 · 2016: 29 · 2015: 37 · 2014: 34 · 2013: 44 · 2012: 42
- FWCI
- 3.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- circadian clock, circadian rhythm, tumor suppression, cell proliferation, cancer chronotherapy, circadian rhythm disruption, cancer, therapeutic target
- MeSH terms
- Animals, Biological Clocks, Circadian Rhythm, Eye Proteins, Humans, Neoplasms, Suprachiasmatic Nucleus, Tumor Suppressor Protein p53, Proto-Oncogene Proteins c-myc
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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